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Conserved domains on  [gi|528489162|ref|XP_005167466|]
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integrin alpha-6 isoform X1 [Danio rerio]

Protein Classification

integrin alpha( domain architecture ID 12192626)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 476-939 1.44e-158

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 477.58  E-value: 1.44e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   476 VISIKKDIKVTPKEIDLTKKTCG----NSICLTVEACFSYRANPTtYNPKITISCTFEAEWYRRKlGLPSRVVFLDktei 551
Cdd:pfam08441    3 VVSVSASLQVEPNSINPEKKNCTltgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   552 DQDYQSTGTLELRGQNKKACYKTKLRLQDGIRDKLRAIPIEVSVAIQsaKRGKRQSSLPQLVPILDSTVPNKTLTEVNFL 631
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   632 KEgCGTDNICQSNLNLQYRFCYRESKQDIfpplplengvpviSLSDQKDIALEVTVRNRnGDDAHEAKLVSHFDDSLSYS 711
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESDEPL-------------LLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   712 GFRSLrTNDKHVICAANQNGS--LADCELGNPFKRDSEVTFYIILSTGKISLETKEVEIDLQLETTSSQEG-LSKVKAKA 788
Cdd:pfam08441  220 GVRRE-GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSnSNPVSLKV 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   789 KVVIELLLSVQGVAKPSQVyFGGEVKGMSAMK--KEEEVGSLIEYEFRVINLGKPlkSFGTASLNIQWPKESSVGKWLLY 866
Cdd:pfam08441  299 PVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLY 375

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162   867 LMKINTrdLQLVTCSPEREINPLKLREDSSIRKKRELEERRPSEGNKISLFTDKRKH---KILSCSGDARCVEIKC 939
Cdd:pfam08441  376 LLDVQG--QGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-431 6.48e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.02  E-value: 6.48e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162    378 DSMFGLSVENIGDVNLDSFEDIAVGAPYADSG--FGSVYIYHGSADGISTKPAQIL 431
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgeTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-358 6.32e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.91  E-value: 6.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528489162   320 FGYDVAVVDLNGDGWQDVVVGAPQFFQRDeevGGAVYVY 358
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-101 2.85e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.85e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528489162     40 PGSLFGFSIALHRQLQPHDKTILLIGAPKAralsnQGANVTGGLYSCDITTHPNDCSRVDFD 101
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 257-293 1.79e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 528489162    257 ANSYLGFSLDSGHSITEKGKLIIVSGAPRANHS---GAVV 293
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVY 40
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 440-463 4.42e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 4.42e-03
                            10        20
                    ....*....|....*....|....
gi 528489162    440 MFGYSLAGNMDLDHNSYPDLAVGS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 476-939 1.44e-158

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 477.58  E-value: 1.44e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   476 VISIKKDIKVTPKEIDLTKKTCG----NSICLTVEACFSYRANPTtYNPKITISCTFEAEWYRRKlGLPSRVVFLDktei 551
Cdd:pfam08441    3 VVSVSASLQVEPNSINPEKKNCTltgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   552 DQDYQSTGTLELRGQNKKACYKTKLRLQDGIRDKLRAIPIEVSVAIQsaKRGKRQSSLPQLVPILDSTVPNKTLTEVNFL 631
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   632 KEgCGTDNICQSNLNLQYRFCYRESKQDIfpplplengvpviSLSDQKDIALEVTVRNRnGDDAHEAKLVSHFDDSLSYS 711
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESDEPL-------------LLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   712 GFRSLrTNDKHVICAANQNGS--LADCELGNPFKRDSEVTFYIILSTGKISLETKEVEIDLQLETTSSQEG-LSKVKAKA 788
Cdd:pfam08441  220 GVRRE-GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSnSNPVSLKV 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   789 KVVIELLLSVQGVAKPSQVyFGGEVKGMSAMK--KEEEVGSLIEYEFRVINLGKPlkSFGTASLNIQWPKESSVGKWLLY 866
Cdd:pfam08441  299 PVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLY 375

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162   867 LMKINTrdLQLVTCSPEREINPLKLREDSSIRKKRELEERRPSEGNKISLFTDKRKH---KILSCSGDARCVEIKC 939
Cdd:pfam08441  376 LLDVQG--QGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-431 6.48e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.02  E-value: 6.48e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162    378 DSMFGLSVENIGDVNLDSFEDIAVGAPYADSG--FGSVYIYHGSADGISTKPAQIL 431
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgeTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-358 6.32e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.91  E-value: 6.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528489162   320 FGYDVAVVDLNGDGWQDVVVGAPQFFQRDeevGGAVYVY 358
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 318-368 6.02e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 6.02e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 528489162    318 SSFGYDVA-VVDLNGDGWQDVVVGAPQFFQRDEevGGAVYVYINKA--GRWRDV 368
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSggGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-101 2.85e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.85e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528489162     40 PGSLFGFSIALHRQLQPHDKTILLIGAPKAralsnQGANVTGGLYSCDITTHPNDCSRVDFD 101
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 381-416 1.91e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.50  E-value: 1.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528489162   381 FGLSVEnIGDVNLDSFEDIAVGAPYAD-SGFGSVYIY 416
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGgAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 257-293 1.79e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 528489162    257 ANSYLGFSLDSGHSITEKGKLIIVSGAPRANHS---GAVV 293
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVY 40
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 440-463 4.42e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 4.42e-03
                            10        20
                    ....*....|....*....|....
gi 528489162    440 MFGYSLAGNMDLDHNSYPDLAVGS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 476-939 1.44e-158

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 477.58  E-value: 1.44e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   476 VISIKKDIKVTPKEIDLTKKTCG----NSICLTVEACFSYRANPTtYNPKITISCTFEAEWYRRKlGLPSRVVFLDktei 551
Cdd:pfam08441    3 VVSVSASLQVEPNSINPEKKNCTltgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   552 DQDYQSTGTLELRGQNKKACYKTKLRLQDGIRDKLRAIPIEVSVAIQsaKRGKRQSSLPQLVPILDSTVPNKTLTEVNFL 631
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   632 KEgCGTDNICQSNLNLQYRFCYRESKQDIfpplplengvpviSLSDQKDIALEVTVRNRnGDDAHEAKLVSHFDDSLSYS 711
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESDEPL-------------LLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   712 GFRSLrTNDKHVICAANQNGS--LADCELGNPFKRDSEVTFYIILSTGKISLETKEVEIDLQLETTSSQEG-LSKVKAKA 788
Cdd:pfam08441  220 GVRRE-GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSnSNPVSLKV 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528489162   789 KVVIELLLSVQGVAKPSQVyFGGEVKGMSAMK--KEEEVGSLIEYEFRVINLGKPlkSFGTASLNIQWPKESSVGKWLLY 866
Cdd:pfam08441  299 PVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLY 375

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162   867 LMKINTrdLQLVTCSPEREINPLKLREDSSIRKKRELEERRPSEGNKISLFTDKRKH---KILSCSGDARCVEIKC 939
Cdd:pfam08441  376 LLDVQG--QGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-431 6.48e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.02  E-value: 6.48e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 528489162    378 DSMFGLSVENIGDVNLDSFEDIAVGAPYADSG--FGSVYIYHGSADGISTKPAQIL 431
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgeTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-358 6.32e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.91  E-value: 6.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528489162   320 FGYDVAVVDLNGDGWQDVVVGAPQFFQRDeevGGAVYVY 358
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 318-368 6.02e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 6.02e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 528489162    318 SSFGYDVA-VVDLNGDGWQDVVVGAPQFFQRDEevGGAVYVYINKA--GRWRDV 368
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSggGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-101 2.85e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.85e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528489162     40 PGSLFGFSIALHRQLQPHDKTILLIGAPKAralsnQGANVTGGLYSCDITTHPNDCSRVDFD 101
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 328-401 5.45e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.61  E-value: 5.45e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528489162   328 DLNGDGWQDVVVGAPqffqrdeevgGAVYVYINKA-GRWRDVTPVRLNGTKDSMfglSVEnIGDVNLDSFEDIAV 401
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNGdGTFTFITSVSLGGGGGGL---SVA-VGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 381-416 1.91e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.50  E-value: 1.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528489162   381 FGLSVEnIGDVNLDSFEDIAVGAPYAD-SGFGSVYIY 416
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGgAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 257-293 1.79e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 528489162    257 ANSYLGFSLDSGHSITEKGKLIIVSGAPRANHS---GAVV 293
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVY 40
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 440-463 4.42e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 4.42e-03
                            10        20
                    ....*....|....*....|....
gi 528489162    440 MFGYSLAGNMDLDHNSYPDLAVGS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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