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    NUA nuclear pore anchor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844268, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUA
    Official Full Name
    nuclear pore anchor
    Primary source
    TAIR:AT1G79280
    Locus tag
    AT1G79280
    See related
    Araport:AT1G79280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTPR; nuclear pore anchor; TRANSLOCATED PROMOTER REGION; YUP8H12R.12; YUP8H12R_12
    Summary
    Encodes a 237-kDA protein with similarity to vertebrate Tpr, a long coiled-coil proteins of nuclear pore inner basket filaments. It is localized to the inner surface of the nuclear envelope and is a component of the nuclear pore-associated steps of sumoylation and mRNA export in plants. Mutations affect flowering time regulation and other developmental processes. Probably acts in the same pathway as ESD4 in affecting flowering time, vegetative and inflorescence development.
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    Genomic context

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    See NUA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    49
    Sequence:
    Chromosome: 1; NC_003070.9 (29818970..29833016, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene AGC kinase 1.7 Neighboring gene nitrobindin heme-binding domain protein Neighboring gene evolutionarily conserved C-terminal region 8 Neighboring gene tRNA-Lys Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NUCLEAR PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/megator, is involved in mRNA export and SUMO homeostasis and affects diverse aspects of plant development. Xu XM, et al. Plant Cell, 2007 May. PMID 17513499, Free PMC Article
    2. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis. Xie B, et al. New Phytol, 2024 Jan. PMID 37786257,
    3. Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA. Ding D, et al. Plant Mol Biol, 2012 Jun. PMID 22457071
    4. bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis. Frerigmann H, et al. Plant Physiol, 2014 Sep. PMID 25049362, Free PMC Article
    5. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
      Title: NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
    2. Data suggest that NUA scaffolds AtMAD1 and AtMAD2 at the nuclear pore to form a functional complex and that both NUA and AtMAD2 suppress premature exit from cell division at the Arabidopsis root meristem.
      Title: Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA.
    3. These data indicate that NUA is a component of nuclear pore-associated steps of sumoylation and mRNA export in plants and that defects in these processes affect the signaling events of flowering time regulation and additional developmental processes.[NUA]
      Title: NUCLEAR PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/megator, is involved in mRNA export and SUMO homeostasis and affects diverse aspects of plant development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198506.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stamen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    nuclear pore anchor
    NP_001185435.1
    • nuclear pore anchor (NUA); CONTAINS InterPro DOMAIN/s: Tetratricopeptide, MLP1/MLP2-like (InterPro:IPR012929).
    NP_001185436.1
    • nuclear pore anchor (NUA); CONTAINS InterPro DOMAIN/s: Tetratricopeptide, MLP1/MLP2-like (InterPro:IPR012929).
    NP_178048.2
    • nuclear pore anchor (NUA); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: poly(A)+ mRNA export from nucleus, stamen development, negative regulation of protein sumoylation, negative regulation of flower development; LOCATED IN: cytosol, nuclear envelope, nucleolus, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide, MLP1/MLP2-like (InterPro:IPR012929); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29818970..29833016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106578.3 → NP_178048.2  nuclear pore anchor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178048.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4GSN8, F4IDK8, F4IDK9, O64521, O64522, O64524, O64525, Q8H7F1
      UniProtKB/TrEMBL
      A0A178W7V3, A0A654ERY6
      Conserved Domains (4) summary
      PTZ00121
      Location:1224 → 1984
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:715 → 1557
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:243 → 1102
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07926
      Location:1044 → 1171
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein

    2. NM_001198507.1 → NP_001185436.1  nuclear pore anchor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7V3
      Conserved Domains (3) summary
      COG1196
      Location:50 → 920
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07851
      Location:1363 → 1483
      TMPIT; TMPIT-like protein
      pfam07926
      Location:1066 → 1193
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein

    3. NM_001198506.1 → NP_001185435.1  nuclear pore anchor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7V3
      Conserved Domains (3) summary
      TIGR02168
      Location:411 → 1143
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07851
      Location:1342 → 1462
      TMPIT; TMPIT-like protein
      pfam07926
      Location:1045 → 1172
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4GSN8.1

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