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    NIP6;1 NOD26-like intrinsic protein 6;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844415, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIP6;1
    Official Full Name
    NOD26-like intrinsic protein 6;1
    Primary source
    TAIR:AT1G80760
    Locus tag
    AT1G80760
    See related
    Araport:AT1G80760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNIP6; F23A5.11; F23A5_11; NIP6; NLM7; NOD26-like intrinsic protein 6;1
    Summary
    Encodes a protein with boron transporter activity. It helps to preferentially direct boron to young developing tissues in the shoot, such as immature leaves, under low boron conditions. This boron channel appears to be impermeable to water, unlike the closely related NIP5;1 boron transporter. This protein also allows the transport of glycerol, urea, and formimide but not larger uncharged solutes such as arabitol and sucrose when it is expressed heterologously.
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    Genomic context

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    See NIP6;1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (30350539..30352208, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene chromomethylase 1 Neighboring gene Transcription factor TFIIIC, tau55-related protein Neighboring gene Ribosomal protein L30/L7 family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct transport selectivity of two structural subclasses of the nodulin-like intrinsic protein family of plant aquaglyceroporin channels. Wallace IS, et al. Biochemistry, 2005 Dec 27. PMID 16363796
    2. NIP6;1 is a boric acid channel for preferential transport of boron to growing shoot tissues in Arabidopsis. Tanaka M, et al. Plant Cell, 2008 Oct. PMID 18952773, Free PMC Article
    3. A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes. Bienert GP, et al. BMC Biol, 2008 Jun 10. PMID 18544156, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NIP6;1 is involved in xylem-phloem transfer of boric acid at the nodal regions and the water-tight property of NIP6;1 is important for this function.
      Title: NIP6;1 is a boric acid channel for preferential transport of boron to growing shoot tissues in Arabidopsis.
    2. Nodulin26-like Intrinsic Proteins (NIPs) AtNIP5;1 and AtNIP6;1 from Arabidopsis thaliana are bi-directional As(III) channels [Nodulin26-like Intrinsic Proteins (NIPs)] [AtNIP6;1]
      Title: A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes.
    3. Data show that alanine residue of water-impermeable glyceroporins (AtNIP6;1) in helix 2 position (H2) can predict the transport profile for water and glycerol.
      Title: Distinct transport selectivity of two structural subclasses of the nodulin-like intrinsic protein family of plant aquaglyceroporin channels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106724.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables active borate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables urea transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables water transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within borate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to boron-containing substance levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NOD26-like intrinsic protein 6;1
    NP_178191.1
    • NOD26-like intrinsic protein 6;1 (NIP6;1); CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like intrinsic protein 5;1 (TAIR:AT4G10380.1); Has 10266 Blast hits to 10221 proteins in 2131 species: Archae - 103; Bacteria - 5136; Metazoa - 1354; Fungi - 440; Plants - 2031; Viruses - 2; Other Eukaryotes - 1200 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30350539..30352208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106724.3 → NP_178191.1  NOD26-like intrinsic protein 6;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5PP68, Q9SAI4
      UniProtKB/TrEMBL
      A0A5S9WW53, A0A654EQT6
      Conserved Domains (1) summary
      PLN00026
      Location:1 → 305
      PLN00026; aquaporin NIP; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAI4.1

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