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    PIE1 SNF2 domain-containing protein / helicase domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820463, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIE1
    Official Full Name
    SNF2 domain-containing protein / helicase domain-containing protein
    Primary source
    TAIR:AT3G12810
    Locus tag
    AT3G12810
    See related
    Araport:AT3G12810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    chr13; PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1; SRCAP
    Summary
    Encodes a protein similar to ATP-dependent, chromatin-remodeling proteins of the ISWI and SWI2/SNF2 family. Genetic analyses suggest that this gene is involved in multiple flowering pathways. Mutations in PIE1 results in suppression of FLC-mediated delay of flowering and causes early flowering in noninductive photoperiods independently of FLC. PIE1 is required for expression of FLC in the shoot apex but not in the root.Along with ARP6 forms a complex to deposit modified histone H2A.Z at several loci within the genome. This modification alters the expression of the target genes (i.e. FLC, MAF4, MAF6).
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    Genomic context

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    See PIE1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Sequence:
    Chromosome: 3; NC_003074.8 (4065042..4074194)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme family protein Neighboring gene phosphoglycerate kinase 1 Neighboring gene short-chain dehydrogenase-reductase B Neighboring gene myb domain protein 10 Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PIE1, an ISWI family gene, is required for FLC activation and floral repression in Arabidopsis. Noh YS, et al. Plant Cell, 2003 Jul. PMID 12837955, Free PMC Article
    2. Actin-Related Protein 4 Interacts with PIE1 and Regulates Gene Expression in Arabidopsis. Nie WF, et al. Genes (Basel), 2021 Apr 2. PMID 33918349, Free PMC Article
    3. The Arabidopsis SWR1 chromatin-remodeling complex is important for DNA repair, somatic recombination, and meiosis. Rosa M, et al. Plant Cell, 2013 Jun. PMID 23780875, Free PMC Article
    4. SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6. March-Díaz R, et al. Plant Physiol, 2007 Feb. PMID 17142478, Free PMC Article
    5. Histone H2A.Z and homologues of components of the SWR1 complex are required to control immunity in Arabidopsis. March-Díaz R, et al. Plant J, 2008 Feb. PMID 17988222

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Actin-Related Protein 4 Interacts with PIE1 and Regulates Gene Expression in Arabidopsis.
      Title: Actin-Related Protein 4 Interacts with PIE1 and Regulates Gene Expression in Arabidopsis.
    2. Data indicate that mutations in genes for SWR1 complex subunits photoperiod-independent Early Flowering1 (PIE1), actin-related protein6 (ARP6), and SWR1 complex6 (SWC6) cause hypersensitivity to various DNA damaging agents.
      Title: The Arabidopsis SWR1 chromatin-remodeling complex is important for DNA repair, somatic recombination, and meiosis.
    3. Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through full activation of FLOWERING LOCUS C
      Title: Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development.
    4. The identification and characterization of SERRATED LEAVES AND EARLY FLOWERING (SEF) in A. thaliana and its interactions with other proteins, including ATARP6 and PIE1, are reported.
      Title: SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338008.1
    NM_112117.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within petal development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within petal formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    SNF2 domain-containing protein / helicase domain-containing protein
    NP_187887.3
    • PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1); FUNCTIONS IN: helicase activity, DNA binding, ATP binding, nucleic acid binding; INVOLVED IN: in 6 processes; LOCATED IN: SWI/SNF complex, cell wall, chromatin remodeling complex; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: HSA (InterPro:IPR006562), HAS subgroup (InterPro:IPR013999), Helicase/SANT-associated, DNA binding (InterPro:IPR014012), SNF2-related (InterPro:IPR000330), MYB-like (InterPro:IPR017877), SANT, DNA-binding (InterPro:IPR001005), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: INO80 ortholog (TAIR:AT3G57300.1); Has 42311 Blast hits to 26312 proteins in 2357 species: Archae - 246; Bacteria - 10217; Metazoa - 11172; Fungi - 7336; Plants - 2916; Viruses - 500; Other Eukaryotes - 9924 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4065042..4074194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112117.5 → NP_187887.3  SNF2 domain-containing protein / helicase domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187887.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7X9V2, Q9LTV5
      UniProtKB/TrEMBL
      A0A5S9XBS4, A0A654F7V3
      Conserved Domains (3) summary
      smart00573
      Location:36 → 106
      HSA; domain in helicases and associated with SANT domains
      COG0553
      Location:529 → 1230
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18003
      Location:536 → 758
      DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP

    2. NM_001338008.1 → NP_001326839.1  SNF2 domain-containing protein / helicase domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQH7, A0A5S9XBS4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7X9V2.1

    Gene LinkOut

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