U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827695, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT4G19530
    Locus tag
    AT4G19530
    See related
    Araport:AT4G19530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24J7.90; F24J7_90
    Summary
    Encodes a TIR-NB-LRR resistance protein. Transient expression in tobacco induces cell death.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (10651744..10657282)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) Neighboring gene disease resistance protein (TIR-NBS-LRR class) family Neighboring gene zinc ion binding / transcription regulator Neighboring gene INDH1(iron-sulfur protein required for NADH dehydrogenase) Neighboring gene Cyclin family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction. Swiderski MR, et al. Mol Plant Microbe Interact, 2009 Feb. PMID 19132868
    2. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
    3. Identification and dynamics of Arabidopsis adaptor protein-2 complex and its involvement in floral organ development. Yamaoka S, et al. Plant Cell, 2013 Aug. PMID 23975897, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_118073.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response-activating signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    disease resistance protein (TIR-NBS-LRR class) family
    NP_193688.1
    • disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: defense response signaling pathway, resistance gene-dependent, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G45250.1); Has 17572 Blast hits to 11989 proteins in 539 species: Archae - 6; Bacteria - 936; Metazoa - 1722; Fungi - 81; Plants - 14067; Viruses - 2; Other Eukaryotes - 758 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10651744..10657282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341356.1 → NP_001328514.1  disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B4W0, O49471
      UniProtKB/TrEMBL
      A0A5S9XU29, A0A654FRB5
      Conserved Domains (2) summary
      PLN03210
      Location:15 → 1125
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:714 → 735
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_118073.2 → NP_193688.1  disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FRB5
      Conserved Domains (3) summary
      PLN03210
      Location:15 → 1103
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:714 → 735
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:15 → 178
      TIR; TIR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49471.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.