U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    iars1 isoleucyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 334393, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    iars1provided by ZNC
    Official Full Name
    isoleucyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6325
    See related
    Ensembl:ENSDARG00000007955 AllianceGenome:ZFIN:ZDB-GENE-030131-6325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    iars; fi46h05; zgc:63790; wu:fi46h05
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Acts upstream of or within regulation of sprouting angiogenesis. Is expressed in several structures, including brain; digestive system; optic cup; pectoral fin bud; and swim bladder. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See iars1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1337620..1392468, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1311032..1365880, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 11b Neighboring gene ATPase plasma membrane Ca2+ transporting 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ribosomal protein L29

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biallelic IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy. Kopajtich R, et al. Am J Hum Genet, 2016 Aug 4. PMID 27426735, Free PMC Article
    2. Compound heterozygous variations in IARS1 cause recurrent liver failure and growth retardation in a Chinese patient: a case report. Zou TT, et al. BMC Pediatr, 2022 Jun 7. PMID 35668413, Free PMC Article
    3. Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Castranova D, et al. Arterioscler Thromb Vasc Biol, 2016 Apr. PMID 26821951, Free PMC Article
    4. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004
    5. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in isoleucyl tRNA synthetase (iars(y68)) leads to increased branching angiogenesis in developing zebrafish.
      Title: Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    NP_956190.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199896.2 → NP_956190.2  isoleucine--tRNA ligase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      CABZ01073866, CABZ01073867, CABZ01073868, CABZ01073869, CABZ01073870, CABZ01073871, CABZ01073872, CABZ01073873, CABZ01073874, CABZ01073875, CABZ01073876, EH583791, EH601215
      UniProtKB/TrEMBL
      A0A8N7UZX0
      Related
      ENSDARP00000009149.9, ENSDART00000004423.10
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:39 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:11 → 1070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      1337620..1392468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools