gnai2a guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnai2aprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8365
See related: Ensembl:ENSDARG00000018174 AllianceGenome:ZFIN:ZDB-GENE-030131-8365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Gnai2; gnai2l; zgc:92609; wu:fb10b04; wu:fb19c04
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled adenosine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in centrosome. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including head; nervous system; paraxial mesoderm; pronephric duct; and vein. Orthologous to human GNAI2 (G protein subunit alpha i2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (34921492..35042194)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (34659499..34780201)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb19c04.x1 (e-PCR)
- UniSTS:203032

fb10b04.x1 (e-PCR)
- UniSTS:202797

fk31h09.y1 (e-PCR)
- UniSTS:200812

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(i) subunit alpha-2a

Names: Galpha i2b; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001818.2 → NP_001001818.1 guanine nucleotide-binding protein G(i) subunit alpha-2a

See identical proteins and their annotated locations for NP_001001818.1

Status: PROVISIONAL

Source sequence(s)

BC076100

UniProtKB/TrEMBL

A8WGL6, Q6TNT8

Related

ENSDARP00000106050.2, ENSDART00000128070.3

Conserved Domains (2) summary

cd00066
Location:34 → 349

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:14 → 353

G_alpha; G protein alpha subunit