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gnai2a guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a [ Danio rerio (zebrafish) ]

Gene ID: 336421, updated on 9-Dec-2024

Summary

Official Symbol
gnai2aprovided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8365
See related
Ensembl:ENSDARG00000018174 AllianceGenome:ZFIN:ZDB-GENE-030131-8365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Gnai2; gnai2l; zgc:92609; wu:fb10b04; wu:fb19c04
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled adenosine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in centrosome. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including head; nervous system; paraxial mesoderm; pronephric duct; and vein. Orthologous to human GNAI2 (G protein subunit alpha i2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See gnai2a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (34921492..35042194)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (34659499..34780201)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC560659 Neighboring gene solute carrier family 38 member 3a Neighboring gene uncharacterized LOC137496719 Neighboring gene inka box actin regulator 1a Neighboring gene uncharacterized LOC137496720

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor binding  
enables G-protein beta/gamma-subunit complex binding  
enables G-protein beta/gamma-subunit complex binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity  
enables guanyl nucleotide binding  
enables nucleotide binding  
Component Evidence Code Pubs
located_in centrosome  
is_active_in cytoplasm  
part_of heterotrimeric G-protein complex  

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-2a
Names
Galpha i2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001818.2NP_001001818.1  guanine nucleotide-binding protein G(i) subunit alpha-2a

    See identical proteins and their annotated locations for NP_001001818.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076100
    UniProtKB/TrEMBL
    A8WGL6, Q6TNT8
    Related
    ENSDARP00000106050.2, ENSDART00000128070.3
    Conserved Domains (2) summary
    cd00066
    Location:34349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:14353
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    34921492..35042194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394823.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    161979..244531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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