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    jag1b jagged canonical Notch ligand 1b [ Danio rerio (zebrafish) ]

    Gene ID: 140423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jag1bprovided by ZNC
    Official Full Name
    jagged canonical Notch ligand 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011128-4
    See related
    Ensembl:ENSDARG00000013168 AllianceGenome:ZFIN:ZDB-GENE-011128-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kmi; puc; jag3; unp1069
    Summary
    Predicted to enable Notch binding activity. Acts upstream of or within several processes, including exocrine pancreas development; face morphogenesis; and inner ear development. Predicted to be located in plasma membrane. Is expressed in several structures, including digestive system; endocrine system; nervous system; otic vesicle; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jag1b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35339182..35390095)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35213350..35264263)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882067 Neighboring gene uncharacterized LOC137487338 Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC137487424 Neighboring gene MKKS centrosomal shuttling protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b. Gwak JW, et al. Mol Cells, 2010 Aug. PMID 20680491
    2. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Bai MR, et al. Front Genet, 2023. PMID 37255715, Free PMC Article
    3. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance. Colombo M, et al. Haematologica, 2020 Jul. PMID 31582544, Free PMC Article
    4. Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Obholzer N, et al. Development, 2012 Nov. PMID 23052906, Free PMC Article
    5. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Vieira NM, et al. Cell, 2015 Nov 19. PMID 26582133, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
      Title: Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
    2. Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
      Title: Endoderm Jagged induces liver and pancreas duct lineage in zebrafish.
    3. Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue.
      Title: Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish.
    4. Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
      Title: Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b.
    5. Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
      Title: Expression analysis of jagged genes in zebrafish embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cranial skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within face morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hepaticobiliary system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intrahepatic bile duct development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pancreas development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within semicircular canal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within semicircular canal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein jagged-1b
    Names
    jagged 1b
    jagged3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131863.2 → NP_571938.2  protein jagged-1b precursor

      Status: VALIDATED

      Source sequence(s)
      CU138575
      UniProtKB/Swiss-Prot
      Q90Y54
      UniProtKB/TrEMBL
      A0A8M1PCD3, F1R986
      Related
      ENSDARP00000008197.6, ENSDART00000019323.7
      Conserved Domains (5) summary
      smart00215
      Location:860 → 927
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:484 → 520
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:337 → 365
      EGF; EGF-like domain
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:29 → 102
      MNNL; N terminus of Notch ligand

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      35339182..35390095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90Y54.1 GenPept UniProtKB/Swiss-Prot:Q90Y54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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