N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001184326   29 SGHFELEILSMQNANGELQNGACCDGARNPADRKCtRDECDTYFKVCLKEYQSRVSSAGACSFGTGSTPVLGGNKFSTKG 108
Cdd:pfam07657    1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1001184326  109 T--RSEKSRIVLPFSFAWPRSYTLIVEALDFNNET--ASESGKLIEKAYHSGMINPNRQWQRLTHNGPVAQFEYQIRV 182
Cdd:pfam07657   80 LlkGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTdsGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157

von Willebrand factor (vWF) type C domain;

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1001184326   860 CIANGQVTADGAKWEEDCNICQCQNGRIHCTMMWCGPKSCRTGKARGGCPASQSCVPIKEEqCFVKPC 927
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLLHNLSGECPLGQGCVPSLSD-CLSSPC 67

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  447 NINDC--KGQCLNGGTCKDLVNGYRCLCPPGYTGEQCE 482
Cdd:cd00054      1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  817 NINECQS-SPCAFGSTCVDEINGYRCLCPPGRIGPDCQ 853
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1001184326  293 DLNYCGTHQPCLNGGTCSNTgPDKYQCSCEDGYSGVNCE 331
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  779 NTNDC-NPHPCYNSGTCVDGENWYRCECAPGFAGPDC 814
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  409 DANECEDK-PCVNAKSCHNLIGAYFCECLPGWSGQNC 444
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20
                   ....*....|....*....|....*....
gi 1001184326  337 CLSNPCANGGTCKETSQGYECHCAIGWSG 365
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001184326   29 SGHFELEILSMQNANGELQNGACCDGARNPADRKCtRDECDTYFKVCLKEYQSRVSSAGACSFGTGSTPVLGGNKFSTKG 108
Cdd:pfam07657    1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1001184326  109 T--RSEKSRIVLPFSFAWPRSYTLIVEALDFNNET--ASESGKLIEKAYHSGMINPNRQWQRLTHNGPVAQFEYQIRV 182
Cdd:pfam07657   80 LlkGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTdsGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1001184326  184 CLEHYYGFGCNKFCRPRDEFFGHYTCDQNGNKTCLEGWTGPDCNTA 229
Cdd:pfam01414    1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  484 DVDECAS-SPCLNGGRCQDEVNGFQCLCPAGFSGQLCQ 520
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  626 NINDCES-NPCRNGGTCIDKVNVYQCICADGWEGVHCE 662
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  817 NINECQS-SPCAFGSTCVDEINGYRCLCPPGRIGPDCQ 853
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1001184326  293 DLNYCGTHQPCLNGGTCSNTgPDKYQCSCEDGYSGVNCE 331
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  522 DIDYCK-PNPCQNGAQCFNLASDYFCKCPDDYEGKNC 557
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  779 NTNDC-NPHPCYNSGTCVDGENWYRCECAPGFAGPDC 814
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  664 NIDDC-SLNPCLNKGACQDLVNDFYCECRNGWKGKTC 699
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1001184326  375 CTPNQCKHGGTCQDLVNGFKCACPPHWTGKT 405
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1001184326   371 NVDDC-TPNQCKHGGTCQDLVNGFKCACPPHWT-GKTCQ 407
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1001184326  745 CLPNPCENGGTCVVNGDSFNCVCKEGWEGST 775
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.

                           10        20
                   ....*....|....*....|..
gi 1001184326  455 CLNGGTCKDLVNGYRCLCPPGY 476
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20
                   ....*....|....*....|....*....
gi 1001184326  337 CLSNPCANGGTCKETSQGYECHCAIGWSG 365
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20
                   ....*....|....*....|....*....
gi 1001184326  488 CASSPCLNGGRCQDEVNGFQCLCPAGFSG 516
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1001184326  340 NPCANGGTCKETSQGYECHCAIGWSGTSCE 369
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1001184326   664 NIDDC-SLNPCLNKGACQDLVNDFYCECRNGWK-GKTC 699
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1001184326  706 CDEATCNNGGTCHDEGDTFKCRCSPGWEGAT 736
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001184326   29 SGHFELEILSMQNANGELQNGACCDGARNPADRKCtRDECDTYFKVCLKEYQSRVSSAGACSFGTGSTPVLGGNKFSTKG 108
Cdd:pfam07657    1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1001184326  109 T--RSEKSRIVLPFSFAWPRSYTLIVEALDFNNET--ASESGKLIEKAYHSGMINPNRQWQRLTHNGPVAQFEYQIRV 182
Cdd:pfam07657   80 LlkGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTdsGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1001184326  184 CLEHYYGFGCNKFCRPRDEFFGHYTCDQNGNKTCLEGWTGPDCNTA 229
Cdd:pfam01414    1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  484 DVDECAS-SPCLNGGRCQDEVNGFQCLCPAGFSGQLCQ 520
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  626 NINDCES-NPCRNGGTCIDKVNVYQCICADGWEGVHCE 662
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1001184326  817 NINECQS-SPCAFGSTCVDEINGYRCLCPPGRIGPDCQ 853
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1001184326  293 DLNYCGTHQPCLNGGTCSNTgPDKYQCSCEDGYSGVNCE 331
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  522 DIDYCK-PNPCQNGAQCFNLASDYFCKCPDDYEGKNC 557
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  779 NTNDC-NPHPCYNSGTCVDGENWYRCECAPGFAGPDC 814
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1001184326  664 NIDDC-SLNPCLNKGACQDLVNDFYCECRNGWKGKTC 699
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1001184326  375 CTPNQCKHGGTCQDLVNGFKCACPPHWTGKT 405
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1001184326   371 NVDDC-TPNQCKHGGTCQDLVNGFKCACPPHWT-GKTCQ 407
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1001184326  745 CLPNPCENGGTCVVNGDSFNCVCKEGWEGST 775
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.

                           10        20
                   ....*....|....*....|..
gi 1001184326  455 CLNGGTCKDLVNGYRCLCPPGY 476
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20
                   ....*....|....*....|....*....
gi 1001184326  337 CLSNPCANGGTCKETSQGYECHCAIGWSG 365
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                           10        20
                   ....*....|....*....|....*....
gi 1001184326  488 CASSPCLNGGRCQDEVNGFQCLCPAGFSG 516
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1001184326  340 NPCANGGTCKETSQGYECHCAIGWSGTSCE 369
Cdd:cd00054      9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1001184326   779 NTNDC-NPHPCYNSGTCVDGENWYRCECAPGF-AGPDC 814
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1001184326   664 NIDDC-SLNPCLNKGACQDLVNDFYCECRNGWK-GKTC 699
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1001184326  487 ECA-SSPCLNGGRCQDEVNGFQCLCPAGFSGQ 517
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20
                   ....*....|....*....|....*..
gi 1001184326  711 CNNGGTCHDEGDTFKCRCSPGWEGATC 737
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1001184326  631 ESNPCRNGGTCIDKVNVYQCICADGWEGV-HCE 662
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36