rrm1 ribonucleotide reductase M1 polypeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rrm1provided by ZNC
Official Full Name: ribonucleotide reductase M1 polypeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-247
See related: Ensembl:ENSDARG00000014017 AllianceGenome:ZFIN:ZDB-GENE-990415-247
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: r1; cb396; cb838; sb:cb548; CHUNP6866; wu:fb39b07; wu:fi14b02; wu:fk95f07
Summary: Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including immature eye; nervous system; neural tube; presumptive telencephalon; and tail bud. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (30772188..30787414, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (30735190..30750719, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk95f07.x1 (e-PCR)
- UniSTS:201782

RRM1 (e-PCR)
- UniSTS:205426

fb39b07.x1 (e-PCR)
- UniSTS:203186

fj93h03.y1 (e-PCR)
- UniSTS:200379

rrm1 (e-PCR), detects polymorphism
- UniSTS:205518

fi14b02.x1 (e-PCR)
- UniSTS:196837

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyribonucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase large subunit

Names: ribonucleoside-diphosphate reductase subunit M1; ribonucleotide reductase large subunit; ribonucleotide reductase protein r1 class I

NP_571530.2

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131455.2 → NP_571530.2 ribonucleoside-diphosphate reductase large subunit

Status: VALIDATED

Source sequence(s)

BX511168, CT631855, CT676109, EB847840, EH588550

UniProtKB/Swiss-Prot

P79732

UniProtKB/TrEMBL

A0A8M1PC36, F1R2K9

Related

ENSDARP00000010800.7, ENSDART00000012091.9

Conserved Domains (3) summary

cd01679
Location:167 → 741

RNR_I; Class I ribonucleotide reductase

PLN02437
Location:1 → 794

PLN02437; ribonucleoside--diphosphate reductase large subunit

pfam03477
Location:1 → 89

ATP-cone; ATP cone domain