|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-794 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1587.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSDFVDPTQITMKVIQGLYSGVTTVELDTLAAEIAATLTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 81 IAVSNLHKETKKVFSEVMEDLYNYVNPLNSRHSPMISKETLDIVLANKDRLNSAIIYDRDFSYNFFGFKTLERSYLLKIN 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 161 GKVAERPQHMLMRVSVGIHKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMKDDSIEGIYDTLKQCAL 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 241 ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAMYLEPWHFDIFDFLELKKNTGK 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 321 EEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRVVKAQQLWYAIIESQTET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 401 GTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYV-------------------TSERTF 461
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 462 DFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALE 541
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 542 SSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYT 621
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 622 SNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAY 701
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 702 IDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTKPAANPIQFTLNKEKLKETQKTTSSEDEETKERNKAAMVC 781
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETKMAQMVC 800
|
810
....*....|...
gi 568815674 782 SLENRDECLMCGS 794
Cdd:PLN02437 801 SLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-754 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 852.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 85 NLHKETKKVFsevmEDLYNYVNPLNSrhsPMISKETLDivlANKDRLNSAIIYDRDFSYNFFGFKTLERSYLLK-INGKV 163
Cdd:COG0209 1 QLRKEALGQY----KSFSEKIKYVEE---GLYDERLLE---EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 164 AERPQHMLMRVSVGIH-----KEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQC 238
Cdd:COG0209 71 LETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 239 ALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNT 318
Cdd:COG0209 150 ALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 319 GKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRVVKAQQLWYAIIESQT 398
Cdd:COG0209 229 GDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 399 ETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYVTsERTFDFQKLASVTKVIVKNLN 478
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFLD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 479 KIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAG 558
Cdd:COG0209 388 NVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEG 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 559 CPVSKGILQYDMW--EKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEFQ 635
Cdd:COG0209 468 SKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFT 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 636 IVNPHLLKDLTERGLWNEEMKNQiIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIA-E 714
Cdd:COG0209 548 VVNPYLVRALKELGLWDEELVEK-IKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnD 626
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 568815674 715 PNYGKLTSMHFYGWKQGLKTgMYYLRTKPAANPIQFTLNK 754
Cdd:COG0209 627 ATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-741 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 768.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 167 PQHMLMRVSVGIHKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQCALISKSAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 247 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNTGKEEQRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 327 DLFYALWIPDLFMKRVEtngdwslmcpndcpgldecwgeefeklyakyeqegrakrvvkaQQLWYAIIESQTETGTPYML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 407 YKDACNRKSNQQNLGTIKCSNLCTEIVEYTSA-----DEVAVCNLASIALNMYVTsertfdFQKLASVTKVIVKNLNKII 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 482 DINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGpyqtyagcpv 561
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 562 skgilqydmwektptdlwdwaalkekiakhGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 641
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 642 LKDLTERGlwneemknqiiaqngsiqtipaipddlkeLYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIAEP-NYGKL 720
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 568815674 721 TSMHFYGWKQGLKTGmYYLRT 741
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-738 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 747.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 216 SSCFLLaMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLL-SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 296 AFAMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKL-YAKY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 375 EQEGRAKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMY 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 455 VTSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFET 534
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 535 IYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTD------LWDWAALKEKIAKHGVRNSLLLAPMPTASTA 608
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 609 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwneemknqiiaqngsiqtipaipDDLKELYKTVWEISQ 688
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 568815674 689 KTILKMAADRGAYIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 738
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 738.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 145 FFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 218 CFLLAMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 298 AMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQE 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 378 GRAK---RVVKAQQLWYAIIESQTETGTPYMLYKDACNRK-SNQQNLGTIKCSNLCTEIVEYTSAD---EVAVCNLASIA 450
Cdd:TIGR02506 240 VEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 451 LNMYVTsERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQ 530
Cdd:TIGR02506 320 LANFVM-EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 531 IFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDLW-------DWAALKEKIAKHGVRNSLLLAPMP 603
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 604 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTV 683
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 684 WEISQKTILKMAADRGAYIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTK 742
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-794 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1587.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSDFVDPTQITMKVIQGLYSGVTTVELDTLAAEIAATLTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 81 IAVSNLHKETKKVFSEVMEDLYNYVNPLNSRHSPMISKETLDIVLANKDRLNSAIIYDRDFSYNFFGFKTLERSYLLKIN 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 161 GKVAERPQHMLMRVSVGIHKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMKDDSIEGIYDTLKQCAL 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 241 ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAMYLEPWHFDIFDFLELKKNTGK 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 321 EEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRVVKAQQLWYAIIESQTET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 401 GTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYV-------------------TSERTF 461
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 462 DFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALE 541
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 542 SSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYT 621
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 622 SNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAY 701
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 702 IDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTKPAANPIQFTLNKEKLKETQKTTSSEDEETKERNKAAMVC 781
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETKMAQMVC 800
|
810
....*....|...
gi 568815674 782 SLENRDECLMCGS 794
Cdd:PLN02437 801 SLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-754 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 852.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 85 NLHKETKKVFsevmEDLYNYVNPLNSrhsPMISKETLDivlANKDRLNSAIIYDRDFSYNFFGFKTLERSYLLK-INGKV 163
Cdd:COG0209 1 QLRKEALGQY----KSFSEKIKYVEE---GLYDERLLE---EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 164 AERPQHMLMRVSVGIH-----KEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQC 238
Cdd:COG0209 71 LETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 239 ALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNT 318
Cdd:COG0209 150 ALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 319 GKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRVVKAQQLWYAIIESQT 398
Cdd:COG0209 229 GDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 399 ETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYVTsERTFDFQKLASVTKVIVKNLN 478
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFLD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 479 KIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAG 558
Cdd:COG0209 388 NVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEG 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 559 CPVSKGILQYDMW--EKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEFQ 635
Cdd:COG0209 468 SKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFT 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 636 IVNPHLLKDLTERGLWNEEMKNQiIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIA-E 714
Cdd:COG0209 548 VVNPYLVRALKELGLWDEELVEK-IKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnD 626
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 568815674 715 PNYGKLTSMHFYGWKQGLKTgMYYLRTKPAANPIQFTLNK 754
Cdd:COG0209 627 ATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-741 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 768.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 167 PQHMLMRVSVGIHKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQCALISKSAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 247 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNTGKEEQRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 327 DLFYALWIPDLFMKRVEtngdwslmcpndcpgldecwgeefeklyakyeqegrakrvvkaQQLWYAIIESQTETGTPYML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 407 YKDACNRKSNQQNLGTIKCSNLCTEIVEYTSA-----DEVAVCNLASIALNMYVTsertfdFQKLASVTKVIVKNLNKII 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 482 DINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGpyqtyagcpv 561
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 562 skgilqydmwektptdlwdwaalkekiakhGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 641
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 642 LKDLTERGlwneemknqiiaqngsiqtipaipddlkeLYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIAEP-NYGKL 720
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 568815674 721 TSMHFYGWKQGLKTGmYYLRT 741
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-738 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 747.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 216 SSCFLLaMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLL-SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 296 AFAMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKL-YAKY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 375 EQEGRAKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMY 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 455 VTSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFET 534
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 535 IYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTD------LWDWAALKEKIAKHGVRNSLLLAPMPTASTA 608
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 609 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwneemknqiiaqngsiqtipaipDDLKELYKTVWEISQ 688
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 568815674 689 KTILKMAADRGAYIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 738
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 738.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 145 FFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 218 CFLLAMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 298 AMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQE 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 378 GRAK---RVVKAQQLWYAIIESQTETGTPYMLYKDACNRK-SNQQNLGTIKCSNLCTEIVEYTSAD---EVAVCNLASIA 450
Cdd:TIGR02506 240 VEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 451 LNMYVTsERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQ 530
Cdd:TIGR02506 320 LANFVM-EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 531 IFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDLW-------DWAALKEKIAKHGVRNSLLLAPMP 603
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 604 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTV 683
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 684 WEISQKTILKMAADRGAYIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTK 742
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-792 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 670.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGrqERVMFDkiTSRIQKL----CYGLnsDFVDPTQITMKVIQGLYSGVTTVELDTlAAEIAA-TLTTKHPDYA 75
Cdd:PRK07207 149 LNVTLDDG--VRRPLD--MARLRALieeaCEGL--EAVDAEPILAETLKNLYDGVPMDEVYK-ALILAArTLIEKEPNYS 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 76 ILAARIAVSNLHKE-------TKKVFSEVMEDLYNYVNPLNSRHSpmISKETLDIVLANKD--RLNSAIIYDRDFSYNFF 146
Cdd:PRK07207 222 YVTARLLLDTLRREalgflgvPEEVTQAEMATRYAEYFPAFIKKG--IEAELLDPKLAQFDleRLGAALDPERDLQFTYL 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 147 GFKTLERSYLLKINGKVAERPQHMLMRVSVG-----IHKEdiAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLL 221
Cdd:PRK07207 300 GLQTLYDRYFLHVDGTRIELPQAFFMRVAMGlalneIDRE--ARAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCYLT 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 222 AMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYL 301
Cdd:PRK07207 378 TVPDD-LDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCAYL 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 302 EPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQ---EG 378
Cdd:PRK07207 456 ETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAkaaRG 535
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 379 RAK--RVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYVT 456
Cdd:PRK07207 536 EIKlfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIK 615
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 457 SERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIY 536
Cdd:PRK07207 616 DGAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVS 695
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 537 YAALESSCELAAEYGPYQTYAGCPVSKGILQYD-----------MWEKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTA 605
Cdd:PRK07207 696 YYAIWASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTA 775
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 606 STAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWE 685
Cdd:PRK07207 776 TISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFE 855
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 686 ISQKTILKMAADRGAYIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTKPAANPIQFTLNKEKLK----ETQ 761
Cdd:PRK07207 856 VDPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGALNavssGGG 934
|
810 820 830
....*....|....*....|....*....|.
gi 568815674 762 KTTSSEDEETKERNKAAMVCSLENRDeCLMC 792
Cdd:PRK07207 935 GAGGAAAAAAAPPAADPKACSIDDPD-CEAC 964
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-792 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 566.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 3 VIKRDGRQERVMFDKITSRIQKLCYGLnSDFVDPTQITMKVIQGLYSGVTTVELdTLAAEIAATLTT-KHPDYAILAARI 81
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRF-PETTDAALLADMAFANFYSGIKESEV-VLACIMAARANIeKEPDYAFVAAEL 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 82 AVSNLHKET--KKVFSEVMEDLY-----NYV-NPLNSRHSPMISKETLDIvlankdrLNSAIIYDRDFSYNFFGFKTLER 153
Cdd:PRK12365 316 LLDVVYKEAlgKSKYDEDLEEAHkdhfkRYIlEGDTYRLNPELKHYDLDA-------LAEALDLSRDLQFSYMGVQNLYD 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 154 SYLLKINGKVAERPQHMLMRVSVGI----HKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMKDDsIE 229
Cdd:PRK12365 389 RYFNHHEGRRLETPQIFWMRVSMGLalneGQDKTSWAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQDD-LV 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 230 GIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIF 309
Cdd:PRK12365 468 HIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGG-KRKGAVCVYLEVWHLDYE 546
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 310 DFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQ-----EGRAKRVV 384
Cdd:PRK12365 547 DFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERkvdtgEIRLYKKV 626
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 385 KAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYVTSERtFDFQ 464
Cdd:PRK12365 627 EAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDG-LDEE 705
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 465 KLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSC 544
Cdd:PRK12365 706 KLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASS 785
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 545 ELAAEYGPYQTYAGCPVSKGILQYDMWE-----KTPTDLW-------DWAALKEKIAKHGVRNSLLLAPMPTASTAQILG 612
Cdd:PRK12365 786 LLAKERGTYSSYKGSKWDRGYLPIDTIEllkeyRGEANLLmdtssrkDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIG 865
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 613 NNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWEISQKTIL 692
Cdd:PRK12365 866 VTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPEWII 945
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 693 KMAADRGAYIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTKpAANPIQ--FT-LNKEKLKET-QKTTSSED 768
Cdd:PRK12365 946 ECASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSS-AATSVEksFVdINKRGIQPRwMKNKSAST 1023
|
810 820
....*....|....*....|....
gi 568815674 769 EETKERNKAAMVCSLEnrDECLMC 792
Cdd:PRK12365 1024 SIVVERAKKTPVCSLE--EGCESC 1045
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-759 |
5.88e-165 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 498.29 E-value: 5.88e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 3 VIKRDGRQERVMFDKITSRIQKLCYGLNSDFVDPTQITMKVIQGLYSGVTTVELDTLAAEIAATLTTKHPDYAILAARIA 82
Cdd:PRK06539 5 VVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDDPAFDTVAARLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 83 VsnlhketKKVFSEVMEDlynYVNP-----LNSRHSP-MISKETLDIVLANK-------DRLNSAIIYDRDFSYNFFGFK 149
Cdd:PRK06539 85 L-------KKIYKRVLGD---YDSPeelqdLHANHFRrTIEKGVAEGLLDSRlgglfdlERLAAALDPTRDELLKYIGVV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 150 TLERSYLLKI-NGKVAERPQHMLMRVSVGI---HKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMKD 225
Cdd:PRK06539 155 TLNNRYGIRArNGDALEVPQYFWMRIAMGLslnEDDPTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 226 DsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWH 305
Cdd:PRK06539 235 D-IEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYMENWH 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 306 FDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRV-- 383
Cdd:PRK06539 313 MDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYVEQAEAGRIrm 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 384 ---VKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYVTSERt 460
Cdd:PRK06539 393 fkrITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLADGE- 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 461 FDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAAL 540
Cdd:PRK06539 472 LDWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAI 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 541 ESSCELAAEYGPYQTYAGCPVSKGILQYD---MWEK---TPTDL-----WDWAALKEKIaKHGVRNSLLLAPMPTASTAQ 609
Cdd:PRK06539 552 DESADLAAERGAYPNFEGSRWSRGMVPVDsiaLLEAdrgVPVDVnrttrLDWDALRAKV-RGGMRNATLMAIAPTASIGL 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWnEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWEISQK 689
Cdd:PRK06539 631 VAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQLSPY 709
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 690 TILKMAADRGAYIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTKPAANPIQFTLNKEKLKE 759
Cdd:PRK06539 710 AFLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTVKVNKSAE 778
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-742 |
1.09e-144 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 444.56 E-value: 1.09e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSdfVDPTQITMKVIQGLYSGVTTVEL-DTLAAEIAATLTTKHPDYAILAA 79
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEG--VSQSELEVDAKIQFRDGITTEEIqQTLIKTAVDKIDIDRPNWTFVAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 80 RIAVSNL-HKETKKVFSEVMEDlYNYVNPLNSRHSPMIsKETLDIvlankDRLNSAIIYDRDFSYNFFGFKTLERSYLLK 158
Cdd:PRK08447 80 RLFLYDLyHKVSGFTGYNHLKE-YFEKGEKEGRILLGL-KEKYDL-----DDLNAYIKPERDLQFNYLGIKTLYDRYLIK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 159 -INGKVAERPQHMLMRVSVGI---HKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLAMKDDsIEGIYDT 234
Cdd:PRK08447 153 dRNNNPIELPQHMFMAIAMFLaqnELDPQKWAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDN-IEGIFDS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 235 LKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNkRPGAFAMYLEPWHFDIFDFLEL 314
Cdd:PRK08447 232 YKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGAIAVYLEPWHMDISDFIDL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 315 KKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQ-EGRAKRVVKAQQLWYAI 393
Cdd:PRK08447 311 RKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKdEKIIKEYINAKELWKKI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 394 IESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEI------------VEYTSADEV-------------------- 441
Cdd:PRK08447 391 LTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhykikIEFEDGSIEffeeeelvtvdsgitkkakk 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 442 ------------------------AVCNLASIALNMYVTSErtfdfqKLASVTKVIVKNLNKIIDINYYPVKEAENSNKR 497
Cdd:PRK08447 471 itsldslkgkkiyivekekkdgktAVCNLASINLSKINTKE------DIERVVPIAIRMLDNVIDLNFYPNRKVKATNLK 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 498 HRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTD 577
Cdd:PRK08447 545 SRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKK 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 578 L----------WDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPytsnIYTRRV----LSGEFQIVNPHLLK 643
Cdd:PRK08447 625 LvergglfdsaCDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP----VYKRKWfeenLSGLIPVVVPNLSP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 644 DltergLWNeemknqiiaqngsiqtipaipddlkeLYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIA-EPNYGK-LT 721
Cdd:PRK08447 701 E-----TWQ--------------------------YYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKyLN 749
|
810 820
....*....|....*....|.
gi 568815674 722 SMHFYGWKQGLKTgMYYLRTK 742
Cdd:PRK08447 750 EIYTLAWKLGLKS-TYYLRSE 769
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-741 |
1.39e-131 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 409.50 E-value: 1.39e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKitSRIQKLCYGLNSDF--VDPTQITMKVIQGLYSGVTTVE---LDTLAAEIAATLTTKHPDYA 75
Cdd:PRK09209 8 TTWIVKEAGNRKLPFDK--ERLDRYIDQIHAEFpqLDVEDYKRRVFNFVERKESVTAddlVDYLIREAEARVDLEEPEWT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 76 ILAARIAVSNLHKETKK----VFSEVMEDLYNYVNPLNSR--HSPMI----SKETLDivlankdRLNSAIIYDRD--FSY 143
Cdd:PRK09209 86 FFAARLYLNRLYKRASRnrfyDASEKYGSFVGLQESLAERgiYSNDLlkrySKEELI-------EAGKMIDPERDklFTY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 144 NffGFKTLERSYLLK-INGKVAERPQHMLMRVSVGI-HKED----IAAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:PRK09209 159 I--GLYLLADRYLATdSDRNVYELPQERWLTIALYLmQNEPrerrMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 218 CFLLAMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:PRK09209 237 CFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLG-QRKGAI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 298 AMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCP-----GL----DECWGE-EF 367
Cdd:PRK09209 315 AVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLedfyDEKKGDgSF 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 368 EKLYAKYEQEGR-AKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIV----------EYT 436
Cdd:PRK09209 395 REKYEECVADERlSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMqnmsptvmiqEII 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 437 SADEV---------AVCNLASIALNmyvtseRTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQG 507
Cdd:PRK09209 475 SGGQIvitkqpgdfVVCNLSSINLG------RAVTADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 508 LADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGilQYdmWEKTPTDLWDWAALKEK 587
Cdd:PRK09209 549 WHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EY--FERRGYNSPQWDELAAQ 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 588 IAKHGVRNSLLLAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWNEEMKNqiiaqngsiQ 667
Cdd:PRK09209 625 VAENGVRNAYLMAVAPNMSTAQIAGSTASIDP----IYSA----------------------FYYEEKKD---------Y 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 668 TIPAIPDDLKE-----LYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIaePN---YGKLTSMHFYGWKQGLKTgMYYL 739
Cdd:PRK09209 670 RRPVTAPDLSLdtwpyYEKGAYKVDQFWSIRQNAARQRHVDQSISFNFYV--PStirASELLDLHMTAWKEGLKT-TYYV 746
|
..
gi 568815674 740 RT 741
Cdd:PRK09209 747 RS 748
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
126-792 |
7.51e-126 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 389.32 E-value: 7.51e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 126 ANKDRLNSAIIYDRDFSYNFFGFKTLERSYLLKingkvAERPQHMLMRVSVGIHKEDIAAAIETYNLLSEKWFTHASPTL 205
Cdd:PRK09102 4 QNKLVFQINIDRSRDAWLTEFGKATLRDRYLLE-----GESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 206 FNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIaGTNGNSNGLVPMLRVYNNTARY 285
Cdd:PRK09102 79 SNGGTDRGLPISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDSLTLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 286 VDQGGNKRpGAFAMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDcpgldecwge 365
Cdd:PRK09102 157 ISQGSLRR-GSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPKD---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 366 efeklyakyeqeGRAKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRK--SNQQNLG-TIKCSNLCTEI-----VEYTS 437
Cdd:PRK09102 226 ------------KSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDHLG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 438 ADEVAVCNLASiaLNMYvtserTFDFQKlasVTKVIVKNLNKIID------INYYP--VKEAENSNKRHRPIGIGVQGLA 509
Cdd:PRK09102 294 EDRTAVCCLSS--LNLE-----YYDEWK---DTDAFIEDLMRFLDnvlqdfIDKAPdeMERAKYSAMRERSVGLGVMGFH 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 510 DAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPyqtyagCPVSKGilqYDMWEktptdlwdwaalkekia 589
Cdd:PRK09102 364 SYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGE------CPDAAG---YGVMR----------------- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 590 khgvRNSLLLAPMPTASTAQILGN-NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQT 668
Cdd:PRK09102 418 ----RFSTKMAIAPTASISIILGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQH 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 669 IPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTgMYYLRTKPAAnp 747
Cdd:PRK09102 494 LDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQ-- 570
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 568815674 748 iqftlnkeklketQKTTSSEDEETKERNKAAMvcSLENRDECLMC 792
Cdd:PRK09102 571 -------------RADKVSHDVLKKRLVEKSA--FNRDYDECLAC 600
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-742 |
7.96e-121 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 381.46 E-value: 7.96e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 5 KRDGRQERVMFDKITSRIQKLCYGLNSDfvDPTQITMKVIQGLYSGVTTVELDTLAAEIAATLTTK-------------H 71
Cdd:PRK07088 7 KRDGQYEPLQVEKTKKMVKLACEGLYGC--DPLELELDSRIQFRDGMTTKEIQKSLIQTAIEKVIQnskdnngnntkktN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 72 PDYAILAARIAVSNLHKETKK---VFSEVMEDLYNYVNplnsrhspMISKETL--DIVLANKDR-----LNSAIIYDRDF 141
Cdd:PRK07088 85 PNWQYVAARLYVFDLYKEARInrhYNSFGYGDYYELVK--------KLVEEKLygEYLLQNYSKeeikeLEKYIKPERDF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 142 SYNFFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGI-----HKEDIAAAIETYNLLSEKWFTHASPTLFNAGTNRPQL 215
Cdd:PRK07088 157 LFNYEGLKLLADRYLVKgFNREILELPQERFMGIAMHLaipegKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 216 SSCFLLAMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:PRK07088 237 SSCFISVV-DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLG-KRKG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 296 AFAMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGL---------DECWGEE 366
Cdd:PRK07088 315 GAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysledyyDEEDRKE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 367 FEKLYAKYEQEGR-AKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVA--- 442
Cdd:PRK07088 395 FTKKYLECEEDTNiPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeee 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 443 --------------------VCNLASIALNmyvtserTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIG 502
Cdd:PRK07088 475 iidengyyevvqkikagdmvTCNLNSIVLG-------NVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 503 IGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGilqyDMWEKTPTDLWDWA 582
Cdd:PRK07088 548 LGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERWK 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 583 ALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWNEEMKNQIIAq 662
Cdd:PRK07088 624 KLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR----------------------FFMEEKKGSFTP- 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 663 ngsiQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIAePNYGKLTSMHFY--GWKQGLKTgMYYLR 740
Cdd:PRK07088 677 ----KTAPDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYYVR 750
|
..
gi 568815674 741 TK 742
Cdd:PRK07088 751 NK 752
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
55-742 |
3.06e-120 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 382.18 E-value: 3.06e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 55 ELDTLAAEIAAT--LTTKH-PDYAILAARIAVSNLHKETKKVFSEV-MEDLYNYVNPLnsrhspmiSKETL--DIVLAN- 127
Cdd:PRK12364 145 EGESLAALIKAAveLTTQEaPDWEFIAARLLMLQFSKKLGKSLEKLgIHSFYDKIKYL--------TEEGLygSYILEHy 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 128 -KDRLNSA---IIYDRDFSYNFFGFKTLERSYLLKI-NGKVAERPQHMLMrvSVGIH------KEDIAAAIETYNLLSEK 196
Cdd:PRK12364 217 sREEIEEAagfIDPERDKLFTYSGLDLLLKRYVIRThSHEPLESPQEMFL--GIALHlampekQDRMGWVKRFYDMLSKL 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 197 WFTHASPTLFNAGTNRPQLSSCFLLAMKDdSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML 276
Cdd:PRK12364 295 KVTMATPTLSNARKPFHQLSSCFIDTVPD-SLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWI 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 277 RVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVE--TNGDWSLMCPN 354
Cdd:PRK12364 374 KLANDTAVAVDQLG-MRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPH 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 355 DCP-----GLDECWGEEFEKLYAKYEQEGR-AKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNL 428
Cdd:PRK12364 453 EILtvkgyALEDYYGEEWEKRYLDCVNDARiSKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNL 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 429 CTEI-----------------------VEYTSADEVAVCNLASIAL-NMYVTSErtfdfQKLASVTKVIVKNLNKIIDIN 484
Cdd:PRK12364 533 CTEIaqnmsaietvsteietedgdtvvVTTTRPGDFVVCNLASLSLgNIDLEDE-----EELEEVVRTVVRALDNVIDLN 607
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 485 YYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKG 564
Cdd:PRK12364 608 FYPVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG 687
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 565 ilQYdmWEKTPTDLWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPytsniytrrvlsgefqIVNPHLLkd 644
Cdd:PRK12364 688 --AY--FRKRGYTSEEWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL-- 745
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 645 lterglwnEEMKNQIIAqngsiQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIA-EPNYGKLTSM 723
Cdd:PRK12364 746 --------EEKKGALMP-----RVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDL 812
|
730
....*....|....*....
gi 568815674 724 HFYGWKQGLKTgMYYLRTK 742
Cdd:PRK12364 813 YLLAWEEGVKT-IYYVRSK 830
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
151-733 |
2.17e-97 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 314.26 E-value: 2.17e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 151 LERSYLLKI-NGKVAERPQHMLMRVSvgihkEDIAAAIETYN-------------LLSEKWFTHASPTLFN-AGTNRPQL 215
Cdd:TIGR02504 2 LAARYLLKDeDGNIIESPEDLFRRVA-----RALAAAEDKYNspvwkqwyerfydLMVNLGFIPNSPTLMNaGGTRLGQL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 216 SSCFLLAMKDDSiEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:TIGR02504 77 SACFVLPVEDSM-EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 296 AFAMYLEPWHFDIFDFLELKKNTGKEEQrardlF-YALWIPDLFMKRVETNGDWSLMCPNDcpgldecwGEEfeklyaky 374
Cdd:TIGR02504 155 AQMGILDVWHPDIEEFIEAKAKEGKLQN-----FnISVGVTDEFMEAVENDEEYELRNPRT--------GEY-------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 375 eqegrakRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEI--VEYTSadevavCNLASIALN 452
Cdd:TIGR02504 214 -------KEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQplLPYES------CNLGSINLA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 453 MYV----TSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLN 528
Cdd:TIGR02504 281 KFVkndfGDEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELA 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 529 TQIFETIYYAALESSCELAAEYGPYQTYAGcpvSKGILQYDMWEKTPTDLwdWAALKEKIAKHGVRNSLLLAPMPTASTA 608
Cdd:TIGR02504 361 EEVMEFIADAAYRASAELAKERGAFPLYDA---SKYPMGRAMGARIPSAL--PAEIREAIRKYGIRNAQLTTIAPTGTIS 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 609 QILGNNESIEPYTSNIYTRRVL-SGEFQIVNPHLLKDLTERGLWNEEmKNQIIAQNGSIQTIPaIPDDLKELYKTVWEIS 687
Cdd:TIGR02504 436 LIAGTSSGIEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAP-GPEELPKVFVTAMDIS 513
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 568815674 688 QKTILKMAADRGAYIDQSQSLNIHIaePN----------YgkltsmhFYGWKQGLK 733
Cdd:TIGR02504 514 PEDHVLMQAAIQPWVDSSISKTINM--PSdatvedvkavY-------LEAWKLGLK 560
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-756 |
9.29e-96 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 315.12 E-value: 9.29e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNsdfVDPTQITMKVIQGLYSGVTTVELDTLAAEIAATL-TTKHPDYAILAA 79
Cdd:PHA02572 4 INVIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDIQEILIKSAADLiSVEEPDYQYVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 80 RIAVSNLHKEtkkVFSEV-MEDLYNYVnplnsrhSPMISKETLDIVLANK------DRLNSAIIYDRDFSYNFFGFKTLE 152
Cdd:PHA02572 81 RLLMFALRKQ---VYGQFePPSFIDHI-------SKCVNEGKYDPEILSKysaeeiTYLESFIDHDRDFEFTYAGAMQLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 153 RSYLLK--INGKVAERPQHMLMRVSVGIHKED-----IAAAIETYNLLSEKWFThaSPTLFNAGTNRP--QLSSCFLLAM 223
Cdd:PHA02572 151 EKYLVQdrSTGEIYETPQFAYMLIAMALHQDEpkedrLEHVIRFYNAVSTRKIS--LPTPIMAGVRTPtrQFSSCVVIES 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 224 kDDSIEGIYDTLKQCA-LISKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLE 302
Cdd:PHA02572 229 -GDSLDSINKTAMAIVkYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 303 PWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGldECWG------EEFEKLYAKYEQ 376
Cdd:PHA02572 306 IWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGG--ELYDayfadqDRFRELYEALEK 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 377 EGRA-KRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNqqNLGTIKCSNLCTEIVEYTS-------ADEVAVCNLAS 448
Cdd:PHA02572 384 DPSVrKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIALPTKplnhidgEGEIALCTLSA 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 449 IALNMYVtsertfDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRhRPIGIGVQGLAdAFILMRF-PFESAEAQLL 527
Cdd:PHA02572 462 IVLGNFE------DQDEIEELAEVAVRALDNLLDYQDYPVPAALKAKKR-RSLGVGVTNYA-HYLAKNFaSYEDANADLV 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 528 NtQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDL------WDWAALKEKIAKHGVRNSLLLAP 601
Cdd:PHA02572 534 H-ELFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKKKVDELvapkynCDWESLREDLKKYGIRNSTLSAL 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 602 MPTASTAQILGNNESIEPYTSNIYTRRVLSGEFqivnphllkdlterglwneemkNQIIAQNgsiqtipaipDDLKELYK 681
Cdd:PHA02572 613 MPCESSSQVSNSTNGIEPPRGPVSIKKSKEGPF----------------------NQVVPNV----------ETLKDLYD 660
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 682 TVWEISQKT---ILKMAADRGAYIDQSQSLNIHIAEPNY--GKL-TSMHF----YGWKQGLKTgMYYLRTKPAANPIQFT 751
Cdd:PHA02572 661 LLWDLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpnGKVpMSVMLddllYFYYYGGKT-LYYHNTRDGKGTEDYE 739
|
....*
gi 568815674 752 LNKEK 756
Cdd:PHA02572 740 IETPK 744
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
188-620 |
2.26e-93 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 299.92 E-value: 2.26e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 188 ETYNLLSEKWFTHASPTLFNAGTN-RPQLSSCFLLAMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTN 266
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTGeLGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 267 GNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKntgKEEQRAR----DLFYALWipDLFMKRV 342
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLDVDHPDIEEFIDAKM---KEEKTVVlqnfNISVAVT--DAFMEAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 343 ETNGDWSLMCPNDCPGLdECWGEefeklyakyeqegrakrvVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGT 422
Cdd:cd02888 157 ENDEPWELRNPREPDTG-KVYRT------------------VPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 423 IKCSNLCTEIV--EYTSadevavCNLASIALNMYVTSERT---FDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKR 497
Cdd:cd02888 218 INATNPCGEQPllPYES------CNLGSINLSKFVKNPFGgasFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEETKA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 498 HRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCpvskgilQYDMWEKTPTD 577
Cdd:cd02888 292 TRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIVNA 364
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 568815674 578 LWDWAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPY 620
Cdd:cd02888 365 KELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
151-696 |
1.83e-78 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 268.34 E-value: 1.83e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 151 LERSYLLK-INGKVAERPQHMLMRVSVGI--------HKEDIAA-AIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFL 220
Cdd:PRK08665 20 LEKRYLKKdEDGKPIETPEDMFRRVARTIaaaeliydSKADVEAlADRFYDLMTSLEFLPNSPTLMNAGRELGQLSACFV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 221 LAMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAMY 300
Cdd:PRK08665 100 LPV-GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRR-GANMGI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 301 LEPWHFDIFDFLELKKNTGKeeqrARDLFYALWIPDLFMKRVETNGDWSLMCPNDcpgldecwgeefeklyakyeqeGRA 380
Cdd:PRK08665 178 LRVDHPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT----------------------GEV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 381 KRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTE--IVEYTSadevavCNLASIALNMYVTsE 458
Cdd:PRK08665 232 VGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMVK-N 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 459 RTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYA 538
Cdd:PRK08665 305 GDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 539 ALESSCELAAEYGPYQTYAGcpvskgilqyDMWEKtptdlwdwaalkEKIAKhgVRNSLLLAPMPTASTAQILGNNESIE 618
Cdd:PRK08665 385 AHAASRELAEERGPFPNYEG----------SIYDK------------DGLGP--MRNATVTTIAPTGTISIIAGCSSGIE 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 619 PYTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWNEE-MKNqiIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAA 696
Cdd:PRK08665 441 PLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEElMEK--IAEKGSIQDIDEVPEDVRRVFVTAHDISPEWHVRMQA 518
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-749 |
9.37e-76 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 261.07 E-value: 9.37e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSdfVDPTQITMKV-IQgLYSGVTTVEL-DTLAAEIAATLTTKHPDYAILA 78
Cdd:PRK09103 2 LLVTKRDGRTERINLDKIHRVITWAAEGLHN--VSVSQVELRShIQ-FYDGIKTSDIhETIIKAAADLISRDAPDYQYLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 79 ARIAVSNLHKETKKVFSEvmEDLYNYVnplnsrhSPMISKETLDIVLANK------DRLNSAIIYDRDFSYNFFGFKTLE 152
Cdd:PRK09103 79 ARLAIFHLRKKAYGQFEP--PALYDHV-------VKMVEMGKYDKHLLEDyteeefDQMDTFIDHWRDMNFSYAAVKQLE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 153 RSYLL--KINGKVAERPQHMLMRVSV----GIHKEDIAAAIET-YNLLSEkwFTHASPTLFNAGTNRP--QLSSCFLLAM 223
Cdd:PRK09103 150 GKYLVqnRVTGEIYESAQFLYILVAAclfsNYPKETRLDYVKRfYDAVST--FKISLPTPIMSGVRTPtrQFSSCVLIEC 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 224 kDDSIEGIYDTlkQCALI---SKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMY 300
Cdd:PRK09103 228 -GDSLDSINAT--SSAIVkyvSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 301 LEPWHFDIFDFLELKKNTGKEEQRARDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECW---GEEFEKLYAKYEQE 377
Cdd:PRK09103 303 YPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQD 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 378 GRA-KRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSN-QQNLGTIKCSNLCTEIVEYTSA--------DEVAVCNLA 447
Cdd:PRK09103 383 DSIrKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIALPTKPlndvndenGEIALCTLS 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 448 SIALNmyvTSERTFDFQKLASvtkVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLL 527
Cdd:PRK09103 463 AFNLG---AINSLDELEELAD---LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNL 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 528 NTQIFETIYYAALESSCELAAEYGPyqtyagCPV------SKGILQYDMWEKTPTDL------WDWAALKEKIAKHGVRN 595
Cdd:PRK09103 537 THKTFEAIQYYLLKASNELAKEQGA------CPWfnettyAQGILPIDTYKKDLDAIcneplhYDWETLREEIKTHGLRN 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 596 SLLLAPMPTASTAQILGNNESIEPytsniytrrvlsgefqivnPhllkdlteRGLWN-EEMKNQIIAQngsiqtipAIPD 674
Cdd:PRK09103 611 STLSALMPSETSSQISNATNGIEP-------------------P--------RGYVSiKASKDGILKQ--------VVPD 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 675 --DLKELYKTVWEI-SQKTILKMAADRGAYIDQSQSLNIHIaEPN---YGKLTSMHF-----YGWKQGLKTgMYYLRTKP 743
Cdd:PRK09103 656 yeRLKDAYELLWEMpNNDGYLQLVGIMQKFVDQSISANTNY-DPSrfpSGKVPMKQLlkdllTAYKFGVKT-LYYHNTRD 733
|
....*.
gi 568815674 744 AANPIQ 749
Cdd:PRK09103 734 GAEDAQ 739
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
1-712 |
5.51e-72 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 250.92 E-value: 5.51e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRqeRVMFD--KITSRIQKLCYGL-NSDFVDPTQITMKVIQGLYSG-VTTVEldTLAAEIAATLTTKHPDYAI 76
Cdd:PRK06406 5 KEVIKRDGT--VVPFDkkKIAMAIYKAMLSVkNGSMEDAEELTDKVVERLKKYeRPTVE--QIQDIVEKVLMTKKINGKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 77 LAARIAVSNLHKETKKVFSEvmedlynyvnplnsrhspmiSKETLDIvlanKDrlnsaiiydrDFSYNFFGFKTLERSYL 156
Cdd:PRK06406 81 FTDVAKSYILYREKRRKIRE--------------------EKELIGV----KD----------DLKLTLNAIKVLEARYL 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 157 LK-INGKVAERPQHMLMRV------------------------------SVGIHKEDIAAAIETY--------------- 190
Cdd:PRK06406 127 LKdEDGKIIETPRQMFRRVarhiaivealyddevydktgkqkenaevigKLSVTQEDMLKRAFRYlkeegimkgdfeefl 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 191 NLLSEKW------------------FTHASPTLFNAGTNRPQLSSCFLLAMkDDSIEGIYDTLKQCALISKSAGGIGVAV 252
Cdd:PRK06406 207 DFLKTKWdsieeyinkfeevmsnlkFVPNSPTLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSF 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 253 SCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAMYLEPWHFDIFDFLELKKNtgkEEQRARDLFYAL 332
Cdd:PRK06406 286 SRLRPKDDIVASTKGVASGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYHHPDIMEFITSKDS---ENKVLSNFNISV 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 333 WIPDLFMKRVETNGDWSLMCPNDcpgldecwGEEFEKlyakyeqegrakrvVKAQQLWYAIIESQTETGTPYMLYKDACN 412
Cdd:PRK06406 362 AVTDEFFDKLDNDDYYPLRNPRN--------GKEVKR--------------IKARQVWDLIITQAWKTGDPGVIFLDEIN 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 413 RKSNQQNLGTIKCSNLCTE--IVEYTSadevavCNLASIALNMYVTSERtFDFQKLASVTKVIVKNLNKIIDINYYPVKE 490
Cdd:PRK06406 420 RKNPVKNLGEIESTNPCGEqpLLPYES------CNLGSINLSKFVENGK-IDWDRLRETVHIATRFLDNVIDANKFPVPQ 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 491 AENSNKRHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPvskgilqydm 570
Cdd:PRK06406 493 IKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGSE---------- 562
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 571 WEKTptdlwdwaALKekiakhgVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQI-VNPHLLKDLTERG 649
Cdd:PRK06406 563 WEKK--------GIK-------MRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGQELLeVNPLFEEITRKRG 627
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568815674 650 LWNEEMKNQiIAQNGSIQTIPaIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHI 712
Cdd:PRK06406 628 LYSEELMRK-VAETGNLQNID-VPEDIKRIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINL 688
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
190-654 |
1.18e-41 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 163.86 E-value: 1.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 190 YNLLSEKWFTHASPTLFNAGTNRP-QLSSCFLLAMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGN 268
Cdd:PRK08115 160 YQELVNMNFVPAGRVLYGAGSKTDvTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 269 SNGLVPMLRVYNNTARYVDQGGNKRpGAFAMYLEPWHFDIFDFL-----------ELKKNTGKEE--------------- 322
Cdd:PRK08115 240 SSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWHPDILEFIiskmqnprilrYLLENTEDEQikrlvkeklkftpls 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 323 ---------------------------QRARDLF-----YALWIPDL-------------FMKRVETNGDWSLMCPNDcp 357
Cdd:PRK08115 319 eveeamyqaivnykniegqggfdtkviKEAENKLrtggtYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDV-- 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 358 gldECWGEEFEKLYAK----------YEQEG---RAKRVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLG-TI 423
Cdd:PRK08115 397 ---ENYTEEEMEIYNEewhevgdvreWEKMGypvRTYRKIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKV 473
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 424 KCSNLCTE--IVEYTsadevaVCNLASIAL-NMYVTSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRP 500
Cdd:PRK08115 474 VATNPCGEqpLAPYS------VCNLAAINLaNMADKETKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERR 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 501 IGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAG------CPVSKGILQYDMWEKT 574
Cdd:PRK08115 548 VGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGqteeetAKLREAFINTGYMKKM 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 575 PTDlwdwaaLKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEE 654
Cdd:PRK08115 628 PED------IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
189-675 |
2.49e-41 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 163.22 E-value: 2.49e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 189 TYNLLSEKwFTHASPTLFNAGTN-RPQLSSCFLLAMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGtNG 267
Cdd:PRK06556 123 TWLLLHQK-FSFNSPVWFNVGTEsPQQVSACFILSV-DDSMESILNWYKEEGMLFKGGSGTGTNLSRIRSSKELLSG-GG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 268 NSNGLVPMLRVYNNTARYVDQGGNKRPGAFAMYLEPWHFDIFDFLELKkntGKEEQRARDLFYALWIPDL---------- 337
Cdd:PRK06556 200 TASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALRDAGYDMDLggeayssvqy 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 338 ------------FMKRVETNGDWSLmcpndcpgldecwgeefeklyaKYEQEGRAKRVVKAQQLWYAIIESQTETGTPYM 405
Cdd:PRK06556 277 qnannsvrvsdeFMRAVENDGEFGL----------------------RARTDGEVIETVDAKELFRKIAEAAWECADPGI 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 406 LYKDACNRKSNQQNLGTIKCSNLCTeivEYTSADEVAvCNLASIALNMYVTSERTFDFQKLASVTKVIVKNLNKIIDINY 485
Cdd:PRK06556 335 QYDDTINDWHTCPESGRINASNPCS---EYMFLDNSS-CNLASLNLMKFLRDDGTFDVESFRHAVELVITAMEISICFAD 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 486 YPVKE-AENSNKrHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYA------- 557
Cdd:PRK06556 411 FPTEKiARNTRA-FRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGVVGPFEGYArnaephl 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 558 ----------GCPVSKGILQYDMWEKTpTDLWDwAALKEKiAKHGVRNS--LLLAP-------MPTASTaqilgnneSIE 618
Cdd:PRK06556 490 rvmrkhaaanDAIRPLGEVDAALLEAA-KEAWD-DALELG-EKNGYRNAqaSVLAPtgtigfmMDCDTT--------GIE 558
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568815674 619 PYTSNI-YTRRVLSGEFQIVNPHLLKDLTERGlWNEEMKNQI---IAQNGSIQTIPAIPDD 675
Cdd:PRK06556 559 PDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQIEAIveyIAEHGHIEGAPGLKPE 618
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
426-686 |
2.37e-37 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 151.46 E-value: 2.37e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 426 SNLCTE--IVEYTSadevavCNLASIALNMYVTSERT----FDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHR 499
Cdd:PRK08332 1294 SHNCGEepLYEYES------CNLASINLAKFVKYDENgkpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 500 PIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTptDLW 579
Cdd:PRK08332 1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEGFYHP--EIW 1445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 580 D--WAALKEKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKN 657
Cdd:PRK08332 1446 NlpWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSEELLK 1525
|
250 260
....*....|....*....|....*....
gi 568815674 658 QIIAQNGSIQTIPAIPDDLKELYKTVWEI 686
Cdd:PRK08332 1526 KISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
201-636 |
8.18e-34 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 137.62 E-value: 8.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 201 ASPTLFNAGTNRPQ-LSSCFL--LAMKDDSIEGIYD---TLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVP 274
Cdd:PRK06948 70 AGRIMANAGAAPDQtMVNCFVhpIRAPAALTAVHPNldrALDDARLTLLMGGGIGYDFSAIPPADARPDADHPDSPGVCA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 275 MLRVYNNTARYVDQGGNKRpGAFAMYLEPWHFDIFDFLELKKNtgkeeqRAR--DLFYALWIPDLFMKRVETNGDWSLM- 351
Cdd:PRK06948 150 ALDRFDRICAALPFRDGRR-GAQMAVLRCDHPDLLAFVAAKRG------RARwtTFNLSVAVTDAFMQAVAQDLPWALRh 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 352 --CPNDCPG-----LDECWgeefekLYAkyeqegrakrVVKAQQLWYAIIESQTETGTPYMLYKDACNRKSNQQNLGTIK 424
Cdd:PRK06948 223 raPPRRAAGgalrgADGAW------TYA----------TVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREHERID 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 425 CSNLCTE--IVEYTSadevavCNLASIALNMYVT------SERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNK 496
Cdd:PRK06948 287 ATNPCGEqpLPPYGS------CVLGPIDLSRFVRhpfgvgGEPRFDFAALATAVRIQVRMLDNALDLTRWPLAAHAREAR 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 497 RHRPIGIGVQGLADAFILMRFPFESAEAQLLNTQIFETIYYAALESSCELAAEYGPY-----QTYAGCPVSKGILQYdmw 571
Cdd:PRK06948 361 QKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAYplcdpAAHLDALRAGPPLPH--- 437
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568815674 572 ektptdlwdwaALKEKIAKHGVRNSLLLAPMPTASTAQILGNNES--IEPYTSNIYTRRVLSGEFQI 636
Cdd:PRK06948 438 -----------AVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPARAWIEHRPVRAGAGGA 493
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-210 |
1.19e-20 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 86.52 E-value: 1.19e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568815674 143 YNFFGFKTLERSYLLKI-NGKVAERPQHMLMRVSVGIH-----KEDIAAAIETYNLLSEKWFTHASPTLFNAGT 210
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDeDGELLETPQDMFMRVALALAgaeleEDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
1-89 |
1.19e-16 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 75.38 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSDFVDPT-QITMKVIQGLYSGVTTVELDTLAAEIAAtlttKHPDYAILAA 79
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQADELAsEVEEELEKSLEDGISTEEIQDLVEKTLA----EHPDYAVARA 76
|
90
....*....|
gi 568815674 80 RIAVSNLHKE 89
Cdd:pfam03477 77 YILYRNLRKE 86
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
334-557 |
1.27e-08 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 58.82 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 334 IPDLFMKRVETNGDWSLmcpndcpgldecwgeefeklyaKYEQEGRAKRVVKAQQLWYAIIESQTETGTPYMLYKDACNR 413
Cdd:PRK07562 403 VTDEFLRAVENDGDWNL----------------------TARTDGKVAKTLKARDLWEKIGYAAWASADPGLQFNTTIND 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 414 KSNQQNLGTIKCSNLCTeivEYTSADEVAvCNLASIAL-NMYVTSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKE-A 491
Cdd:PRK07562 461 WHTCPASGPIRASNPCS---EYMFLDDTA-CNLASLNLlTFRDEDTKRFDVEAYEHACRLWTVVLEISVLMAQFPSKEiA 536
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568815674 492 ENSNKrHRPIGIGVQGLADAFILMRFPFESAEAQLLN---TQIFETIYYAAlesSCELAAEYGPYQTYA 557
Cdd:PRK07562 537 ELSYE-FRTLGLGYANIGGLLMTMGIPYDSDEGRAICgalSAIMTGVAYAT---SAEMAKELGPFPGYE 601
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
137-292 |
3.86e-05 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 47.45 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 137 YDRDFSYNFFGFKTLERSYLLKINGKVAERPQ---------HMLMRVSVGIHKEDIAaaiETYNLLSEKWFTHASPTLFN 207
Cdd:PRK08332 186 FDGKYSIGKYKLNKYHFERMVNLYRELAEKGKmkvsideflKMLERGEFDKYEKEIE---EYFRLMTNQIFMPNTPALIN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568815674 208 AGTNRPQLSSCFLLAMKDDsIEGIYDTLKQCALISKSAGGigvavsCIRATGSYIAGTNGNSN--GLVPMLRVYNNTARY 285
Cdd:PRK08332 263 SGRPLGMLSACFVVPIEDD-MESIMKAAHDVAMIQKAGGG------CIDGNAKIIFENEGEEHltTMAEMYERYKHLGEF 335
|
....*..
gi 568815674 286 VDQGGNK 292
Cdd:PRK08332 336 YDEEYNR 342
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
249-319 |
1.02e-03 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 42.83 E-value: 1.02e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568815674 249 GVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAMYLEPWHFDIFDFLELK-KNTG 319
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRR-GANMGILEIWHPDIEKFIHAKeKNIG 827
|
|
| |
