asb3 ankyrin repeat and SOCS box containing 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: asb3provided by ZNC
Official Full Name: ankyrin repeat and SOCS box containing 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6142
See related: Ensembl:ENSDARG00000005246 AllianceGenome:ZFIN:ZDB-GENE-030131-6142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi36b12; zgc:56163; wu:fi36b12
Summary: Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Orthologous to several human genes including ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (24060982..24077141)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (23939763..23955922)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199874.1 → NP_956168.1 ankyrin repeat and SOCS box protein 3

See identical proteins and their annotated locations for NP_956168.1

Status: PROVISIONAL

Source sequence(s)

BC045958

UniProtKB/TrEMBL

Q7ZV89

Related

ENSDARP00000012869.4, ENSDART00000021298.5

Conserved Domains (5) summary

cd00204
Location:74 → 198

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd03722
Location:468 → 518

SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...

pfam12796
Location:151 → 240

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:214 → 267

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:146 → 176

ANK; ANK repeat [structural motif]