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Conserved domains on  [gi|41054071|ref|NP_956168|]
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ankyrin repeat and SOCS box protein 3 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-244 7.39e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.95  E-value: 7.39e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   8 ADSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFA 87
Cdd:COG0666  52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD----VNARDKDGETPLHLA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  88 AKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGTYSlSGWSCLHQAVYKGHIEIVRYLV 167
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLL 206

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071 168 SL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNE 244
Cdd:COG0666 207 EAgADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 468-518 2.77e-19

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239692  Cd Length: 51  Bit Score: 81.38  E-value: 2.77e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQDYLHFSDVSGLL 518
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
PHA02875 super family cl31516
ankyrin repeat protein; Provisional
 154-356 5.21e-05

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA02875:

Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  154 AVYKGHIEIVRYLVSLCTLEAVDDY-GITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLL 232
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYdGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  233 ahgaDPNLYCNEYCWQ---LPILAAAQFNRLSILEKLIsvtKRECD---RGEGKVSPVYLAVLGGHADSLRALLQKGYSP 306
Cdd:PHA02875  89 ----DLGKFADDVFYKdgmTPLHLATILKKLDIMKLLI---ARGADpdiPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 41054071  307 DAQSCpqFGYScPLEMALwtwldaswnlnseCHQAQEITLILLAAGAHVN 356
Cdd:PHA02875 162 DIEDC--CGCT-PLIIAM-------------AKGDIAICKMLLDSGANID 195
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-244 7.39e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.95  E-value: 7.39e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   8 ADSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFA 87
Cdd:COG0666  52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD----VNARDKDGETPLHLA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  88 AKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGTYSlSGWSCLHQAVYKGHIEIVRYLV 167
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLL 206

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071 168 SL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNE 244
Cdd:COG0666 207 EAgADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 468-518 2.77e-19

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 81.38  E-value: 2.77e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQDYLHFSDVSGLL 518
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-109 1.28e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    16 LAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIP-AAVNCEDyvntlthNSETPLYFAAKYGHLR 94
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNLKD-------NGRTALHYAARSGHLE 75

                          90
                  ....*....|....*
gi 41054071    95 AVKWLIKAGADINRK 109
Cdd:pfam12796  76 IVKLLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 17-276 1.49e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.93  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   17 AARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVN-------------------CEDYVNTLT 77
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildCGIDVNIKD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   78 HNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNgTYSLSGWSCLHQAVYK 157
Cdd:PHA02874 122 AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN-VKDNNGESPLHNAAEY 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  158 GHIEIVRYLVSLCTLEAVD-DYGITPLFVAAQYgHHQCLDILANaGANVNCQANDLATPLLIAAQ-EGHEQCVECLLAHG 235
Cdd:PHA02874 201 GDYACIKLLIDHGNHIMNKcKNGFTPLHNAIIH-NRSAIELLIN-NASINDQDIDGSTPLHHAINpPCDIDIIDILLYHK 278

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 41054071  236 ADPNLYCNEycWQLPILAAAQF-NRLSILEKLI--SVTKRECDR 276
Cdd:PHA02874 279 ADISIKDNK--GENPIDTAFKYiNKDPVIKDIIanAVLIKEADK 320
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 154-356 5.21e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  154 AVYKGHIEIVRYLVSLCTLEAVDDY-GITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLL 232
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYdGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  233 ahgaDPNLYCNEYCWQ---LPILAAAQFNRLSILEKLIsvtKRECD---RGEGKVSPVYLAVLGGHADSLRALLQKGYSP 306
Cdd:PHA02875  89 ----DLGKFADDVFYKdgmTPLHLATILKKLDIMKLLI---ARGADpdiPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 41054071  307 DAQSCpqFGYScPLEMALwtwldaswnlnseCHQAQEITLILLAAGAHVN 356
Cdd:PHA02875 162 DIEDC--CGCT-PLIIAM-------------AKGDIAICKMLLDSGANID 195
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 467-509 5.80e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 5.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 41054071    467 FESVPVLAHLCRLAVGAHVGSDTLSKpsfiqlLPIPSLLQDYL 509
Cdd:smart00253   4 PSNVPSLQHLCRFTIRRCTRTDQIKT------LPLPPKLKDYL 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 473-510 6.67e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 40.23  E-value: 6.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41054071   473 LAHLCRLAVGAHVGSDTLSKpsfIQLLPIPSLLQDYLH 510
Cdd:pfam07525   5 LQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 16-190 1.09e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  16 LAARDGKSRRVQKLIRRGfAVDV--KDNRGWNALHEA-------AAAGTAGCVRLLIPAAVNCEDYVntlthnSETPLYF 86
Cdd:cd22192  23 LAAKENDVQAIKKLLKCP-SCDLfqRGALGETALHVAalydnleAAVVLMEAAPELVNEPMTSDLYQ------GETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  87 AAKYGHLRAVKWLIKAGADIN---------RKTNDLSC-----PLYAAVDGGHKDVIELLVRNGAEVNGTYSLsGWSCLH 152
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL-GNTVLH 174

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 41054071 153 ----QAVYKGHIEIVRYLVSL------CTLEAVDDY-GITPLFVAAQYG 190
Cdd:cd22192 175 ilvlQPNKTFACQMYDLILSYdkeddlQPLDLVPNNqGLTPFKLAAKEG 223
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 87-267 2.61e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    87 AAKYGHLRAVKWLIKAGADINRKTND---LSCPLYAAVDGGHKDVIELLVRNGAEVNgtyslSGWSCLHQAV--YKGHIE 161
Cdd:TIGR00870  24 AAERGDLASVYRDLEEPKKLNINCPDrlgRSALFVAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   162 -IVRYLV-----SLCTLEAVDDY------GITPLFVAAQYGHHQCLDILANAGANVNCQANdlatplliaaqegheqCVE 229
Cdd:TIGR00870  99 aILLHLLaafrkSGPLELANDQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPARAC----------------GDF 162

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 41054071   230 CLLAHGADpNLYCNEYcwqlPILAAAQFNRLSILEKLI 267
Cdd:TIGR00870 163 FVKSQGVD-SFYHGES----PLNAAACLGSPSIVALLS 195
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 178-207 3.83e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 41054071    178 YGITPLFVAAQYGHHQCLDILANAGANVNC 207
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-364 4.77e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 4.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 195 LDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEYCWQLPILAAAQFNRLSILEKLISVTKREC 274
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 275 DRGEGKVSPVYLAVLGGHADSLRALLQKGYSPDAQScpQFGYScPLEMALWtwldaswnlnsecHQAQEITLILLAAGAH 354
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD--KDGET-PLHLAAY-------------NGNLEIVKLLLEAGAD 145

                       170
                ....*....|.
gi 41054071 355 VN-TSIYGFTL 364
Cdd:COG0666 146 VNaQDNDGNTP 156
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-244 7.39e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.95  E-value: 7.39e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   8 ADSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFA 87
Cdd:COG0666  52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD----VNARDKDGETPLHLA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  88 AKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGTYSlSGWSCLHQAVYKGHIEIVRYLV 167
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLL 206

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071 168 SL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNE 244
Cdd:COG0666 207 EAgADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-303 2.54e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 2.54e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  39 KDNRGWNALHEAAAAGTAGCVRLLIPAAVNCEDYVNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLY 118
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 119 AAVDGGHKDVIELLVRNGAEVNGTYSlSGWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDI 197
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAgADVNAQDNDGNTPLHLAAANGNLEIVKL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 198 LANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEYCWqlPILAAAQFNRLSILEKLISVTKRECDRG 277
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEIVKLLLEAGADLNAKD 249

                       250       260
                ....*....|....*....|....*.
gi 41054071 278 EGKVSPVYLAVLGGHADSLRALLQKG 303
Cdd:COG0666 250 KDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-216 1.60e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 134.31  E-value: 1.60e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  12 SAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFAAKYG 91
Cdd:COG0666  89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD----VNAQDNDGNTPLHLAAANG 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  92 HLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNgTYSLSGWSCLHQAVYKGHIEIVRYLVS-LC 170
Cdd:COG0666 165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTALDLAAENGNLEIVKLLLEaGA 243

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 41054071 171 TLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPL 216
Cdd:COG0666 244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
61-303 2.77e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 119.67  E-value: 2.77e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  61 LLIPAAVNCEDYVNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVN 140
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 141 GTYSlSGWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIA 219
Cdd:COG0666  82 AKDD-GGNTLLHAAARNGDLEIVKLLLEAgADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 220 AQEGHEQCVECLLAHGADPNLYCNEYcwQLPILAAAQFNRLSILEKLISVTKRECDRGEGKVSPVYLAVLGGHADSLRAL 299
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDG--ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238


                ....
gi 41054071 300 LQKG 303
Cdd:COG0666 239 LEAG 242
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 468-518 2.77e-19

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 81.38  E-value: 2.77e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQDYLHFSDVSGLL 518
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-109 1.28e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    16 LAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIP-AAVNCEDyvntlthNSETPLYFAAKYGHLR 94
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNLKD-------NGRTALHYAARSGHLE 75

                          90
                  ....*....|....*
gi 41054071    95 AVKWLIKAGADINRK 109
Cdd:pfam12796  76 IVKLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
117-208 2.27e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   117 LYAAVDGGHKDVIELLVRNGAEVNgTYSLSGWSCLHQAVYKGHIEIVRYLVSLCTLEaVDDYGITPLFVAAQYGHHQCLD 196
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 41054071   197 ILANAGANVNCQ 208
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-168 3.45e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 3.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    84 LYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNgaeVNGTYSLSGWSCLHQAVYKGHIEIV 163
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77


                  ....*
gi 41054071   164 RYLVS 168
Cdd:pfam12796  78 KLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
151-240 4.40e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 4.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   151 LHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANaGANVNCQANDLaTPLLIAAQEGHEQCVE 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 41054071   230 CLLAHGADPNL 240
Cdd:pfam12796  79 LLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 17-276 1.49e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.93  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   17 AARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVN-------------------CEDYVNTLT 77
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildCGIDVNIKD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   78 HNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNgTYSLSGWSCLHQAVYK 157
Cdd:PHA02874 122 AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN-VKDNNGESPLHNAAEY 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  158 GHIEIVRYLVSLCTLEAVD-DYGITPLFVAAQYgHHQCLDILANaGANVNCQANDLATPLLIAAQ-EGHEQCVECLLAHG 235
Cdd:PHA02874 201 GDYACIKLLIDHGNHIMNKcKNGFTPLHNAIIH-NRSAIELLIN-NASINDQDIDGSTPLHHAINpPCDIDIIDILLYHK 278

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 41054071  236 ADPNLYCNEycWQLPILAAAQF-NRLSILEKLI--SVTKRECDR 276
Cdd:PHA02874 279 ADISIKDNK--GENPIDTAFKYiNKDPVIKDIIanAVLIKEADK 320
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 59-268 1.68e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.47  E-value: 1.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   59 VRLLIPAAVNCedyVNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAE 138
Cdd:PHA02874  17 IEKIIKNKGNC---INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  139 VN----------------------GTYSLSGWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCL 195
Cdd:PHA02874  94 TSilpipciekdmiktildcgidvNIKDAELKTFLHYAIKKGDLESIKMLFEYgADVNIEDDNGCYPIHIAIKHNFFDII 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41054071  196 DILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEYCwqLPILAAAQFNRlSILEKLIS 268
Cdd:PHA02874 174 KLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGF--TPLHNAIIHNR-SAIELLIN 243
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 26-206 3.24e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.78  E-value: 3.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   26 VQKLIRRGFAVDVKDNRGWNALHEAAAAG-TAGCVRLLIPAAVNCEDYVNTLTHNSETPLYFAA--KYGHLRAVKWLIKA 102
Cdd:PHA03100  51 VKILLDNGADINSSTKNNSTPLHYLSNIKyNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  103 GADINRKTNDLSCPLYAAVDGGHKD--VIELLVRNGAEVNGT----YSLS-----------GWSCLHQAVYKGHIEIVRY 165
Cdd:PHA03100 131 GANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKnrvnYLLSygvpinikdvyGFTPLHYAVYNNNPEFVKY 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 41054071  166 LVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVN 206
Cdd:PHA03100 211 LLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-140 3.72e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 3.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    47 LHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFAAKYGHLRAVKWLIKaGADINRKTNDLScPLYAAVDGGHK 126
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD----ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRT-ALHYAARSGHL 74

                          90
                  ....*....|....
gi 41054071   127 DVIELLVRNGAEVN 140
Cdd:pfam12796  75 EIVKLLLEKGADIN 88
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-279 1.70e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.41  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    9 DSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNCEDyvnTLTHNSETPLYFAA 88
Cdd:PHA02875  34 DGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLAT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   89 KYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRngaevngtyslsgwsclHQAvykghieivrylvs 168
Cdd:PHA02875 111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID-----------------HKA-------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  169 lcTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANVN-CQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYC---NE 244
Cdd:PHA02875 160 --CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDyFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMFmieGE 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 41054071  245 YCWQLPILAAAQFNRLS------ILEKLISVTKRECDRGEG 279
Cdd:PHA02875 238 ECTILDMICNMCTNLESeaidalIADIAIRIHKKTIRRDEG 278
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-237 1.23e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.78  E-value: 1.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   72 YVNTLTHNSETPLYFAAKYGH-----LRAVKWLIKAGADINRKTNDLSCPLYAAVDG--GHKDVIELLVRNGAEVNGTYS 144
Cdd:PHA03100  60 DINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  145 lSGWSCLHQAVYKGHIEI------------------VRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDILANAGANV 205
Cdd:PHA03100 140 -DGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYgVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANP 218

                        170       180       190
                 ....*....|....*....|....*....|..
gi 41054071  206 NCQANDLATPLLIAAQEGHEQCVECLLAHGAD 237
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-309 4.89e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.21  E-value: 4.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   16 LAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGC---VRLLIPAAVNcedyVNTLTHNSETPLYFAAKYGH 92
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGAD----VNAPERCGFTPLHLYLYNAT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   93 -LRAVKWLIKAGADINRKTNDLSCPL--YAAVDGGHKDVIELLVRNGAEVNGTySLSGWSCLHqAVYKGH---IEIVRYL 166
Cdd:PHA03095  96 tLDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNAL-DLYGMTPLA-VLLKSRnanVELLRLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  167 VS-LCTLEAVDDYGITPLFVAAQYGH--HQCLDILANAGANVNCQANDLATPLLIAAQegHEQC----VECLLAHGADPN 239
Cdd:PHA03095 174 IDaGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLHSMAT--GSSCkrslVLPLLIAGISIN 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41054071  240 lYCNEYcWQLPILAAAQFNRLSILEKLIsvtKRECD---RGEGKVSPVYLAVLGGHADSLRALLQKgySPDAQ 309
Cdd:PHA03095 252 -ARNRY-GQTPLHYAAVFNNPRACRRLI---ALGADinaVSSDGNTPLSLMVRNNNGRAVRAALAK--NPSAE 317
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 73-356 2.42e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.32  E-value: 2.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   73 VNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGTySLSgwscLH 152
Cdd:PHA02876 171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKN-DLS----LL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  153 QAVYKGHIEIVRYLV-SLCTLEAVDDYGITPLFVAAQYGH-HQCLDILANAGANVNCQANDLATPLLIAAQEGHE-QCVE 229
Cdd:PHA02876 246 KAIRNEDLETSLLLYdAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIR 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  230 CLLAHGADPNlyCNEYCWQLPILAAAQFNR-----LSILEKLISVTKRE-CDRgegkvSPVYLAVLGGHADSLRALLQKG 303
Cdd:PHA02876 326 TLIMLGADVN--AADRLYITPLHQASTLDRnkdivITLLELGANVNARDyCDK-----TPIHYAAVRNNVVIINTLLDYG 398

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41054071  304 YSPDAQScPQFG-------YSCPLEMALWTWLDASWNLNSE-------CHQA------QEITLILLAAGAHVN 356
Cdd:PHA02876 399 ADIEALS-QKIGtalhfalCGTNPYMSVKTLIDRGANVNSKnkdlstpLHYAckknckLDVIEMLLDNGADVN 470
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 82-268 2.67e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 2.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   82 TPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGH-----KDVIELLVRNGAEVNGTYSlSGWSCLHQAVY 156
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDN-NGITPLLYAIS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  157 K--GHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQcLDI---LANAGANVN--CQANDL--------------AT 214
Cdd:PHA03100 116 KksNSYSIVEYLLDNgANVNIKNSDGENLLHLYLESNKID-LKIlklLIDKGVDINakNRVNYLlsygvpinikdvygFT 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 41054071  215 PLLIAAQEGHEQCVECLLAHGADPNLyCNEYCwQLPILAAAQFNRLSILEKLIS 268
Cdd:PHA03100 195 PLHYAVYNNNPEFVKYLLDLGANPNL-VNKYG-DTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
183-268 3.38e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   183 LFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHgADPNLYCNEYCwqlPILAAAQFNRLSI 262
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT---ALHYAARSGHLEI 76


                  ....*.
gi 41054071   263 LEKLIS 268
Cdd:pfam12796  77 VKLLLE 82
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1-239 5.64e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.98  E-value: 5.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    1 MDFTECYADSCSAV-------ALAARDGKSrrVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNC---- 69
Cdd:PHA02878  23 IDHTENYSTSASLIpfiplhqAVEARNLDV--VKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCsvfy 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   70 -EDYVNTLTHNSETPL-------YFAAKYG---------------HLRAVKWLIKAGADINRKT-NDLSCPLYAAVDGGH 125
Cdd:PHA02878 101 tLVAIKDAFNNRNVEIfkiiltnRYKNIQTidlvyidkkskddiiEAEITKLLLSYGADINMKDrHKGNTALHYATENKD 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  126 KDVIELLVRNGAEVNgTYSLSGWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQY-GHHQCLDILANAGA 203
Cdd:PHA02878 181 QRLTELLLSYGANVN-IPDKTNNSPLHHAVKHYNKPIVHILLENgASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGV 259

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 41054071  204 NVNCQANDLA-TPLLIAAQEghEQCVECLLAHGADPN 239
Cdd:PHA02878 260 DVNAKSYILGlTALHSSIKS--ERKLKLLLEYGADIN 294
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 12-139 1.58e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.65  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   12 SAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAA--VNCED-----------------Y 72
Cdd:PLN03192 527 SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHAcnVHIRDangntalwnaisakhhkI 606

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41054071   73 VNTLTHNSETP--------LYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEV 139
Cdd:PLN03192 607 FRILYHFASISdphaagdlLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PHA03095 PHA03095
ankyrin-like protein; Provisional
 96-310 2.74e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.27  E-value: 2.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   96 VKWLIKAGADINRKTNDLSCPLYAAVDGGH---KDVIELLVRNGAEVNgTYSLSGWSCLHQAVYKGH-IEIVRYLVSL-C 170
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVN-APERCGFTPLHLYLYNATtLDVIKLLIKAgA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  171 TLEAVDDYGITPLfvaaqyghHQCL----------DILANAGANVNCQANDLATPL----------------LIAAQEG- 223
Cdd:PHA03095 109 DVNAKDKVGRTPL--------HVYLsgfninpkviRLLLRKGADVNALDLYGMTPLavllksrnanvellrlLIDAGADv 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  224 --------------------HEQCVECLLAHGADPNLYCNEYCWQLPILAAAQFNRLSILEKLI----SVTKREcDRGEg 279
Cdd:PHA03095 181 yavddrfrsllhhhlqsfkpRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLiagiSINARN-RYGQ- 258

                        250       260       270
                 ....*....|....*....|....*....|.
gi 41054071  280 kvSPVYLAVLGGHADSLRALLQKGYSPDAQS 310
Cdd:PHA03095 259 --TPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 2-140 2.83e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.29  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    2 DFTECYADSCS--AVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAaaagTAGC------VRLLIP--AAVNCED 71
Cdd:PHA03100  98 NVNAPDNNGITplLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLY----LESNkidlkiLKLLIDkgVDINAKN 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41054071   72 YVNTL-THNS---------ETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVN 140
Cdd:PHA03100 174 RVNYLlSYGVpinikdvygFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-258 4.58e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 4.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   23 SRRVQKLIRRGFAVDVKDNRGwnalheaaaagtagcvrllipaavncedyvntlthnsETPLYFAAKYGH-LRAVKWLIK 101
Cdd:PHA02876 287 SRLVPKLLERGADVNAKNIKG-------------------------------------ETPLYLMAKNGYdTENIRTLIM 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  102 AGADINRKTNDLSCPLY-AAVDGGHKDVIELLVRNGAEVNGTySLSGWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYG 179
Cdd:PHA02876 330 LGADVNAADRLYITPLHqASTLDRNKDIVITLLELGANVNAR-DYCDKTPIHYAAVRNNVVIINTLLDYgADIEALSQKI 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  180 ITPLFVAAqYGHHQCLDI--LANAGANVNCQANDLATPLLIAAQEGHE-QCVECLLAHGADPNLYC--NEYcwqlPILAA 254
Cdd:PHA02876 409 GTALHFAL-CGTNPYMSVktLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINiqNQY----PLLIA 483


                 ....
gi 41054071  255 AQFN 258
Cdd:PHA02876 484 LEYH 487
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 84-219 6.71e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 54.22  E-value: 6.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   84 LYFAAKYGHLRAVKWLIKAGADIN----RKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNgTYSlsgwsclhqavykgh 159
Cdd:PHA02884  37 LYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDCDNDDAAKLLIRYGADVN-RYA--------------- 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  160 ieivRYLVslctleavddygITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIA 219
Cdd:PHA02884 101 ----EEAK------------ITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-133 6.84e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 6.84e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41054071    82 TPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLV 133
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 87-303 1.61e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   87 AAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGTYSlSGWSCLHQAVYKGHIEIVRYL 166
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP-DIESELHDAVEEGDVKAVEEL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  167 VSLCTLeaVDDY----GITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLyc 242
Cdd:PHA02875  88 LDLGKF--ADDVfykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI-- 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071  243 NEYCWQLPILAAAQFNRLSILEKLIS-------VTKRECdrgegkVSPVYLAVLGGHADSLRALLQKG 303
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIAICKMLLDsganidyFGKNGC------VAALCYAIENNKIDIVRLFIKRG 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 96-323 2.19e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   96 VKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNGT----YSLSGWSCLHQAVYKGHIEIVRYLVSL-C 170
Cdd:PHA03100  18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSStknnSTPLHYLSNIKYNLTDVKEIVKLLLEYgA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  171 TLEAVDDYGITPLFVAAQY--GHHQCLDILANAGANVNCQANDLATPLLIAAQEGHE--QCVECLLAHGADPNlycneyc 246
Cdd:PHA03100  98 NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------- 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41054071  247 wqlpilaaaQFNRLSILEKLISVTKRECDRGEgkvSPVYLAVLGGHADSLRALLQKGYSPDAQSCpqFGYSCpLEMA 323
Cdd:PHA03100 171 ---------AKNRVNYLLSYGVPINIKDVYGF---TPLHYAVYNNNPEFVKYLLDLGANPNLVNK--YGDTP-LHIA 232
Ank_4 pfam13637
Ankyrin repeats (many copies);
181-232 2.45e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 2.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41054071   181 TPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLL 232
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 47-138 2.82e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 2.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   47 LHEAAAAGTAGCVRLLIP--AAVNCEDYvntlthNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGG 124
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTggADPNCRDY------DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159

                         90
                 ....*....|....
gi 41054071  125 HKDVIELLVRNGAE 138
Cdd:PTZ00322 160 FREVVQLLSRHSQC 173
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 469-511 6.30e-07

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 45.92  E-value: 6.30e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41054071 469 SVPVLAHLCRLAVGAHVGSDTLSKpsfIQLLPIPSLLQDYLHF 511
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDL---IDKLPLPPRLKDYLLY 40
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 29-245 7.36e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 51.67  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   29 LIRRGFAV-DVKDNRGWNALH---EAAAAGTaGCVRLLIPAAVNCEDYVNtLTHNSETPLYF--AAKYGHLRAVKWLIKA 102
Cdd:PHA02989 130 LLSKGINVnDVKNSRGYNLLHmylESFSVKK-DVIKILLSFGVNLFEKTS-LYGLTPMNIYLrnDIDVISIKVIKYLIKK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  103 GADINRKTNdlscplyaavdgGHKDVIELLVRNgaevngtyslsgwsclHQAVYKGHIEIVRYLVSLCTLEAVDDYGITP 182
Cdd:PHA02989 208 GVNIETNNN------------GSESVLESFLDN----------------NKILSKKEFKVLNFILKYIKINKKDKKGFNP 259

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41054071  183 LFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEY 245
Cdd:PHA02989 260 LLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRILQLKPGKYLIKKTF 322
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 468-511 9.19e-07

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 45.56  E-value: 9.19e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDtlsKPSFIQLLPIPSLLQDYLHF 511
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRR---RLELIKKLPLPPRLKDYLLY 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-201 1.26e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    9 DSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGwnalheaaaagtagcvrllipaavncedyvntlthnsETPLYFAA 88
Cdd:PHA02874 156 NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG-------------------------------------ESPLHNAA 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   89 KYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDgGHKDVIELLVrNGAEVNGTySLSGWSCLHQAV-YKGHIEIVRYLV 167
Cdd:PHA02874 199 EYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLI-NNASINDQ-DIDGSTPLHHAInPPCDIDIIDILL 275

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 41054071  168 -SLCTLEAVDDYGITPLFVAAQYGHHQCL--DILANA 201
Cdd:PHA02874 276 yHKADISIKDNKGENPIDTAFKYINKDPVikDIIANA 312
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 16-163 1.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   16 LAARDG-KSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAG--CVRLL-IPAAVNCEDY-----------------VN 74
Cdd:PHA02876 313 LMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdiVITLLeLGANVNARDYcdktpihyaavrnnvviIN 392

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   75 TL----------THNSETPLYFAAkYGH--LRAVKWLIKAGADINRKTNDLSCPL-YAAVDGGHKDVIELLVRNGAEVNG 141
Cdd:PHA02876 393 TLldygadiealSQKIGTALHFAL-CGTnpYMSVKTLIDRGANVNSKNKDLSTPLhYACKKNCKLDVIEMLLDNGADVNA 471

                        170       180
                 ....*....|....*....|..
gi 41054071  142 TYSLSGWSCLHQAVYKGHIEIV 163
Cdd:PHA02876 472 INIQNQYPLLIALEYHGIVNIL 493
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 7-150 2.35e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    7 YADSCSAVALAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIP--AAVNCEDYVNTlthnseTPL 84
Cdd:PHA02875  99 YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDhkACLDIEDCCGC------TPL 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071   85 YFAAKYGHLRAVKWLIKAGADIN--RKTNDLSCPLYaAVDGGHKDVIELLVRNGAEVNGTYSLSGWSC 150
Cdd:PHA02875 173 IIAMAKGDIAICKMLLDSGANIDyfGKNGCVAALCY-AIENNKIDIVRLFIKRGADCNIMFMIEGEEC 239
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 108-244 3.97e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 48.83  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  108 RKTN--DLSCPLYAAVDGGHKDVIELLVRNGAEVNGTYSLSgwsclhqavykghiEIVRylvslctleavddygITPLFV 185
Cdd:PHA02884  26 KKKNkiCIANILYSSIKFHYTDIIDAILKLGADPEAPFPLS--------------ENSK---------------TNPLIY 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  186 AAQYGHHQCLDILANAGANVNCQANDLA-TPLLIAAQEGHEQCVECLLAHGADPNLYCNE 244
Cdd:PHA02884  77 AIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTND 136
Ank_4 pfam13637
Ankyrin repeats (many copies);
43-100 7.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 7.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071    43 GWNALHEAAAAGTAGCVRLLIPAAVNcedyVNTLTHNSETPLYFAAKYGHLRAVKWLI 100
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
147-198 1.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 41054071   147 GWSCLHQAVYKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDIL 198
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKgADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
73-117 3.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 3.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 41054071    73 VNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPL 117
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
214-267 4.03e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 4.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 41054071   214 TPLLIAAQEGHEQCVECLLAHGADPNlYCNEYCWQlPILAAAQFNRLSILEKLI 267
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 154-356 5.21e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  154 AVYKGHIEIVRYLVSLCTLEAVDDY-GITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLL 232
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYdGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  233 ahgaDPNLYCNEYCWQ---LPILAAAQFNRLSILEKLIsvtKRECD---RGEGKVSPVYLAVLGGHADSLRALLQKGYSP 306
Cdd:PHA02875  89 ----DLGKFADDVFYKdgmTPLHLATILKKLDIMKLLI---ARGADpdiPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 41054071  307 DAQSCpqFGYScPLEMALwtwldaswnlnseCHQAQEITLILLAAGAHVN 356
Cdd:PHA02875 162 DIEDC--CGCT-PLIIAM-------------AKGDIAICKMLLDSGANID 195
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 467-509 5.80e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 5.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 41054071    467 FESVPVLAHLCRLAVGAHVGSDTLSKpsfiqlLPIPSLLQDYL 509
Cdd:smart00253   4 PSNVPSLQHLCRFTIRRCTRTDQIKT------LPLPPKLKDYL 40
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 59-183 6.37e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 45.50  E-value: 6.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   59 VRLLIP--AAVNCEDYVNT----LTHNSE-TPlyfaAKYGHLraVKWLIKAGADINRKTNDLSCPLYAAVDGGH---KDV 128
Cdd:PHA02989  53 VKLLIDngADVNYKGYIETplcaVLRNREiTS----NKIKKI--VKLLLKFGADINLKTFNGVSPIVCFIYNSNinnCDM 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41054071  129 IELLVRNGAEVNGTYSLSGWSCLHQ-----AVYKGHIEI-VRYLVSLctLEAVDDYGITPL 183
Cdd:PHA02989 127 LRFLLSKGINVNDVKNSRGYNLLHMylesfSVKKDVIKIlLSFGVNL--FEKTSLYGLTPM 185
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 473-510 6.67e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 40.23  E-value: 6.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41054071   473 LAHLCRLAVGAHVGSDTLSKpsfIQLLPIPSLLQDYLH 510
Cdd:pfam07525   5 LQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 16-190 1.09e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  16 LAARDGKSRRVQKLIRRGfAVDV--KDNRGWNALHEA-------AAAGTAGCVRLLIPAAVNCEDYVntlthnSETPLYF 86
Cdd:cd22192  23 LAAKENDVQAIKKLLKCP-SCDLfqRGALGETALHVAalydnleAAVVLMEAAPELVNEPMTSDLYQ------GETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  87 AAKYGHLRAVKWLIKAGADIN---------RKTNDLSC-----PLYAAVDGGHKDVIELLVRNGAEVNGTYSLsGWSCLH 152
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSL-GNTVLH 174

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 41054071 153 ----QAVYKGHIEIVRYLVSL------CTLEAVDDY-GITPLFVAAQYG 190
Cdd:cd22192 175 ilvlQPNKTFACQMYDLILSYdkeddlQPLDLVPNNqGLTPFKLAAKEG 223
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 468-510 1.24e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 39.50  E-value: 1.24e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDTlskpsfIQLLPIPSLLQDYLH 510
Cdd:cd03717   1 TSVRSLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYLK 37
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 87-267 2.61e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071    87 AAKYGHLRAVKWLIKAGADINRKTND---LSCPLYAAVDGGHKDVIELLVRNGAEVNgtyslSGWSCLHQAV--YKGHIE 161
Cdd:TIGR00870  24 AAERGDLASVYRDLEEPKKLNINCPDrlgRSALFVAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   162 -IVRYLV-----SLCTLEAVDDY------GITPLFVAAQYGHHQCLDILANAGANVNCQANdlatplliaaqegheqCVE 229
Cdd:TIGR00870  99 aILLHLLaafrkSGPLELANDQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPARAC----------------GDF 162

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 41054071   230 CLLAHGADpNLYCNEYcwqlPILAAAQFNRLSILEKLI 267
Cdd:TIGR00870 163 FVKSQGVD-SFYHGES----PLNAAACLGSPSIVALLS 195
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 473-513 3.39e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 38.66  E-value: 3.39e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 41054071 473 LAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQDYLHFSD 513
Cdd:cd03731   6 LKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKE 46
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 178-207 3.83e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 41054071    178 YGITPLFVAAQYGHHQCLDILANAGANVNC 207
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 3.87e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.87e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41054071    81 ETPLYFAA-KYGHLRAVKWLIKAGADINRKTN 111
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 167-313 3.88e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 3.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  167 VSLCTLEAVDDYgitplfVAAQyghhqcldILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEyc 246
Cdd:PTZ00322  84 VELCQLAASGDA------VGAR--------ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKD-- 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41054071  247 WQLPILAAAQFNRLSILEKLISVTKRECDRGEGKVSPVYLAVLGGHADSLRALLQkgysPDAQSCPQ 313
Cdd:PTZ00322 148 GKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFTGKPPSLEDSPISSHH----PDFSAVPQ 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-107 4.06e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 4.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 41054071     79 NSETPLYFAAKYGHLRAVKWLIKAGADIN 107
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 468-513 4.57e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.29  E-value: 4.57e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41054071 468 ESVPVLAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQDYLHFSD 513
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKE 46
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 214-240 5.45e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 5.45e-04
                           10        20
                   ....*....|....*....|....*..
gi 41054071    214 TPLLIAAQEGHEQCVECLLAHGADPNL 240
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 176-310 5.62e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.55  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  176 DDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECL--LAHGADPNLYCNEYCwqlpilA 253
Cdd:PLN03192 555 DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAGDLLC------T 628

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 41054071  254 AAQFNRLSILEKLISVTKRECDRGEGKVSPVYLAVLGGHADSLRALLQKGYSPDAQS 310
Cdd:PLN03192 629 AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 70-378 7.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   70 EDYVNTLTHNSETPLYFAAKYGHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVR--NGAEVNGTYSLSG 147
Cdd:PHA02878  27 ENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRsiNKCSVFYTLVAIK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  148 WSCLHQAVYKGHIEIVRY--------LVSLCTLEAVD--DYGITPLFVAaqyghhqcldilanAGANVNCQ-ANDLATPL 216
Cdd:PHA02878 107 DAFNNRNVEIFKIILTNRykniqtidLVYIDKKSKDDiiEAEITKLLLS--------------YGADINMKdRHKGNTAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  217 LIAAQEGHEQCVECLLAHGADPNlycneycwqlpilaaaqfnrlsILEKlisvtkreCDRgegkvSPVYLAVLGGHADSL 296
Cdd:PHA02878 173 HYATENKDQRLTELLLSYGANVN----------------------IPDK--------TNN-----SPLHHAVKHYNKPIV 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  297 RALLQKGYSPDAQScpQFGySCPLEMALWTWLDAswnlnsechqaqEITLILLAAGAHVN--TSIYGFT---LQGHVPEH 371
Cdd:PHA02878 218 HILLENGASTDARD--KCG-NTPLHISVGYCKDY------------DILKLLLEHGVDVNakSYILGLTalhSSIKSERK 282


                 ....*..
gi 41054071  372 LPLILKH 378
Cdd:PHA02878 283 LKLLLEY 289
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-107 7.63e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 7.63e-04
                          10        20
                  ....*....|....*....|....*..
gi 41054071    81 ETPLYFAAKYGHLRAVKWLIKAGADIN 107
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 473-510 9.09e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 36.62  E-value: 9.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41054071    473 LAHLCRLAVGAHVGsdtlskpsFIQLLPIPSLLQDYLH 510
Cdd:smart00969   3 LQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLL 32
PHA02798 PHA02798
ankyrin-like protein; Provisional
 59-210 1.00e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   59 VRLLIPAAVNcedyVNTLTHNSETPLYFA----AKYGH-LRAVKWLIKAGADINRKTNDLSCPLYAAVDGGH---KDVIE 130
Cdd:PHA02798  54 VKLFINLGAN----VNGLDNEYSTPLCTIlsniKDYKHmLDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEILL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  131 LLVRNGAEVNgtyslsgwsclhqavykghieivrylvslctleAVDDYGITPLFVAAQYGHHQCLDI---LANAGANVNC 207
Cdd:PHA02798 130 FMIENGADTT---------------------------------LLDKDGFTMLQVYLQSNHHIDIEIiklLLEKGVDINT 176


                 ...
gi 41054071  208 QAN 210
Cdd:PHA02798 177 HNN 179
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 82-140 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.12  E-value: 1.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   82 TPLYFAAKYGHLRAVKWLIKAGADINRKTNDLS-CPLYAAVDGGHKDVIELLVRNGAEVN 140
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADIN 131
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 72-169 1.77e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.80  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   72 YVNTLTHNSETPLY--FAAKYGHLRAVKWLIKAGADINRKT--NDLScPL--YAAVDGG-HKDVIELLVRNGAEVNGTYS 144
Cdd:PHA02859  43 FVNDCNDLYETPIFscLEKDKVNVEILKFLIENGADVNFKTrdNNLS-ALhhYLSFNKNvEPEILKILIDSGSSITEEDE 121

                         90       100
                 ....*....|....*....|....*....
gi 41054071  145 lSGWSCLHqaVYKGH----IEIVRYLVSL 169
Cdd:PHA02859 122 -DGKNLLH--MYMCNfnvrINVIKLLIDS 147
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 214-240 2.21e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 2.21e-03
                          10        20
                  ....*....|....*....|....*...
gi 41054071   214 TPLLIAA-QEGHEQCVECLLAHGADPNL 240
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
PHA02791 PHA02791
ankyrin-like protein; Provisional
 22-168 2.46e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.03  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   22 KSRRVQKLI--RRGFAVDVkdnRGWNALHEAAAAGTAGCVRLLIPAAVncedyVNTLTHNsETPLYFAAKYGHLRAVKWL 99
Cdd:PHA02791  10 KSKQLKSFLssKDAFKADV---HGHSALYYAIADNNVRLVCTLLNAGA-----LKNLLEN-EFPLHQAATLEDTKIVKIL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  100 IKAGADINRKTNDLSCPLYAAVDGGHKDVIELLVRNGAEVNgTYSLSGW-SCLHQAVYKGHIEIVRYLVS 168
Cdd:PHA02791  81 LFSGMDDSQFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLM-FYGKTGWkTSFYHAVMLNDVSIVSYFLS 149
PHA02798 PHA02798
ankyrin-like protein; Provisional
 73-224 3.21e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071   73 VNTLTHNSETPLY--FAAKY-GHLRAVKWLIKAGADINRKTNDLSCPLYAAVDGGHK---DVIELLVRNGAEVNGTYSLS 146
Cdd:PHA02798 102 INKKNSDGETPLYclLSNGYiNNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNKE 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  147 GWSCLHqAVYKGHIE---------------------------IVRYLVSLCTLEA------------------VDDYGIT 181
Cdd:PHA02798 182 KYDTLH-CYFKYNIDridadilklfvdngfiinkenkshkkkFMEYLNSLLYDNKrfkknildfifsyidinqVDELGFN 260

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 41054071  182 PLFVAAQYGHHQCLDILANAGANVNCqANDLATPLLIAAQEGH 224
Cdd:PHA02798 261 PLYYSVSHNNRKIFEYLLQLGGDINI-ITELGNTCLFTAFENE 302
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-364 4.77e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 4.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 195 LDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEYCWQLPILAAAQFNRLSILEKLISVTKREC 274
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071 275 DRGEGKVSPVYLAVLGGHADSLRALLQKGYSPDAQScpQFGYScPLEMALWtwldaswnlnsecHQAQEITLILLAAGAH 354
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD--KDGET-PLHLAAY-------------NGNLEIVKLLLEAGAD 145

                       170
                ....*....|.
gi 41054071 355 VN-TSIYGFTL 364
Cdd:COG0666 146 VNaQDNDGNTP 156
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 173-240 6.33e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.47  E-value: 6.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054071  173 EAVDDYGITPLFVAAQYGHHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNL 240
Cdd:PLN03192 519 EHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI 586
PHA02798 PHA02798
ankyrin-like protein; Provisional
 127-245 8.31e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 38.66  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054071  127 DVIELLVRNGAEVNG---TYSLSGWSCLHQAV-YKGHIEIVRYLVSL-CTLEAVDDYGITPLFVAAQYGHHQCLDILA-- 199
Cdd:PHA02798  52 DIVKLFINLGANVNGldnEYSTPLCTILSNIKdYKHMLDIVKILIENgADINKKNSDGETPLYCLLSNGYINNLEILLfm 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 41054071  200 -NAGANVNCQANDLATPLLIAAQEGHE---QCVECLLAHGADPNLYCNEY 245
Cdd:PHA02798 132 iENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNKE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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