Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Nef protein and potentiates HIV-1 LTR promoter activity |
PubMed
|
Pol
|
gag-pol
|
HIV-1 Pol is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
Tat
|
tat
|
Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Tat protein and potentiates HIV-1 LTR promoter activity |
PubMed
|
|
tat
|
The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway |
PubMed
|
|
tat
|
HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells |
PubMed
|
reverse transcriptase
|
gag-pol
|
HIV-1 RT is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
Go to the HIV-1, Human Interaction Database