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    Disp1 dispatched RND transporter family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Disp1provided by RGD
    Official Full Name
    dispatched RND transporter family member 1provided by RGD
    Primary source
    RGD:1307675
    See related
    EnsemblRapid:ENSRNOG00000003635 AllianceGenome:RGD:1307675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in diaphragm development and smoothened signaling pathway. Predicted to act upstream of or within several processes, including patched ligand maturation; peptide transport; and regionalization. Predicted to be active in membrane. Orthologous to human DISP1 (dispatched RND transporter family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 41.4), Kidney (RPKM 30.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Disp1 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97252574..97398329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94720928..94866695, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101451932..101597570, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, pseudogene 19 Neighboring gene toll-like receptor 5 Neighboring gene uncharacterized LOC108352652 Neighboring gene uncharacterized LOC108352653

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of dispatched RND transporter family member 1 is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia. Takahashi T, et al. Pediatr Surg Int, 2019 Jan. PMID 30382378
    2. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Etheridge LA, et al. Development, 2010 Jan. PMID 20023168, Free PMC Article
    3. Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH. Kantarci S, et al. Am J Med Genet A, 2010 Oct. PMID 20799323, Free PMC Article
    4. Hedgehog signaling update. Cohen MM Jr. Am J Med Genet A, 2010 Aug. PMID 20635334
    5. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Ma Y, et al. Cell, 2002 Oct 4. PMID 12372301

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased Disp-1 expression during diaphragmatic development and lung branching morphogenesis may interrupt mesenchymal cell proliferation, thus leading to diaphragmatic defects and PH in the nitrofen-induced CDH model.
      Title: Expression of dispatched RND transporter family member 1 is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diaphragm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within patched ligand maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein dispatched homolog 1
    Names
    dispatched homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105983.2 → NP_001099453.1  protein dispatched homolog 1

      See identical proteins and their annotated locations for NP_001099453.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2
      Related
      ENSRNOP00000004834.4, ENSRNOT00000004834.6
      Conserved Domains (1) summary
      cl25655
      Location:433 → 1113
      Patched; Patched family

    2. NM_001415783.1 → NP_001402712.1  protein dispatched homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      97252574..97398329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090573.2 → XP_038946501.1  protein dispatched homolog 1 isoform X1

      Related
      ENSRNOP00000101881.1, ENSRNOT00000169721.1
      Conserved Domains (1) summary
      cl25655
      Location:467 → 1147
      Patched; Patched family

    2. XM_039090576.1 → XP_038946504.1  protein dispatched homolog 1 isoform X3

      Conserved Domains (1) summary
      cl25655
      Location:196 → 876
      Patched; Patched family

    3. XM_039090575.1 → XP_038946503.1  protein dispatched homolog 1 isoform X3

      Conserved Domains (1) summary
      cl25655
      Location:196 → 876
      Patched; Patched family

    4. XM_017598736.2 → XP_017454225.1  protein dispatched homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2
      Conserved Domains (1) summary
      cl25655
      Location:433 → 1113
      Patched; Patched family

    5. XM_063272175.1 → XP_063128245.1  protein dispatched homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2

    6. XM_006250384.5 → XP_006250446.1  protein dispatched homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006250446.1

      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2
      Conserved Domains (1) summary
      cl25655
      Location:433 → 1113
      Patched; Patched family

    7. XM_006250383.5 → XP_006250445.1  protein dispatched homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006250445.1

      UniProtKB/TrEMBL
      A6JGM9, D3ZWU2
      Conserved Domains (1) summary
      cl25655
      Location:433 → 1113
      Patched; Patched family

    8. XM_039090577.1 → XP_038946505.1  protein dispatched homolog 1 isoform X3

      Conserved Domains (1) summary
      cl25655
      Location:196 → 876
      Patched; Patched family

    9. XM_063272176.1 → XP_063128246.1  protein dispatched homolog 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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