|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
494-1133 |
1.31e-41 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 165.42 E-value: 1.31e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 494 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 571
Cdd:COG1033 212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 572 A-FVLCDVWNYTKSDKPRAEtseAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWL 650
Cdd:COG1033 289 GiHLLNRYREERRKGLDKRE---ALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 651 PAVIVLheryllniftcFRKPqpqayhkscwtvlcRKGRKALFAISEASRIFfeKVLPCIVIKFRYLWLVWFLALTVGGA 730
Cdd:COG1033 366 PALLSL-----------LPRP--------------KPKTRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 731 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeLTLD 810
Cdd:COG1033 419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 811 STFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcIKKA 890
Cdd:COG1033 465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----LAQL 528
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 891 IMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLShgWFVS--NL 968
Cdd:COG1033 529 LLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgsAV 594
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 969 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVD 1048
Cdd:COG1033 595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVD 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 1049 FAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQC 1126
Cdd:COG1033 675 YTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPA 754
|
....*..
gi 564382060 1127 LCRCLGP 1133
Cdd:COG1033 755 LLLLLDP 761
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
433-1113 |
7.10e-23 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 105.90 E-value: 7.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 433 DFMTSKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 509
Cdd:pfam02460 144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 510 AIVLLIM-----CVYTKSVFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 576
Cdd:pfam02460 222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 577 DVW-NYTKSDKPRaetsEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIV 655
Cdd:pfam02460 301 AAWqRTTATLSVK----KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMA 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 656 LHERYLLNIFTCFRKPqPQAYHKSCWTVLCRKgRKALFAISEASRIFFEKVLPCI----VIKFRYLWLVWFLALTVGGay 731
Cdd:pfam02460 377 ICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEP-DKSHNIEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG-- 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 732 ivCINPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL---- 807
Cdd:pfam02460 453 --CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnemv 513
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 808 -TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevfe 884
Cdd:pfam02460 514 dEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA--------- 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 885 lcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapegL 959
Cdd:pfam02460 573 --------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE----F 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 960 SHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTI 1039
Cdd:pfam02460 620 NVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITI 699
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564382060 1040 SVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAIAVAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 1113
Cdd:pfam02460 700 IMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
506-660 |
6.86e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 6.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 506 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKS 584
Cdd:COG1033 612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564382060 585 DKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 660
Cdd:COG1033 687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
971-1124 |
6.98e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 971 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1050
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564382060 1051 VHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVA-GAMM-MPSTVLAytQLGTFMMLVMCVSWAFATFFF 1124
Cdd:COG1033 290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
505-669 |
5.21e-15 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 73.77 E-value: 5.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 505 PAIAIAIVLLIMCVYTKSVfiTLMTMFAIISSLIVSyflyrvvfnfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKS 584
Cdd:pfam12349 6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 585 DKPraeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHER----Y 660
Cdd:pfam12349 67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143
|
....*....
gi 564382060 661 LLNIFTCFR 669
Cdd:pfam12349 144 RLDVACCIR 152
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
453-1080 |
1.77e-10 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 66.09 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 453 FSPTEKGESMM---NIYLDNFENWNSSDGITTVTgieFGIKHSLfQDYLLMDTVYPAIAIAIVLLIMCVYT--------- 520
Cdd:TIGR00917 522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 521 -KSVFITLMTMFAIISSLIVsyfLYRVVFNFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNY-------TKS 584
Cdd:TIGR00917 598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYleyfyrqVGV 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 585 DKPRAETSE-AVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HER 659
Cdd:TIGR00917 675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 660 YLLNIFTCFRkpqpqayhkscwtvLCRKGRKALFAISEAS----RIFFEKVLPCIVIK--FRYLWLVWFLALTVGG-AYI 732
Cdd:TIGR00917 755 KRVDCFPCIK--------------TSKSSISAEKGSGQRKagllTRYFKEVYAPVLLHwiVKIVVIAFFVGLLMAGiALS 820
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 733 VCINP----KMKLPSleLSEFQVFRSShpferydaefkklfMFERVHHGEELHMPI------TVIWGVSPEDSGDPLNPK 802
Cdd:TIGR00917 821 TRVEIgldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIkgdynyTDFESQNKLCTMGGCDKD 884
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 803 SKGELTLDSTFnIASPASqAWILHF-----------CQKLRNQTFFHQTEQQDFtSCFIET-----------FKQWMENQ 860
Cdd:TIGR00917 885 SIVNVFNNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWF 961
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 861 DCDEPAlyPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHlnnktpgprfdindtiraVVLEFQSTFLFTLayEKMQQF 940
Cdd:TIGR00917 962 LNALPS--ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYH------------------TPLNTQVDFINAM--RAAQEF 1019
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 941 YKEVDSwishelSSAPEGLSHGWFVSnleFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTCNIIISLYAIASIAGTIFV 1019
Cdd:TIGR00917 1020 AAKVSR------SSKMEVYPYSVFYV---FFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVF 1090
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564382060 1020 TVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAI 1080
Cdd:TIGR00917 1091 CVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
976-1153 |
1.59e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 62.71 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 976 SLSDGTLIAMGLSVaVAFSVMLLttcniiISLYAIASIAGtIFVT--VGSLVLLGWELNVLESVT-ISVA-----VGLSV 1047
Cdd:TIGR03480 266 TVSEGATVAGLLSF-VLVLVLLW------LALRSPRLVFA-VLVTliVGLILTAAFATLAVGHLNlISVAfavlfIGLGV 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 1048 DFAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 1124
Cdd:TIGR03480 338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416
|
170 180
....*....|....*....|....*....
gi 564382060 1125 QCLCRCLGPQGTCGQIPLPKKLQCSAFSH 1153
Cdd:TIGR03480 417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
450-656 |
2.46e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 62.16 E-value: 2.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 450 SMLFSPTEKgESMMNIYLDNFENWNSSDGIT-TVTG--IEFGIKHSLFQDYLLMDTVYPAIAIAIVLLImcVY---TKSV 523
Cdd:TIGR00921 519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 524 FiTLMTMFAIISSLIVSYFLYRVVFnfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKSDKPRAETS--EAVSVTLQ 600
Cdd:TIGR00921 596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 564382060 601 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 656
Cdd:TIGR00921 664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
969-1107 |
7.08e-09 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 60.55 E-value: 7.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 969 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLV--------LLGWELNVLESVT-- 1038
Cdd:COG2409 507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 1039 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLGRMGSAIAVAAL---TTFVAgamMMPSTVLAYTQL 1105
Cdd:COG2409 587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRVITSAALimaAVFAA---FATSPLVFLKQI 657
|
..
gi 564382060 1106 GT 1107
Cdd:COG2409 658 GF 659
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
972-1108 |
2.21e-08 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 57.69 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 972 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 1047
Cdd:pfam03176 135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564382060 1048 --DFAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTtfVAGAMMmpstVLAYTQLGTF 1108
Cdd:pfam03176 214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
527-679 |
3.44e-07 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 55.27 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 527 LMTMFAIISSLIVSYFLyRVVFN---FEFFPFMNLtaliilvGIGADDAFVLCDVwnYTKSDkPRAETSEAVSVTLQHAA 603
Cdd:TIGR00918 435 LLVALSVAAGLGLCALL-GISFNaatTQVLPFLAL-------GVGVDDVFLLAHA--FSETG-QNIPFEERTGECLKRTG 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 604 LSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFRKP-------- 671
Cdd:TIGR00918 504 ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSPcsarviqi 583
|
....*...
gi 564382060 672 QPQAYHKS 679
Cdd:TIGR00918 584 EPQAYADG 591
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
506-656 |
1.80e-06 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 52.69 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 506 AIAIAIVLLIMCVYTKS---VFITLMTMFAiisSLIVSyflyrvvfnFEFFPFM----NL--TALIIL-VGIGADDA--F 573
Cdd:TIGR03480 276 LLSFVLVLVLLWLALRSprlVFAVLVTLIV---GLILT---------AAFATLAvghlNLisVAFAVLfIGLGVDFAiqF 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 574 VLcdvwNYTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAV 653
Cdd:TIGR03480 344 SL----RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPAL 419
|
...
gi 564382060 654 IVL 656
Cdd:TIGR03480 420 LRL 422
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
506-658 |
2.28e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 52.53 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 506 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSlivsyflyrVVFNFEFFPFM-------NLTALIILVGIGAD-DAFVLCD 577
Cdd:TIGR00921 200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTLNR 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 578 VwnYTKSDKPRAeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLH 657
Cdd:TIGR00921 271 Y--EEERDIGRA-KGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSI 347
|
.
gi 564382060 658 E 658
Cdd:TIGR00921 348 D 348
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
506-673 |
7.72e-06 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 50.74 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 506 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSYFLYRVVFNFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 580
Cdd:TIGR00833 180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 581 YTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 660
Cdd:TIGR00833 256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335
|
170
....*....|...
gi 564382060 661 LLniftcFRKPQP 673
Cdd:TIGR00833 336 GL-----MKPGRK 343
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
506-656 |
1.56e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 48.83 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 506 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSL-----IVSYFLYRVVFNFEFFPFMNLTalIILVGIGADDAFVLcdVWN 580
Cdd:pfam03176 149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgLVAILAHILGIGLSTFALNLLV--VLLIAVGTDYALFL--VSR 224
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564382060 581 YTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 656
Cdd:pfam03176 225 YREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1040-1124 |
8.35e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.15 E-value: 8.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 1040 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLGRMGSAIAVAALTTFVAGAMMM--PSTVLAytQLGTFMMLVMCVSW 1117
Cdd:COG4258 310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383
|
....*..
gi 564382060 1118 AFATFFF 1124
Cdd:COG4258 384 LTTLLWL 390
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
970-1108 |
1.73e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 46.30 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 970 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 1045
Cdd:COG2409 160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564382060 1046 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLGRMGSAIAVAALTtfVAGAMMmpstVLAYTQLGTF 1108
Cdd:COG2409 239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
970-1122 |
2.15e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 45.98 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 970 FYDLQDSLSDGtlIAMGLSVAVAFSVMLLTTC--NIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSV 1047
Cdd:TIGR00921 558 FAEMHELVNEG--MRRMTIAGAILVLMILLAVfrNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGM 635
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564382060 1048 DFAVHygVAYRLAPDPDREGKV---IFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGtFMMLVMCVSWAFATF 1122
Cdd:TIGR00921 636 DYSIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
489-656 |
7.52e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.99 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 489 IKHSLFQDYLLMdtVypAIAIAIVLLIMCVYTKSVFI----TLMTMFAIISSLIVSYFLY---RVVFNFE------FFPF 555
Cdd:COG2409 511 ISDALADDLPLV--I--PVVLGLIFLLLLLLFRSVVAplkaVLTNLLSLGAALGVLVLVFqhgWLLLGFTpgpldsFVPL 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 556 MnltALIILVGIGAD-DAFVLCDVW-NYTKSDKPRaetsEAVSVTLQH-------AALSMFVTsFttaAAFyanYVSNIT 626
Cdd:COG2409 587 L---LFVILFGLGMDyEVFLVSRIReEYDRGGGTR----EAVIRGLARtgrvitsAALIMAAV-F---AAF---ATSPLV 652
|
170 180 190
....*....|....*....|....*....|.
gi 564382060 627 AIRCFGVYAGTAILVNYVLMVTWL-PAVIVL 656
Cdd:COG2409 653 FLKQIGFGLAVGVLLDAFVVRMLLvPALMAL 683
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
971-1123 |
1.86e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.90 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 971 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1050
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564382060 1051 VHYGVAYRlapDPDREGK-----VIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1123
Cdd:TIGR00921 265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
985-1087 |
2.21e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 42.53 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 985 MGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 1064
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718
|
90 100
....*....|....*....|...
gi 564382060 1065 REGkvifSLGRMGSAIAVAALTT 1087
Cdd:COG4258 719 DKG----ELARTLLSILLAALTT 737
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
507-587 |
7.61e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 41.16 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564382060 507 IAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSyFLYRVVFNFEfFPFMNLTALIILVGIGADDAF-VLCDVWNYTKSD 585
Cdd:NF033617 338 EAVALVILVVFLFLRNLRATLIPAVTVPLSLIGT-FAVMYLFGFS-INLLTLMALVLAIGLVVDDAIvVVENIHRHIEEG 415
|
..
gi 564382060 586 KP 587
Cdd:NF033617 416 ES 417
|
|
| |
