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    GPR15LG G protein-coupled receptor 15 ligand [ Homo sapiens (human) ]

    Gene ID: 387695, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR15LGprovided by HGNC
    Official Full Name
    G protein-coupled receptor 15 ligandprovided by HGNC
    Primary source
    HGNC:HGNC:31428
    See related
    Ensembl:ENSG00000188373 MIM:617775; AllianceGenome:HGNC:31428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP57; CSBF; AP-57; GPR15L; UNQ1833; C10orf99
    Summary
    Enables chemokine activity. Involved in several processes, including defense response to other organism; mast cell degranulation; and negative regulation of cell cycle G1/S phase transition. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon (RPKM 85.6), esophagus (RPKM 74.6) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR15LG in Genome Data Viewer
    Location:
    10q23.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (84173801..84185294)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (85052266..85063813)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (85933557..85945050)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85899203-85899772 Neighboring gene growth hormone inducible transmembrane protein Neighboring gene NANOG hESC enhancer GRCh37_chr10:85915068-85915581 Neighboring gene NANOG hESC enhancer GRCh37_chr10:85920657-85921158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85921491-85922206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85931151-85931652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3677 Neighboring gene competing endogenous lncRNA 2 for microRNA let-7b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85936583-85937084 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85939583-85940403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2551 Neighboring gene cadherin related family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85963048-85963548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85963549-85964049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85974015-85974538 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Role of GPR15 Function in Blood and Vasculature. Bauer M. Int J Mol Sci, 2021 Oct 6. PMID 34639163, Free PMC Article
    2. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes. Chen C, et al. Sci Rep, 2018 Jun 5. PMID 29872130, Free PMC Article
    3. GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes. Chen C, et al. Biosci Rep, 2024 Jun 26. PMID 38393364, Free PMC Article
    4. Tyrosine sulfation and O-glycosylation of chemoattractant receptor GPR15 differentially regulate interaction with GPR15L. Okamoto Y, et al. J Cell Sci, 2021 Apr 15. PMID 33758080, Free PMC Article
    5. AP-57/C10orf99 is a new type of multifunctional antimicrobial peptide. Yang M, et al. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25585381

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
      Title: GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
    2. Results indicate that chromosome 10 open reading frame 99 protein (C10orf99) plays a contributive role in psoriasis pathogenesis and may serve as a new target for psoriasis treatment.
      Title: C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.
    3. Compared with other antimicrobial peptides, AP-57 has its distinct characteristics, including longer sequence length, four cysteines, highly cationic character, cell-specific toxicity, DNA binding and tissue-specific expressing patterns.
      Title: AP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21763

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lymphocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle G1/S phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of T cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein GPR15LG
    Names
    RLLV1833
    anti-microbial peptide with 57 amino acid residues
    antimicrobial peptide with 57 amino acid residues
    antimicrobial peptide-57
    colon-derived SUSD2 binding factor
    protein GPR15 ligand
    protein GPR15L
    secreted protein C10orf99

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207373.3 → NP_997256.1  protein GPR15LG precursor

      See identical proteins and their annotated locations for NP_997256.1

      Status: VALIDATED

      Source sequence(s)
      AI831407, AW351839, AY358751
      Consensus CDS
      CCDS7371.1
      UniProtKB/Swiss-Prot
      Q6UWK7
      Related
      ENSP00000361199.3, ENST00000372126.4
      Conserved Domains (1) summary
      pfam15854
      Location:17 → 80
      DUF4725; Domain of unknown function (DUF4725)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      84173801..84185294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269811.4 → XP_005269868.1  protein GPR15LG isoform X1

      Conserved Domains (1) summary
      pfam15854
      Location:17 → 53
      DUF4725; Domain of unknown function (DUF4725)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      85052266..85063813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365882.1 → XP_054221857.1  protein GPR15LG isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWK7.1 GenPept UniProtKB/Swiss-Prot:Q6UWK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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