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    Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15519, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hsp90aa1provided by MGI
    Official Full Name
    heat shock protein 90, alpha (cytosolic), class A member 1provided by MGI
    Primary source
    MGI:MGI:96250
    See related
    Ensembl:ENSMUSG00000021270 AllianceGenome:MGI:96250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1
    Summary
    Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including cellular response to heat; positive regulation of nitric oxide biosynthetic process; and protein folding. Located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Hsp90aa1 in Genome Data Viewer
    Location:
    12 F1; 12 60.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110657470..110662829, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110691036..110696395, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K19 gene Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene WD repeat domain 20 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene MOK protein kinase Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 53
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein folding chaperone  
    enables CTP binding  
    enables CTP binding  
    enables DNA polymerase binding  
    enables DNA polymerase binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase binding  
    enables GTPase binding  
    enables Rho GDP-dissociation inhibitor binding  
    enables Rho GDP-dissociation inhibitor binding  
    enables TPR domain binding  
    enables TPR domain binding  
    enables UTP binding  
    enables UTP binding  
    enables dATP binding  
    enables dATP binding  
    enables disordered domain specific binding  
    enables disordered domain specific binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables mRNA binding  
    enables mRNA binding  
    enables nitric-oxide synthase regulator activity PubMed 
    enables nitric-oxide synthase regulator activity  
    enables protein binding PubMed 
    enables protein folding chaperone PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein tyrosine kinase binding  
    enables protein tyrosine kinase binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables sulfonylurea receptor binding  
    enables sulfonylurea receptor binding  
    enables tau protein binding  
    enables tau protein binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    enables unfolded protein binding PubMed 
    Items 1 - 25 of 53
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in activation of innate immune response  
    involved_in activation of innate immune response  
    involved_in cardiac muscle cell apoptotic process  
    involved_in cellular response to heat  
    involved_in cellular response to heat PubMed 
    involved_in cellular response to virus  
    involved_in cellular response to virus  
    involved_in chaperone-mediated protein complex assembly  
    involved_in chaperone-mediated protein complex assembly  
    involved_in neurofibrillary tangle assembly  
    involved_in neuron migration  
    involved_in neuron migration  
    involved_in nitric oxide biosynthetic process PubMed 
    involved_in positive regulation of cardiac muscle contraction  
    involved_in positive regulation of cell size  
    involved_in positive regulation of cell size  
    involved_in positive regulation of cytotoxic T cell differentiation PubMed 
    involved_in positive regulation of defense response to virus by host  
    involved_in positive regulation of defense response to virus by host  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of nitric oxide biosynthetic process PubMed 
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of tau-protein kinase activity  
    involved_in protein folding  
    involved_in protein folding PubMed 
    involved_in protein insertion into mitochondrial outer membrane  
    involved_in protein insertion into mitochondrial outer membrane  
    involved_in protein refolding PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of apoptotic process  
    involved_in regulation of apoptotic process  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of protein localization PubMed 
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein ubiquitination  
    involved_in response to antibiotic  
    involved_in response to cocaine  
    involved_in response to cold  
    involved_in response to estrogen  
    involved_in response to heat  
    involved_in response to salt stress  
    involved_in response to unfolded protein PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in skeletal muscle contraction  
    involved_in telomerase holoenzyme complex assembly  
    involved_in telomerase holoenzyme complex assembly  
    involved_in telomere maintenance via telomerase  
    acts_upstream_of_positive_effect telomere maintenance via telomerase  
    Items 1 - 25 of 60
    Items 1 - 20 of 45
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in axonal growth cone PubMed 
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in brush border membrane  
    located_in brush border membrane  
    located_in cell surface  
    located_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol PubMed 
    located_in dendritic growth cone PubMed 
    located_in intracellular anatomical structure PubMed 
    located_in melanosome  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in myelin sheath PubMed 
    is_active_in myelin sheath  
    located_in myelin sheath  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    located_in sperm flagellum  
    located_in sperm mitochondrial sheath  
    located_in sperm mitochondrial sheath  
    located_in sperm plasma membrane  
    located_in sperm plasma membrane  
    Items 1 - 20 of 45

    General protein information

    Preferred Names
    heat shock protein HSP 90-alpha
    Names
    HSP 86
    HSP86
    TSTA
    heat shock 86 kDa
    heat shock protein 1, alpha
    heat shock protein 90kDa alpha (cytosolic), class A member 1
    heat shock protein, 1
    heat shock protein, 86 kDa 1
    heat shock protein, 89 kDa
    tumor-specific transplantation 86 kDa antigen
    NP_034610.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010480.5NP_034610.1  heat shock protein HSP 90-alpha

      See identical proteins and their annotated locations for NP_034610.1

      Status: PROVISIONAL

      Source sequence(s)
      AC152827, AL596265
      Consensus CDS
      CCDS26172.1
      UniProtKB/Swiss-Prot
      P07901
      UniProtKB/TrEMBL
      Q3TKA2, Q80Y52
      Related
      ENSMUSP00000091921.5, ENSMUST00000094361.11
      Conserved Domains (3) summary
      smart00387
      Location:40191
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:18733
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:196723
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110657470..110662829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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