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Fbxo3 F-box protein 3 [ Mus musculus (house mouse) ]

Gene ID: 57443, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo3provided by MGI
Official Full Name
F-box protein 3provided by MGI
Primary source
MGI:MGI:1929084
See related
Ensembl:ENSMUSG00000027180 AllianceGenome:MGI:1929084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fba; 1200002G09Rik; 1700026K02Rik
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO3 (F-box protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 12.3), liver E14 (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo3 in Genome Data Viewer
Location:
2 E2; 2 54.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103858144..103893582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104027799..104063237)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39896 Neighboring gene LIM domain only 2 Neighboring gene predicted gene, 38515 Neighboring gene RIKEN cDNA 4931422A03 gene Neighboring gene STARR-seq mESC enhancer starr_05277 Neighboring gene STARR-positive B cell enhancer ABC_E5954 Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene predicted gene, 24644 Neighboring gene CD59b antigen Neighboring gene STARR-seq mESC enhancer starr_05280 Neighboring gene CD59a antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Gao Y, et al. Int J Mol Sci, 2022 Nov 7. PMID 36362432, Free PMC Article
  2. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Chen BB, et al. Nat Immunol, 2013 May. PMID 23542741, Free PMC Article
  3. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. Xu J, et al. PLoS Biol, 2023 Dec. PMID 38134227, Free PMC Article
  4. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Ilyin GP, et al. Genomics, 2000 Jul 1. PMID 10945468
  5. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). Shao W, et al. J Biol Chem, 2016 Aug 19. PMID 27365398, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
    Title: FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
  2. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
    Title: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
  3. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity.
    Title: FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 3
Names
F-box protein FBA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355504.1 → NP_001342433.1  F-box only protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BX640578
    Conserved Domains (2) summary
    smart00860
    Location:91 → 219
    SMI1_KNR4; SMI1 / KNR4 family
    cl01119
    Location:249 → 374
    DUF525; ApaG domain

  2. NM_001355505.1 → NP_001342434.1  F-box only protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX640578
    Related
    ENSMUSP00000106765.2, ENSMUST00000111135.8
    Conserved Domains (3) summary
    smart00860
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family
    pfam12937
    Location:13 → 57
    F-box-like; F-box-like
    cl01119
    Location:279 → 404
    DUF525; ApaG domain

  3. NM_001355506.1 → NP_001342435.1  F-box only protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX640578
    Conserved Domains (2) summary
    smart00860
    Location:91 → 219
    SMI1_KNR4; SMI1 / KNR4 family
    cl01119
    Location:249 → 374
    DUF525; ApaG domain

  4. NM_001355507.1 → NP_001342436.1  F-box only protein 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK085686, BX640578
    Consensus CDS
    CCDS89529.1
    UniProtKB/TrEMBL
    A2BHN6
    Related
    ENSMUSP00000106766.2, ENSMUST00000111136.8
    Conserved Domains (3) summary
    smart00860
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family
    pfam12937
    Location:13 → 57
    F-box-like
    cl01119
    Location:279 → 358
    DUF525; ApaG domain

  5. NM_020593.2 → NP_065618.1  F-box only protein 3 isoform 2

    See identical proteins and their annotated locations for NP_065618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF233226, AK006392, BY105498
    Consensus CDS
    CCDS16485.1
    UniProtKB/Swiss-Prot
    Q9DC63
    UniProtKB/TrEMBL
    Q9CVV6
    Related
    ENSMUSP00000099625.4, ENSMUST00000102565.4
    Conserved Domains (3) summary
    pfam09346
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:13 → 57
    F-box-like; F-box-like
    cl01119
    Location:279 → 404
    DUF525; Protein of unknown function (DUF525)

  6. NM_212433.1 → NP_997598.1  F-box only protein 3 isoform 1

    See identical proteins and their annotated locations for NP_997598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK029594, AK049870, BB470024, BE980708, BY105498
    Consensus CDS
    CCDS16484.1
    UniProtKB/Swiss-Prot
    A2BHN5, A2BHN7, Q3TKB0, Q3U9C1, Q8C7I0, Q8CEJ0, Q91VI9, Q9D2J5, Q9DC63, Q9JIE4
    Related
    ENSMUSP00000028603.4, ENSMUST00000028603.10
    Conserved Domains (3) summary
    pfam09346
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:13 → 57
    F-box-like; F-box-like
    cl01119
    Location:279 → 404
    DUF525; Protein of unknown function (DUF525)

RNA

  1. NR_149726.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK150097, BX640578
    Related
    ENSMUST00000143799.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103858144..103893582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC63.1 GenPept UniProtKB/Swiss-Prot:Q9DC63

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