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    FLP Duplicated homeodomain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837997, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLP
    Official Full Name
    Duplicated homeodomain-like superfamily protein
    Primary source
    TAIR:AT1G14350
    Locus tag
    AT1G14350
    See related
    Araport:AT1G14350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMYB124; F14L17.12; F14L17_12; FOUR LIPS; myb domain protein 124; MYB124
    Summary
    Encodes a putative MYB transcription factor involved in stomata development, loss of FLP activity results in a failure of guard mother cells (GMCs) to adopt the guard cell fate, thus they continue to divide resulting in abnormal stomata consisting of clusters of numerous guard cell-like cells. This phenotype is enhanced in double mutants with MYB88. Its transcript levels change after inducing MUTE expression in a mute background.
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    Genomic context

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    See FLP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (4907887..4911168)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UDP-galactose transporter 3 Neighboring gene ncRNA Neighboring gene protein kinase 2A Neighboring gene IQ-domain 28 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis. Li P, et al. Plant J, 2023 Apr. PMID 36786686
    2. Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes. Lee E, et al. Plant J, 2014 May. PMID 24654956
    3. Divergent regulation of stomatal initiation and patterning in organ and suborgan regions of the Arabidopsis mutants too many mouths and four lips. Geisler M, et al. Planta, 1998 Aug. PMID 9684356
    4. The Arabidopsis R2R3 MYB proteins FOUR LIPS and MYB88 restrict divisions late in the stomatal cell lineage. Lai LB, et al. Plant Cell, 2005 Oct. PMID 16155180, Free PMC Article
    5. Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses. Xie Z, et al. Plant J, 2010 Dec. PMID 21105921

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis.
      Title: FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis.
    2. FLP and MYB88 inhibit the production of nonstomatal epidermal cells largely in a growth-condition-dependent manner.
      Title: The FOUR LIPS (FLP) and MYB88 genes conditionally suppress the production of nonstomatal epidermal cells in Arabidopsis cotyledons.
    3. Both flp and myb88 genes were expressed in many, previously unreported locations, consistent with the possibility of additional functions for FLP and MYB88. Moreover, expression domains especially of FLP display sharp cutoffs or boundaries.
      Title: The FOUR LIPS and MYB88 transcription factor genes are widely expressed in Arabidopsis thaliana during development.
    4. FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.
      Title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism.
    5. ARF7 and FLP transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation.
      Title: A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development.
    6. Data indicate that MYB transcription factor FOUR LIPS (FLP) and bHLH transcription factor FAMA complement respective mutant phenotypes.
      Title: Deep functional redundancy between FAMA and FOUR LIPS in stomatal development.
    7. Data indicate that bHLH transcription factor FAMA and MYB transcription factor FOUR LIPS (FLP) genes stabilize guard cell fate.
      Title: Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes.
    8. FLP and MYB88 restrict the G1/S transition during stomatal formation.
      Title: FOUR LIPS and MYB88 conditionally restrict the G1/S transition during stomatal formation.
    9. FLP and MYB88 are important regulators of entry into megasporogenesis, and probably act via the regulation of cell cycle genes.
      Title: The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate female reproductive development.
    10. flp-1 myb88 double mutant plants show enhanced sensitivity to drought and salt stress.
      Title: Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    General gene information

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    Homology

    NM_001084065.3
    NM_001332112.1
    NM_001332113.1
    NM_101302.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within guard cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in guard cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within guard cell differentiation NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in guard mother cell cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guard mother cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf pavement cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megasporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to gravity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stomatal complex formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stomatal complex formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Duplicated homeodomain-like superfamily protein
    NP_001077534.1
    • FOUR LIPS (FLP); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 88 (TAIR:AT2G02820.2); Has 8538 Blast hits to 7627 proteins in 543 species: Archae - 0; Bacteria - 2; Metazoa - 904; Fungi - 528; Plants - 5146; Viruses - 6; Other Eukaryotes - 1952 (source: NCBI BLink).
    NP_563948.1
    • FOUR LIPS (FLP); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 88 (TAIR:AT2G02820.2); Has 8541 Blast hits to 7630 proteins in 544 species: Archae - 0; Bacteria - 2; Metazoa - 904; Fungi - 531; Plants - 5146; Viruses - 6; Other Eukaryotes - 1952 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4907887..4911168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084065.3 → NP_001077534.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077534.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94FL6, Q9M9S7
      UniProtKB/TrEMBL
      A0A178W3Z3, A0A5S9UE35, A0A654E9M7
      Conserved Domains (1) summary
      PLN03091
      Location:28 → 223
      PLN03091; hypothetical protein; Provisional

    2. NM_001332112.1 → NP_001321792.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS18, A0A654E9M7

    3. NM_101302.3 → NP_563948.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563948.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94FL6, Q9M9S7
      UniProtKB/TrEMBL
      A0A178W3Z3, A0A5S9UE35, A0A654E9M7
      Conserved Domains (1) summary
      PLN03091
      Location:28 → 223
      PLN03091; hypothetical protein; Provisional

    4. NM_001332113.1 → NP_001321793.1  Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS18, A0A654E9M7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94FL6.1

    Gene LinkOut

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