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    RPL POX (plant homeobox) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831745, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPL
    Official Full Name
    POX (plant homeobox) family protein
    Primary source
    TAIR:AT5G02030
    Locus tag
    AT5G02030
    See related
    Araport:AT5G02030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BEL1-LIKE HOMEODOMAIN 9; BELLRINGER; BLH9; BLR; HB-6; LARSON; LSN; PENNYWISE; PNY; REPLUMLESS; T7H20.80; T7H20_80; VAAMANA; VAN
    Summary
    Mutant has additional lateral organs and phyllotaxy defect. Encodes a homeodomain transcription factor. Has sequence similarity to the Arabidopsis ovule development regulator Bell1. Binds directly to the AGAMOUS cis-regulatory element. Its localization to the nucleus is dependent on the coexpression of either STM or BP.
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    Genomic context

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    See RPL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (395567..399125)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RHO guanyl-nucleotide exchange factor 7 Neighboring gene E3 ubiquitin-protein ligase RLIM-like protein Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene prenylated RAB acceptor 1.A1 Neighboring gene Mitochondrial glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The REPLUMLESS Transcription Factor Controls the Expression of the RECEPTOR-LIKE CYTOPLASMIC KINASE VI_A2 Gene Involved in Shoot and Fruit Patterning of Arabidopsis thaliana. Kenesi E, et al. Int J Mol Sci, 2024 Jul 22. PMID 39063242, Free PMC Article
    2. The transcription factor BELLRINGER modulates phyllotaxis by regulating the expression of a pectin methylesterase in Arabidopsis. Peaucelle A, et al. Development, 2011 Nov. PMID 21965608
    3. The same regulatory point mutation changed seed-dispersal structures in evolution and domestication. Arnaud N, et al. Curr Biol, 2011 Jul 26. PMID 21737279
    4. Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis. Khan M, et al. Plant Physiol, 2015 Nov. PMID 26417006, Free PMC Article
    5. Competence to respond to floral inductive signals requires the homeobox genes PENNYWISE and POUND-FOOLISH. Smith HM, et al. Curr Biol, 2004 May 4. PMID 15120075

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The REPLUMLESS Transcription Factor Controls the Expression of the RECEPTOR-LIKE CYTOPLASMIC KINASE VI_A2 Gene Involved in Shoot and Fruit Patterning of Arabidopsis thaliana.
      Title: The REPLUMLESS Transcription Factor Controls the Expression of the RECEPTOR-LIKE CYTOPLASMIC KINASE VI_A2 Gene Involved in Shoot and Fruit Patterning of Arabidopsis thaliana.
    2. The data reveal a potential mechanism by which repression of lateral organ boundary genes by PNY-PNF is essential for flowering.
      Title: Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis.
    3. NTT loss of function leads to reduced replum width and cell number, whereas increased expression promotes replum enlargement. NTT activates the homeobox gene BP, which, together with RPL, is important for replum development.
      Title: The NTT transcription factor promotes replum development in Arabidopsis fruits.
    4. These data support a role for BLR in ordering the shoot apex.
      Title: A role for BELLRINGER in cell wall development is supported by loss-of-function phenotypes.
    5. Regulation of meristem central zone integrity by PNY and PNF is crucial for vegetative and reproductive development.
      Title: Regulation of shoot meristem integrity during Arabidopsis vegetative development.
    6. SPL3, SPL4, and SPL5 function is dependent upon PNY and PNF
      Title: Regulation of the SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE genes/microRNA156 module by the homeodomain proteins PENNYWISE and POUND-FOOLISH in Arabidopsis.
    7. Results report a dual function for the homeodomain transcription factor BELLRINGER (BLR) in the establishment and maintenance of the phyllotactic pattern in Arabidopsis.
      Title: The transcription factor BELLRINGER modulates phyllotaxis by regulating the expression of a pectin methylesterase in Arabidopsis.
    8. Reduced repla resembling Arabidopsis rpl mutant correlated across the Brassicaceae with a point mutation in a conserved cis-element of RPL. When introduced in Arabidopsis, this nucleotide change specifically reduced RPL expression + function in the fruit.
      Title: The same regulatory point mutation changed seed-dispersal structures in evolution and domestication.
    9. PNY and PNF act to restrict organogenesis to the peripheral zone by maintaining a boundary between the central zone and peripheral zone.
      Title: The role of PENNYWISE and POUND-FOOLISH in the maintenance of the shoot apical meristem in Arabidopsis.
    10. combined lesions in ATH1, PNY and PNF result in a full phenocopy of shoot apical meristem loss-of-function mutants.
      Title: Shoot apical meristem function in Arabidopsis requires the combined activities of three BEL1-like homeodomain proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120281.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral whorl morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fruit development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within internode patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral meristem identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of inflorescence meristem identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant organ formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    POX (plant homeobox) family protein
    NP_195823.1
    • REPLUMLESS (RPL); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 8 (TAIR:AT2G27990.1); Has 5109 Blast hits to 5109 proteins in 341 species: Archae - 0; Bacteria - 2; Metazoa - 2052; Fungi - 344; Plants - 2481; Viruses - 0; Other Eukaryotes - 230 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      395567..399125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120281.3 → NP_195823.1  POX (plant homeobox) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H147, Q8LGJ2, Q9LZM8
      UniProtKB/TrEMBL
      A0A5S9Y1A2, A0A7G2F538
      Conserved Domains (2) summary
      smart00574
      Location:165 → 292
      POX; domain associated with HOX domains
      pfam05920
      Location:366 → 405
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZM8.1

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