ARC6 Chaperone DnaJ-domain superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ARC6
Official Full Name: Chaperone DnaJ-domain superfamily protein
Primary source: TAIR:AT5G42480
Locus tag: AT5G42480
See related: Araport:AT5G42480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6; MDH9.18; MDH9_18
Summary: Shows homology to the cyanobacterial cell division protein Ftn2, mutant only has two mesophyll cell chloroplasts. Protein was localized to a ring at the center of the chloroplasts. Probably involved in functions in the assembly and/or stabilization of the plastid-dividing FtsZ ring, inhibiting FtsZ filament formation in the chloroplast.
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Genomic context

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See ARC6 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (16985096..16988796)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that ARC6 is involved in mediating Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
Title: ARC6-mediated Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
PDV2 inserts its carboxy terminus into a pocket formed in ARC6, and this interaction further induces the dimerization of the intermembrane space regions of two ARC6 molecules. A pdv2 mutant attenuating PDV2-induced ARC6 dimerization showed abnormal morphology of ARC6 rings and compromised chloroplast division in plant cells.
Title: Structural insights into the coordination of plastid division by the ARC6-PDV2 complex.
results support the notion that ARC5 is dispensable in the process of equal division of epidermal plastids, and indicate that dysfunctions in ARC5 and ARC6 differentially affect plastid replication among mesophyll cells, PCs, and GCs within a single leaf
Title: The Arabidopsis arc5 and arc6 mutations differentially affect plastid morphology in pavement and guard cells in the leaf epidermis.
The ARC6 intermembrane space region bears a structurally uncharacterized domain of unknown function, DUF4101, that is highly conserved among ARC6 and Ftn2 proteins. This study reports the crystal structure of this domain.
Title: Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.
These results suggest that besides ARC6-mediated anchoring, an additional FtsZ-anchoring mechanism is present in chloroplasts.
Title: Single particle tracking analysis of the chloroplast division protein FtsZ anchoring to the inner envelope membrane.
Data show that ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.
Title: Arabidopsis ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.
alteration in stromule length in arc3 and arc6 mutants occurred despite wild-type plastid densities
Title: Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana.
Results describe the in vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
Title: In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
The effect of reduced chloroplast number on the photosynthetic competence of leaves of A. thaliana with mutations at accumulation and replication of chloroplasts (ARC) sites ARC3, ARC5, and ARC6 are reported.
Title: Photosynthesis in Arabidopsis thaliana mutants with reduced chloroplast number.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001344453.1

Supported by ESTs:

NM_123613.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: Chaperone DnaJ-domain superfamily protein

NP_199063.1

ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6 (ARC6); FUNCTIONS IN: protein binding; INVOLVED IN: protein folding, chloroplast fission, chloroplast organization; LOCATED IN: chloroplast, chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein DnaJ, N-terminal (InterPro:IPR001623); BEST Arabidopsis thaliana protein match is: paralog of ARC6 (TAIR:AT3G19180.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16985096..16988796

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123613.4 → NP_199063.1 Chaperone DnaJ-domain superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199063.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7XAR9, Q7XAS0, Q7XAS1, Q9FIG9

UniProtKB/TrEMBL

A0A654G7U0

Conserved Domains (1) summary

pfam13355
Location:679 → 794

DUF4101; Protein of unknown function (DUF4101)
NM_001344453.1 → NP_001331076.1 Chaperone DnaJ-domain superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BCR9, A0A654G7U0