Folr1 folate receptor alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Folr1provided by RGD
Official Full Name: folate receptor alphaprovided by RGD
Primary source: RGD:71032
See related: EnsemblRapid:ENSRNOG00000019902 AllianceGenome:RGD:71032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fbp1
Summary: Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1929.3) and Testes (RPKM 104.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165631462..165650430, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156219460..156238436, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (166934457..166945864, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
Title: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
Folr1 plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.
Title: Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.
These observations have implications in the pathology of FRa-autoantibodies associated with neural tube defect pregnancy, preterm birth and neurodevelopmental disorders including autism
Title: Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study.
inherited variation in the expression of Folr1 in the kidney influences the development of the metabolic syndrome
Title: Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables folic acid binding	ISO Inferred from Sequence Orthology more info
enables folic acid receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterior neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to folic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within folic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in folic acid transport	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration involved in heart formation	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in sperm-egg recognition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: folate receptor alpha

Names: folate binding protein 1; folate receptor 1 (adult)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133527.2 → NP_598211.2 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

FM059473, FM060472, JAXUCZ010000001

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Related

ENSRNOP00000026962.3, ENSRNOT00000026962.6

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

165631462..165650430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085707.2 → XP_038941635.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_039085665.2 → XP_038941593.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_039085757.2 → XP_038941685.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_063273361.1 → XP_063129431.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6
XM_063273405.1 → XP_063129475.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6
XM_017588710.3 → XP_017444199.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_017588711.3 → XP_017444200.1 folate receptor alpha isoform X1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_006229842.5 → XP_006229904.1 folate receptor alpha isoform X1

See identical proteins and their annotated locations for XP_006229904.1

UniProtKB/TrEMBL

A6I6X2, G3V8M6, Q9JL02

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
XM_063273293.1 → XP_063129363.1 folate receptor alpha isoform X2