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Conserved domains on  [gi|1046840295|ref|XP_017444200|]
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folate receptor alpha isoform X1 [Rattus norvegicus]

Protein Classification

folate receptor family protein( domain architecture ID 10503420)

folate receptor family protein similar to folate receptors that bind to folate and reduced folic acid derivatives and mediate delivery of 5-methyltetrahydrofolate to the interior of cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 34-209 5.48e-91

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


:

Pssm-ID: 397250  Cd Length: 172  Bit Score: 265.86  E-value: 5.48e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295  34 VCMDAKHHKEKPGPEDKLHDQCSPWKTNACCSTNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGP 113
Cdd:pfam03024   1 VCLDGKHHKPKPSPEPNLHELCAPWKENSCCTANTSEEAHRDPSILYNFNWNHCGTLSPECEKFFIQLQCFYECSPNLGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295 114 WIQQvdqsWRKERILDVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWSH 193
Cdd:pfam03024  81 WIQP----WRRERILNVPLCKEFCDAWFEACKDDYTCKSNWGKGWLWSSGKNGCPDEPSCRPFKQMFPNGTDLCESIWGH 156

                         170
                  ....*....|....*.
gi 1046840295 194 SYKLSNYSRGSGRCIQ 209
Cdd:pfam03024 157 SFKVSPSSRGSGRCLQ 172
 
Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 34-209 5.48e-91

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 265.86  E-value: 5.48e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295  34 VCMDAKHHKEKPGPEDKLHDQCSPWKTNACCSTNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGP 113
Cdd:pfam03024   1 VCLDGKHHKPKPSPEPNLHELCAPWKENSCCTANTSEEAHRDPSILYNFNWNHCGTLSPECEKFFIQLQCFYECSPNLGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295 114 WIQQvdqsWRKERILDVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWSH 193
Cdd:pfam03024  81 WIQP----WRRERILNVPLCKEFCDAWFEACKDDYTCKSNWGKGWLWSSGKNGCPDEPSCRPFKQMFPNGTDLCESIWGH 156

                         170
                  ....*....|....*.
gi 1046840295 194 SYKLSNYSRGSGRCIQ 209
Cdd:pfam03024 157 SFKVSPSSRGSGRCLQ 172
 
Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 34-209 5.48e-91

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 265.86  E-value: 5.48e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295  34 VCMDAKHHKEKPGPEDKLHDQCSPWKTNACCSTNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGP 113
Cdd:pfam03024   1 VCLDGKHHKPKPSPEPNLHELCAPWKENSCCTANTSEEAHRDPSILYNFNWNHCGTLSPECEKFFIQLQCFYECSPNLGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046840295 114 WIQQvdqsWRKERILDVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWSH 193
Cdd:pfam03024  81 WIQP----WRRERILNVPLCKEFCDAWFEACKDDYTCKSNWGKGWLWSSGKNGCPDEPSCRPFKQMFPNGTDLCESIWGH 156

                         170
                  ....*....|....*.
gi 1046840295 194 SYKLSNYSRGSGRCIQ 209
Cdd:pfam03024 157 SFKVSPSSRGSGRCLQ 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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