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    Naa15-16 N(alpha)-acetyltransferase 15/16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa15-16provided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 15/16provided by FlyBase
    Primary source
    FLYBASE:FBgn0031020
    Locus tag
    Dmel_CG12202
    See related
    AllianceGenome:FB:FBgn0031020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12202; Dmel\CG12202; dNaa15; dNat1; l(1)G0311; Naa15; NAA15-16; Naa15/16; Nat1; NAT1
    Summary
    Predicted to enable acetyltransferase activator activity. Part of NatA complex. Is expressed in adult head. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) and NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa15-16 in Genome Data Viewer
    Location:
    18C7-18C7; 1-62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19479984..19484643)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19374017..19378676)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kekkon 5 Neighboring gene long non-coding RNA:CR43260 Neighboring gene uncharacterized protein Neighboring gene narya Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene pacman

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered. Grima DP, et al. Biol Cell, 2008 Dec. PMID 18547166
    2. Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper. Waldron JA, et al. Biol Open, 2015 Apr 2. PMID 25836675, Free PMC Article
    3. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Williams BC, et al. Curr Biol, 2003 Dec 2. PMID 14653991
    4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
    5. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 15/16
    Names
    CG12202-PA
    CG12202-PB
    N(alpha)-acetyltransferase 15
    NAT1 ortholog
    Naa15-16-PA
    Naa15-16-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19479984..19484643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298510.1 → NP_001285439.1  N(alpha)-acetyltransferase 15/16, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWI2
      Conserved Domains (2) summary
      sd00006
      Location:83 → 109
      TPR; TPR repeat [structural motif]
      pfam12569
      Location:187 → 703
      NARP1; NMDA receptor-regulated protein 1

    2. NM_133156.2 → NP_573384.1  N(alpha)-acetyltransferase 15/16, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWI2
      Related
      FBpp0074480
      Conserved Domains (2) summary
      sd00006
      Location:83 → 109
      TPR; TPR repeat [structural motif]
      pfam12569
      Location:187 → 703
      NARP1; NMDA receptor-regulated protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWI2 Q9VWI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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