NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24643243|ref|NP_573384|]
View 

N(alpha)-acetyltransferase 15/16, isoform A [Drosophila melanogaster]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11420860)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NatA_aux_su pfam12569
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-703 0e+00

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


:

Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 789.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   187 YRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIA 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   267 ARQVT--DSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVNVRTLHQIPERAAVIEE 344
Cdd:pfam12569  81 ALGISkeDHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEKVDIIEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   345 LALQYFENLTRSGHFSREDADAGiPVEPASALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHA 424
Cdd:pfam12569 161 LVEGYVSSLKTNGKFSGSDNGDG-EKEPPSTLLWTYYFLAQHYDYLGSYEKALEYIDKAIDHTPTLIELYMTKARIYKHA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   425 GDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRANMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRW 504
Cdd:pfam12569 240 GDLQKAAEWMDEARSLDLADRYINSKCAKYMLRANEVEEAEETCSKFTRNGVGALGNLNEMQCMWFLTEDGEAYQRQGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   505 GESLKKCHEVERHFAEIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEE 584
Cdd:pfam12569 320 GLALKRFHAVEKHFDEWEEDQFDFHTYCLRKMTLRAYVDMLRWEDRLRSHPFYFKAAKGAIEVYLRLHDKPLLKEGPEEE 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   585 IDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKReQHQKSKQQANQETDPDAPqldELVAEKLERTDDPLDKAIE 664
Cdd:pfam12569 400 GDNGNLSPAERKKARKKQKKAEKKAEKEEAEKAAKKKKK-KAEKKAKGEDGETKKEDP---DPLGEKLAQTEDPLEEAMK 475

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 24643243   665 FLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRA 703
Cdd:pfam12569 476 FLKPLLKLAPDNIETHLLAFEVYIRKKKYLLALQCLKAA 514
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
45-269 9.03e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  45 EHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLL 124
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 125 QIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMAnsiLETFSQSQtsieAHDYRHSELLLYQNQILIESN 204
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA---IEAYERAL----ELDPDDADALYNLGIALEKLG 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24643243 205 RLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIAARQ 269
Cdd:COG0457 159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELL 223
 
Name Accession Description Interval E-value
NatA_aux_su pfam12569
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-703 0e+00

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 789.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   187 YRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIA 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   267 ARQVT--DSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVNVRTLHQIPERAAVIEE 344
Cdd:pfam12569  81 ALGISkeDHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEKVDIIEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   345 LALQYFENLTRSGHFSREDADAGiPVEPASALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHA 424
Cdd:pfam12569 161 LVEGYVSSLKTNGKFSGSDNGDG-EKEPPSTLLWTYYFLAQHYDYLGSYEKALEYIDKAIDHTPTLIELYMTKARIYKHA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   425 GDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRANMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRW 504
Cdd:pfam12569 240 GDLQKAAEWMDEARSLDLADRYINSKCAKYMLRANEVEEAEETCSKFTRNGVGALGNLNEMQCMWFLTEDGEAYQRQGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   505 GESLKKCHEVERHFAEIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEE 584
Cdd:pfam12569 320 GLALKRFHAVEKHFDEWEEDQFDFHTYCLRKMTLRAYVDMLRWEDRLRSHPFYFKAAKGAIEVYLRLHDKPLLKEGPEEE 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   585 IDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKReQHQKSKQQANQETDPDAPqldELVAEKLERTDDPLDKAIE 664
Cdd:pfam12569 400 GDNGNLSPAERKKARKKQKKAEKKAEKEEAEKAAKKKKK-KAEKKAKGEDGETKKEDP---DPLGEKLAQTEDPLEEAMK 475

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 24643243   665 FLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRA 703
Cdd:pfam12569 476 FLKPLLKLAPDNIETHLLAFEVYIRKKKYLLALQCLKAA 514
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
45-269 9.03e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  45 EHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLL 124
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 125 QIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMAnsiLETFSQSQtsieAHDYRHSELLLYQNQILIESN 204
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA---IEAYERAL----ELDPDDADALYNLGIALEKLG 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24643243 205 RLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIAARQ 269
Cdd:COG0457 159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELL 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-259 3.17e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.40  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243    91 QRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANS 170
Cdd:TIGR02917 645 YAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQ 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   171 ILETFSQSQTSieahdyrhSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESL 250
Cdd:TIGR02917 725 AYRKALKRAPS--------SQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTV 796


                  ....*....
gi 24643243   251 IRRNPENVL 259
Cdd:TIGR02917 797 VKKAPDNAV 805
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 194-466 4.07e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 194 LYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQ----YIAARQ 269
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLElaqdYLKAGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 270 VTDSsavVSIYRVFQEQYPRALCPRRLPLNIangdefrvvtdeYLRRG-LRKGIPPLfvnVRTLHQIPERAAVIEELALQ 348
Cdd:COG2956  92 LDRA---EELLEKLLELDPDDAEALRLLAEI------------YEQEGdWEKAIEVL---ERLLKLGPENAHAYCELAEL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 349 YFENltrsGHF--SREDADAGIPVEPASALVWtaLFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGD 426
Cdd:COG2956 154 YLEQ----GDYdeAIEALEKALKLDPDCARAL--LLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGD 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 24643243 427 PVEAYVWLEEAQSMDTADRYINSKcAKYMLRANMVQEAEE 466
Cdd:COG2956 228 PEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALA 266
 
Name Accession Description Interval E-value
NatA_aux_su pfam12569
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-703 0e+00

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 789.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   187 YRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIA 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   267 ARQVT--DSSAVVSIYRVFQEQYPRALCPRRLPLNIANGDEFRVVTDEYLRRGLRKGIPPLFVNVRTLHQIPERAAVIEE 344
Cdd:pfam12569  81 ALGISkeDHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEKVDIIEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   345 LALQYFENLTRSGHFSREDADAGiPVEPASALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHA 424
Cdd:pfam12569 161 LVEGYVSSLKTNGKFSGSDNGDG-EKEPPSTLLWTYYFLAQHYDYLGSYEKALEYIDKAIDHTPTLIELYMTKARIYKHA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   425 GDPVEAYVWLEEAQSMDTADRYINSKCAKYMLRANMVQEAEEICAKFTREGVSAMDNLNEMQCMWFQTECALAYQRMGRW 504
Cdd:pfam12569 240 GDLQKAAEWMDEARSLDLADRYINSKCAKYMLRANEVEEAEETCSKFTRNGVGALGNLNEMQCMWFLTEDGEAYQRQGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   505 GESLKKCHEVERHFAEIVEDQFDFHTYCMRKMTLRAYVGLLRLEDVLRQHPFYFKAAKCAIEVYIRLYDKPLKSETTIEE 584
Cdd:pfam12569 320 GLALKRFHAVEKHFDEWEEDQFDFHTYCLRKMTLRAYVDMLRWEDRLRSHPFYFKAAKGAIEVYLRLHDKPLLKEGPEEE 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   585 IDIENLPPSELKKLRSKQRKAKKKAELESAQAAQAQVKReQHQKSKQQANQETDPDAPqldELVAEKLERTDDPLDKAIE 664
Cdd:pfam12569 400 GDNGNLSPAERKKARKKQKKAEKKAEKEEAEKAAKKKKK-KAEKKAKGEDGETKKEDP---DPLGEKLAQTEDPLEEAMK 475

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 24643243   665 FLKPLQQLAKERIETHLLAFELYYRKNKLLLMLQCIRRA 703
Cdd:pfam12569 476 FLKPLLKLAPDNIETHLLAFEVYIRKKKYLLALQCLKAA 514
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
45-269 9.03e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  45 EHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLL 124
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 125 QIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMAnsiLETFSQSQtsieAHDYRHSELLLYQNQILIESN 204
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA---IEAYERAL----ELDPDDADALYNLGIALEKLG 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24643243 205 RLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIAARQ 269
Cdd:COG0457 159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELL 223
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 45-261 1.17e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 1.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  45 EHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLL 124
Cdd:COG2956  40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 125 QIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILETfsqsqtsIEAHDYRHSELLLYQNQILIESN 204
Cdd:COG2956 120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEK-------ALKLDPDCARALLLLAELYLEQG 192

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24643243 205 RLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYY 261
Cdd:COG2956 193 DYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-213 5.20e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.71  E-value: 5.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  13 ALFRKLLKCYELKQYKNGLKLAKQILS-NPkymEHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQ 91
Cdd:COG0457  10 AYNNLGLAYRRLGRYEEAIEDYEKALElDP---DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  92 RSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMAnsi 171
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEA--- 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 24643243 172 LETFSQSQTSIEAHDYRHSELLLYQNQILIESNRLQQAVDHL 213
Cdd:COG0457 164 LELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-259 3.17e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.40  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243    91 QRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANS 170
Cdd:TIGR02917 645 YAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQ 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   171 ILETFSQSQTSieahdyrhSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESL 250
Cdd:TIGR02917 725 AYRKALKRAPS--------SQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTV 796


                  ....*....
gi 24643243   251 IRRNPENVL 259
Cdd:TIGR02917 797 VKKAPDNAV 805
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 84-261 1.10e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  84 WHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLG 163
Cdd:COG2956  11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 164 DYDMANSILEtfsqsqtSIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKA 243
Cdd:COG2956  91 LLDRAEELLE-------KLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEA 163

                       170
                ....*....|....*...
gi 24643243 244 VPIFESLIRRNPENVLYY 261
Cdd:COG2956 164 IEALEKALKLDPDCARAL 181
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-205 1.86e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 1.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  13 ALFRKLLKCYELKQYKNGLKLAKQILS-NPkymEHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQ 91
Cdd:COG3914  80 LLELAALLLQALGRYEEALALYRRALAlNP---DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  92 RSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSI 171
Cdd:COG3914 157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRF 236

                       170       180       190
                ....*....|....*....|....*....|....
gi 24643243 172 LETFSQSQTSIEAHDyrhSELLLYQNQILIESNR 205
Cdd:COG3914 237 EELLAALARGPSELS---PFALLYLPDDDPAELL 267
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 194-466 4.07e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 194 LYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQ----YIAARQ 269
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLElaqdYLKAGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 270 VTDSsavVSIYRVFQEQYPRALCPRRLPLNIangdefrvvtdeYLRRG-LRKGIPPLfvnVRTLHQIPERAAVIEELALQ 348
Cdd:COG2956  92 LDRA---EELLEKLLELDPDDAEALRLLAEI------------YEQEGdWEKAIEVL---ERLLKLGPENAHAYCELAEL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 349 YFENltrsGHF--SREDADAGIPVEPASALVWtaLFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGD 426
Cdd:COG2956 154 YLEQ----GDYdeAIEALEKALKLDPDCARAL--LLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGD 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 24643243 427 PVEAYVWLEEAQSMDTADRYINSKcAKYMLRANMVQEAEE 466
Cdd:COG2956 228 PEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALA 266
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 61-254 1.82e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  61 GRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHH 140
Cdd:COG2956  90 GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEK 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 141 LFTLRPSQHASWIGFAMSYHLLGDYDMANSILEtfsqsqtSIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTKYQgQI 220
Cdd:COG2956 170 ALKLDPDCARALLLLAELYLEQGDYEEAIAALE-------RALEQDPDYLPALPRLAELYEKLGDPEEALELLRKAL-EL 241

                       170       180       190
                ....*....|....*....|....*....|....
gi 24643243 221 VDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRN 254
Cdd:COG2956 242 DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 374-509 8.16e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 8.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 374 SALVWTALFLAQHYDYMRDTDRALEYINVAIDHTPTLIELLITKGRIFKHAGDPVEAYVWLEEAQSMDTADRYINSKCAK 453
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24643243 454 YMLRANMVQEAEEICAKFTREGVSAMDNLNEMqcmwfqtecALAYQRMGRWGESLK 509
Cdd:COG4783  81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRL---------ARAYRALGRPDEAIA 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
74-269 1.20e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.69  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  74 LRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWI 153
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 154 GFAMSYHLLGDYDMAnsiLETFSQsqtsIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDL 233
Cdd:COG0457  81 NLGLALQALGRYEEA---LEDYDK----ALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 24643243 234 YIKLQQQEKAVPIFESLIRRNPENVLYYEQYIAARQ 269
Cdd:COG0457 154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALA 189
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 87-216 1.90e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 1.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  87 YGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYD 166
Cdd:COG4783  10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24643243 167 MANSILETfsqsqtsIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTKY 216
Cdd:COG4783  90 EALALLEK-------ALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 22-148 4.42e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 4.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  22 YELKQYKNGLKLAKQILSnpKYMEHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAI 101
Cdd:COG4783  15 LLAGDYDEAEALLEKALE--LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEAL 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24643243 102 KCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQ 148
Cdd:COG4783  93 ALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 95-270 5.22e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243    95 KKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILET 174
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEK 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   175 FSQSQTSIEahdyrhsELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRN 254
Cdd:TIGR02917 559 AAELNPQEI-------EPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQ 631

                         170
                  ....*....|....*.
gi 24643243   255 PENVLYYEQYIAARQV 270
Cdd:TIGR02917 632 PDSALALLLLADAYAV 647
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 44-202 1.68e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 1.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  44 MEHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSL 123
Cdd:COG3914  75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 124 LQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLGDYDMAnsiLETFSQS-QTSIEAHDYRHSELLLYQNQILIE 202
Cdd:COG3914 155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEA---IAAYRRAlELDPDNADAHSNLLFALRQACDWE 231
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 147-269 1.71e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 1.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243 147 SQHASWIGFAMSYHLLGDYDMANSILETfsqsqtsIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTKYQGQIVDKLAV 226
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEK-------ALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24643243 227 RETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYYEQYIAARQ 269
Cdd:COG4783  75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 22-132 7.71e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 7.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  22 YELKQYKNGLKLAKQILSNPKYMEHGETLAMKGLTLNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAI 101
Cdd:COG5010  29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAK 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 24643243 102 KCYRNALKWEKDNLQILKDLSLLQIQMRDLE 132
Cdd:COG5010 109 EYYEKALALSPDNPNAYSNLAALLLSLGQDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 84-288 9.33e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243    84 WHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLG 163
Cdd:TIGR02917 604 WLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAK 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   164 DYDMANSILEtfsqsqtSIEAHDYRHSELLLYQNQILIESNRLQQAVDHLTK-YQGQIVDKLAVRetMGDLYIKLQQQEK 242
Cdd:TIGR02917 684 RTESAKKIAK-------SLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKaLKRAPSSQNAIK--LHRALLASGNTAE 754

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 24643243   243 AVPIFESLIRRNPEN--VLYY--EQYIAARqvtDSSAVVSIYRVFQEQYP 288
Cdd:TIGR02917 755 AVKTLEAWLKTHPNDavLRTAlaELYLAQK---DYDKAIKHYQTVVKKAP 801
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 84-168 9.51e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 9.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  84 WHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKETRHHLFTLRPSQHASWIGFAMSYHLLG 163
Cdd:COG4235  20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQG 99


                ....*
gi 24643243 164 DYDMA 168
Cdd:COG4235 100 DYAEA 104
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 57-173 1.33e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243  57 LNGLGRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEGYKE 136
Cdd:COG5010  30 ALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKE 109

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24643243 137 TRHHLFTLRPSQHASWIGFAMSYHLLGDYDMANSILE 173
Cdd:COG5010 110 YYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 61-275 9.03e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243    61 GRREEAYKYVRLGLRNDLRSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWEKDNLQILKDLSLLQIQMRDLEgykETRHH 140
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFE---EAEKH 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643243   141 LFTLR---PSQHASWIGFAMSYHLLGDYDMANSILETFSQSQTSieahdyrHSELLLYQNQILIESNRLQQAVDHLTKYQ 217
Cdd:TIGR02917 250 ADALLkkaPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPE-------YLPALLLAGASEYQLGNLEQAYQYLNQIL 322

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24643243   218 GQIVDKLAVRETMGDLYIKLQQQEKAVPIFESLIRRNPENVLYY----EQYIAARQVTDSSA 275
Cdd:TIGR02917 323 KYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALsllgEAYLALGDFEKAAE 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH