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    Pfas Phosphoribosylformylglycinamidine synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfasprovided by FlyBase
    Official Full Name
    Phosphoribosylformylglycinamidine synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000052
    Locus tag
    Dmel_CG9127
    See related
    AllianceGenome:FB:FBgn0000052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153122_at; ade2; Ade2; CG9127; Dmel\CG9127; Paics; pfas; pym
    Summary
    Enables phosphoribosylformylglycinamidine synthase activity. Involved in purine nucleobase biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; hindgut proper primordium; and visceral mesoderm derivative. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pfas in Genome Data Viewer
    Location:
    26B3-26B3; 2-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6041181..6046050, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6041181..6046050, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene myotubularin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-966 stem loop Neighboring gene uncharacterized protein Neighboring gene slowmo Neighboring gene Inositol phosphatase interacting protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The adenosine 2 locus of Drosophila melanogaster: clarification of the map position and eye phenotype of the ade2 mutant. Keizer C, et al. Biochem Genet, 1989 Jun. PMID 2508621
    2. Ade2 Functions in the Drosophila Fat Body To Promote Sleep. Yurgel ME, et al. G3 (Bethesda), 2018 Nov 6. PMID 30249751, Free PMC Article
    3. The adenosine2 gene of Drosophila melanogaster encodes a formylglycineamide ribotide amidotransferase. Tiong SY, et al. Genome, 1993 Oct. PMID 8270203
    4. Nucleoside auxotrophy in Drosophila: an autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides. Naguib FN, et al. Mol Gen Genet, 1976 Aug 10. PMID 822279
    5. Two Drosophila melanogaster mutations block successive steps of de novo purine synthesis. Henikoff S, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3086869, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest Ade2 functions within the fat body to promote both sleep and energy storage, providing a functional link between these processes.
      Title: Ade2 Functions in the Drosophila Fat Body To Promote Sleep.
    2. together with the fact that the EJC-disassembly activity of DmPYM is regulated, implicates PYM as an effector of EJC homeostasis in vivo.
      Title: The EJC binding and dissociating activity of PYM is regulated in Drosophila.
    3. Data show the presence of apoptosis at the cellular level in both ade2 and Prat mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
      Title: A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoribosylformylglycinamidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphoribosylformylglycinamidine synthase
    Names
    CG9127-PA
    CG9127-PB
    CG9127-PC
    Pfas-PA
    Pfas-PB
    Pfas-PC
    adenosine 2
    adenosine2
    NP_477212.1
    NP_723146.1
    NP_723147.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6041181..6046050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164675.2 → NP_723146.1  phosphoribosylformylglycinamidine synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V099, P35421, Q6NNY9, Q9VMI7
      Related
      FBpp0078851
      Conserved Domains (4) summary
      cd02203
      Location:223 → 612
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:715 → 1004
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      PLN03206
      Location:18 → 1349
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      pfam13507
      Location:1085 → 1349
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain

    2. NM_057864.4 → NP_477212.1  phosphoribosylformylglycinamidine synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V099, P35421, Q6NNY9, Q9VMI7
      Related
      FBpp0078850
      Conserved Domains (4) summary
      cd02203
      Location:223 → 612
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:715 → 1004
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      PLN03206
      Location:18 → 1349
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      pfam13507
      Location:1085 → 1349
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain

    3. NM_164676.2 → NP_723147.1  phosphoribosylformylglycinamidine synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V099, P35421, Q6NNY9, Q9VMI7
      Related
      FBpp0078852
      Conserved Domains (4) summary
      cd02203
      Location:223 → 612
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:715 → 1004
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      PLN03206
      Location:18 → 1349
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      pfam13507
      Location:1085 → 1349
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35421.2 P35421

    Gene LinkOut

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