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    PUR7 purin 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821663, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUR7
    Official Full Name
    purin 7
    Primary source
    TAIR:AT3G21110
    Locus tag
    AT3G21110
    See related
    Araport:AT3G21110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    5'-PHOSPHORIBOSYL-4-(N-SUCCINOCARBOXAMIDE)- 5-AMINOIMIDAZOLE SYNTHETASE; ATPURC; PURC; purin 7; PURIN C; SAIRCAR SYNTHETASE
    Summary
    5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole synthetase (PUR7, syn. SAICAR synthetase), catalyzes aspartate addition at the alpha-amino group to the growing purine backbone.
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    Genomic context

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    See PUR7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (7402477..7405674, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ABC transporter-like protein Neighboring gene ABC-2 type transporter family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo purine synthesis in Arabidopsis thaliana. II. The PUR7 gene encoding 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole synthetase is expressed in rapidly dividing tissues. Senecoff JF, et al. Plant Physiol, 1996 Nov. PMID 8938402, Free PMC Article
    2. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001035662.2
    NM_001338505.1
    NM_113005.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    purin 7
    NP_001319605.1
    • purin 7 (PUR7); FUNCTIONS IN: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; INVOLVED IN: response to auxin stimulus, purine nucleotide biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SAICAR synthetase, conserved site (InterPro:IPR018236), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), SAICAR synthetase (InterPro:IPR001636); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_188748.1
    • purin 7 (PUR7); FUNCTIONS IN: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; INVOLVED IN: response to auxin stimulus, purine nucleotide biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SAICAR synthetase, conserved site (InterPro:IPR018236), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), SAICAR synthetase (InterPro:IPR001636); Has 6539 Blast hits to 6539 proteins in 2290 species: Archae - 136; Bacteria - 4333; Metazoa - 76; Fungi - 152; Plants - 62; Viruses - 0; Other Eukaryotes - 1780 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7402477..7405674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113005.4 → NP_188748.1  purin 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188748.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38025, Q8RXX4, Q9LJC1
      UniProtKB/TrEMBL
      A0A178VEX8, A0A5S9XFR2, A0A654FEK9
      Conserved Domains (1) summary
      PLN02544
      Location:32 → 401
      PLN02544; phosphoribosylaminoimidazole-succinocarboxamide synthase

    2. NM_001338505.1 → NP_001319605.1  purin 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38025, Q8RXX4, Q9LJC1
      UniProtKB/TrEMBL
      A0A178VEX8, A0A5S9XFR2, A0A654FEK9
      Conserved Domains (1) summary
      PLN02544
      Location:32 → 401
      PLN02544; phosphoribosylaminoimidazole-succinocarboxamide synthase

    3. NM_001035662.2 → NP_001030739.1  purin 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38025, Q8RXX4, Q9LJC1
      UniProtKB/TrEMBL
      A0A178VEX8, A0A5S9XFR2, A0A654FEK9
      Conserved Domains (1) summary
      PLN02544
      Location:32 → 401
      PLN02544; phosphoribosylaminoimidazole-succinocarboxamide synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38025.2

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