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Conserved domains on  [gi|1063712857|ref|NP_001319605|]
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purin 7 [Arabidopsis thaliana]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10791397)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
32-401 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase


:

Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 723.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857  32 VSFLRAVPEFNKYPKPCSLVMSCQGKAQNQQEERPQLSLDDLVTSNRKGEVLGTIKDSLSNCLSETNLLATVPGLKSRIK 111
Cdd:PLN02544    1 VSSLRTLPEFMKPASPSSGVGGASGKFRAQQLPSPALSLDDLSSSGRRPEVLGAIKEALSNCLTETNLDLTVPGLGSRRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIYDAGDYLVLITTDRLSAFDRNLASIPFKGQVLNETSLWWFNNTQHITPNAIVSSPDRNVVIAKKCSVFPIEFVV 191
Cdd:PLN02544   81 GKVRDIYDLGDYLVLVTTDRQSAFDRVLASIPFKGQVLNQTSAWWFNNTKHITPNALVSSPDPNVTIAKKCSVFPVEFVV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 192 RGYVTGSTDTSLWTVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTKAADHDVPISPNEIVEGGFMTQAEFDEASMKAL 271
Cdd:PLN02544  161 RGYMTGSTSTSLWTVYNKGVRNYCGNDLPDGMVKNQKLPANILTPTTKAADHDVPISPEEIVEEGLMTQEDFDEVSSKAL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 272 SLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEERFQKGLEPENVDKEFLRLWFKENCNP 351
Cdd:PLN02544  241 ALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVHTPDSSRYWLADSYEERHAAGLEPENIDKEFLRLWFKENCDP 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063712857 352 YEDEVLPAAPAELVTELAWRYIFLYETITGSRIDIIPTQEPIHDRISRNT 401
Cdd:PLN02544  321 YKDEVLPEAPAELVCELSWRYIKLYETITGEKFEVPDTQEPIHERISRNV 370
 
Name Accession Description Interval E-value
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
32-401 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 723.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857  32 VSFLRAVPEFNKYPKPCSLVMSCQGKAQNQQEERPQLSLDDLVTSNRKGEVLGTIKDSLSNCLSETNLLATVPGLKSRIK 111
Cdd:PLN02544    1 VSSLRTLPEFMKPASPSSGVGGASGKFRAQQLPSPALSLDDLSSSGRRPEVLGAIKEALSNCLTETNLDLTVPGLGSRRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIYDAGDYLVLITTDRLSAFDRNLASIPFKGQVLNETSLWWFNNTQHITPNAIVSSPDRNVVIAKKCSVFPIEFVV 191
Cdd:PLN02544   81 GKVRDIYDLGDYLVLVTTDRQSAFDRVLASIPFKGQVLNQTSAWWFNNTKHITPNALVSSPDPNVTIAKKCSVFPVEFVV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 192 RGYVTGSTDTSLWTVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTKAADHDVPISPNEIVEGGFMTQAEFDEASMKAL 271
Cdd:PLN02544  161 RGYMTGSTSTSLWTVYNKGVRNYCGNDLPDGMVKNQKLPANILTPTTKAADHDVPISPEEIVEEGLMTQEDFDEVSSKAL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 272 SLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEERFQKGLEPENVDKEFLRLWFKENCNP 351
Cdd:PLN02544  241 ALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVHTPDSSRYWLADSYEERHAAGLEPENIDKEFLRLWFKENCDP 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063712857 352 YEDEVLPAAPAELVTELAWRYIFLYETITGSRIDIIPTQEPIHDRISRNT 401
Cdd:PLN02544  321 YKDEVLPEAPAELVCELSWRYIKLYETITGEKFEVPDTQEPIHERISRNV 370
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
111-381 3.76e-131

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 378.04  E-value: 3.76e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGD-YLVLITTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHITPNAIVSS-------------PDRN 175
Cdd:cd01414     4 SGKVRDVYDLGDgRLLFVATDRISAFDVILPPdIPGKGEVLTQISAFWFELTEDIIPNHLISTdvedlpeikepedPDGR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 176 VVIAKKCSVFPIEFVVRGYVTGSTdtslWTVYNKGVRNyCGNELSDGLVKNQKLPANILTPTTKAA-DHDVPISPNEIVE 254
Cdd:cd01414    84 SMVVKKAKPIPIECIVRGYLTGSG----WKEYQKGGTV-CGIKLPEGLREAQKLPEPIFTPSTKAEeGHDENISFEEAVE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 255 GgfMTQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEErfqkGLEPE 334
Cdd:cd01414   159 I--IGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEP----GKEQP 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1063712857 335 NVDKEFLRLWFKENCNPYEDEVLPAAPAELVTELAWRYIFLYETITG 381
Cdd:cd01414   233 SFDKQFVRDWLEASGWDKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
104-383 1.15e-91

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 276.19  E-value: 1.15e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 104 PGLKSRIKGKVRDIYDAG-DYLVLITTDRLSAFDRNL-ASIPFKGQVLNETSLWWFNNTQHIT-PNAIVSSPDRNVVIAK 180
Cdd:COG0152     2 PKLELLYEGKVKDVYATDdDTLLMVFKDRISAFDGVKpDPIPGKGEVLNQISAFWFELLEDIGiPTHFIETLSGREMLVK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 181 KCSVFPIEFVVRGYVTGStdtsLWTVYNKGVRnycgneLSDGLVKNQKLPANILTPTTKAAD-HDVPISPNEIVEGGFMT 259
Cdd:COG0152    82 KLEMIPVEVVVRNYAAGS----LWKRYQAGIA------LPLGLEEGTKLPEPIFEPSTKADEgHDPNISEEHIVALGLAT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 260 QAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYeERFqkglepenvDKE 339
Cdd:COG0152   152 EEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTY-ESL---------DKD 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063712857 340 FLRLWfkencnpyedevlpaapaeLVTELAWRYIFLYETITGSR 383
Cdd:COG0152   221 RFRDW-------------------LGGNTSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
111-354 1.93e-90

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 272.70  E-value: 1.93e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGD--YLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWFNNTQ-HITPNAIVSSPDRNVVIAKKCSVFP 186
Cdd:pfam01259   4 EGKVKDVYETDDpdTLLVVAKDRISAFDGVKKgTIPGKGAVNNQISAFWFELLEiAGIPTHFIKSLSGREMLVKKVKIIP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 187 IEFVVRGYVTGSTDTSLwtvynkgvrnycgnelsDGLVKNQKLPANILTPTTKAAD-HDVPISPNEIVEGGFMTQAEFDE 265
Cdd:pfam01259  84 LEVVVRNYAAGSLGKRL-----------------PGLKEGTKLPEPIFEPSTKADAlGDPNINEEHIVALGLATEEEAEE 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 266 ASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYEErfqkglEPENVDKEFLRLWF 345
Cdd:pfam01259 147 IRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYEK------SQESLDKDRFRDDL 219

                  ....*....
gi 1063712857 346 KENCNPYED 354
Cdd:pfam01259 220 GDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
112-332 1.53e-36

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 133.29  E-value: 1.53e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIY--DAGDYLVLITTDRLSAFDRNL-ASIPFKGQVLNETSLWWFNNTQHI-TPNAIVSSPDRNVVIAKKCSVFPI 187
Cdd:TIGR00081  12 GKAKDIYetDDPDLLRFVFRDDISAFDGEKkDQIPGKGRLNTKISAFIFEKLEEAgIPTHYIDLIEDREMLVKKLDIIPL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 188 EFVVRGYVTGStdtslwtvynkGVRNYcgnELSDGLVKNQKLPANILTPTtKAADHDVPISPneIVEGGFMTQAEFDEAS 267
Cdd:TIGR00081  92 EVIVRNIAAGS-----------LLKRL---GIPEGLELEQPLVEFIFKPD-EVGDPMLNESY--AEALGLATEEELERIK 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063712857 268 MKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYE--------ERFQKGLE 332
Cdd:TIGR00081 155 ELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETYEvgapkldkDIFRRTLG 226
 
Name Accession Description Interval E-value
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
32-401 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 723.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857  32 VSFLRAVPEFNKYPKPCSLVMSCQGKAQNQQEERPQLSLDDLVTSNRKGEVLGTIKDSLSNCLSETNLLATVPGLKSRIK 111
Cdd:PLN02544    1 VSSLRTLPEFMKPASPSSGVGGASGKFRAQQLPSPALSLDDLSSSGRRPEVLGAIKEALSNCLTETNLDLTVPGLGSRRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIYDAGDYLVLITTDRLSAFDRNLASIPFKGQVLNETSLWWFNNTQHITPNAIVSSPDRNVVIAKKCSVFPIEFVV 191
Cdd:PLN02544   81 GKVRDIYDLGDYLVLVTTDRQSAFDRVLASIPFKGQVLNQTSAWWFNNTKHITPNALVSSPDPNVTIAKKCSVFPVEFVV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 192 RGYVTGSTDTSLWTVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTKAADHDVPISPNEIVEGGFMTQAEFDEASMKAL 271
Cdd:PLN02544  161 RGYMTGSTSTSLWTVYNKGVRNYCGNDLPDGMVKNQKLPANILTPTTKAADHDVPISPEEIVEEGLMTQEDFDEVSSKAL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 272 SLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEERFQKGLEPENVDKEFLRLWFKENCNP 351
Cdd:PLN02544  241 ALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVHTPDSSRYWLADSYEERHAAGLEPENIDKEFLRLWFKENCDP 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063712857 352 YEDEVLPAAPAELVTELAWRYIFLYETITGSRIDIIPTQEPIHDRISRNT 401
Cdd:PLN02544  321 YKDEVLPEAPAELVCELSWRYIKLYETITGEKFEVPDTQEPIHERISRNV 370
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
89-407 3.19e-163

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 460.89  E-value: 3.19e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857  89 SLSNCLSETNLlatvPGLKSRIKGKVRDIYDAGDY-LVLITTDRLSAFDRNLASIPFKGQVLNETSLWWFNNTQHITPNA 167
Cdd:PRK12607    2 MLPRTLTEFNF----PELPNVYRGKVRDNYDLPDGrRVMVATDRISAFDRVLPAIPYKGQVLNQTAAFWFEATKDICPNH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 168 IVSSPDRNVVIAKKCSVFPIEFVVRGYVTGSTdtslWTVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTKAAD--HDV 245
Cdd:PRK12607   78 VLAVPDPNVVVGKRCEPFPVEMVVRGYLAGST----WRLYKAGKREMYGVTLPDGLRENQKLPEPIITPTTKAEEggHDE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 246 PISPNEIVEGGFMTQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEE 325
Cdd:PRK12607  154 PISPEEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIHTPDSSRYWYADGYEE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 326 RFQKGLEPENVDKEFLRLWFKENCNPYEDEVlPAAPAELVTELAWRYIFLYETITGSRIdIIPTQEPIHDRISRNTSQAL 405
Cdd:PRK12607  234 RFAAGEPQEQLDKEFVRQWLIERCGPYGQEI-PEIPDEVIVSVSERYIELYEKITGETF-VPDSGSPPLARIRKNLAAYL 311

                  ..
gi 1063712857 406 SS 407
Cdd:PRK12607  312 AR 313
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
111-381 3.76e-131

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 378.04  E-value: 3.76e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGD-YLVLITTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHITPNAIVSS-------------PDRN 175
Cdd:cd01414     4 SGKVRDVYDLGDgRLLFVATDRISAFDVILPPdIPGKGEVLTQISAFWFELTEDIIPNHLISTdvedlpeikepedPDGR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 176 VVIAKKCSVFPIEFVVRGYVTGSTdtslWTVYNKGVRNyCGNELSDGLVKNQKLPANILTPTTKAA-DHDVPISPNEIVE 254
Cdd:cd01414    84 SMVVKKAKPIPIECIVRGYLTGSG----WKEYQKGGTV-CGIKLPEGLREAQKLPEPIFTPSTKAEeGHDENISFEEAVE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 255 GgfMTQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEErfqkGLEPE 334
Cdd:cd01414   159 I--IGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEP----GKEQP 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1063712857 335 NVDKEFLRLWFKENCNPYEDEVLPAAPAELVTELAWRYIFLYETITG 381
Cdd:cd01414   233 SFDKQFVRDWLEASGWDKQDPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
104-383 1.15e-91

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 276.19  E-value: 1.15e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 104 PGLKSRIKGKVRDIYDAG-DYLVLITTDRLSAFDRNL-ASIPFKGQVLNETSLWWFNNTQHIT-PNAIVSSPDRNVVIAK 180
Cdd:COG0152     2 PKLELLYEGKVKDVYATDdDTLLMVFKDRISAFDGVKpDPIPGKGEVLNQISAFWFELLEDIGiPTHFIETLSGREMLVK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 181 KCSVFPIEFVVRGYVTGStdtsLWTVYNKGVRnycgneLSDGLVKNQKLPANILTPTTKAAD-HDVPISPNEIVEGGFMT 259
Cdd:COG0152    82 KLEMIPVEVVVRNYAAGS----LWKRYQAGIA------LPLGLEEGTKLPEPIFEPSTKADEgHDPNISEEHIVALGLAT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 260 QAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYeERFqkglepenvDKE 339
Cdd:COG0152   152 EEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTY-ESL---------DKD 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063712857 340 FLRLWfkencnpyedevlpaapaeLVTELAWRYIFLYETITGSR 383
Cdd:COG0152   221 RFRDW-------------------LGGNTSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
111-354 1.93e-90

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 272.70  E-value: 1.93e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGD--YLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWFNNTQ-HITPNAIVSSPDRNVVIAKKCSVFP 186
Cdd:pfam01259   4 EGKVKDVYETDDpdTLLVVAKDRISAFDGVKKgTIPGKGAVNNQISAFWFELLEiAGIPTHFIKSLSGREMLVKKVKIIP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 187 IEFVVRGYVTGSTDTSLwtvynkgvrnycgnelsDGLVKNQKLPANILTPTTKAAD-HDVPISPNEIVEGGFMTQAEFDE 265
Cdd:pfam01259  84 LEVVVRNYAAGSLGKRL-----------------PGLKEGTKLPEPIFEPSTKADAlGDPNINEEHIVALGLATEEEAEE 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 266 ASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYEErfqkglEPENVDKEFLRLWF 345
Cdd:pfam01259 147 IRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYEK------SQESLDKDRFRDDL 219

                  ....*....
gi 1063712857 346 KENCNPYED 354
Cdd:pfam01259 220 GDVEEAYQE 228
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
95-385 6.25e-78

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 242.80  E-value: 6.25e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857  95 SETNLLATVPGLKSRIKGKVRDIYDA-GDYLVLITTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHITPNAIVSSP 172
Cdd:PRK13961    1 MSTLMESDLPSLPLLGRGKVRDIYAVdDDRLLMVATDRISAFDVILPEpIPDKGRVLTQMSNFWFDKLAHIVPNHLTGID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 173 DRNV-------------VIAKKCSVFPIEFVVRGYVTGSTdtslWTVYNKGvRNYCGNELSDGLVKNQKLPANILTPTTK 239
Cdd:PRK13961   81 VDDVvpadeadqvlgraVVVKKLKPLPVECVVRGYLTGSG----WKDYQAT-GTVCGIKLPAGLVEASKLPEPIFTPATK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 240 AA--DHDVPISPNEIVEggfMTQAE-FDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSR 316
Cdd:PRK13961  156 AElgDHDENISFEEVVE---LVGAElAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPDSSR 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063712857 317 YWLAGSYEErfqkGLEPENVDKEFLRLWFkENCNPYEDEVLPAAPAELVTELAWRYIFLYETITGSRID 385
Cdd:PRK13961  233 FWPADSYQP----GTSQPSFDKQFVRDWL-ETSGWDKTAPAPPLPADVIEKTRAKYREALERLTGKSLD 296
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
112-332 1.53e-36

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 133.29  E-value: 1.53e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIY--DAGDYLVLITTDRLSAFDRNL-ASIPFKGQVLNETSLWWFNNTQHI-TPNAIVSSPDRNVVIAKKCSVFPI 187
Cdd:TIGR00081  12 GKAKDIYetDDPDLLRFVFRDDISAFDGEKkDQIPGKGRLNTKISAFIFEKLEEAgIPTHYIDLIEDREMLVKKLDIIPL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 188 EFVVRGYVTGStdtslwtvynkGVRNYcgnELSDGLVKNQKLPANILTPTtKAADHDVPISPneIVEGGFMTQAEFDEAS 267
Cdd:TIGR00081  92 EVIVRNIAAGS-----------LLKRL---GIPEGLELEQPLVEFIFKPD-EVGDPMLNESY--AEALGLATEEELERIK 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063712857 268 MKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYE--------ERFQKGLE 332
Cdd:TIGR00081 155 ELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETYEvgapkldkDIFRRTLG 226
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
125-393 3.30e-34

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 130.59  E-value: 3.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 125 VLITTDRLSAFD------RNLASIPFKGQVLNETSLWWFN--NTQHITPNAIVSSPDRNVVIAKKCSVFPIEFVVRGYVT 196
Cdd:PRK13960   57 IMVISDRISAFDciwhgeGGLNGVPGKGAALNAISNHWFKlfKENGLADSHILDIPHPFVWIVQKARPVMIEAICRQYIT 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 197 GStdtsLWTVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTK----------AADhDVPISPNEIvEGGFmtqAEFDEA 266
Cdd:PRK13960  137 GS----MWRAYSKGEREFCGITLPEGLEKDQKLPELLITPSTKgiltgipgvpEAD-DVNISRSDI-EANY---QAFNFS 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 267 SMKALSLFE------FG--QGVAKKHGLILVDTKYEFGRSSDGS----ILLIDEIHTPDSSRYWLAGSYeerfQKGLEPE 334
Cdd:PRK13960  208 SADDIDLYEkllkegFKviSDALAKLDQIFVDTKFEFGYVTDAAgnekLIYMDEVGTPDSSRIWDGAAY----RDGKIVE 283
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063712857 335 NvDKEFLRLWFKeNCNPYEDEVLP--------------AAPAELVTELAWRYIFLYETITGSRIDII--PTQEPI 393
Cdd:PRK13960  284 N-SKEGFRQFLL-NHFPDPDILLNkdrmperealardnALPLEAMMDVSRTYTGIAEKITGAKIVLSanPKAEII 356
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
111-332 1.31e-31

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 119.88  E-value: 1.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGD-YLVLITTDRLSAFDRNL-ASIPFKGQVLNETSLWWFNNTQHI-TPNAIVSSPDRNVVIAKKCSVFPI 187
Cdd:cd00476     4 RGKTKIVYETKDgVLLLEFKDDISAGDGARrNFLDEKGDITAKLTLFIFKYLSEAgIPTHFVERLGPRTLLVDKLK*IPL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 188 EFVVRGYVTGSTdtslwtvynkgVRNYCGNElsdglvKNQKLPANILTPTTKA-ADHDVPISPNEIVEGGFMTQAEFDEA 266
Cdd:cd00476    84 EVVVRNRATGSF-----------VKRYGGFK------EGREFPPPLVEFFYKDdAEHDPIVSEDQLERLGFIGKVDVER* 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063712857 267 SMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYE-----ERFQKGLE 332
Cdd:cd00476   147 KELAVKINTVLKKLFSPAGLELWDFKLEFGLDEEGEIVLGDEI-SPDSSRLWRKGGEPydkdlFRRRASLG 216
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
112-331 1.26e-23

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 98.29  E-value: 1.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIYDAGDYLVLITT--DRLSAFD-RNLASIPFKGQVLNETSLWWFNN-TQHITPNAIVSSPDRNVVIAKKCSVFPI 187
Cdd:cd01415     5 GKAKIVYATDDPDVLIVEfkDDATAFNgKKKDTIEGKGVLNNEISALIFKYlEENGIKTHFIEKLSDREQLVKKVEIIPL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 188 EFVVRGYVTGSTdtslwtvynkgVRNYcgnelsdGLVKNQKLPANILTPTTKAADHDVP-ISPNEIVEGGFMTQAEFDEA 266
Cdd:cd01415    85 EVVVRNIAAGSL-----------VKRL-------GIEEGTVLDPPIVEFYYKNDELGDPlINEDHILALGLATEEELKEI 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063712857 267 SMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYE----ERFQKGL 331
Cdd:cd01415   147 KELALKINEVLSEFFAEIGIILVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDKETGEkldkDRFRRDL 214
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
112-331 1.88e-20

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 89.40  E-value: 1.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 112 GKVRDIYDAGDYLVLIT--TDRLSAFD---RnlASIPFKGQVLNETSLWWFN--NTQHItPNAIVSSPDRNVVIAKKCSV 184
Cdd:PRK09362   10 GKAKIVYSTDDPDLLIVefKDDATAFNgekK--EQIDGKGVLNNQISSFIFKklEEAGI-PTHFIEKLSDREQLVKKVEI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 185 FPIEFVVRGYVTGSTdtslwtvynkgVRNYcgnelsdGLVKNQKLPANILTPTTKAADHDVP-ISPNEIVEGGFMTQAEF 263
Cdd:PRK09362   87 IPLEVVVRNVAAGSL-----------VKRL-------GIEEGTVLPPPIVEFYYKNDALGDPmINEDHILALGWATPEEL 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063712857 264 DEasMKALSL--FEFGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIhTPDSSRYWLAGSYE----ERFQKGL 331
Cdd:PRK09362  149 AE--IKELALkiNDVLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDKETNEkldkDRFRRDL 219
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
110-342 1.21e-15

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 76.18  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 110 IKGKVRDIYDAGDY--LVLI-TTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHI-TPNAIVSSPDRNVVIAKKCSV 184
Cdd:cd01416     8 IEGKTKIVYELPDQpgLVLIqSKDRITAGDGARKDeIEGKAAISNKTTSNVFELLQEAgIKTHFVKQCSPTAFIARKCEM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 185 FPIEFVVRGYVTGStdtslWTVYNKGVRNycGNELSDGLV----KNQklpaniltpttkaADHDVPISPNEIVEGGFM-- 258
Cdd:cd01416    88 IPIEWVCRRIATGS-----FLKRNPGVKE--GYRFSPPKLeffyKDD-------------ANHDPQWSEEQLLEAKLNcg 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 259 ----TQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSSD-GSILLIDEIHTpDSSRYWLAGsyEERFQKglep 333
Cdd:cd01416   148 glkiGKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTtGEILLADVIDN-DSWRLWPSG--DKRLMK---- 220

                  ....*....
gi 1063712857 334 envDKEFLR 342
Cdd:cd01416   221 ---DKQVYR 226
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
111-399 3.72e-12

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 67.01  E-value: 3.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 111 KGKVRDIYDAGDYL-------VLITTDRLSAFDRNL--ASIPFKGQVLNETSLWWFN---------------NTQHITPN 166
Cdd:PRK13959    1 MGSVKDFYVDEEPTetdlgrgRFVFSDRYSVFDWGImpDEIPDKGASLCTMGAYNFElleeegikthyigvvEDGEVVRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 167 AIVSSPDRNVVIaKKCSVF------------------------PIEFVVRGYV-TGStdtSLWTvynkgvRNYCGN-ELS 220
Cdd:PRK13959   81 AEASEPPNEMAV-KLTQVPdlpfeggsydydayheaagenyliPLEVIFRNYVpVGS---SLRD------RIKEGKiKPE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 221 D-GLVKN------QKLPANILTPTTKAADHDVPISPNEIVEGGFMTQAEFDEASMKALSLFEFGQGVAKKHGLILVDTKY 293
Cdd:PRK13959  151 DlGLDADewpeegVKLPEPIVEFSTKYEEQDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKI 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712857 294 EFGRSSDGSILLIDEIHTPDSSRYwlagSYEerfqkGLEpenVDKEFLRLWFK----------------ENCNPYEDEVL 357
Cdd:PRK13959  231 EFALYEEREIRVVDVVGTFDENRF----SYE-----GQE---LSKEVVRQYYRrtewveavkeakeedvADWRSLCEPDP 298
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1063712857 358 PAAPAELVTELAWRYIFLYETITGSRIDIIPtqePIHDRISR 399
Cdd:PRK13959  299 PPLPDEVVEAVSDLYKAGTNAYTGREWFDAP---PLKDAVDR 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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