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    Cdc23 cell division cycle 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291689, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc23provided by RGD
    Official Full Name
    cell division cycle 23provided by RGD
    Primary source
    RGD:1304819
    See related
    EnsemblRapid:ENSRNOG00000024241 AllianceGenome:RGD:1304819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 179.6), Spleen (RPKM 133.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc23 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26511019..26534872, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26236891..26260611, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27430924..27452569, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482927 Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene kinesin family member 20A Neighboring gene GDNF family receptor alpha 3 Neighboring gene cell division cycle 25C Neighboring gene stem-loop binding protein like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Zhao N, et al. Genomics, 1998 Oct 15. PMID 9790767
    2. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. Kraft C, et al. EMBO J, 2003 Dec 15. PMID 14657031, Free PMC Article
    3. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
    4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
    5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 23 homolog
    Names
    CDC23 (cell division cycle 23, yeast, homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100659.1 → NP_001094129.1  cell division cycle protein 23 homolog

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      F1LRQ6
      Related
      ENSRNOP00000089789.2, ENSRNOT00000101231.2
      Conserved Domains (3) summary
      COG0457
      Location:216 → 451
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:367 → 393
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:45 → 148
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26511019..26534872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277222.1 → XP_063133292.1  cell division cycle protein 23 homolog isoform X1

    2. XM_008772028.4 → XP_008770250.1  cell division cycle protein 23 homolog isoform X2

      See identical proteins and their annotated locations for XP_008770250.1

      UniProtKB/TrEMBL
      A0A8I5ZTG0, A6J2V5, F1LRQ6
      Related
      ENSRNOP00000082129.1, ENSRNOT00000110937.2
      Conserved Domains (5) summary
      COG0457
      Location:212 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:367 → 393
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:331 → 364
      TPR_1; Tetratricopeptide repeat
      pfam04049
      Location:28 → 154
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
      pfam13414
      Location:367 → 430
      TPR_11; TPR repeat

    RNA

    1. XR_010059562.1 RNA Sequence

    2. XR_010059563.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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