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    Ccpg1 cell cycle progression 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363098, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ccpg1provided by RGD
    Official Full Name
    cell cycle progression 1provided by RGD
    Primary source
    RGD:1311261
    See related
    EnsemblRapid:ENSRNOG00000053428 AllianceGenome:RGD:1311261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and regulation of Rho guanyl-nucleotide exchange factor activity. Predicted to be active in membrane. Orthologous to human CCPG1 (cell cycle progression 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 319.1), Kidney (RPKM 204.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccpg1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (82600677..82633082)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (73719960..73752437)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (79660634..79692044)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene piercer of microtubule wall 2 Neighboring gene microRNA 628 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class B Neighboring gene PIGB opposite strand 1 Neighboring gene RAB27A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNAi screen indicates widespread biological function for human natural antisense transcripts. Faghihi MA, et al. PLoS One, 2010 Oct 4. PMID 20957177, Free PMC Article
    2. Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Kostenko EV, et al. Mol Cell Biol, 2006 Dec. PMID 17000758, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle progression protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108770.2 → NP_001102240.1  cell cycle progression protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001102240.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZQA8, A6KEL6
      Related
      ENSRNOP00000080289.1, ENSRNOT00000101354.2
      Conserved Domains (3) summary
      PLN02328
      Location:85 → 228
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:288 → 517
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04375
      Location:187 → 281
      HemX; HemX

    2. NM_001401186.1 → NP_001388115.1  cell cycle progression protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEL4

    3. NM_001401187.1 → NP_001388116.1  cell cycle progression protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEL4
      Related
      ENSRNOP00000110475.1, ENSRNOT00000164511.1

    4. NM_001401188.1 → NP_001388117.1  cell cycle progression protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEL7
      Related
      ENSRNOP00000103186.1, ENSRNOT00000143856.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      82600677..82633082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243332.5 → XP_006243394.1  cell cycle progression protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006243394.1

      UniProtKB/TrEMBL
      A0A8I5ZKK0, A6KEL4
      Related
      ENSRNOP00000078279.1, ENSRNOT00000107289.2
      Conserved Domains (2) summary
      PLN02328
      Location:110 → 260
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:331 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_008766318.4 → XP_008764540.1  cell cycle progression protein 1 isoform X3

      UniProtKB/TrEMBL
      A6KEL4
      Conserved Domains (2) summary
      PLN02328
      Location:110 → 260
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:331 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_008766320.4 → XP_008764542.1  cell cycle progression protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZQA8
      Conserved Domains (2) summary
      PLN02328
      Location:110 → 260
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:331 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_008766317.4 → XP_008764539.1  cell cycle progression protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KEL4
      Conserved Domains (2) summary
      PLN02328
      Location:110 → 260
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:322 → 551
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_063265778.1 → XP_063121848.1  cell cycle progression protein 1 isoform X5

      UniProtKB/TrEMBL
      A6KEL4

    6. XM_039081758.2 → XP_038937686.1  cell cycle progression protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZQA8
      Conserved Domains (2) summary
      PLN02328
      Location:110 → 260
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:322 → 551
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006243337.5 → XP_006243399.1  cell cycle progression protein 1 isoform X4

      UniProtKB/TrEMBL
      A6KEL4
      Related
      ENSRNOP00000112412.1, ENSRNOT00000143399.1
      Conserved Domains (2) summary
      PLN02328
      Location:85 → 228
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:299 → 528
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006243341.4 → XP_006243403.1  cell cycle progression protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQA8, D4AE99
      Related
      ENSRNOP00000080256.1, ENSRNOT00000106816.2
      Conserved Domains (3) summary
      PLN02328
      Location:85 → 228
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:290 → 519
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04375
      Location:187 → 283
      HemX; HemX

    9. XM_063265779.1 → XP_063121849.1  cell cycle progression protein 1 isoform X6

      UniProtKB/TrEMBL
      A6KEL4

    10. XM_063265780.1 → XP_063121850.1  cell cycle progression protein 1 isoform X7

      UniProtKB/TrEMBL
      A6KEL4

    11. XM_063265782.1 → XP_063121852.1  cell cycle progression protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQA8, D4AE99
      Related
      ENSRNOP00000070957.2, ENSRNOT00000090970.3

    RNA

    1. XR_356404.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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