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    cyb-2.2 Cyclin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyb-2.2
    Official Full Name
    Cyclin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000867
    Locus tag
    CELE_H31G24.4
    See related
    AllianceGenome:WB:WBGene00000867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in anterior/posterior axis specification, embryo; meiotic cell cycle; and oocyte maturation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to several human genes including CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyb-2.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (4114861..4116370)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DEgenerin Like Neighboring gene DEgenerin Linked to Mechanosensation Neighboring gene BTB domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. van der Voet M, et al. Cell Cycle, 2009 Dec 15. PMID 19829076, Free PMC Article
    2. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. Balachandran RS, et al. J Cell Biol, 2016 Oct 24. PMID 27810909, Free PMC Article
    3. CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo. Rabilotta A, et al. PLoS One, 2015. PMID 25658117, Free PMC Article
    4. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Burrows AE, et al. Development, 2006 Feb. PMID 16421191, Free PMC Article
    5. Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation. Deyter GM, et al. PLoS Genet, 2010 Nov 24. PMID 21124864, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterior/posterior axis specification, embryo IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oocyte maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin N-terminal domain-containing protein
    NP_491297.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4114861..4116370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058896.6 → NP_491297.1  Cyclin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BLB5
      Conserved Domains (2) summary
      COG5024
      Location:54 → 322
      COG5024; Cyclin [Cell division and chromosome partitioning]
      pfam00134
      Location:56 → 181
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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