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Conserved domains on  [gi|17507963|ref|NP_491297|]
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Cyclin N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

cyclin family protein( domain architecture ID 15334112)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Caenorhabditis elegans G2/mitotic-specific cyclin-B1 that is essential for the control of the cell cycle at the G2/M (mitosis) transition

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 53-178 4.89e-57

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 181.19  E-value: 4.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  53 MAEDIYNYLVHHEKKYVLDDSFI-NGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLG 131
Cdd:cd20507   4 YVKDIYKYLRQLEKKYAIDPDYLsGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20507  84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 183-310 2.23e-18

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


:

Pssm-ID: 397230  Cd Length: 119  Bit Score: 79.59  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963   183 PSSLVFLRYISKtlteNDVNPIDKETfyyvHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPktaasM 262
Cdd:pfam02984   1 PTPLSFLRRFSK----AADYLHDLEL----RTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTE-----T 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17507963   263 IRKQFGASKQDIYDAISLLAQVaYKNFRHQKLCAIREKYQSSKFGRVS 310
Cdd:pfam02984  68 LEHYTGYSEEDLKPCVKLLLEL-LLNAPSSKLQAVRRKYSSSKFMKVS 114
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 53-178 4.89e-57

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 181.19  E-value: 4.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  53 MAEDIYNYLVHHEKKYVLDDSFI-NGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLG 131
Cdd:cd20507   4 YVKDIYKYLRQLEKKYAIDPDYLsGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20507  84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 56-181 8.65e-47

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 154.60  E-value: 8.65e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963    56 DIYNYLVHHEKKYVLDDSFING-GNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAA 134
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 17507963   135 LFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFDLS 181
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
54-322 4.13e-43

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 154.16  E-value: 4.13e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLD-DSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGV 132
Cdd:COG5024 181 ASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGI 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 133 AALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFDLSCPSSLVFLRYISKTltenDVNPIDKETfyyv 212
Cdd:COG5024 261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA----SDYDIFSRT---- 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 213 hnISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKTaasmIRKQFGASKQDIYDAISLLAQVAYKNFRHQ 292
Cdd:COG5024 333 --PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTL----IHYSGNYTNPDLKPLNESNKENLQNPSVHH 406

                       250       260       270
                ....*....|....*....|....*....|
gi 17507963 293 KlcAIREKYQSSKFGRVSYLMTDEILEKIH 322
Cdd:COG5024 407 D--AIFPKYPSPTFGKASSPTGEWIRSNSS 434
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 183-310 2.23e-18

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 79.59  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963   183 PSSLVFLRYISKtlteNDVNPIDKETfyyvHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPktaasM 262
Cdd:pfam02984   1 PTPLSFLRRFSK----AADYLHDLEL----RTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTE-----T 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17507963   263 IRKQFGASKQDIYDAISLLAQVaYKNFRHQKLCAIREKYQSSKFGRVS 310
Cdd:pfam02984  68 LEHYTGYSEEDLKPCVKLLLEL-LLNAPSSKLQAVRRKYSSSKFMKVS 114
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 90-174 1.92e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 70.31  E-value: 1.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963     90 DWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITEntFSKKQILAME 169
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 17507963    170 QTILN 174
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 183-309 3.44e-08

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 51.07  E-value: 3.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 183 PSSLVFLRYISKtltendVNPIDKETfyyvHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKtaasm 262
Cdd:cd20509   1 PLPLHFLRRFSK------AGGADAQK----HTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPT----- 65

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 263 IRKQFGASKQDIYDAISLLAQVaYKNFRHQKLCAIREKYQSSKFGRV 309
Cdd:cd20509  66 LEHYSTYSEEDLLPIVQKMAKL-VVKSQTSKYQAVKNKYSSSKFMRI 111
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 53-178 4.89e-57

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 181.19  E-value: 4.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  53 MAEDIYNYLVHHEKKYVLDDSFI-NGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLG 131
Cdd:cd20507   4 YVKDIYKYLRQLEKKYAIDPDYLsGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20507  84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 56-181 8.65e-47

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 154.60  E-value: 8.65e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963    56 DIYNYLVHHEKKYVLDDSFING-GNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAA 134
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 17507963   135 LFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFDLS 181
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
54-322 4.13e-43

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 154.16  E-value: 4.13e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLD-DSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGV 132
Cdd:COG5024 181 ASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGI 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 133 AALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFDLSCPSSLVFLRYISKTltenDVNPIDKETfyyv 212
Cdd:COG5024 261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA----SDYDIFSRT---- 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 213 hnISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKTaasmIRKQFGASKQDIYDAISLLAQVAYKNFRHQ 292
Cdd:COG5024 333 --PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTL----IHYSGNYTNPDLKPLNESNKENLQNPSVHH 406

                       250       260       270
                ....*....|....*....|....*....|
gi 17507963 293 KlcAIREKYQSSKFGRVSYLMTDEILEKIH 322
Cdd:COG5024 407 D--AIFPKYPSPTFGKASSPTGEWIRSNSS 434
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 53-178 4.07e-40

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 137.38  E-value: 4.07e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  53 MAEDIYNYLVHHEKKYVLDDSFINGGN-VNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLG 131
Cdd:cd20504   2 YADDIYEYLRESELKHRPKPDYMRKQPdINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20504  82 TACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 54-178 4.53e-37

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 129.72  E-value: 4.53e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLDDSFIN-GGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGV 132
Cdd:cd20568   9 VPEIFEYLRELELKTLPNPNYMDdQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17507963 133 AALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20568  89 SALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 55-178 4.95e-37

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 130.16  E-value: 4.95e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  55 EDIYNYLVHHEKKY-VLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVA 133
Cdd:cd20567  23 EDIYSFYRKVEPEScVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVT 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 17507963 134 ALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20567 103 AMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 56-178 4.10e-36

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 127.29  E-value: 4.10e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  56 DIYNYLVHHEKKYVLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAAL 135
Cdd:cd20566  11 DIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTAL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 17507963 136 FVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20566  91 LLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 55-178 6.82e-36

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 126.53  E-value: 6.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  55 EDIYNYLVHHEKKYVLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAA 134
Cdd:cd20565   6 KDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17507963 135 LFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20565  86 MFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 54-179 2.19e-32

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 117.74  E-value: 2.19e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVA 133
Cdd:cd20508  17 AKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGAT 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17507963 134 ALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFD 179
Cdd:cd20508  97 AILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 54-179 3.52e-32

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 117.13  E-value: 3.52e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLDDSFING--GNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLG 131
Cdd:cd20562   9 ATDIYLNLRVAELKRRPLPDYMEKiqRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLG 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFD 179
Cdd:cd20562  89 VSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 54-179 6.15e-30

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 110.92  E-value: 6.15e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLDDSFINGG-NVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGV 132
Cdd:cd20561   5 HEDIHTYLREMEVKCKPKVGYMKKQpDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 133 AALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNFD 179
Cdd:cd20561  85 AAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 85-180 2.83e-29

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 108.18  E-value: 2.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  85 RRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENTFSKKQ 164
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 17507963 165 ILAMEQTILNALNFDL 180
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 19-179 1.46e-28

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 108.39  E-value: 1.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  19 SSVKNQHENGSSTPVNTegLAVgprtkleEEFncmAEDIYNYLVHHEKKYVLDDSFING-GNVNSKMRRILVDWLVQVHL 97
Cdd:cd20560  14 TSLQSQSEDDSAADVDV--LAV-------PEY---AEDIHQYLREAELKHRPKPGYMRKqPDITTGMRTILVDWLVEVGE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  98 RFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALN 177
Cdd:cd20560  82 EYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLA 161


                ..
gi 17507963 178 FD 179
Cdd:cd20560 162 FD 163
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 84-176 5.01e-26

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 99.32  E-value: 5.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  84 MRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENTFSKK 163
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                        90
                ....*....|...
gi 17507963 164 QILAMEQTILNAL 176
Cdd:cd20536  81 QICNLECIILTKL 93
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 55-178 6.31e-26

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 100.47  E-value: 6.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  55 EDIYNYLVHHEKKYVLDDSFING-GNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRII-VKNIVSKAEFQLLGV 132
Cdd:cd20519   6 EEVWDLMLKKEELYKRDRDFLNRhPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVPKTQLQLIGI 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17507963 133 AALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20519  86 TCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 54-178 2.92e-21

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 87.98  E-value: 2.92e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  54 AEDIYNYLVHHEKKYVLDDSFI-NGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIV--KNIvSKAEFQLL 130
Cdd:cd20580  11 SKDVWLNMLKKESKYVHDKHFLqLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLtqKNI-NKSMLQLI 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17507963 131 GVAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20580  90 GITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 55-178 6.91e-21

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 87.24  E-value: 6.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  55 EDIYNYLVHHEKKYVLDDSFINGG-NVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIV--KNIVsKAEFQLLG 131
Cdd:cd20579  12 DEVWKNMLNKDKTYLRDKNFLQKHpLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtqENVV-KTRLQLIG 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 132 VAALFVASKFEDIYLPDILEYELITENTFSKKQILAMEQTILNALNF 178
Cdd:cd20579  91 ISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 183-310 2.23e-18

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 79.59  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963   183 PSSLVFLRYISKtlteNDVNPIDKETfyyvHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPktaasM 262
Cdd:pfam02984   1 PTPLSFLRRFSK----AADYLHDLEL----RTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTE-----T 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17507963   263 IRKQFGASKQDIYDAISLLAQVaYKNFRHQKLCAIREKYQSSKFGRVS 310
Cdd:pfam02984  68 LEHYTGYSEEDLKPCVKLLLEL-LLNAPSSKLQAVRRKYSSSKFMKVS 114
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 90-174 1.92e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 70.31  E-value: 1.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963     90 DWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITEntFSKKQILAME 169
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 17507963    170 QTILN 174
Cdd:smart00385  79 RLLLE 83
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 88-179 4.46e-15

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 69.72  E-value: 4.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  88 LVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFED--IYLPDILEYELITENTFSKKQI 165
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWEskARVPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|....
gi 17507963 166 LAMEQTILNALNFD 179
Cdd:cd20559  82 IQMEMHILNTLNWD 95
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 83-178 1.08e-14

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 69.17  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  83 KMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYlPDILEYE----LITEN 158
Cdd:cd20528   5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELD-DNIPKISdlnrYLCNS 83

                        90       100
                ....*....|....*....|
gi 17507963 159 TFSKKQILAMEQTILNALNF 178
Cdd:cd20528  84 VYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 82-176 1.37e-14

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 68.50  E-value: 1.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  82 SKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENTFS 161
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                        90
                ....*....|....*
gi 17507963 162 KKQILAMEQTILNAL 176
Cdd:cd20521  81 YEDVVRMMGEIVAAL 95
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 85-177 4.60e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 55.79  E-value: 4.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  85 RRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEF---QLLGVAALFVASKFEDIYLPDILEY-ELITENTF 160
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPwmlQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVF 81

                        90
                ....*....|....*..
gi 17507963 161 SKKQILAMEQTILNALN 177
Cdd:cd20543  82 EAKTIQRMELLVLSTLE 98
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 89-180 5.73e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 55.78  E-value: 5.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  89 VDWLVQVHLRFHLTPETLHLTIFVLDRIIvkNIVsKAE---FQLLGVAALFVASKF--EDIYLPDILEYELITENTFSKK 163
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFL--ASV-KARpkyLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVA 82

                        90
                ....*....|....*..
gi 17507963 164 QILAMEQTILNALNFDL 180
Cdd:cd20526  83 EVLRMERIILDKLHWDL 99
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 65-179 6.91e-10

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 56.92  E-value: 6.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  65 EKKYVLDDSFING--GNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFE 142
Cdd:cd20515  34 EERYLPSASYFKCvqTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLK 113

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 17507963 143 DiylPDILEYELI---TENTFSKKQILAMEQTILNALNFD 179
Cdd:cd20515 114 E---TIPLTAEKLciyTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 83-179 2.36e-08

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 52.29  E-value: 2.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  83 KMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIyLPDILEYELI-TENTFS 161
Cdd:cd20573  53 SMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKET-IPLTAEKLCIyTDNSIR 131

                        90
                ....*....|....*...
gi 17507963 162 KKQILAMEQTILNALNFD 179
Cdd:cd20573 132 PEELLQMELLVLNKLKWD 149
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 61-179 2.44e-08

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 52.30  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  61 LVHHEKKYVLDDSFIN--GGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVA 138
Cdd:cd20575  30 LLRLEERYVPRVSYFQcvQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17507963 139 SKFEDIyLPDILEYELI-TENTFSKKQILAMEQTILNALNFD 179
Cdd:cd20575 110 SKLRET-TPLTIEKLCIyTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 183-309 3.44e-08

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 51.07  E-value: 3.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 183 PSSLVFLRYISKtltendVNPIDKETfyyvHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKtaasm 262
Cdd:cd20509   1 PLPLHFLRRFSK------AGGADAQK----HTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPT----- 65

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17507963 263 IRKQFGASKQDIYDAISLLAQVaYKNFRHQKLCAIREKYQSSKFGRV 309
Cdd:cd20509  66 LEHYSTYSEEDLLPIVQKMAKL-VVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 88-170 8.25e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 48.95  E-value: 8.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  88 LVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPdILEYELITENtfSKKQILA 167
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAKVSGV--SEKELRK 78


                ...
gi 17507963 168 MEQ 170
Cdd:cd00043  79 AEK 81
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 80-176 3.56e-07

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 47.94  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  80 VNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIYLPDILEYELITENT 159
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                        90
                ....*....|....*..
gi 17507963 160 FSKKQILAMEQTILNAL 176
Cdd:cd20517  81 FTNLELINQEKDILEAL 97
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 81-180 3.98e-06

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 45.25  E-value: 3.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  81 NSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDI----YLPDILEYeliT 156
Cdd:cd20556   3 LSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDDvkkeDLKSLLEE---I 79

                        90       100
                ....*....|....*....|....*.
gi 17507963 157 ENTF--SKKQILAMEQTILNALNFDL 180
Cdd:cd20556  80 EDVFrlTRKELIAFEFPVLVALEFSL 105
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 84-179 1.74e-05

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 44.21  E-value: 1.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  84 MRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDIyLPDILEYELI-TENTFSK 162
Cdd:cd20574  55 MRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKET-IPLTAEKLCIyTDNSIKP 133

                        90
                ....*....|....*..
gi 17507963 163 KQILAMEQTILNALNFD 179
Cdd:cd20574 134 QELLEWELVVLGKLKWN 150
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 183-307 1.35e-04

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 40.74  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 183 PSSLVFLRYISKTLTENDVnpidketfyyVHNISKCLGELALLDS--VMSTVPrSHVASASMI---ITLNIISVDginpk 257
Cdd:cd20505   1 PTSNWFLERFLKHSNADEK----------TKSLAMYLCELSLIDAdpYLKYLP-SVIAAAAVClanHTLGNEVWP----- 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 17507963 258 taaSMIRKQFGASKQDIYDAISLLAQvAYKNFRHQKLCAIREKYQSSKFG 307
Cdd:cd20505  65 ---QKLARSTGYSLEDLLPCLRDLHR-TFLNAPSSPQQAIREKYKSSKYH 110
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 95-249 2.99e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 42.03  E-value: 2.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963  95 VHLRFHLTpeTLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFED-IYLPDILEYELITENTF----SKKQILAME 169
Cdd:COG5333  57 TRLNLPQT--VLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDtPRDISIESFEARDLWSEepksSRERILEYE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 170 QTILNALNFDLSCPSSLVFLRYISKTLTENDvnpidketFYYVHNISKCLGELALLDSVMSTVPRSHVASASMIITLNII 249
Cdd:COG5333 135 FELLEALDFDLHVHHPYKYLEGFLKDLQEKD--------KYKLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVL 206
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 184-310 1.17e-03

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 38.36  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 184 SSLVFLRYISKTlTENDVNpidketfyyVHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPK-TAASm 262
Cdd:cd20512   1 NPMNFLRRISKA-DDYDIQ---------TRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNlVHYS- 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17507963 263 irkqfGASKQDIYDAISLLAQVAYKNFRHQklCAIREKYQSSKFGRVS 310
Cdd:cd20512  70 -----GYTESQLIPCADIMLEYLVKPIKHH--DAFFKKYSSKKFLKAS 110
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 183-285 9.31e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 34.98  E-value: 9.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507963 183 PSSLVFLRYISKTLTENDVnpidketfyyVHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISvdgiNPKTAASM 262
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDEK----------VRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILG----EPPPSPQL 66

                        90       100
                ....*....|....*....|...
gi 17507963 263 IRKQFGASKQDIYDAISLLAQVA 285
Cdd:cd20537  67 LQLVTGYSENDLQECAKELLELL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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