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    dmd-3 Doublesex- and mab-3-related transcription factor dmd-3 [ Caenorhabditis elegans ]

    Gene ID: 189878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dmd-3
    Official Full Name
    Doublesex- and mab-3-related transcription factor dmd-3
    Primary source
    WormBase:WBGene00012832
    Locus tag
    CELE_Y43F8C.10
    See related
    AllianceGenome:WB:WBGene00012832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron differentiation; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in neuronal cell body. Is expressed in several structures, including PHC; epithelial cell; gonad; ray neuron type A; and tail hypodermis. Orthologous to human DMRTB1 (DMRT like family B with proline rich C-terminal 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dmd-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (19650025..19655251, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Mitochondrial Ribosomal Protein, Small Neighboring gene MS Related Protein Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two C. elegans DM domain proteins, DMD-3 and MAB-3, function in late stages of male somatic gonad development.
      Title: Two C. elegans DM domain proteins, DMD-3 and MAB-3, function in late stages of male somatic gonad development.
    2. dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans.
      Title: dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Doublesex- and mab-3-related transcription factor dmd-3
    NP_001256882.1
    • Confirmed by transcript evidence
    NP_001256883.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19650025..19655251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269953.2 → NP_001256882.1  Doublesex- and mab-3-related transcription factor dmd-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8TDI6, Q9XWN9
      Conserved Domains (2) summary
      smart00301
      Location:113 → 166
      DM; Doublesex DNA-binding motif
      pfam00751
      Location:15 → 60
      DM; DM DNA binding domain

    2. NM_001269954.4 → NP_001256883.1  Doublesex- and mab-3-related transcription factor dmd-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8TDI6
      Conserved Domains (1) summary
      smart00301
      Location:19 → 72
      DM; Doublesex DNA-binding motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWN9.2

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