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    rad-54.L2 Helicase ARIP4;Helicase ATP-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad-54.L2
    Official Full Name
    Helicase ARIP4;Helicase ATP-binding domain-containing protein
    Primary source
    WormBase:WBGene00007761
    Locus tag
    CELE_C27B7.4
    See related
    AllianceGenome:WB:WBGene00007761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO binding activity. Involved in negative regulation of vulval development. Predicted to be located in membrane. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Orthologous to human RAD54L2 (RAD54 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rad-54.L2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (8894077..8901389)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Suppressor of presenilin-2 Neighboring gene Phospholipid scramblase Neighboring gene CCHC-type domain-containing protein Neighboring gene Putative serine/threonine-protein phosphatase C27B7.6 Neighboring gene Ig-like and fibronectin type-III domain-containing protein C27B7.7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator. Leight ER, et al. Genetics, 2015 Mar. PMID 25567989, Free PMC Article
    2. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article
    3. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Weng C, et al. Genes Dev, 2019 Jan 1. PMID 30567997, Free PMC Article
    4. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SUMO binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helicase ARIP4;Helicase ATP-binding domain-containing protein
    NP_001368704.1
    • Confirmed by transcript evidence
    NP_501545.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8894077..8901389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380389.2 → NP_001368704.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E4Z6
      Conserved Domains (2) summary
      COG0553
      Location:256 → 875
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18069
      Location:256 → 547
      DEXHc_ARIP4; DEXH-box helicase domain of ARIP4

    2. NM_069144.7 → NP_501545.1  Helicase ARIP4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18241, Q18243
      Conserved Domains (3) summary
      cd00046
      Location:285 → 398
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:259 → 629
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:778 → 904
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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