|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
256-547 |
6.01e-135 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 411.13 E-value: 6.01e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 336 IPKFSDTG-DRIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18069 81 LPPPEALPnVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFR---------------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqklrdeelefetgftsggrvrqeayslirsalLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18069 133 --------------------------------------LRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 17538806 495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18069 175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
256-547 |
1.41e-91 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 294.97 E-value: 1.41e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTIESLGEYKKsdGFGCILAHSMGLGKTIQVITFSEIFLRATK-AKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGTDVGSDE--GGGCILAHTMGLGKTLQVITFLHTYLAAAPrRSRPLVLCPASTLYNWEDEFKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKFsdtgdrIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIkmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18007 79 WLPPD------LRPLLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRNLA------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdsSEDQKLRDEELEFEtgftsggrvrqeayslirSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18007 128 ---SNATTDPRLKQEFI------------------AALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTP 186
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 17538806 495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18007 187 LQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
256-547 |
1.91e-81 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 267.14 E-value: 1.91e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFL---RATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 333 DKWIpKFSDTGDRIRSFEVfllgDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIKMTLPKKQKKGRPKLnlsgissg 412
Cdd:cd18068 81 EKWQ-EGLKDEEKIEVNEL----ATYKRPQERSYKLQRWQEEGGVMIIGYDMYRILAQERNVKSREKLKEIF-------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 413 fskdssedqklrdeelefetgftsggrvrqeaysliRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18068 148 ------------------------------------NKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTG 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 17538806 493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18068 192 TPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVDVRVMKKR 246
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
60-940 |
1.04e-69 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 248.22 E-value: 1.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 60 AEDLDENVLEAQRLEKQRLERLEKIKPENDHIQQMESLFLAGASEGQLPQLDLQDDDFEEMFGFSVENDNKKYRYGDEEK 139
Cdd:COG0553 35 LARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLLALALLLLALL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 140 PEPMFHLQEPSTSRGHVDVVDLTLDDSDDDCLITDVKSVMPQVVPGRRMRWAQAEKDRIDADQMDIQHNIEARRLKKMRS 219
Cdd:COG0553 115 GLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 220 AKDLESTEKKEGRLLVNAGHPEEDPDIFVISHLTHVLQ-----------PHQLGGIRFMYdntieSLGEYkksdGFGCIL 288
Cdd:COG0553 195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALEslpaglkatlrPYQLEGAAWLL-----FLRRL----GLGGLL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 289 AHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfevFLLGDGVKTFDQRVNLI 368
Cdd:COG0553 266 ADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLR-----------VLVLDGTRERAKGANPF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 369 EQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfskdssedqklRDEELefetgftsggrvrqeaysli 448
Cdd:COG0553 335 EDAD----LVITSYGLLR-------------------------------------RDIEL-------------------- 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 449 rsaLLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPI 528
Cdd:COG0553 354 ---LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 529 kngqcvdsspddVKIALQRTHVLVELVKGFVQRRTHHLLKKILPESKEYVLLLRKSQIQRQLYRNFVLWAKNEI--AANN 606
Cdd:COG0553 431 ------------EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELegAEGI 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 607 DAVFNPLMAFSACSKIWNHPDILYrlveqkkraeEDKKRveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfgaqfhp 686
Cdd:COG0553 499 RRRGLILAALTRLRQICSHPALLL----------EEGAE----------------------------------------- 527
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 687 qqngmmmqngswhpnnYQMPSPfnsipsnpstptssstsksakktkkprgskkapksdeedeevekesrmKYDWTFELFE 766
Cdd:COG0553 528 ----------------LSGRSA------------------------------------------------KLEALLELLE 543
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 767 kyqegvlengykivislEILDEstqiGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADR 846
Cdd:COG0553 544 -----------------ELLAE----GEKVLVFSQFTDTLDLLEERLEERGIE--------------YAYLHGGTSAEER 588
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 847 EKLINRFNSEPGLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFN 926
Cdd:COG0553 589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668
|
890
....*....|....
gi 17538806 927 RQISKHGLQQRVVD 940
Cdd:COG0553 669 LLEEKRALAESVLG 682
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
256-562 |
1.27e-55 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 193.27 E-value: 1.27e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDntieSLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATK-----AKKVLVIVPINTIQNWYS 330
Cdd:cd18004 1 LRPHQREGVQFLYD----CLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPygkptAKKALIVCPSSLVGNWKA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 331 EYDKWIPkfsdtgdrIRSFEVFLLGDGVKTFDQRVnLIEQWDQTGGVMLVGYDMFRLLikmtlpkkqkkgrpklnlsgiS 410
Cdd:cd18004 77 EFDKWLG--------LRRIKVVTADGNAKDVKASL-DFFSSASTYPVLIISYETLRRH---------------------A 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 411 SGFSKDSSedqklrdeelefetgftsggrvrqeayslirsallepgPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18004 127 EKLSKKIS--------------------------------------IDLLICDEGHRLKNSESKTTKALNSLPCRRRLLL 168
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538806 491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18004 169 TGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
259-629 |
5.08e-49 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 176.33 E-value: 5.08e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 259 HQLGGIRFMYDntieslgEYKKSdGFGCILAHSMGLGKTIQVITFseifLRATKA------KKVLVIVPINTIQNWYSEY 332
Cdd:pfam00176 1 YQIEGVNWMLS-------LENNL-GRGGILADEMGLGKTLQTISL----LLYLKHvdknwgGPTLIVVPLSLLHNWMNEF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 333 DKWIPKfsdtgDRIRSFEvfLLGDGVKTFDQRVNLIEQWDQtgGVMLVGYDMfrllikmtLPKkqkkgrpklnlsgissg 412
Cdd:pfam00176 69 ERWVSP-----PALRVVV--LHGNKRPQERWKNDPNFLADF--DVVITTYET--------LRK----------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 413 fskdssedqklrdeelefetgftsggrvrqeayslIRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:pfam00176 115 -----------------------------------HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTG 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSpddvkialqrtHVLVELVKGFVQRRTHHLLKKILP 572
Cdd:pfam00176 160 TPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGV-----------SRLHKLLKPFLLRRTKKDVEKSLP 228
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17538806 573 ESKEYVLLLRKSQIQRQLYRNFVLWAK-------NEIAANNDAVFNPLMAFsacSKIWNHPDIL 629
Cdd:pfam00176 229 PKVEYILFCRLSKLQRKLYQTFLLKKDlnaiktgEGGREIKASLLNILMRL---RKICNHPGLI 289
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
778-915 |
3.20e-46 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 162.26 E-value: 3.20e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 778 KIVISLEILDESTQIGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSEP 857
Cdd:cd18793 12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIK--------------YLRLDGSTSSKERQKLVDRFNEDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806 858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLI 915
Cdd:cd18793 78 DIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
256-562 |
1.13e-40 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 150.70 E-value: 1.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTieslgEYKKSDGF-GCILAHSMGLGKTIQVITFSEIFLRAT-----KAKKVLVIVPINTIQNWY 329
Cdd:cd18067 1 LRPHQREGVKFLYRCV-----TGRRIRGShGCIMADEMGLGKTLQCITLMWTLLRQSpqckpEIDKAIVVSPSSLVKNWA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 330 SEYDKWIpkfsdtGDRIRSFEVfllgDGvKTFDQRVNLIEQWDQTGG------VMLVGYDMFRLLIkmtlpkkqkkgrpk 403
Cdd:cd18067 76 NELGKWL------GGRLQPLAI----DG-GSKKEIDRKLVQWASQQGrrvstpVLIISYETFRLHV-------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 404 lnlsgissgfskdssedqklrDEELEFETGftsggrvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAIN 483
Cdd:cd18067 131 ---------------------EVLQKGEVG-------------------------LVICDEGHRLKNSDNQTYQALDSLN 164
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17538806 484 TKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18067 165 TQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
256-562 |
1.45e-39 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 147.13 E-value: 1.45e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYdntieSLGEYKKsdgfGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18001 1 LYPHQREGVAWLW-----SLHDGGK----GGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 336 IPkfsdtGDRIRSFEvfllgdGVKTFDQRVNLiEQWDQTGGVMLVGYDMFrllikmtlpkkqkkgrpklnlsgissgfsk 415
Cdd:cd18001 72 TP-----GLRVKVFH------GTSKKERERNL-ERIQRGGGVLLTTYGMV------------------------------ 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 416 DSSEDQKLRDEELEFETgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPL 495
Cdd:cd18001 110 LSNTEQLSADDHDEFKW-------------------------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPI 164
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806 496 QNNLLEYFCMIDFVRP-KYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18001 165 QNNLKELWALFDFACNgSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
256-514 |
2.09e-39 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 144.63 E-value: 2.09e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNtieslgeYKKsdGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17919 1 LRPYQLEGLNFLLEL-------YEN--GPGGILADEMGLGKTLQAIAFlAYLLKEGKERGPVLVVCPLSVLENWEREFEK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPkfsdtgdrirSFEVFLLGDGVKtfDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd17919 72 WTP----------DLRVVVYHGSQR--ERAQIRAKEKLDKFDVVLTTYETLR---------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqklRDEElefetgftsggrvrqeayslirsALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17919 112 ---------RDKA-----------------------SLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
|
250 260
....*....|....*....|
gi 17538806 495 LQNNLLEYFCMIDFVRPKYL 514
Cdd:cd17919 160 LQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
256-562 |
2.00e-38 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 144.06 E-value: 2.00e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNtieslgeYKksDGFGCILAHSMGLGKTIQVITF-------------SEIFLRATKAKK------- 315
Cdd:cd18005 1 LRDYQREGVEFMYDL-------YK--NGRGGILGDDMGLGKTVQVIAFlaavlgktgtrrdRENNRPRFKKKPpassakk 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 316 -VLVIVPINTIQNWYSEYDKWipkfsdtgdriRSFEVFLLGDGVKTFDQRVNLieqwdQTGG--VMLVGYDMFRLLIkmt 392
Cdd:cd18005 72 pVLIVAPLSVLYNWKDELDTW-----------GHFEVGVYHGSRKDDELEGRL-----KAGRleVVVTTYDTLRRCI--- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 393 lpkkqkkgrPKLNlsgissgfskdssedqklrdeELEFetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNIT 472
Cdd:cd18005 133 ---------DSLN---------------------SINW---------------------------SAVIADEAHRIKNPK 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 473 AEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLV 552
Cdd:cd18005 156 SKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELA 235
|
330
....*....|
gi 17538806 553 ELVKGFVQRR 562
Cdd:cd18005 236 VKLSKFFLRR 245
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
256-562 |
1.31e-34 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 132.66 E-value: 1.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYdntiESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATK------AKKVLVIVPINTIQNWY 329
Cdd:cd18066 1 LRPHQREGIEFLY----ECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvIKRALIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 330 SEYDKWIPKfsdtgDRIRSFEVfllgDGVKTFDQRVNLIeqwdqTGGVMLVGYDMfrlLIKmtlpkkqkkgrpklNLSGI 409
Cdd:cd18066 77 KEFQKWLGS-----ERIKVFTV----DQDHKVEEFIASP-----LYSVLIISYEM---LLR--------------SLDQI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 410 SSgfskdssedqklrdeeLEFetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIV 489
Cdd:cd18066 126 SK----------------LNF---------------------------DLVICDEGHRLKNTSIKTTTALTSLSCERRII 162
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806 490 LTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18066 163 LTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
256-563 |
8.19e-32 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 124.22 E-value: 8.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYdntieSLGEYkksdGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18012 5 LRPYQKEGFNWLS-----FLRHY----GLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 336 IPKFSdtgdrirsfevFLLGDGVKTFDQRVNLIEQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfsk 415
Cdd:cd18012 76 APELK-----------VLVIHGTKRKREKLRALEDYD----LVITSYGLLR----------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 416 dssedqklRDEELEFETGFtsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPL 495
Cdd:cd18012 112 --------RDIELLKEVKF-----------------------HYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806 496 QNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdssPDDVKIALQRthvlveLVKGFVQRRT 563
Cdd:cd18012 161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDG-----DEEALEELKK------LISPFILRRL 217
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
256-958 |
6.42e-30 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 129.15 E-value: 6.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITF----SEifLRATKAKKvLVIVPINTIQNW 328
Cdd:PLN03142 170 MRDYQLAGLNWLirlYENGING------------ILADEMGLGKTLQTISLlgylHE--YRGITGPH-MVVAPKSTLGNW 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 329 YSEYDKWIPKfsdtgdrIRSFEvfllgdgvktfdqrvnlieqwdqtggvmlvgydmfrllikmtlpkkqkkgrpklnlsg 408
Cdd:PLN03142 235 MNEIRRFCPV-------LRAVK---------------------------------------------------------- 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 409 issgFSKDSSEDQKLRDEEL---EFETGFTSGGRVRQEaysliRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTK 485
Cdd:PLN03142 250 ----FHGNPEERAHQREELLvagKFDVCVTSFEMAIKE-----KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTN 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 486 RRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRTHvlvELVKGFVQRRTHH 565
Cdd:PLN03142 321 YRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQ---------QEVVQQLH---KVLRPFLLRRLKS 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 566 LLKKILPESKEYVLLLRKSQIQRQLYRnfVLWAKNEIAANNDA----VFNPLMAFSACSkiwNHPdILYRlveqkkraee 641
Cdd:PLN03142 389 DVEKGLPPKKETILKVGMSQMQKQYYK--ALLQKDLDVVNAGGerkrLLNIAMQLRKCC---NHP-YLFQ---------- 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 642 dkkrveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfGAQFHPqqngmmmqngswhpnnyqmpsPFNSipsnpstpts 721
Cdd:PLN03142 453 ---------------------------------------GAEPGP---------------------PYTT---------- 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 722 sstsksakktkkprgskkapksdeedeevekesrmkydwtfelfekyQEGVLENGYKIVISLEILDESTQIGEKILIFSQ 801
Cdd:PLN03142 463 -----------------------------------------------GEHLVENSGKMVLLDKLLPKLKERDSRVLIFSQ 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 802 NLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNsEPGLS--LFLISTRAGSLGINLVSAN 879
Cdd:PLN03142 496 MTRLLDILEDYLMYRGYQ--------------YCRIDGNTGGEDRDASIDAFN-KPGSEkfVFLLSTRAGGLGINLATAD 560
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17538806 880 RCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFNRQISKHGLQQRVVDDAQVDANISQKELETLLM 958
Cdd:PLN03142 561 IVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQM 639
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
256-514 |
3.78e-24 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 101.25 E-value: 3.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDntieslgeyKKSDGFGCILAHSMGLGKTIQVITF------SEIFLRatkakKVLVIVPINTIQNWY 329
Cdd:cd18000 1 LFKYQQTGVQWLWE---------LHCQRVGGILGDEMGLGKTIQIIAFlaalhhSKLGLG-----PSLIVCPATVLKQWV 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 330 SEYDKWIPKFsdtgdRI----RSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIKMTLPKKQkkgrpkln 405
Cdd:cd18000 67 KEFHRWWPPF-----RVvvlhSSGSGTGSEEKLGSIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNW-------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 406 lsgissgfskdssedqklrdeelefetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTK 485
Cdd:cd18000 134 ----------------------------------------------------QYVILDEGHKIRNPDAEITLACKQLRTP 161
|
250 260
....*....|....*....|....*....
gi 17538806 486 RRIVLTGYPLQNNLLEYFCMIDFVRPKYL 514
Cdd:cd18000 162 HRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
256-530 |
9.70e-22 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 95.51 E-value: 9.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSeIFLRATKAKK--VLVIVPINTIQNWYS 330
Cdd:cd17996 4 LKEYQLKGLQWMvslYNNNLNG------------ILADEMGLGKTIQTISLI-TYLMEKKKNNgpYLVIVPLSTLSNWVS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 331 EYDKWIPKFSdtgdrirsfEVFLLGdgvkTFDQRVNLIEQWDQTG-GVMLVGYDMfrlLIKmtlpkkqkkGRPKLnlsgi 409
Cdd:cd17996 71 EFEKWAPSVS---------KIVYKG----TPDVRKKLQSQIRAGKfNVLLTTYEY---IIK---------DKPLL----- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 410 ssgfskdssedqklrdeelefetgftsgGRVRQeAYSLIrsallepgpdlvvcDEGHKIKNITAEISMTLG-AINTKRRI 488
Cdd:cd17996 121 ----------------------------SKIKW-KYMII--------------DEGHRMKNAQSKLTQTLNtYYHARYRL 157
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 17538806 489 VLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKN 530
Cdd:cd17996 158 LLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFAN 199
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
256-524 |
4.17e-21 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 93.47 E-value: 4.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNtieslgeYKKsdGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17995 1 LRDYQLEGVNWLLFN-------WYN--RRNCILADEMGLGKTIQSIAFlEHLYQVEGIRGPFLVIAPLSTIPNWQREFET 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPkfsdtgdrirsfevfllgdgvktfdqrVNLIEQWDQTGGvmlvgyDMFRLLIKMTLPKKQKKGRPklnlsgissgfs 414
Cdd:cd17995 72 WTD---------------------------MNVVVYHGSGES------RQIIQQYEMYFKDAQGRKKK------------ 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqklrdEELEFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17995 107 -----------GVYKFDVLITTYEMVIADAEELRKIPW-----RVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTP 170
|
250 260 270
....*....|....*....|....*....|
gi 17538806 495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd17995 171 LQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
256-562 |
8.17e-20 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 89.72 E-value: 8.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMydntiESLGEYKKSDgfgcILAHSMGLGKTIQ--VITFSEIFLRATKAK----KVLVIVPINTIQNWY 329
Cdd:cd17999 1 LRPYQQEGINWL-----AFLNKYNLHG----ILCDDMGLGKTLQtlCILASDHHKRANSFNsenlPSLVVCPPTLVGHWV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 330 SEYDKWIPKFSDTgdrirsfevFLLGDGVktFDQRVNLIEQWDQtGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgi 409
Cdd:cd17999 72 AEIKKYFPNAFLK---------PLAYVGP--PQERRRLREQGEK-HNVIVASYDVLR----------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 410 ssgfskdssedqklRDEELEFETGFTsggrvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIV 489
Cdd:cd17999 117 --------------NDIEVLTKIEWN-----------------------YCVLDEGHIIKNSKTKLSKAVKQLKANHRLI 159
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806 490 LTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd17999 160 LSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
778-904 |
1.02e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 85.73 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 778 KIVISLEILDESTqiGEKILIFSQNLTALDmlEEILKKRqirgkdgpgqrweKNRNYLRLDGTTSGADREKLINRFNSep 857
Cdd:pfam00271 2 KLEALLELLKKER--GGKVLIFSQTKKTLE--AELLLEK-------------EGIKVARLHGDLSQEEREEILEDFRK-- 62
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 17538806 858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYG 904
Cdd:pfam00271 63 GKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
256-512 |
2.18e-19 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 87.44 E-value: 2.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRF---MYDNTIEslgeykksdgfgCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd17998 1 LKDYQLIGLNWlnlLYQKKLS------------GILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 333 DKWIPKF--------SDTGDRIRSFEVfllgDGVKTFDqrvnlieqwdqtggVMLVGYDMfrllikmtlpkkqkkgrpkl 404
Cdd:cd17998 69 KRWCPSLkvepyygsQEERKHLRYDIL----KGLEDFD--------------VIVTTYNL-------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 405 nlsgissgfSKDSSEDQK-LRDEELefetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAIN 483
Cdd:cd17998 111 ---------ATSNPDDRSfFKRLKL-----------------------------NYVVYDEGHMLKNMTSERYRHLMTIN 152
|
250 260
....*....|....*....|....*....
gi 17538806 484 TKRRIVLTGYPLQNNLLEYFCMIDFVRPK 512
Cdd:cd17998 153 ANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
287-563 |
1.51e-18 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 85.84 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 287 ILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfEVFLLGD--GVKTFD 362
Cdd:cd17997 26 ILADEMGLGKTLQTISLLG-YLKHYKniNGPHLIIVPKSTLDNWMREFKRWCPSLR---------VVVLIGDkeERADII 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 363 QRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSGIssgfskdssedqklrdeelefetgftsggrvrq 442
Cdd:cd17997 96 RDVLLPGKFD----VCITSYEMV---------IKEKTVLKKFNWRYI--------------------------------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 443 eayslirsallepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd17997 130 ------------------IIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDE 191
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 17538806 523 RFEkpikngqcVDSSPDDVKIALQRTHvlvELVKGFVQRRT 563
Cdd:cd17997 192 WFN--------VNNCDDDNQEVVQRLH---KVLRPFLLRRI 221
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
255-562 |
3.11e-18 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 85.52 E-value: 3.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 255 VLQPHQLGGIRFM---YDNtieslgeykksdGFGCILAHSMGLGKTIQVITFSEiFLRATKAK-KVLVIVPINTIQNWYS 330
Cdd:cd18009 3 VMRPYQLEGMEWLrmlWEN------------GINGILADEMGLGKTIQTIALLA-HLRERGVWgPFLVIAPLSTLPNWVN 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 331 EYDKWIPkfsdtgdrirSFEVfLLGDGVKtfDQRVNLIEQwdqtggvmlvgydmfrllikmtlpKKQKKGRPKLNLSGIS 410
Cdd:cd18009 70 EFARFTP----------SVPV-LLYHGTK--EERERLRKK------------------------IMKREGTLQDFPVVVT 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 411 SgfskdssedqklrdeeleFETGFTSGGRVRQEAYSLIrsallepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18009 113 S------------------YEIAMRDRKALQHYAWKYL------------IVDEGHRLKNLNCRLIQELKTFNSDNRLLL 162
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538806 491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18009 163 TGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
807-904 |
1.89e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 78.02 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 807 DMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSepGLSLFLISTRAGSLGINLVSANRCIIIDA 886
Cdd:smart00490 1 EELAELLKELGIK--------------VARLHGGLSQEEREEILDKFNN--GKIKVLVATDVAERGLDLPGVDLVIIYDL 64
|
90
....*....|....*...
gi 17538806 887 CWNPCHDAQAVCRVYRYG 904
Cdd:smart00490 65 PWSPASYIQRIGRAGRAG 82
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
287-562 |
7.47e-16 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 78.16 E-value: 7.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 287 ILAHSMGLGKTIQVITFseiFLRATKAKKV----LVIVPINTIQNWYSEYDKWIPKFsdtgdrirsfevfllgdgvktfd 362
Cdd:cd18003 23 ILADEMGLGKTIQTIAL---LAHLACEKGNwgphLIVVPTSVMLNWEMEFKRWCPGF----------------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 363 qrvnlieqwdqtggvmlvgydmfRLLIKMTLPKKQKKGRpklnlsgisSGFSKDSSedqklrdeeleFETGFTSGGRVRQ 442
Cdd:cd18003 77 -----------------------KILTYYGSAKERKLKR---------QGWMKPNS-----------FHVCITSYQLVVQ 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 443 EAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd18003 114 DHQVFKRKKW-----KYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKE 188
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 17538806 523 RFEKPIKngQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18003 189 WFSNPLT--AMSEGSQEENEELVRRLH---KVLRPFLLRR 223
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
256-524 |
1.18e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 77.39 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTieslgeYKKSDgfgCILAHSMGLGKTIQVITF-SEIFLRATKAkKVLVIVPINTIQNWYSEYDK 334
Cdd:cd18058 1 LREYQLEGMNWLLFNW------YNRKN---CILADEMGLGKTIQSITFlSEIFLMGIRG-PFLIIAPLSTITNWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIpkfsdtgdrirsfevfllgdgvktfdQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkKQKKGRPklnLSGISsgfs 414
Cdd:cd18058 71 WT--------------------------EMNAIVYHGSQISRQMIQQYEMYY---------RDEQGNP---LSGIF---- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqKLRDEELEFETGFTSGGRVRQEAYSlirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18058 109 -------KFQVVITTFEMILADCPELKKINWS------------CVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTP 169
|
250 260 270
....*....|....*....|....*....|
gi 17538806 495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd18058 170 LQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
256-562 |
2.07e-14 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 74.25 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDntieslgeykksdgFGCILAHSMGLGKTIQVI------------TFSEIFLRATKAKKV------L 317
Cdd:cd18008 1 LLPYQKQGLAWMLP--------------RGGILADEMGLGKTIQALalilatrpqdpkIPEELEENSSDPKKLylskttL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 318 VIVPINTIQNWYSEydkwIPKFSDTGdrirSFEVFLL-GDGVKTfdqRVNLIEQWDqtggVMLVGYDMFRllikMTLPKK 396
Cdd:cd18008 67 IVVPLSLLSQWKDE----IEKHTKPG----SLKVYVYhGSKRIK---SIEELSDYD----IVITTYGTLA----SEFPKN 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 397 QKKGRPKLNLSGISSGFSkdssedqklrdeeLEFEtgftsggrvrqeaysliRsallepgpdlVVCDEGHKIKNITAEIS 476
Cdd:cd18008 128 KKGGGRDSKEKEASPLHR-------------IRWY-----------------R----------VILDEAHNIKNRSTKTS 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 477 MTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRthvLVELVK 556
Cdd:cd18008 168 RAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKND---------RKALER---LQALLK 235
|
....*.
gi 17538806 557 GFVQRR 562
Cdd:cd18008 236 PILLRR 241
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
256-532 |
1.20e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 72.02 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18057 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKgPYLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKF---SDTGDR-----IRSFEVFLLGDGVKTfdqrvnlieqwdqtggvmlvGYDMFRLlikmtlpkkqkkgrpklnl 406
Cdd:cd18057 72 WAPDFyvvTYTGDKesrsvIRENEFSFEDNAIRS--------------------GKKVFRM------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 407 sgissgfskdssedqkLRDEELEFETGFTSggrvrQEAYSLIRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKR 486
Cdd:cd18057 113 ----------------KKEAQIKFHVLLTS-----YELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDY 171
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 17538806 487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18057 172 KLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQ 217
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
254-532 |
3.89e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 70.43 E-value: 3.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 254 HVLQPHQLGGIRFMYdntieslgeykkSDGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18055 2 HMYQLEGLNWLRFSW------------AQGTDTILADEMGLGKTIQTIVFlYSLYKEGHTKGPFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 333 DKWIPKF---SDTGDR-----IRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpkl 404
Cdd:cd18055 70 QMWAPDFyvvTYTGDKdsraiIRENEFSFDDNAVKGGKKAFKMKREAQVKFHVLLTSYELVT------------------ 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 405 nlsgissgfskdssedqklrdeelefetgftsggrVRQEAYSLIRSALLepgpdlvVCDEGHKIKNITAEISMTLGAINT 484
Cdd:cd18055 132 -----------------------------------IDQAALGSIRWACL-------VVDEAHRLKNNQSKFFRVLNGYKI 169
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 17538806 485 KRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18055 170 DHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQ 217
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
256-532 |
5.38e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 69.01 E-value: 5.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd17994 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKFsdtgdrirsFEVFLLGDgvktfdqrvnlieqwdqtgGVMLVGYDmfrlLIKMTlpkkqkkgrpklnlsgissgfs 414
Cdd:cd17994 72 WAPDF---------YVVTYVGD-------------------HVLLTSYE----LISID---------------------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqklrdeelefetgftsggrvrQEAYSLIRSALLepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17994 98 ---------------------------QAILGSIDWAVL-------VVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
250 260 270
....*....|....*....|....*....|....*...
gi 17538806 495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQ 181
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
256-522 |
2.19e-12 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 67.77 E-value: 2.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYdntieslgeYKKSDGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17993 2 LRDYQLTGLNWLA---------HSWCKGNNGILADEMGLGKTVQTISFlSYLFHSQQQYGPFLVVVPLSTMPAWQREFAK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKFS------DTGDR--IRSFEVFLLGdgvktfDQRVNLieqwdqtgGVMLVGYDMFrllikmtLPKKQKkgrpklnL 406
Cdd:cd17993 73 WAPDMNvivylgDIKSRdtIREYEFYFSQ------TKKLKF--------NVLLTTYEII-------LKDKAF-------L 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 407 SGISSGFskdssedqklrdeelefetgftsggrvrqeayslirsallepgpdLVVcDEGHKIKNITAEISMTLGAINTKR 486
Cdd:cd17993 125 GSIKWQY---------------------------------------------LAV-DEAHRLKNDESLLYEALKEFKTNN 158
|
250 260 270
....*....|....*....|....*....|....*.
gi 17538806 487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd17993 159 RLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEE 194
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
282-575 |
3.26e-12 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 67.77 E-value: 3.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 282 DGFGCILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKfsdtgdrIRSfeVFLLGDGVK 359
Cdd:cd18064 33 NGINGILADEMGLGKTLQTISLLG-YMKHYRniPGPHMVLVPKSTLHNWMAEFKRWVPT-------LRA--VCLIGDKDQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 360 --TFDQRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSgissgfskdssedqklrdeelefetgftsg 437
Cdd:cd18064 103 raAFVRDVLLPGEWD----VCVTSYEML---------IKEKSVFKKFNWR------------------------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 438 grvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTr 517
Cdd:cd18064 140 ---------------------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNS- 197
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806 518 ksfIDRFEKPIKNGQCVdsspDDVKIaLQRTHVlveLVKGFVQRRTHHLLKKILPESK 575
Cdd:cd18064 198 ---AEDFDSWFDTNNCL----GDQKL-VERLHM---VLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
256-524 |
3.75e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 67.39 E-value: 3.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTieslgeYKKSDgfgCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18060 1 LREYQLEGVNWLLFNW------YNRQN---CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 336 IpkfsdtgdrirsfevfllgdgvktfdQRVNLIEQWDQTGGVMLVGYDMFrllikmtlpKKQKKGR---PKLNLSGISSG 412
Cdd:cd18060 72 T--------------------------EMNTIVYHGSLASRQMIQQYEMY---------CKDSRGRlipGAYKFDALITT 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 413 FSKDSSEDQKLRdeELEFETgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18060 117 FEMILSDCPELR--EIEWRC---------------------------VIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTG 167
|
250 260 270
....*....|....*....|....*....|..
gi 17538806 493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd18060 168 TPLQNTVEELFSLLHFLEPSQFPSESEFLKDF 199
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
256-562 |
3.77e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 67.78 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSE 331
Cdd:cd18063 24 LKHYQLQGLEWMvslYNNNLNG------------ILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLSTLSNWTYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 332 YDKWIPKfsdtgdrirsfevfllgdgvktfdqrvnlieqwdqtggVMLVGYdmfrllikmtlpkkqkKGRPKLNLSGISs 411
Cdd:cd18063 92 FDKWAPS--------------------------------------VVKISY----------------KGTPAMRRSLVP- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 412 gfskdssedqKLRDEEleFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGA-INTKRRIVL 490
Cdd:cd18063 117 ----------QLRSGK--FNVLLTTYEYIIKDKHILAKIRW-----KYMIVDEGHRMKNHHCKLTQVLNThYVAPRRILL 179
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806 491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIK-NGQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18063 180 TGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmTGERVDLNEEETILIIRRLH---KVLRPFLLRR 249
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
257-531 |
1.32e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 65.80 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 257 QPHQLGGIRF-MYDNTIESLGEYKKS--DGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18054 10 QPSYIGGENLeLRDYQLEGLNWLAHSwcKNNSVILADEMGLGKTIQTISFlSYLFHQHQLYGPFLLVVPLSTLTSWQREF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 333 DKWIPKFSdtgdrirsfEVFLLGDGVKTfdqrvNLIEQWDQTggvmlvgydmfrllikmtlpkKQKKGRPKLNlsgissg 412
Cdd:cd18054 90 EIWAPEIN---------VVVYIGDLMSR-----NTIREYEWI---------------------HSQTKRLKFN------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 413 fSKDSSEDQKLRDEELefetgftsggrvrqeaYSLIRSALLEpgpdlvvCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18054 128 -ALITTYEILLKDKTV----------------LGSINWAFLG-------VDEAHRLKNDDSLLYKTLIDFKSNHRLLITG 183
|
250 260 270
....*....|....*....|....*....|....*....
gi 17538806 493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNG 531
Cdd:cd18054 184 TPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENG 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
256-532 |
1.49e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 65.86 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18056 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKFsdtgdrirsFEVFLLGDgvktfdqrvnlieqwdqtggvmlvgydmfrllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18056 72 WAPDM---------YVVTYVGD---------------------------------------------------------- 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 KDSSedQKLRDEELEFETGFTSGG----RVRQEA----------YSLIRSALLEPGP---DLVVCDEGHKIKNITAEISM 477
Cdd:cd18056 85 KDSR--AIIRENEFSFEDNAIRGGkkasRMKKEAsvkfhvlltsYELITIDMAILGSidwACLIVDEAHRLKNNQSKFFR 162
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 17538806 478 TLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18056 163 VLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQ 217
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
286-524 |
7.38e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 63.51 E-value: 7.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 286 CILAHSMGLGKTIQVITF-SEIFLRATKAkKVLVIVPINTIQNWYSEYDKWIpkfsdtgdrirSFEVFLLgDGVKTFDQR 364
Cdd:cd18059 22 CILADEMGLGKTIQSITFlYEIYLKGIHG-PFLVIAPLSTIPNWEREFRTWT-----------ELNVVVY-HGSQASRRT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 365 VNLIEQW-DQTGGVMLVGYDMFRLLIKMtlpkkqkkgrpklnlsgissgfskdssedqklrdeeleFETGFTSGGRVRQE 443
Cdd:cd18059 89 IQLYEMYfKDPQGRVIKGSYKFHAIITT--------------------------------------FEMILTDCPELRNI 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 444 AYSlirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDR 523
Cdd:cd18059 131 PWR------------CVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQE 198
|
.
gi 17538806 524 F 524
Cdd:cd18059 199 F 199
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
256-536 |
1.24e-10 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 62.46 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMydntIESLGEykksdGFGCILAHSMGLGKTIQVITFSeIFLRATKAKK--VLVIVPINTIQNWYSEYD 333
Cdd:cd18006 1 LRPYQLEGVNWL----LQCRAE-----QHGCILGDEMGLGKTCQTISLL-WYLAGRLKLLgpFLVLCPLSVLDNWKEELN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 334 KWIPKFSdtgdrirsfEVFLLGDGVKTFDQRVNLIE--QWDqtggVMLVGYDmfrllikmtlpkkqkkgrpklnlsgiss 411
Cdd:cd18006 71 RFAPDLS---------VITYMGDKEKRLDLQQDIKStnRFH----VLLTTYE---------------------------- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 412 gfskdssedqklrdeelefetgftsggrvrqeaYSLIRSALLEPGP-DLVVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18006 110 ---------------------------------ICLKDASFLKSFPwASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 17538806 491 TGYPLQNNLLEYFCMIDFVRPKYLGTRK--SFIDRFEKPIKNGQCVDS 536
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFPKDKldDFIKAYSETDDESETVEE 204
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
286-524 |
3.44e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 61.56 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 286 CILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWipkfsdtgdrirsfevfllgdgvktfdQRV 365
Cdd:cd18061 22 CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW---------------------------TDL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 366 NLI-EQWDQTGGVMLVGYDMFrllikmtlpkkqkkgrpklnlsgissgfskdssedqkLRDEElefetGFTSGGRVRQEA 444
Cdd:cd18061 75 NVVvYHGSLISRQMIQQYEMY-------------------------------------FRDSQ-----GRIIRGAYRFQA 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 445 YSLIRSALLEPGPDL-------VVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTR 517
Cdd:cd18061 113 IITTFEMILGGCPELnaidwrcVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSE 192
|
....*..
gi 17538806 518 KSFIDRF 524
Cdd:cd18061 193 STFMQEF 199
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
255-562 |
3.71e-10 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 61.98 E-value: 3.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 255 VLQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYS 330
Cdd:cd18062 23 VLKQYQIKGLEWLvslYNNNLNG------------ILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 331 EYDKWIPKfsdtgdrirsfevfllgdgvktfdqrvnlieqwdqtggVMLVGYdmfrllikmtlpkkqkKGRP---KLNLS 407
Cdd:cd18062 91 EFDKWAPS--------------------------------------VVKVSY----------------KGSPaarRAFVP 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 408 GISSGfskdssedqklrdeelEFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGA-INTKR 486
Cdd:cd18062 117 QLRSG----------------KFNVLLTTYEYIIKDKQILAKIRW-----KYMIVDEGHRMKNHHCKLTQVLNThYVAPR 175
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17538806 487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIK-NGQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18062 176 RLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmTGEKVDLNEEETILIIRRLH---KVLRPFLLRR 249
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
256-547 |
1.34e-09 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 59.22 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNTIeslgeykksdgFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSE-YDK 334
Cdd:cd18011 1 PLPHQIDAVLRALRKPP-----------VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDElQDK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 -WIPKFSDTGDRIrsfevfllgdgvktfDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgf 413
Cdd:cd18011 70 fGLPFLILDRETA---------------AQLRRLIGNPFEEFPIVIVSLDLLK--------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 414 skdssedqklRDEELefetgftsggrvrqeaysliRSALLEPGPDLVVCDEGHKIKNITAEIS---MTLG---AINTKRR 487
Cdd:cd18011 108 ----------RSEER--------------------RGLLLSEEWDLVVVDEAHKLRNSGGGKEtkrYKLGrllAKRARHV 157
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 488 IVLTGYPLQNNLLEYFCMIDFVRPkylgtrksfiDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18011 158 LLLTATPHNGKEEDFRALLSLLDP----------GRFAVLGRFLRLDGLREVLAKVLLRR 207
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
256-562 |
4.33e-09 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 58.63 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFM-------------------YDNTIESLGEYKKSD-GFGCILAHSMGLGKTIQVITFseiflraTKAKK 315
Cdd:cd18071 1 LLPHQKQALAWMvsrensqdlppfweeavglFLNTITNFSQKKRPElVRGGILADDMGLGKTLTTISL-------ILANF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 316 VLVIVPINTIQNWYSEYdkwipkfsdtGDRIRS--FEVFLLGDGVKTFDqrVNLIEQWDqtggVMLVGYDMfrllikmtl 393
Cdd:cd18071 74 TLIVCPLSVLSNWETQF----------EEHVKPgqLKVYTYHGGERNRD--PKLLSKYD----IVLTTYNT--------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 394 pkkqkkgrpklnlsgISSGFS-KDSSEDQKLRdeelefetgftsGGRVrqeayslirsallepgpdlvVCDEGHKIKNIT 472
Cdd:cd18071 129 ---------------LASDFGaKGDSPLHTIN------------WLRV--------------------VLDEGHQIRNPN 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 473 AEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRTHVlv 552
Cdd:cd18071 162 AQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGD---------PTGLKRLQV-- 230
|
330
....*....|
gi 17538806 553 eLVKGFVQRR 562
Cdd:cd18071 231 -LMKQITLRR 239
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
282-525 |
7.30e-09 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 57.72 E-value: 7.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 282 DGFGCILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfEVFLLGD--G 357
Cdd:cd18065 33 NGVNGILADEMGLGKTLQTIALLG-YLKHYRniPGPHMVLVPKSTLHNWMNEFKRWVPSLR---------AVCLIGDkdA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 358 VKTFDQRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSgissgfskdssedqklrdeelefetgftsg 437
Cdd:cd18065 103 RAAFIRDVMMPGEWD----VCVTSYEMV---------IKEKSVFKKFNWR------------------------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 438 grvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTR 517
Cdd:cd18065 140 ---------------------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA 198
|
....*...
gi 17538806 518 KSFIDRFE 525
Cdd:cd18065 199 DDFDSWFD 206
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
256-523 |
7.92e-09 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 57.21 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFmydnTIESLGEykksdgfgCILAHSMGLGKTIQVITfseiFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18010 1 LLPFQREGVCF----ALRRGGR--------VLIADEMGLGKTVQAIA----IAAYYREEwPLLIVCPSSLRLTWADEIER 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPkfSDTGDRIRSfeVFLLGDGVKTFDQRVNlieqwdqtggvmLVGYDMFRLLikmtlpKKQKKGRPklnlsgissgfs 414
Cdd:cd18010 65 WLP--SLPPDDIQV--IVKSKDGLRDGDAKVV------------IVSYDLLRRL------EKQLLARK------------ 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdssedqklrdeeleFETgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAI--NTKRRIVLTG 492
Cdd:cd18010 111 ---------------FKV---------------------------VICDESHYLKNSKAKRTKAALPLlkRAKRVILLSG 148
|
250 260 270
....*....|....*....|....*....|.
gi 17538806 493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDR 523
Cdd:cd18010 149 TPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
256-512 |
1.69e-08 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 55.96 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNtieslgeykksdGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVP-INTIQNWYSEYDK 334
Cdd:smart00487 9 LRPYQKEAIEALLSG------------LRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 335 WIPKFsdtgdrirSFEVFLLGDGVKTFDQRVNLIEqwdqtggvmlvgyDMFRLLIkMTlpkkqkkgrpklnlsgissgfs 414
Cdd:smart00487 77 LGPSL--------GLKVVGLYGGDSKREQLRKLES-------------GKTDILV-TT---------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 415 kdsseDQKLRDEelefetgftsggrvrqeaysLIRSALLEPGPDLVVCDEGHKIKNIT-AEISMTLG--AINTKRRIVLT 491
Cdd:smart00487 113 -----PGRLLDL--------------------LENDKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLklLPKNVQLLLLS 167
|
250 260
....*....|....*....|....
gi 17538806 492 GYP---LQNNLLEYFCMIDFVRPK 512
Cdd:smart00487 168 ATPpeeIENLLELFLNDPVFIDVG 191
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
283-562 |
1.69e-08 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 56.74 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 283 GFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFS------DTGDR--IRSFevfl 353
Cdd:cd18002 19 GINGILADEMGLGKTVQSIAVlAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKvlpywgNPKDRkvLRKF---- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 354 lgdgvktfdqrvnlieqWDQtggvmlvgydmfrllikmtlpkkqkkgrpklnlsgissgfskdssedQKLRDEELEFETG 433
Cdd:cd18002 95 -----------------WDR-----------------------------------------------KNLYTRDAPFHVV 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 434 FTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKY 513
Cdd:cd18002 111 ITSYQLVVQDEKYFQRVKW-----QYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTL 185
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 17538806 514 LGTRKSFIDRFEKPIKNGQCVDSSPDDVKiaLQRTHVlveLVKGFVQRR 562
Cdd:cd18002 186 FDSHDEFNEWFSKDIESHAENKTGLNEHQ--LKRLHM---ILKPFMLRR 229
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
257-520 |
3.95e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 55.83 E-value: 3.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 257 QPHQLGGIRFM--YDNTIESLGEYKKS--DGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSE 331
Cdd:cd18053 9 QPSYIGGHEGLelRDYQLNGLNWLAHSwcKGNSCILADEMGLGKTIQTISFlNYLFHEHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 332 YDKWIPKFSdtgdrirsfEVFLLGDgvktFDQRvNLI--EQW--DQTGgvmlvgydmfRLLIKMTLPKKQKKGRPKLNLS 407
Cdd:cd18053 89 IQTWAPQMN---------AVVYLGD----INSR-NMIrtHEWmhPQTK----------RLKFNILLTTYEILLKDKSFLG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 408 GISSGFskdssedqklrdeelefetgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAINTKRR 487
Cdd:cd18053 145 GLNWAF----------------------------------------------IGVDEAHRLKNDDSLLYKTLIDFKSNHR 178
|
250 260 270
....*....|....*....|....*....|...
gi 17538806 488 IVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSF 520
Cdd:cd18053 179 LLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF 211
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
460-510 |
4.91e-06 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 49.40 E-value: 4.91e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 17538806 460 VVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVR 510
Cdd:cd18072 155 IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
256-335 |
3.75e-05 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 46.19 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806 256 LQPHQLGGIRFMYDNtieslgEYkksdgfGCILAhSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQN-WYSEYDK 334
Cdd:cd18013 1 PHPYQKVAINFIIEH------PY------CGLFL-DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEK 67
|
.
gi 17538806 335 W 335
Cdd:cd18013 68 W 68
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
840-912 |
2.55e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.77 E-value: 2.55e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806 840 TTSGADREKLINRFNsepglslFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVY 912
Cdd:cd18785 10 TNSIEHAEEIASSLE-------ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
283-335 |
5.63e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 38.54 E-value: 5.63e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 17538806 283 GFGCILAHSMGLGKTIQVitFSEIFLRA-TKAKKVLVIVPINTIQN-WYSEYDKW 335
Cdd:cd00046 1 GENVLITAPTGSGKTLAA--LLAALLLLlKKGKKVLVLVPTKALALqTAERLREL 53
|
|
|