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Conserved domains on  [gi|17538806|ref|NP_501545|]
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Helicase ARIP4 [Caenorhabditis elegans]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 12785142)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as human DNA excision repair protein ERCC-6-like and DNA repair and recombination protein RAD54-like

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
256-547 6.01e-135

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 411.13  E-value: 6.01e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18069    1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IPKFSDTG-DRIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18069   81 LPPPEALPnVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFR---------------------------- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdeelefetgftsggrvrqeayslirsalLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18069  133 --------------------------------------LRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18069  175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
60-940 1.04e-69

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 248.22  E-value: 1.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   60 AEDLDENVLEAQRLEKQRLERLEKIKPENDHIQQMESLFLAGASEGQLPQLDLQDDDFEEMFGFSVENDNKKYRYGDEEK 139
Cdd:COG0553   35 LARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLLALALLLLALL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  140 PEPMFHLQEPSTSRGHVDVVDLTLDDSDDDCLITDVKSVMPQVVPGRRMRWAQAEKDRIDADQMDIQHNIEARRLKKMRS 219
Cdd:COG0553  115 GLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELAL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  220 AKDLESTEKKEGRLLVNAGHPEEDPDIFVISHLTHVLQ-----------PHQLGGIRFMYdntieSLGEYkksdGFGCIL 288
Cdd:COG0553  195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALEslpaglkatlrPYQLEGAAWLL-----FLRRL----GLGGLL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  289 AHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfevFLLGDGVKTFDQRVNLI 368
Cdd:COG0553  266 ADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLR-----------VLVLDGTRERAKGANPF 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  369 EQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfskdssedqklRDEELefetgftsggrvrqeaysli 448
Cdd:COG0553  335 EDAD----LVITSYGLLR-------------------------------------RDIEL-------------------- 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  449 rsaLLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPI 528
Cdd:COG0553  354 ---LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  529 kngqcvdsspddVKIALQRTHVLVELVKGFVQRRTHHLLKKILPESKEYVLLLRKSQIQRQLYRNFVLWAKNEI--AANN 606
Cdd:COG0553  431 ------------EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELegAEGI 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  607 DAVFNPLMAFSACSKIWNHPDILYrlveqkkraeEDKKRveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfgaqfhp 686
Cdd:COG0553  499 RRRGLILAALTRLRQICSHPALLL----------EEGAE----------------------------------------- 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  687 qqngmmmqngswhpnnYQMPSPfnsipsnpstptssstsksakktkkprgskkapksdeedeevekesrmKYDWTFELFE 766
Cdd:COG0553  528 ----------------LSGRSA------------------------------------------------KLEALLELLE 543
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  767 kyqegvlengykivislEILDEstqiGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADR 846
Cdd:COG0553  544 -----------------ELLAE----GEKVLVFSQFTDTLDLLEERLEERGIE--------------YAYLHGGTSAEER 588
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  847 EKLINRFNSEPGLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFN 926
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668
                        890
                 ....*....|....
gi 17538806  927 RQISKHGLQQRVVD 940
Cdd:COG0553  669 LLEEKRALAESVLG 682
 
Name Accession Description Interval E-value
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
256-547 6.01e-135

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 411.13  E-value: 6.01e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18069    1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IPKFSDTG-DRIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18069   81 LPPPEALPnVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFR---------------------------- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdeelefetgftsggrvrqeayslirsalLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18069  133 --------------------------------------LRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18069  175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
60-940 1.04e-69

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 248.22  E-value: 1.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   60 AEDLDENVLEAQRLEKQRLERLEKIKPENDHIQQMESLFLAGASEGQLPQLDLQDDDFEEMFGFSVENDNKKYRYGDEEK 139
Cdd:COG0553   35 LARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLLALALLLLALL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  140 PEPMFHLQEPSTSRGHVDVVDLTLDDSDDDCLITDVKSVMPQVVPGRRMRWAQAEKDRIDADQMDIQHNIEARRLKKMRS 219
Cdd:COG0553  115 GLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELAL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  220 AKDLESTEKKEGRLLVNAGHPEEDPDIFVISHLTHVLQ-----------PHQLGGIRFMYdntieSLGEYkksdGFGCIL 288
Cdd:COG0553  195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALEslpaglkatlrPYQLEGAAWLL-----FLRRL----GLGGLL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  289 AHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfevFLLGDGVKTFDQRVNLI 368
Cdd:COG0553  266 ADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLR-----------VLVLDGTRERAKGANPF 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  369 EQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfskdssedqklRDEELefetgftsggrvrqeaysli 448
Cdd:COG0553  335 EDAD----LVITSYGLLR-------------------------------------RDIEL-------------------- 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  449 rsaLLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPI 528
Cdd:COG0553  354 ---LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  529 kngqcvdsspddVKIALQRTHVLVELVKGFVQRRTHHLLKKILPESKEYVLLLRKSQIQRQLYRNFVLWAKNEI--AANN 606
Cdd:COG0553  431 ------------EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELegAEGI 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  607 DAVFNPLMAFSACSKIWNHPDILYrlveqkkraeEDKKRveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfgaqfhp 686
Cdd:COG0553  499 RRRGLILAALTRLRQICSHPALLL----------EEGAE----------------------------------------- 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  687 qqngmmmqngswhpnnYQMPSPfnsipsnpstptssstsksakktkkprgskkapksdeedeevekesrmKYDWTFELFE 766
Cdd:COG0553  528 ----------------LSGRSA------------------------------------------------KLEALLELLE 543
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  767 kyqegvlengykivislEILDEstqiGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADR 846
Cdd:COG0553  544 -----------------ELLAE----GEKVLVFSQFTDTLDLLEERLEERGIE--------------YAYLHGGTSAEER 588
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  847 EKLINRFNSEPGLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFN 926
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668
                        890
                 ....*....|....
gi 17538806  927 RQISKHGLQQRVVD 940
Cdd:COG0553  669 LLEEKRALAESVLG 682
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
259-629 5.08e-49

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 5.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    259 HQLGGIRFMYDntieslgEYKKSdGFGCILAHSMGLGKTIQVITFseifLRATKA------KKVLVIVPINTIQNWYSEY 332
Cdd:pfam00176    1 YQIEGVNWMLS-------LENNL-GRGGILADEMGLGKTLQTISL----LLYLKHvdknwgGPTLIVVPLSLLHNWMNEF 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    333 DKWIPKfsdtgDRIRSFEvfLLGDGVKTFDQRVNLIEQWDQtgGVMLVGYDMfrllikmtLPKkqkkgrpklnlsgissg 412
Cdd:pfam00176   69 ERWVSP-----PALRVVV--LHGNKRPQERWKNDPNFLADF--DVVITTYET--------LRK----------------- 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    413 fskdssedqklrdeelefetgftsggrvrqeayslIRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:pfam00176  115 -----------------------------------HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTG 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSpddvkialqrtHVLVELVKGFVQRRTHHLLKKILP 572
Cdd:pfam00176  160 TPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGV-----------SRLHKLLKPFLLRRTKKDVEKSLP 228
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17538806    573 ESKEYVLLLRKSQIQRQLYRNFVLWAK-------NEIAANNDAVFNPLMAFsacSKIWNHPDIL 629
Cdd:pfam00176  229 PKVEYILFCRLSKLQRKLYQTFLLKKDlnaiktgEGGREIKASLLNILMRL---RKICNHPGLI 289
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
778-915 3.20e-46

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 162.26  E-value: 3.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  778 KIVISLEILDESTQIGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSEP 857
Cdd:cd18793   12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIK--------------YLRLDGSTSSKERQKLVDRFNEDP 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806  858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLI 915
Cdd:cd18793   78 DIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
256-958 6.42e-30

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 129.15  E-value: 6.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITF----SEifLRATKAKKvLVIVPINTIQNW 328
Cdd:PLN03142  170 MRDYQLAGLNWLirlYENGING------------ILADEMGLGKTLQTISLlgylHE--YRGITGPH-MVVAPKSTLGNW 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   329 YSEYDKWIPKfsdtgdrIRSFEvfllgdgvktfdqrvnlieqwdqtggvmlvgydmfrllikmtlpkkqkkgrpklnlsg 408
Cdd:PLN03142  235 MNEIRRFCPV-------LRAVK---------------------------------------------------------- 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   409 issgFSKDSSEDQKLRDEEL---EFETGFTSGGRVRQEaysliRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTK 485
Cdd:PLN03142  250 ----FHGNPEERAHQREELLvagKFDVCVTSFEMAIKE-----KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTN 320
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   486 RRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRTHvlvELVKGFVQRRTHH 565
Cdd:PLN03142  321 YRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQ---------QEVVQQLH---KVLRPFLLRRLKS 388
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   566 LLKKILPESKEYVLLLRKSQIQRQLYRnfVLWAKNEIAANNDA----VFNPLMAFSACSkiwNHPdILYRlveqkkraee 641
Cdd:PLN03142  389 DVEKGLPPKKETILKVGMSQMQKQYYK--ALLQKDLDVVNAGGerkrLLNIAMQLRKCC---NHP-YLFQ---------- 452
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   642 dkkrveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfGAQFHPqqngmmmqngswhpnnyqmpsPFNSipsnpstpts 721
Cdd:PLN03142  453 ---------------------------------------GAEPGP---------------------PYTT---------- 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   722 sstsksakktkkprgskkapksdeedeevekesrmkydwtfelfekyQEGVLENGYKIVISLEILDESTQIGEKILIFSQ 801
Cdd:PLN03142  463 -----------------------------------------------GEHLVENSGKMVLLDKLLPKLKERDSRVLIFSQ 495
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   802 NLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNsEPGLS--LFLISTRAGSLGINLVSAN 879
Cdd:PLN03142  496 MTRLLDILEDYLMYRGYQ--------------YCRIDGNTGGEDRDASIDAFN-KPGSEkfVFLLSTRAGGLGINLATAD 560
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17538806   880 RCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFNRQISKHGLQQRVVDDAQVDANISQKELETLLM 958
Cdd:PLN03142  561 IVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQM 639
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
778-904 1.02e-19

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 85.73  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    778 KIVISLEILDESTqiGEKILIFSQNLTALDmlEEILKKRqirgkdgpgqrweKNRNYLRLDGTTSGADREKLINRFNSep 857
Cdd:pfam00271    2 KLEALLELLKKER--GGKVLIFSQTKKTLE--AELLLEK-------------EGIKVARLHGDLSQEEREEILEDFRK-- 62
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 17538806    858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYG 904
Cdd:pfam00271   63 GKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
807-904 1.89e-17

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 78.02  E-value: 1.89e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     807 DMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSepGLSLFLISTRAGSLGINLVSANRCIIIDA 886
Cdd:smart00490    1 EELAELLKELGIK--------------VARLHGGLSQEEREEILDKFNN--GKIKVLVATDVAERGLDLPGVDLVIIYDL 64
                            90
                    ....*....|....*...
gi 17538806     887 CWNPCHDAQAVCRVYRYG 904
Cdd:smart00490   65 PWSPASYIQRIGRAGRAG 82
DEXDc smart00487
DEAD-like helicases superfamily;
256-512 1.69e-08

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 55.96  E-value: 1.69e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     256 LQPHQLGGIRFMYDNtieslgeykksdGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVP-INTIQNWYSEYDK 334
Cdd:smart00487    9 LRPYQKEAIEALLSG------------LRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKK 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     335 WIPKFsdtgdrirSFEVFLLGDGVKTFDQRVNLIEqwdqtggvmlvgyDMFRLLIkMTlpkkqkkgrpklnlsgissgfs 414
Cdd:smart00487   77 LGPSL--------GLKVVGLYGGDSKREQLRKLES-------------GKTDILV-TT---------------------- 112
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     415 kdsseDQKLRDEelefetgftsggrvrqeaysLIRSALLEPGPDLVVCDEGHKIKNIT-AEISMTLG--AINTKRRIVLT 491
Cdd:smart00487  113 -----PGRLLDL--------------------LENDKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLklLPKNVQLLLLS 167
                           250       260
                    ....*....|....*....|....
gi 17538806     492 GYP---LQNNLLEYFCMIDFVRPK 512
Cdd:smart00487  168 ATPpeeIENLLELFLNDPVFIDVG 191
 
Name Accession Description Interval E-value
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
256-547 6.01e-135

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 411.13  E-value: 6.01e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18069    1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IPKFSDTG-DRIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18069   81 LPPPEALPnVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFR---------------------------- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdeelefetgftsggrvrqeayslirsalLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18069  133 --------------------------------------LRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18069  175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
256-547 1.41e-91

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 294.97  E-value: 1.41e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIESLGEYKKsdGFGCILAHSMGLGKTIQVITFSEIFLRATK-AKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd18007    1 LKPHQVEGVRFLWSNLVGTDVGSDE--GGGCILAHTMGLGKTLQVITFLHTYLAAAPrRSRPLVLCPASTLYNWEDEFKK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPKFsdtgdrIRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIkmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18007   79 WLPPD------LRPLLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRNLA------------------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdsSEDQKLRDEELEFEtgftsggrvrqeayslirSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18007  128 ---SNATTDPRLKQEFI------------------AALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTP 186
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18007  187 LQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
256-547 1.91e-81

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 267.14  E-value: 1.91e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFL---RATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18068    1 LKPHQVDGVQFMWDCCCESLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  333 DKWIpKFSDTGDRIRSFEVfllgDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIKMTLPKKQKKGRPKLnlsgissg 412
Cdd:cd18068   81 EKWQ-EGLKDEEKIEVNEL----ATYKRPQERSYKLQRWQEEGGVMIIGYDMYRILAQERNVKSREKLKEIF-------- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  413 fskdssedqklrdeelefetgftsggrvrqeaysliRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18068  148 ------------------------------------NKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTG 191
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17538806  493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18068  192 TPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVDVRVMKKR 246
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
60-940 1.04e-69

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 248.22  E-value: 1.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   60 AEDLDENVLEAQRLEKQRLERLEKIKPENDHIQQMESLFLAGASEGQLPQLDLQDDDFEEMFGFSVENDNKKYRYGDEEK 139
Cdd:COG0553   35 LARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLLALALLLLALL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  140 PEPMFHLQEPSTSRGHVDVVDLTLDDSDDDCLITDVKSVMPQVVPGRRMRWAQAEKDRIDADQMDIQHNIEARRLKKMRS 219
Cdd:COG0553  115 GLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELAL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  220 AKDLESTEKKEGRLLVNAGHPEEDPDIFVISHLTHVLQ-----------PHQLGGIRFMYdntieSLGEYkksdGFGCIL 288
Cdd:COG0553  195 LAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALEslpaglkatlrPYQLEGAAWLL-----FLRRL----GLGGLL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  289 AHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfevFLLGDGVKTFDQRVNLI 368
Cdd:COG0553  266 ADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLR-----------VLVLDGTRERAKGANPF 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  369 EQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfskdssedqklRDEELefetgftsggrvrqeaysli 448
Cdd:COG0553  335 EDAD----LVITSYGLLR-------------------------------------RDIEL-------------------- 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  449 rsaLLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPI 528
Cdd:COG0553  354 ---LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  529 kngqcvdsspddVKIALQRTHVLVELVKGFVQRRTHHLLKKILPESKEYVLLLRKSQIQRQLYRNFVLWAKNEI--AANN 606
Cdd:COG0553  431 ------------EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELegAEGI 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  607 DAVFNPLMAFSACSKIWNHPDILYrlveqkkraeEDKKRveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfgaqfhp 686
Cdd:COG0553  499 RRRGLILAALTRLRQICSHPALLL----------EEGAE----------------------------------------- 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  687 qqngmmmqngswhpnnYQMPSPfnsipsnpstptssstsksakktkkprgskkapksdeedeevekesrmKYDWTFELFE 766
Cdd:COG0553  528 ----------------LSGRSA------------------------------------------------KLEALLELLE 543
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  767 kyqegvlengykivislEILDEstqiGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADR 846
Cdd:COG0553  544 -----------------ELLAE----GEKVLVFSQFTDTLDLLEERLEERGIE--------------YAYLHGGTSAEER 588
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  847 EKLINRFNSEPGLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFN 926
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668
                        890
                 ....*....|....
gi 17538806  927 RQISKHGLQQRVVD 940
Cdd:COG0553  669 LLEEKRALAESVLG 682
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
256-562 1.27e-55

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 193.27  E-value: 1.27e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDntieSLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATK-----AKKVLVIVPINTIQNWYS 330
Cdd:cd18004    1 LRPHQREGVQFLYD----CLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPygkptAKKALIVCPSSLVGNWKA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  331 EYDKWIPkfsdtgdrIRSFEVFLLGDGVKTFDQRVnLIEQWDQTGGVMLVGYDMFRLLikmtlpkkqkkgrpklnlsgiS 410
Cdd:cd18004   77 EFDKWLG--------LRRIKVVTADGNAKDVKASL-DFFSSASTYPVLIISYETLRRH---------------------A 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  411 SGFSKDSSedqklrdeelefetgftsggrvrqeayslirsallepgPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18004  127 EKLSKKIS--------------------------------------IDLLICDEGHRLKNSESKTTKALNSLPCRRRLLL 168
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538806  491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18004  169 TGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
259-629 5.08e-49

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 5.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    259 HQLGGIRFMYDntieslgEYKKSdGFGCILAHSMGLGKTIQVITFseifLRATKA------KKVLVIVPINTIQNWYSEY 332
Cdd:pfam00176    1 YQIEGVNWMLS-------LENNL-GRGGILADEMGLGKTLQTISL----LLYLKHvdknwgGPTLIVVPLSLLHNWMNEF 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    333 DKWIPKfsdtgDRIRSFEvfLLGDGVKTFDQRVNLIEQWDQtgGVMLVGYDMfrllikmtLPKkqkkgrpklnlsgissg 412
Cdd:pfam00176   69 ERWVSP-----PALRVVV--LHGNKRPQERWKNDPNFLADF--DVVITTYET--------LRK----------------- 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    413 fskdssedqklrdeelefetgftsggrvrqeayslIRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:pfam00176  115 -----------------------------------HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTG 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSpddvkialqrtHVLVELVKGFVQRRTHHLLKKILP 572
Cdd:pfam00176  160 TPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGV-----------SRLHKLLKPFLLRRTKKDVEKSLP 228
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17538806    573 ESKEYVLLLRKSQIQRQLYRNFVLWAK-------NEIAANNDAVFNPLMAFsacSKIWNHPDIL 629
Cdd:pfam00176  229 PKVEYILFCRLSKLQRKLYQTFLLKKDlnaiktgEGGREIKASLLNILMRL---RKICNHPGLI 289
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
778-915 3.20e-46

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 162.26  E-value: 3.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  778 KIVISLEILDESTQIGEKILIFSQNLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSEP 857
Cdd:cd18793   12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIK--------------YLRLDGSTSSKERQKLVDRFNEDP 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806  858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLI 915
Cdd:cd18793   78 DIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
256-562 1.13e-40

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 150.70  E-value: 1.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTieslgEYKKSDGF-GCILAHSMGLGKTIQVITFSEIFLRAT-----KAKKVLVIVPINTIQNWY 329
Cdd:cd18067    1 LRPHQREGVKFLYRCV-----TGRRIRGShGCIMADEMGLGKTLQCITLMWTLLRQSpqckpEIDKAIVVSPSSLVKNWA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  330 SEYDKWIpkfsdtGDRIRSFEVfllgDGvKTFDQRVNLIEQWDQTGG------VMLVGYDMFRLLIkmtlpkkqkkgrpk 403
Cdd:cd18067   76 NELGKWL------GGRLQPLAI----DG-GSKKEIDRKLVQWASQQGrrvstpVLIISYETFRLHV-------------- 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  404 lnlsgissgfskdssedqklrDEELEFETGftsggrvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAIN 483
Cdd:cd18067  131 ---------------------EVLQKGEVG-------------------------LVICDEGHRLKNSDNQTYQALDSLN 164
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17538806  484 TKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18067  165 TQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
256-562 1.45e-39

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 147.13  E-value: 1.45e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYdntieSLGEYKKsdgfGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18001    1 LYPHQREGVAWLW-----SLHDGGK----GGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKW 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IPkfsdtGDRIRSFEvfllgdGVKTFDQRVNLiEQWDQTGGVMLVGYDMFrllikmtlpkkqkkgrpklnlsgissgfsk 415
Cdd:cd18001   72 TP-----GLRVKVFH------GTSKKERERNL-ERIQRGGGVLLTTYGMV------------------------------ 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  416 DSSEDQKLRDEELEFETgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPL 495
Cdd:cd18001  110 LSNTEQLSADDHDEFKW-------------------------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPI 164
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806  496 QNNLLEYFCMIDFVRP-KYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18001  165 QNNLKELWALFDFACNgSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
256-514 2.09e-39

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 144.63  E-value: 2.09e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNtieslgeYKKsdGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17919    1 LRPYQLEGLNFLLEL-------YEN--GPGGILADEMGLGKTLQAIAFlAYLLKEGKERGPVLVVCPLSVLENWEREFEK 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPkfsdtgdrirSFEVFLLGDGVKtfDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd17919   72 WTP----------DLRVVVYHGSQR--ERAQIRAKEKLDKFDVVLTTYETLR---------------------------- 111
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklRDEElefetgftsggrvrqeayslirsALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17919  112 ---------RDKA-----------------------SLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
                        250       260
                 ....*....|....*....|
gi 17538806  495 LQNNLLEYFCMIDFVRPKYL 514
Cdd:cd17919  160 LQNNLEELWALLDFLDPPFL 179
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
256-562 2.00e-38

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 144.06  E-value: 2.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNtieslgeYKksDGFGCILAHSMGLGKTIQVITF-------------SEIFLRATKAKK------- 315
Cdd:cd18005    1 LRDYQREGVEFMYDL-------YK--NGRGGILGDDMGLGKTVQVIAFlaavlgktgtrrdRENNRPRFKKKPpassakk 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  316 -VLVIVPINTIQNWYSEYDKWipkfsdtgdriRSFEVFLLGDGVKTFDQRVNLieqwdQTGG--VMLVGYDMFRLLIkmt 392
Cdd:cd18005   72 pVLIVAPLSVLYNWKDELDTW-----------GHFEVGVYHGSRKDDELEGRL-----KAGRleVVVTTYDTLRRCI--- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  393 lpkkqkkgrPKLNlsgissgfskdssedqklrdeELEFetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNIT 472
Cdd:cd18005  133 ---------DSLN---------------------SINW---------------------------SAVIADEAHRIKNPK 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  473 AEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLV 552
Cdd:cd18005  156 SKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELA 235
                        330
                 ....*....|
gi 17538806  553 ELVKGFVQRR 562
Cdd:cd18005  236 VKLSKFFLRR 245
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
256-562 1.31e-34

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 132.66  E-value: 1.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYdntiESLGEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATK------AKKVLVIVPINTIQNWY 329
Cdd:cd18066    1 LRPHQREGIEFLY----ECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvIKRALIVTPGSLVKNWK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  330 SEYDKWIPKfsdtgDRIRSFEVfllgDGVKTFDQRVNLIeqwdqTGGVMLVGYDMfrlLIKmtlpkkqkkgrpklNLSGI 409
Cdd:cd18066   77 KEFQKWLGS-----ERIKVFTV----DQDHKVEEFIASP-----LYSVLIISYEM---LLR--------------SLDQI 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  410 SSgfskdssedqklrdeeLEFetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIV 489
Cdd:cd18066  126 SK----------------LNF---------------------------DLVICDEGHRLKNTSIKTTTALTSLSCERRII 162
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806  490 LTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18066  163 LTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
256-563 8.19e-32

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 124.22  E-value: 8.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYdntieSLGEYkksdGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18012    5 LRPYQKEGFNWLS-----FLRHY----GLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IPKFSdtgdrirsfevFLLGDGVKTFDQRVNLIEQWDqtggVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgfsk 415
Cdd:cd18012   76 APELK-----------VLVIHGTKRKREKLRALEDYD----LVITSYGLLR----------------------------- 111
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  416 dssedqklRDEELEFETGFtsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPL 495
Cdd:cd18012  112 --------RDIELLKEVKF-----------------------HYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806  496 QNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdssPDDVKIALQRthvlveLVKGFVQRRT 563
Cdd:cd18012  161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDG-----DEEALEELKK------LISPFILRRL 217
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
256-958 6.42e-30

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 129.15  E-value: 6.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITF----SEifLRATKAKKvLVIVPINTIQNW 328
Cdd:PLN03142  170 MRDYQLAGLNWLirlYENGING------------ILADEMGLGKTLQTISLlgylHE--YRGITGPH-MVVAPKSTLGNW 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   329 YSEYDKWIPKfsdtgdrIRSFEvfllgdgvktfdqrvnlieqwdqtggvmlvgydmfrllikmtlpkkqkkgrpklnlsg 408
Cdd:PLN03142  235 MNEIRRFCPV-------LRAVK---------------------------------------------------------- 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   409 issgFSKDSSEDQKLRDEEL---EFETGFTSGGRVRQEaysliRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTK 485
Cdd:PLN03142  250 ----FHGNPEERAHQREELLvagKFDVCVTSFEMAIKE-----KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTN 320
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   486 RRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRTHvlvELVKGFVQRRTHH 565
Cdd:PLN03142  321 YRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQ---------QEVVQQLH---KVLRPFLLRRLKS 388
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   566 LLKKILPESKEYVLLLRKSQIQRQLYRnfVLWAKNEIAANNDA----VFNPLMAFSACSkiwNHPdILYRlveqkkraee 641
Cdd:PLN03142  389 DVEKGLPPKKETILKVGMSQMQKQYYK--ALLQKDLDVVNAGGerkrLLNIAMQLRKCC---NHP-YLFQ---------- 452
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   642 dkkrveqmkfaqlqqqqqqqqqqlqgmmmmgnngmmpgfGAQFHPqqngmmmqngswhpnnyqmpsPFNSipsnpstpts 721
Cdd:PLN03142  453 ---------------------------------------GAEPGP---------------------PYTT---------- 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   722 sstsksakktkkprgskkapksdeedeevekesrmkydwtfelfekyQEGVLENGYKIVISLEILDESTQIGEKILIFSQ 801
Cdd:PLN03142  463 -----------------------------------------------GEHLVENSGKMVLLDKLLPKLKERDSRVLIFSQ 495
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806   802 NLTALDMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNsEPGLS--LFLISTRAGSLGINLVSAN 879
Cdd:PLN03142  496 MTRLLDILEDYLMYRGYQ--------------YCRIDGNTGGEDRDASIDAFN-KPGSEkfVFLLSTRAGGLGINLATAD 560
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17538806   880 RCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVYRLIMDNSMERSIFNRQISKHGLQQRVVDDAQVDANISQKELETLLM 958
Cdd:PLN03142  561 IVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQM 639
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
256-514 3.78e-24

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 101.25  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDntieslgeyKKSDGFGCILAHSMGLGKTIQVITF------SEIFLRatkakKVLVIVPINTIQNWY 329
Cdd:cd18000    1 LFKYQQTGVQWLWE---------LHCQRVGGILGDEMGLGKTIQIIAFlaalhhSKLGLG-----PSLIVCPATVLKQWV 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  330 SEYDKWIPKFsdtgdRI----RSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRLLIKMTLPKKQkkgrpkln 405
Cdd:cd18000   67 KEFHRWWPPF-----RVvvlhSSGSGTGSEEKLGSIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNW-------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  406 lsgissgfskdssedqklrdeelefetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAINTK 485
Cdd:cd18000  134 ----------------------------------------------------QYVILDEGHKIRNPDAEITLACKQLRTP 161
                        250       260
                 ....*....|....*....|....*....
gi 17538806  486 RRIVLTGYPLQNNLLEYFCMIDFVRPKYL 514
Cdd:cd18000  162 HRLILSGTPIQNNLKELWSLFDFVFPPYL 190
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
256-530 9.70e-22

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 95.51  E-value: 9.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSeIFLRATKAKK--VLVIVPINTIQNWYS 330
Cdd:cd17996    4 LKEYQLKGLQWMvslYNNNLNG------------ILADEMGLGKTIQTISLI-TYLMEKKKNNgpYLVIVPLSTLSNWVS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  331 EYDKWIPKFSdtgdrirsfEVFLLGdgvkTFDQRVNLIEQWDQTG-GVMLVGYDMfrlLIKmtlpkkqkkGRPKLnlsgi 409
Cdd:cd17996   71 EFEKWAPSVS---------KIVYKG----TPDVRKKLQSQIRAGKfNVLLTTYEY---IIK---------DKPLL----- 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  410 ssgfskdssedqklrdeelefetgftsgGRVRQeAYSLIrsallepgpdlvvcDEGHKIKNITAEISMTLG-AINTKRRI 488
Cdd:cd17996  121 ----------------------------SKIKW-KYMII--------------DEGHRMKNAQSKLTQTLNtYYHARYRL 157
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 17538806  489 VLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKN 530
Cdd:cd17996  158 LLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFAN 199
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
256-524 4.17e-21

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 93.47  E-value: 4.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNtieslgeYKKsdGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17995    1 LRDYQLEGVNWLLFN-------WYN--RRNCILADEMGLGKTIQSIAFlEHLYQVEGIRGPFLVIAPLSTIPNWQREFET 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPkfsdtgdrirsfevfllgdgvktfdqrVNLIEQWDQTGGvmlvgyDMFRLLIKMTLPKKQKKGRPklnlsgissgfs 414
Cdd:cd17995   72 WTD---------------------------MNVVVYHGSGES------RQIIQQYEMYFKDAQGRKKK------------ 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdEELEFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17995  107 -----------GVYKFDVLITTYEMVIADAEELRKIPW-----RVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTP 170
                        250       260       270
                 ....*....|....*....|....*....|
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd17995  171 LQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
256-562 8.17e-20

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 89.72  E-value: 8.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMydntiESLGEYKKSDgfgcILAHSMGLGKTIQ--VITFSEIFLRATKAK----KVLVIVPINTIQNWY 329
Cdd:cd17999    1 LRPYQQEGINWL-----AFLNKYNLHG----ILCDDMGLGKTLQtlCILASDHHKRANSFNsenlPSLVVCPPTLVGHWV 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  330 SEYDKWIPKFSDTgdrirsfevFLLGDGVktFDQRVNLIEQWDQtGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgi 409
Cdd:cd17999   72 AEIKKYFPNAFLK---------PLAYVGP--PQERRRLREQGEK-HNVIVASYDVLR----------------------- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  410 ssgfskdssedqklRDEELEFETGFTsggrvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIV 489
Cdd:cd17999  117 --------------NDIEVLTKIEWN-----------------------YCVLDEGHIIKNSKTKLSKAVKQLKANHRLI 159
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806  490 LTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd17999  160 LSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
778-904 1.02e-19

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 85.73  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806    778 KIVISLEILDESTqiGEKILIFSQNLTALDmlEEILKKRqirgkdgpgqrweKNRNYLRLDGTTSGADREKLINRFNSep 857
Cdd:pfam00271    2 KLEALLELLKKER--GGKVLIFSQTKKTLE--AELLLEK-------------EGIKVARLHGDLSQEEREEILEDFRK-- 62
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 17538806    858 GLSLFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYG 904
Cdd:pfam00271   63 GKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
256-512 2.18e-19

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 87.44  E-value: 2.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRF---MYDNTIEslgeykksdgfgCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd17998    1 LKDYQLIGLNWlnlLYQKKLS------------GILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREF 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  333 DKWIPKF--------SDTGDRIRSFEVfllgDGVKTFDqrvnlieqwdqtggVMLVGYDMfrllikmtlpkkqkkgrpkl 404
Cdd:cd17998   69 KRWCPSLkvepyygsQEERKHLRYDIL----KGLEDFD--------------VIVTTYNL-------------------- 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  405 nlsgissgfSKDSSEDQK-LRDEELefetgftsggrvrqeayslirsallepgpDLVVCDEGHKIKNITAEISMTLGAIN 483
Cdd:cd17998  111 ---------ATSNPDDRSfFKRLKL-----------------------------NYVVYDEGHMLKNMTSERYRHLMTIN 152
                        250       260
                 ....*....|....*....|....*....
gi 17538806  484 TKRRIVLTGYPLQNNLLEYFCMIDFVRPK 512
Cdd:cd17998  153 ANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
287-563 1.51e-18

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 85.84  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  287 ILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfEVFLLGD--GVKTFD 362
Cdd:cd17997   26 ILADEMGLGKTLQTISLLG-YLKHYKniNGPHLIIVPKSTLDNWMREFKRWCPSLR---------VVVLIGDkeERADII 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  363 QRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSGIssgfskdssedqklrdeelefetgftsggrvrq 442
Cdd:cd17997   96 RDVLLPGKFD----VCITSYEMV---------IKEKTVLKKFNWRYI--------------------------------- 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  443 eayslirsallepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd17997  130 ------------------IIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDE 191
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 17538806  523 RFEkpikngqcVDSSPDDVKIALQRTHvlvELVKGFVQRRT 563
Cdd:cd17997  192 WFN--------VNNCDDDNQEVVQRLH---KVLRPFLLRRI 221
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
255-562 3.11e-18

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 85.52  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  255 VLQPHQLGGIRFM---YDNtieslgeykksdGFGCILAHSMGLGKTIQVITFSEiFLRATKAK-KVLVIVPINTIQNWYS 330
Cdd:cd18009    3 VMRPYQLEGMEWLrmlWEN------------GINGILADEMGLGKTIQTIALLA-HLRERGVWgPFLVIAPLSTLPNWVN 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  331 EYDKWIPkfsdtgdrirSFEVfLLGDGVKtfDQRVNLIEQwdqtggvmlvgydmfrllikmtlpKKQKKGRPKLNLSGIS 410
Cdd:cd18009   70 EFARFTP----------SVPV-LLYHGTK--EERERLRKK------------------------IMKREGTLQDFPVVVT 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  411 SgfskdssedqklrdeeleFETGFTSGGRVRQEAYSLIrsallepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18009  113 S------------------YEIAMRDRKALQHYAWKYL------------IVDEGHRLKNLNCRLIQELKTFNSDNRLLL 162
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538806  491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQCVDSSPDDVKIALQRTHVLVELVKGFVQRR 562
Cdd:cd18009  163 TGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
HELICc smart00490
helicase superfamily c-terminal domain;
807-904 1.89e-17

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 78.02  E-value: 1.89e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     807 DMLEEILKKRQIRgkdgpgqrweknrnYLRLDGTTSGADREKLINRFNSepGLSLFLISTRAGSLGINLVSANRCIIIDA 886
Cdd:smart00490    1 EELAELLKELGIK--------------VARLHGGLSQEEREEILDKFNN--GKIKVLVATDVAERGLDLPGVDLVIIYDL 64
                            90
                    ....*....|....*...
gi 17538806     887 CWNPCHDAQAVCRVYRYG 904
Cdd:smart00490   65 PWSPASYIQRIGRAGRAG 82
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
287-562 7.47e-16

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 78.16  E-value: 7.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  287 ILAHSMGLGKTIQVITFseiFLRATKAKKV----LVIVPINTIQNWYSEYDKWIPKFsdtgdrirsfevfllgdgvktfd 362
Cdd:cd18003   23 ILADEMGLGKTIQTIAL---LAHLACEKGNwgphLIVVPTSVMLNWEMEFKRWCPGF----------------------- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  363 qrvnlieqwdqtggvmlvgydmfRLLIKMTLPKKQKKGRpklnlsgisSGFSKDSSedqklrdeeleFETGFTSGGRVRQ 442
Cdd:cd18003   77 -----------------------KILTYYGSAKERKLKR---------QGWMKPNS-----------FHVCITSYQLVVQ 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  443 EAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd18003  114 DHQVFKRKKW-----KYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKE 188
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 17538806  523 RFEKPIKngQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18003  189 WFSNPLT--AMSEGSQEENEELVRRLH---KVLRPFLLRR 223
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
256-524 1.18e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 77.39  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTieslgeYKKSDgfgCILAHSMGLGKTIQVITF-SEIFLRATKAkKVLVIVPINTIQNWYSEYDK 334
Cdd:cd18058    1 LREYQLEGMNWLLFNW------YNRKN---CILADEMGLGKTIQSITFlSEIFLMGIRG-PFLIIAPLSTITNWEREFRT 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIpkfsdtgdrirsfevfllgdgvktfdQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkKQKKGRPklnLSGISsgfs 414
Cdd:cd18058   71 WT--------------------------EMNAIVYHGSQISRQMIQQYEMYY---------RDEQGNP---LSGIF---- 108
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqKLRDEELEFETGFTSGGRVRQEAYSlirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd18058  109 -------KFQVVITTFEMILADCPELKKINWS------------CVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTP 169
                        250       260       270
                 ....*....|....*....|....*....|
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd18058  170 LQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
256-562 2.07e-14

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 74.25  E-value: 2.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDntieslgeykksdgFGCILAHSMGLGKTIQVI------------TFSEIFLRATKAKKV------L 317
Cdd:cd18008    1 LLPYQKQGLAWMLP--------------RGGILADEMGLGKTIQALalilatrpqdpkIPEELEENSSDPKKLylskttL 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  318 VIVPINTIQNWYSEydkwIPKFSDTGdrirSFEVFLL-GDGVKTfdqRVNLIEQWDqtggVMLVGYDMFRllikMTLPKK 396
Cdd:cd18008   67 IVVPLSLLSQWKDE----IEKHTKPG----SLKVYVYhGSKRIK---SIEELSDYD----IVITTYGTLA----SEFPKN 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  397 QKKGRPKLNLSGISSGFSkdssedqklrdeeLEFEtgftsggrvrqeaysliRsallepgpdlVVCDEGHKIKNITAEIS 476
Cdd:cd18008  128 KKGGGRDSKEKEASPLHR-------------IRWY-----------------R----------VILDEAHNIKNRSTKTS 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  477 MTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRthvLVELVK 556
Cdd:cd18008  168 RAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKND---------RKALER---LQALLK 235

                 ....*.
gi 17538806  557 GFVQRR 562
Cdd:cd18008  236 PILLRR 241
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
256-532 1.20e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 72.02  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18057    1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKgPYLVSAPLSTIINWEREFEM 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPKF---SDTGDR-----IRSFEVFLLGDGVKTfdqrvnlieqwdqtggvmlvGYDMFRLlikmtlpkkqkkgrpklnl 406
Cdd:cd18057   72 WAPDFyvvTYTGDKesrsvIRENEFSFEDNAIRS--------------------GKKVFRM------------------- 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  407 sgissgfskdssedqkLRDEELEFETGFTSggrvrQEAYSLIRSALLEPGPDLVVCDEGHKIKNITAEISMTLGAINTKR 486
Cdd:cd18057  113 ----------------KKEAQIKFHVLLTS-----YELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDY 171
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 17538806  487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18057  172 KLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQ 217
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
254-532 3.89e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 70.43  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  254 HVLQPHQLGGIRFMYdntieslgeykkSDGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18055    2 HMYQLEGLNWLRFSW------------AQGTDTILADEMGLGKTIQTIVFlYSLYKEGHTKGPFLVSAPLSTIINWEREF 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  333 DKWIPKF---SDTGDR-----IRSFEVFLLGDGVKTFDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpkl 404
Cdd:cd18055   70 QMWAPDFyvvTYTGDKdsraiIRENEFSFDDNAVKGGKKAFKMKREAQVKFHVLLTSYELVT------------------ 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  405 nlsgissgfskdssedqklrdeelefetgftsggrVRQEAYSLIRSALLepgpdlvVCDEGHKIKNITAEISMTLGAINT 484
Cdd:cd18055  132 -----------------------------------IDQAALGSIRWACL-------VVDEAHRLKNNQSKFFRVLNGYKI 169
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 17538806  485 KRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18055  170 DHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQ 217
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
256-532 5.38e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 69.01  E-value: 5.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd17994    1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPKFsdtgdrirsFEVFLLGDgvktfdqrvnlieqwdqtgGVMLVGYDmfrlLIKMTlpkkqkkgrpklnlsgissgfs 414
Cdd:cd17994   72 WAPDF---------YVVTYVGD-------------------HVLLTSYE----LISID---------------------- 97
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdeelefetgftsggrvrQEAYSLIRSALLepgpdlvVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYP 494
Cdd:cd17994   98 ---------------------------QAILGSIDWAVL-------VVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 17538806  495 LQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd17994  144 LQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQ 181
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
256-522 2.19e-12

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 67.77  E-value: 2.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYdntieslgeYKKSDGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDK 334
Cdd:cd17993    2 LRDYQLTGLNWLA---------HSWCKGNNGILADEMGLGKTVQTISFlSYLFHSQQQYGPFLVVVPLSTMPAWQREFAK 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPKFS------DTGDR--IRSFEVFLLGdgvktfDQRVNLieqwdqtgGVMLVGYDMFrllikmtLPKKQKkgrpklnL 406
Cdd:cd17993   73 WAPDMNvivylgDIKSRdtIREYEFYFSQ------TKKLKF--------NVLLTTYEII-------LKDKAF-------L 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  407 SGISSGFskdssedqklrdeelefetgftsggrvrqeayslirsallepgpdLVVcDEGHKIKNITAEISMTLGAINTKR 486
Cdd:cd17993  125 GSIKWQY---------------------------------------------LAV-DEAHRLKNDESLLYEALKEFKTNN 158
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 17538806  487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFID 522
Cdd:cd17993  159 RLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEE 194
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
282-575 3.26e-12

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 67.77  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  282 DGFGCILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKfsdtgdrIRSfeVFLLGDGVK 359
Cdd:cd18064   33 NGINGILADEMGLGKTLQTISLLG-YMKHYRniPGPHMVLVPKSTLHNWMAEFKRWVPT-------LRA--VCLIGDKDQ 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  360 --TFDQRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSgissgfskdssedqklrdeelefetgftsg 437
Cdd:cd18064  103 raAFVRDVLLPGEWD----VCVTSYEML---------IKEKSVFKKFNWR------------------------------ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  438 grvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTr 517
Cdd:cd18064  140 ---------------------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNS- 197
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17538806  518 ksfIDRFEKPIKNGQCVdsspDDVKIaLQRTHVlveLVKGFVQRRTHHLLKKILPESK 575
Cdd:cd18064  198 ---AEDFDSWFDTNNCL----GDQKL-VERLHM---VLRPFLLRRIKADVEKSLPPKK 244
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
256-524 3.75e-12

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 67.39  E-value: 3.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTieslgeYKKSDgfgCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKW 335
Cdd:cd18060    1 LREYQLEGVNWLLFNW------YNRQN---CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  336 IpkfsdtgdrirsfevfllgdgvktfdQRVNLIEQWDQTGGVMLVGYDMFrllikmtlpKKQKKGR---PKLNLSGISSG 412
Cdd:cd18060   72 T--------------------------EMNTIVYHGSLASRQMIQQYEMY---------CKDSRGRlipGAYKFDALITT 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  413 FSKDSSEDQKLRdeELEFETgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18060  117 FEMILSDCPELR--EIEWRC---------------------------VIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTG 167
                        250       260       270
                 ....*....|....*....|....*....|..
gi 17538806  493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRF 524
Cdd:cd18060  168 TPLQNTVEELFSLLHFLEPSQFPSESEFLKDF 199
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
256-562 3.77e-12

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 67.78  E-value: 3.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSE 331
Cdd:cd18063   24 LKHYQLQGLEWMvslYNNNLNG------------ILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLSTLSNWTYE 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  332 YDKWIPKfsdtgdrirsfevfllgdgvktfdqrvnlieqwdqtggVMLVGYdmfrllikmtlpkkqkKGRPKLNLSGISs 411
Cdd:cd18063   92 FDKWAPS--------------------------------------VVKISY----------------KGTPAMRRSLVP- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  412 gfskdssedqKLRDEEleFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGA-INTKRRIVL 490
Cdd:cd18063  117 ----------QLRSGK--FNVLLTTYEYIIKDKHILAKIRW-----KYMIVDEGHRMKNHHCKLTQVLNThYVAPRRILL 179
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806  491 TGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIK-NGQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18063  180 TGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmTGERVDLNEEETILIIRRLH---KVLRPFLLRR 249
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
257-531 1.32e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 65.80  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  257 QPHQLGGIRF-MYDNTIESLGEYKKS--DGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEY 332
Cdd:cd18054   10 QPSYIGGENLeLRDYQLEGLNWLAHSwcKNNSVILADEMGLGKTIQTISFlSYLFHQHQLYGPFLLVVPLSTLTSWQREF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  333 DKWIPKFSdtgdrirsfEVFLLGDGVKTfdqrvNLIEQWDQTggvmlvgydmfrllikmtlpkKQKKGRPKLNlsgissg 412
Cdd:cd18054   90 EIWAPEIN---------VVVYIGDLMSR-----NTIREYEWI---------------------HSQTKRLKFN------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  413 fSKDSSEDQKLRDEELefetgftsggrvrqeaYSLIRSALLEpgpdlvvCDEGHKIKNITAEISMTLGAINTKRRIVLTG 492
Cdd:cd18054  128 -ALITTYEILLKDKTV----------------LGSINWAFLG-------VDEAHRLKNDDSLLYKTLIDFKSNHRLLITG 183
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 17538806  493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNG 531
Cdd:cd18054  184 TPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENG 222
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
256-532 1.49e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 65.86  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMydntieslgEYKKSDGFGCILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18056    1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPKFsdtgdrirsFEVFLLGDgvktfdqrvnlieqwdqtggvmlvgydmfrllikmtlpkkqkkgrpklnlsgissgfs 414
Cdd:cd18056   72 WAPDM---------YVVTYVGD---------------------------------------------------------- 84
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 KDSSedQKLRDEELEFETGFTSGG----RVRQEA----------YSLIRSALLEPGP---DLVVCDEGHKIKNITAEISM 477
Cdd:cd18056   85 KDSR--AIIRENEFSFEDNAIRGGkkasRMKKEAsvkfhvlltsYELITIDMAILGSidwACLIVDEAHRLKNNQSKFFR 162
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17538806  478 TLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQ 532
Cdd:cd18056  163 VLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQ 217
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
286-524 7.38e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 63.51  E-value: 7.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  286 CILAHSMGLGKTIQVITF-SEIFLRATKAkKVLVIVPINTIQNWYSEYDKWIpkfsdtgdrirSFEVFLLgDGVKTFDQR 364
Cdd:cd18059   22 CILADEMGLGKTIQSITFlYEIYLKGIHG-PFLVIAPLSTIPNWEREFRTWT-----------ELNVVVY-HGSQASRRT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  365 VNLIEQW-DQTGGVMLVGYDMFRLLIKMtlpkkqkkgrpklnlsgissgfskdssedqklrdeeleFETGFTSGGRVRQE 443
Cdd:cd18059   89 IQLYEMYfKDPQGRVIKGSYKFHAIITT--------------------------------------FEMILTDCPELRNI 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  444 AYSlirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDR 523
Cdd:cd18059  131 PWR------------CVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQE 198

                 .
gi 17538806  524 F 524
Cdd:cd18059  199 F 199
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
256-536 1.24e-10

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 62.46  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMydntIESLGEykksdGFGCILAHSMGLGKTIQVITFSeIFLRATKAKK--VLVIVPINTIQNWYSEYD 333
Cdd:cd18006    1 LRPYQLEGVNWL----LQCRAE-----QHGCILGDEMGLGKTCQTISLL-WYLAGRLKLLgpFLVLCPLSVLDNWKEELN 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  334 KWIPKFSdtgdrirsfEVFLLGDGVKTFDQRVNLIE--QWDqtggVMLVGYDmfrllikmtlpkkqkkgrpklnlsgiss 411
Cdd:cd18006   71 RFAPDLS---------VITYMGDKEKRLDLQQDIKStnRFH----VLLTTYE---------------------------- 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  412 gfskdssedqklrdeelefetgftsggrvrqeaYSLIRSALLEPGP-DLVVCDEGHKIKNITAEISMTLGAINTKRRIVL 490
Cdd:cd18006  110 ---------------------------------ICLKDASFLKSFPwASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 17538806  491 TGYPLQNNLLEYFCMIDFVRPKYLGTRK--SFIDRFEKPIKNGQCVDS 536
Cdd:cd18006  157 TGTPIQNSLQELYALLSFIEPNVFPKDKldDFIKAYSETDDESETVEE 204
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
286-524 3.44e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 61.56  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  286 CILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSEYDKWipkfsdtgdrirsfevfllgdgvktfdQRV 365
Cdd:cd18061   22 CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW---------------------------TDL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  366 NLI-EQWDQTGGVMLVGYDMFrllikmtlpkkqkkgrpklnlsgissgfskdssedqkLRDEElefetGFTSGGRVRQEA 444
Cdd:cd18061   75 NVVvYHGSLISRQMIQQYEMY-------------------------------------FRDSQ-----GRIIRGAYRFQA 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  445 YSLIRSALLEPGPDL-------VVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTR 517
Cdd:cd18061  113 IITTFEMILGGCPELnaidwrcVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSE 192

                 ....*..
gi 17538806  518 KSFIDRF 524
Cdd:cd18061  193 STFMQEF 199
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
255-562 3.71e-10

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 61.98  E-value: 3.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  255 VLQPHQLGGIRFM---YDNTIESlgeykksdgfgcILAHSMGLGKTIQVITFSEIFLRATKAK-KVLVIVPINTIQNWYS 330
Cdd:cd18062   23 VLKQYQIKGLEWLvslYNNNLNG------------ILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVY 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  331 EYDKWIPKfsdtgdrirsfevfllgdgvktfdqrvnlieqwdqtggVMLVGYdmfrllikmtlpkkqkKGRP---KLNLS 407
Cdd:cd18062   91 EFDKWAPS--------------------------------------VVKVSY----------------KGSPaarRAFVP 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  408 GISSGfskdssedqklrdeelEFETGFTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGA-INTKR 486
Cdd:cd18062  117 QLRSG----------------KFNVLLTTYEYIIKDKQILAKIRW-----KYMIVDEGHRMKNHHCKLTQVLNThYVAPR 175
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17538806  487 RIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIK-NGQCVDSSPDDVKIALQRTHvlvELVKGFVQRR 562
Cdd:cd18062  176 RLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmTGEKVDLNEEETILIIRRLH---KVLRPFLLRR 249
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
256-547 1.34e-09

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 59.22  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNTIeslgeykksdgFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQNWYSE-YDK 334
Cdd:cd18011    1 PLPHQIDAVLRALRKPP-----------VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDElQDK 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 -WIPKFSDTGDRIrsfevfllgdgvktfDQRVNLIEQWDQTGGVMLVGYDMFRllikmtlpkkqkkgrpklnlsgissgf 413
Cdd:cd18011   70 fGLPFLILDRETA---------------AQLRRLIGNPFEEFPIVIVSLDLLK--------------------------- 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  414 skdssedqklRDEELefetgftsggrvrqeaysliRSALLEPGPDLVVCDEGHKIKNITAEIS---MTLG---AINTKRR 487
Cdd:cd18011  108 ----------RSEER--------------------RGLLLSEEWDLVVVDEAHKLRNSGGGKEtkrYKLGrllAKRARHV 157
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  488 IVLTGYPLQNNLLEYFCMIDFVRPkylgtrksfiDRFEKPIKNGQCVDSSPDDVKIALQR 547
Cdd:cd18011  158 LLLTATPHNGKEEDFRALLSLLDP----------GRFAVLGRFLRLDGLREVLAKVLLRR 207
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
256-562 4.33e-09

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 58.63  E-value: 4.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFM-------------------YDNTIESLGEYKKSD-GFGCILAHSMGLGKTIQVITFseiflraTKAKK 315
Cdd:cd18071    1 LLPHQKQALAWMvsrensqdlppfweeavglFLNTITNFSQKKRPElVRGGILADDMGLGKTLTTISL-------ILANF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  316 VLVIVPINTIQNWYSEYdkwipkfsdtGDRIRS--FEVFLLGDGVKTFDqrVNLIEQWDqtggVMLVGYDMfrllikmtl 393
Cdd:cd18071   74 TLIVCPLSVLSNWETQF----------EEHVKPgqLKVYTYHGGERNRD--PKLLSKYD----IVLTTYNT--------- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  394 pkkqkkgrpklnlsgISSGFS-KDSSEDQKLRdeelefetgftsGGRVrqeayslirsallepgpdlvVCDEGHKIKNIT 472
Cdd:cd18071  129 ---------------LASDFGaKGDSPLHTIN------------WLRV--------------------VLDEGHQIRNPN 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  473 AEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSFIDRFEKPIKNGQcvdsspddvKIALQRTHVlv 552
Cdd:cd18071  162 AQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGD---------PTGLKRLQV-- 230
                        330
                 ....*....|
gi 17538806  553 eLVKGFVQRR 562
Cdd:cd18071  231 -LMKQITLRR 239
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
282-525 7.30e-09

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 57.72  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  282 DGFGCILAHSMGLGKTIQVITFSEiFLRATK--AKKVLVIVPINTIQNWYSEYDKWIPKFSdtgdrirsfEVFLLGD--G 357
Cdd:cd18065   33 NGVNGILADEMGLGKTLQTIALLG-YLKHYRniPGPHMVLVPKSTLHNWMNEFKRWVPSLR---------AVCLIGDkdA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  358 VKTFDQRVNLIEQWDqtggVMLVGYDMFrllikmtlpKKQKKGRPKLNLSgissgfskdssedqklrdeelefetgftsg 437
Cdd:cd18065  103 RAAFIRDVMMPGEWD----VCVTSYEMV---------IKEKSVFKKFNWR------------------------------ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  438 grvrqeayslirsallepgpdLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKYLGTR 517
Cdd:cd18065  140 ---------------------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA 198

                 ....*...
gi 17538806  518 KSFIDRFE 525
Cdd:cd18065  199 DDFDSWFD 206
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
256-523 7.92e-09

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 57.21  E-value: 7.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFmydnTIESLGEykksdgfgCILAHSMGLGKTIQVITfseiFLRATKAK-KVLVIVPINTIQNWYSEYDK 334
Cdd:cd18010    1 LLPFQREGVCF----ALRRGGR--------VLIADEMGLGKTVQAIA----IAAYYREEwPLLIVCPSSLRLTWADEIER 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  335 WIPkfSDTGDRIRSfeVFLLGDGVKTFDQRVNlieqwdqtggvmLVGYDMFRLLikmtlpKKQKKGRPklnlsgissgfs 414
Cdd:cd18010   65 WLP--SLPPDDIQV--IVKSKDGLRDGDAKVV------------IVSYDLLRRL------EKQLLARK------------ 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  415 kdssedqklrdeeleFETgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAI--NTKRRIVLTG 492
Cdd:cd18010  111 ---------------FKV---------------------------VICDESHYLKNSKAKRTKAALPLlkRAKRVILLSG 148
                        250       260       270
                 ....*....|....*....|....*....|.
gi 17538806  493 YPLQNNLLEYFCMIDFVRPKYLGTRKSFIDR 523
Cdd:cd18010  149 TPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
DEXDc smart00487
DEAD-like helicases superfamily;
256-512 1.69e-08

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 55.96  E-value: 1.69e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     256 LQPHQLGGIRFMYDNtieslgeykksdGFGCILAHSMGLGKTIQVITFSEIFLRATKAKKVLVIVP-INTIQNWYSEYDK 334
Cdd:smart00487    9 LRPYQKEAIEALLSG------------LRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKK 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     335 WIPKFsdtgdrirSFEVFLLGDGVKTFDQRVNLIEqwdqtggvmlvgyDMFRLLIkMTlpkkqkkgrpklnlsgissgfs 414
Cdd:smart00487   77 LGPSL--------GLKVVGLYGGDSKREQLRKLES-------------GKTDILV-TT---------------------- 112
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806     415 kdsseDQKLRDEelefetgftsggrvrqeaysLIRSALLEPGPDLVVCDEGHKIKNIT-AEISMTLG--AINTKRRIVLT 491
Cdd:smart00487  113 -----PGRLLDL--------------------LENDKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLklLPKNVQLLLLS 167
                           250       260
                    ....*....|....*....|....
gi 17538806     492 GYP---LQNNLLEYFCMIDFVRPK 512
Cdd:smart00487  168 ATPpeeIENLLELFLNDPVFIDVG 191
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
283-562 1.69e-08

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 56.74  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  283 GFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSEYDKWIPKFS------DTGDR--IRSFevfl 353
Cdd:cd18002   19 GINGILADEMGLGKTVQSIAVlAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKvlpywgNPKDRkvLRKF---- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  354 lgdgvktfdqrvnlieqWDQtggvmlvgydmfrllikmtlpkkqkkgrpklnlsgissgfskdssedQKLRDEELEFETG 433
Cdd:cd18002   95 -----------------WDR-----------------------------------------------KNLYTRDAPFHVV 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  434 FTSGGRVRQEAYSLIRSALlepgpDLVVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVRPKY 513
Cdd:cd18002  111 ITSYQLVVQDEKYFQRVKW-----QYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTL 185
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 17538806  514 LGTRKSFIDRFEKPIKNGQCVDSSPDDVKiaLQRTHVlveLVKGFVQRR 562
Cdd:cd18002  186 FDSHDEFNEWFSKDIESHAENKTGLNEHQ--LKRLHM---ILKPFMLRR 229
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
257-520 3.95e-08

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 55.83  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  257 QPHQLGGIRFM--YDNTIESLGEYKKS--DGFGCILAHSMGLGKTIQVITF-SEIFLRATKAKKVLVIVPINTIQNWYSE 331
Cdd:cd18053    9 QPSYIGGHEGLelRDYQLNGLNWLAHSwcKGNSCILADEMGLGKTIQTISFlNYLFHEHQLYGPFLLVVPLSTLTSWQRE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  332 YDKWIPKFSdtgdrirsfEVFLLGDgvktFDQRvNLI--EQW--DQTGgvmlvgydmfRLLIKMTLPKKQKKGRPKLNLS 407
Cdd:cd18053   89 IQTWAPQMN---------AVVYLGD----INSR-NMIrtHEWmhPQTK----------RLKFNILLTTYEILLKDKSFLG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  408 GISSGFskdssedqklrdeelefetgftsggrvrqeayslirsallepgpdlVVCDEGHKIKNITAEISMTLGAINTKRR 487
Cdd:cd18053  145 GLNWAF----------------------------------------------IGVDEAHRLKNDDSLLYKTLIDFKSNHR 178
                        250       260       270
                 ....*....|....*....|....*....|...
gi 17538806  488 IVLTGYPLQNNLLEYFCMIDFVRPKYLGTRKSF 520
Cdd:cd18053  179 LLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF 211
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
460-510 4.91e-06

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 49.40  E-value: 4.91e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17538806  460 VVCDEGHKIKNITAEISMTLGAINTKRRIVLTGYPLQNNLLEYFCMIDFVR 510
Cdd:cd18072  155 IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
256-335 3.75e-05

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 46.19  E-value: 3.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538806  256 LQPHQLGGIRFMYDNtieslgEYkksdgfGCILAhSMGLGKTIQVITFSEIFLRATKAKKVLVIVPINTIQN-WYSEYDK 334
Cdd:cd18013    1 PHPYQKVAINFIIEH------PY------CGLFL-DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEK 67

                 .
gi 17538806  335 W 335
Cdd:cd18013   68 W 68
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
840-912 2.55e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 40.77  E-value: 2.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17538806  840 TTSGADREKLINRFNsepglslFLISTRAGSLGINLVSANRCIIIDACWNPCHDAQAVCRVYRYGQQKKTFVY 912
Cdd:cd18785   10 TNSIEHAEEIASSLE-------ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
283-335 5.63e-03

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 38.54  E-value: 5.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17538806  283 GFGCILAHSMGLGKTIQVitFSEIFLRA-TKAKKVLVIVPINTIQN-WYSEYDKW 335
Cdd:cd00046    1 GENVLITAPTGSGKTLAA--LLAALLLLlKKGKKVLVLVPTKALALqTAERLREL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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