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    nol-6 Nucleolar protein 6 [ Caenorhabditis elegans ]

    Gene ID: 173520, updated on 9-Dec-2024

    Summary

    Official Symbol
    nol-6
    Official Full Name
    Nucleolar protein 6
    Primary source
    WormBase:WBGene00021789
    Locus tag
    CELE_Y51H7C.11
    See related
    AllianceGenome:WB:WBGene00021789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in negative regulation of innate immune response. Predicted to be located in condensed nuclear chromosome and nucleolus. Predicted to be part of CURI complex; UTP-C complex; and small-subunit processome. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See nol-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    18
    Sequence:
    Chromosome: II; NC_003280.10 (1425732..1437499, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lzipper-MIP1 domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene SCP domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in tRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of CURI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Nucleolar protein 6
    NP_001364780.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1425732..1437499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377698.2NP_001364780.1  Nucleolar protein 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XY4
      Conserved Domains (6) summary
      pfam03813
      Location:104231
      Nrap; Nrap protein domain 1
      pfam17403
      Location:237365
      Nrap_D2; Nrap protein PAP/OAS-like domain
      pfam17404
      Location:369528
      Nrap_D3; Nrap protein domain 3
      pfam17405
      Location:542748
      Nrap_D4; Nrap protein nucleotidyltransferase domain 4
      pfam17406
      Location:750899
      Nrap_D5; Nrap protein PAP/OAS1-like domain 5
      pfam17407
      Location:9081030
      Nrap_D6; Nrap protein domain 6