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Conserved domains on  [gi|1799133513|ref|NP_001364780|]
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Nucleolar protein 6 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 750-890 5.16e-39

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465419  Cd Length: 157  Bit Score: 142.32  E-value: 5.16e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  750 HKFFGSTVQLFKKWLGSKFLSGHhLNDHIIELLVVAA-IGKKGQVPPQSTWSSFCRLLSLISTHPWSARPLIVDFGTKgF 828
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGH-VSEELVELLVASVfLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNS-L 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  829 SEDERSKLEEKFIKMRPILP-----PMVVIYEEDHLGSKFTRENPQGIVLNRLVAVAREALKMMEKQ 890
Cdd:pfam17406   79 TAEDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQ 145
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 542-748 7.99e-34

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465418  Cd Length: 201  Bit Score: 128.88  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  542 STSAEADQQHEKKSQEAVFKAYTDLSTVLRGLKGLPLMITNVHGISGYLRGSEPAYPSVFAATSstnkssedqhYVLPei 621
Cdd:pfam17405    7 PPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA----------YSPP-- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  622 gkiplftptVTVHIKLEYSGKWGNDVEAIRRLTSSFYVKIAERLREQH-KLTAVPTIDQ----------LFILK-SGIVF 689
Cdd:pfam17405   75 ---------IDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNsGYKARVGLDNsippilnqafLDVLYpSGYVF 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1799133513  690 KIVVVNDRILTILEEDVqklKDSGASRIESSIQGMRLSMWKKKFISEPLLQLSLQSFST 748
Cdd:pfam17405  146 RLRIHHDREETLLERQL---KDKGLARYQREEAAEALAKYKRRFIHLPRHTQAIQTLCT 201
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 369-527 1.89e-30

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465417  Cd Length: 159  Bit Score: 117.75  E-value: 1.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  369 FAHYDHVARLHINISQlAEHLVEFGIDSIDNRDVIHKFVLSFEHKIEQTMSERYDFVGIHdissnAEKSTWSLSEYPEKY 448
Cdd:pfam17404    2 LLRFDLVLRIPLPLSA-SLLSKFGPLEKIDFIGFENALLRKLYSLLKRALGDRAKLIHIQ-----LPSPSWSISKRKPSP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  449 RQKTYL-IGFR-STSGWKNPLTVGPPA-QTNDAKEFRELWKETSELRKFADTRICECVVWSEKPSE--KVPRAVLQFVLQ 523
Cdd:pfam17404   76 ANPSSIlIGLLlNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSerLIVEQIVKYILK 155


                   ....
gi 1799133513  524 KMFS 527
Cdd:pfam17404  156 RHLG 159
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 908-1030 1.63e-21

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465420  Cd Length: 128  Bit Score: 91.21  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  908 LSPYDAIINLEPCAVVRKKalmERKPPAETSKFR-------QKIPVVELDPVDELVYQLNNSFQQVAMFFYNKYGGHHIG 980
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLS---SAPGILSKSKFKnldlrltSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIG 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1799133513  981 VMFKPQEDEvPAKIsRCSLHKS---VSDSTLRLNRDEILENIQILGQGIVSDV 1030
Cdd:pfam17407   78 GLWNPAVLK-PRKF-KVNLGYNtkpVDKKEVVLNKEAILEEIARLGGDLVKSI 128
Nrap super family cl09313
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 104-231 7.62e-11

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


The actual alignment was detected with superfamily member pfam03813:

Pssm-ID: 461061  Cd Length: 144  Bit Score: 61.05  E-value: 7.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  104 IFIEIPPKALGNRDFLNLTYAAKRGHFACHVA-----RLLSGKFEKVEFTaggAHRDDPIFADILVDG------------ 166
Cdd:pfam03813    3 LAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAahlskSLKKDDLLKVSFS---YLNGDPLKPILVLRPkktegkfskskf 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  167 -VRIGFYCPE-LAKTKRFAPNIGNLRPATIFEDlfkETEIATPKFNQRMLWSILELEIAQEMEKELK 231
Cdd:pfam03813   80 tIRIIPCAPSgLFPLSKLLPSKNNIRPATDSEE---TTLPPTPFYNSSILSDLTLLAYLKLLHKTKK 143
Nrap_D2 super family cl38683
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 237-365 1.25e-08

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


The actual alignment was detected with superfamily member pfam17403:

Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 54.92  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  237 RLAIFLLGNFFENRHL----QHAITPIILTARVVRLV------KNGKITENQEILTVLRVIFEDFIT--WSADDVEFVDS 304
Cdd:pfam17403    3 KDACILLKVWLRQRGFgsssKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATtdLTKKPIFFKSD 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133513  305 VEDDVDVEE-YSQLFDVNLVWKN--LNLASNLTKNYMERMKKELTICYPLL--GQVYAFDPIFIEK 365
Cdd:pfam17403   83 SDSKYPSEEeFHQHFDPVFVDPSggLNLLAKMTPSSYQLLRHEAKLTLELLndSSVDGFDPLFLTK 148
 
Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 750-890 5.16e-39

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 142.32  E-value: 5.16e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  750 HKFFGSTVQLFKKWLGSKFLSGHhLNDHIIELLVVAA-IGKKGQVPPQSTWSSFCRLLSLISTHPWSARPLIVDFGTKgF 828
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGH-VSEELVELLVASVfLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNS-L 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  829 SEDERSKLEEKFIKMRPILP-----PMVVIYEEDHLGSKFTRENPQGIVLNRLVAVAREALKMMEKQ 890
Cdd:pfam17406   79 TAEDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQ 145
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 542-748 7.99e-34

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 128.88  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  542 STSAEADQQHEKKSQEAVFKAYTDLSTVLRGLKGLPLMITNVHGISGYLRGSEPAYPSVFAATSstnkssedqhYVLPei 621
Cdd:pfam17405    7 PPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA----------YSPP-- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  622 gkiplftptVTVHIKLEYSGKWGNDVEAIRRLTSSFYVKIAERLREQH-KLTAVPTIDQ----------LFILK-SGIVF 689
Cdd:pfam17405   75 ---------IDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNsGYKARVGLDNsippilnqafLDVLYpSGYVF 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1799133513  690 KIVVVNDRILTILEEDVqklKDSGASRIESSIQGMRLSMWKKKFISEPLLQLSLQSFST 748
Cdd:pfam17405  146 RLRIHHDREETLLERQL---KDKGLARYQREEAAEALAKYKRRFIHLPRHTQAIQTLCT 201
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 369-527 1.89e-30

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 117.75  E-value: 1.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  369 FAHYDHVARLHINISQlAEHLVEFGIDSIDNRDVIHKFVLSFEHKIEQTMSERYDFVGIHdissnAEKSTWSLSEYPEKY 448
Cdd:pfam17404    2 LLRFDLVLRIPLPLSA-SLLSKFGPLEKIDFIGFENALLRKLYSLLKRALGDRAKLIHIQ-----LPSPSWSISKRKPSP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  449 RQKTYL-IGFR-STSGWKNPLTVGPPA-QTNDAKEFRELWKETSELRKFADTRICECVVWSEKPSE--KVPRAVLQFVLQ 523
Cdd:pfam17404   76 ANPSSIlIGLLlNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSerLIVEQIVKYILK 155


                   ....
gi 1799133513  524 KMFS 527
Cdd:pfam17404  156 RHLG 159
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 908-1030 1.63e-21

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 91.21  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  908 LSPYDAIINLEPCAVVRKKalmERKPPAETSKFR-------QKIPVVELDPVDELVYQLNNSFQQVAMFFYNKYGGHHIG 980
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLS---SAPGILSKSKFKnldlrltSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIG 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1799133513  981 VMFKPQEDEvPAKIsRCSLHKS---VSDSTLRLNRDEILENIQILGQGIVSDV 1030
Cdd:pfam17407   78 GLWNPAVLK-PRKF-KVNLGYNtkpVDKKEVVLNKEAILEEIARLGGDLVKSI 128
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 104-231 7.62e-11

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 61.05  E-value: 7.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  104 IFIEIPPKALGNRDFLNLTYAAKRGHFACHVA-----RLLSGKFEKVEFTaggAHRDDPIFADILVDG------------ 166
Cdd:pfam03813    3 LAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAahlskSLKKDDLLKVSFS---YLNGDPLKPILVLRPkktegkfskskf 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  167 -VRIGFYCPE-LAKTKRFAPNIGNLRPATIFEDlfkETEIATPKFNQRMLWSILELEIAQEMEKELK 231
Cdd:pfam03813   80 tIRIIPCAPSgLFPLSKLLPSKNNIRPATDSEE---TTLPPTPFYNSSILSDLTLLAYLKLLHKTKK 143
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 237-365 1.25e-08

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 54.92  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  237 RLAIFLLGNFFENRHL----QHAITPIILTARVVRLV------KNGKITENQEILTVLRVIFEDFIT--WSADDVEFVDS 304
Cdd:pfam17403    3 KDACILLKVWLRQRGFgsssKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATtdLTKKPIFFKSD 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133513  305 VEDDVDVEE-YSQLFDVNLVWKN--LNLASNLTKNYMERMKKELTICYPLL--GQVYAFDPIFIEK 365
Cdd:pfam17403   83 SDSKYPSEEeFHQHFDPVFVDPSggLNLLAKMTPSSYQLLRHEAKLTLELLndSSVDGFDPLFLTK 148
 
Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 750-890 5.16e-39

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 142.32  E-value: 5.16e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  750 HKFFGSTVQLFKKWLGSKFLSGHhLNDHIIELLVVAA-IGKKGQVPPQSTWSSFCRLLSLISTHPWSARPLIVDFGTKgF 828
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGH-VSEELVELLVASVfLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNS-L 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  829 SEDERSKLEEKFIKMRPILP-----PMVVIYEEDHLGSKFTRENPQGIVLNRLVAVAREALKMMEKQ 890
Cdd:pfam17406   79 TAEDIKEIETRFEAWRKSDPamnhtALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALKLLEEQ 145
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 542-748 7.99e-34

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 128.88  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  542 STSAEADQQHEKKSQEAVFKAYTDLSTVLRGLKGLPLMITNVHGISGYLRGSEPAYPSVFAATSstnkssedqhYVLPei 621
Cdd:pfam17405    7 PPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA----------YSPP-- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  622 gkiplftptVTVHIKLEYSGKWGNDVEAIRRLTSSFYVKIAERLREQH-KLTAVPTIDQ----------LFILK-SGIVF 689
Cdd:pfam17405   75 ---------IDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNsGYKARVGLDNsippilnqafLDVLYpSGYVF 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1799133513  690 KIVVVNDRILTILEEDVqklKDSGASRIESSIQGMRLSMWKKKFISEPLLQLSLQSFST 748
Cdd:pfam17405  146 RLRIHHDREETLLERQL---KDKGLARYQREEAAEALAKYKRRFIHLPRHTQAIQTLCT 201
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 369-527 1.89e-30

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 117.75  E-value: 1.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  369 FAHYDHVARLHINISQlAEHLVEFGIDSIDNRDVIHKFVLSFEHKIEQTMSERYDFVGIHdissnAEKSTWSLSEYPEKY 448
Cdd:pfam17404    2 LLRFDLVLRIPLPLSA-SLLSKFGPLEKIDFIGFENALLRKLYSLLKRALGDRAKLIHIQ-----LPSPSWSISKRKPSP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  449 RQKTYL-IGFR-STSGWKNPLTVGPPA-QTNDAKEFRELWKETSELRKFADTRICECVVWSEKPSE--KVPRAVLQFVLQ 523
Cdd:pfam17404   76 ANPSSIlIGLLlNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSerLIVEQIVKYILK 155


                   ....
gi 1799133513  524 KMFS 527
Cdd:pfam17404  156 RHLG 159
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 908-1030 1.63e-21

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 91.21  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  908 LSPYDAIINLEPCAVVRKKalmERKPPAETSKFR-------QKIPVVELDPVDELVYQLNNSFQQVAMFFYNKYGGHHIG 980
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLS---SAPGILSKSKFKnldlrltSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIG 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1799133513  981 VMFKPQEDEvPAKIsRCSLHKS---VSDSTLRLNRDEILENIQILGQGIVSDV 1030
Cdd:pfam17407   78 GLWNPAVLK-PRKF-KVNLGYNtkpVDKKEVVLNKEAILEEIARLGGDLVKSI 128
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 104-231 7.62e-11

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 61.05  E-value: 7.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  104 IFIEIPPKALGNRDFLNLTYAAKRGHFACHVA-----RLLSGKFEKVEFTaggAHRDDPIFADILVDG------------ 166
Cdd:pfam03813    3 LAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAahlskSLKKDDLLKVSFS---YLNGDPLKPILVLRPkktegkfskskf 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133513  167 -VRIGFYCPE-LAKTKRFAPNIGNLRPATIFEDlfkETEIATPKFNQRMLWSILELEIAQEMEKELK 231
Cdd:pfam03813   80 tIRIIPCAPSgLFPLSKLLPSKNNIRPATDSEE---TTLPPTPFYNSSILSDLTLLAYLKLLHKTKK 143
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 237-365 1.25e-08

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 54.92  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133513  237 RLAIFLLGNFFENRHL----QHAITPIILTARVVRLV------KNGKITENQEILTVLRVIFEDFIT--WSADDVEFVDS 304
Cdd:pfam17403    3 KDACILLKVWLRQRGFgsssKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATtdLTKKPIFFKSD 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133513  305 VEDDVDVEE-YSQLFDVNLVWKN--LNLASNLTKNYMERMKKELTICYPLL--GQVYAFDPIFIEK 365
Cdd:pfam17403   83 SDSKYPSEEeFHQHFDPVFVDPSggLNLLAKMTPSSYQLLRHEAKLTLELLndSSVDGFDPLFLTK 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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