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    ATP7 ATP7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32142, updated on 9-Dec-2024

    Summary

    Official Symbol
    ATP7provided by FlyBase
    Official Full Name
    ATP7provided by FlyBase
    Primary source
    FLYBASE:FBgn0030343
    Locus tag
    Dmel_CG1886
    See related
    AllianceGenome:FB:FBgn0030343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atp7; Atp7; Atp7A; CG1886; dATP7; dmATP7; DmATP7; Dmel\CG1886; lincRNA.S9122
    Summary
    Enables copper ion transmembrane transporter activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; copper ion import across plasma membrane; and intracellular copper ion homeostasis. Located in cytoplasm and plasma membrane. Is expressed in several structures, including epithelial tube; ganglia; gonad; gut section; and organism subdivision. Used to study Menkes disease and metal metabolism disorder. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ATP7 in Genome Data Viewer
    Location:
    10F1-10F2; 1-37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11855022..11864754)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11749055..11758787)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene p24-related-1 Neighboring gene uncharacterized protein Neighboring gene Nardilysin Neighboring gene uncharacterized protein Neighboring gene BLOC-1 related complex subunit 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity  
    enables P-type divalent copper transporter activity  
    enables copper ion binding  
    enables copper ion binding  
    enables copper ion binding PubMed 
    enables copper ion transmembrane transporter activity PubMed 
    Process Evidence Code Pubs
    involved_in adult chitin-containing cuticle pigmentation PubMed 
    involved_in copper ion export  
    involved_in copper ion import  
    involved_in copper ion import across plasma membrane PubMed 
    involved_in developmental pigmentation PubMed 
    involved_in intracellular copper ion homeostasis  
    involved_in intracellular copper ion homeostasis PubMed 
    involved_in larval development PubMed 
    involved_in monoatomic cation transport  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in trans-Golgi network  

    General protein information

    Preferred Names
    ATP7
    Names
    ATP7-PB
    ATP7-PC
    CG1886-PB
    CG1886-PC
    NP_001259466.1
    NP_572756.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11855022..11864754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272537.2 → NP_001259466.1  ATP7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDF6, Q9VYT4
      Conserved Domains (4) summary
      COG2217
      Location:285 → 1131
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:984 → 1085
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:97 → 159
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:489 → 735
      E1-E2_ATPase; E1-E2 ATPase
    2. NM_132528.3 → NP_572756.3  ATP7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572756.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDF6, Q9VYT4
      Conserved Domains (4) summary
      COG2217
      Location:285 → 1131
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:984 → 1085
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:97 → 159
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:489 → 735
      E1-E2_ATPase; E1-E2 ATPase
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