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    chchd3a coiled-coil-helix-coiled-coil-helix domain containing 3a [ Danio rerio (zebrafish) ]

    Gene ID: 407730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chchd3aprovided by ZNC
    Official Full Name
    coiled-coil-helix-coiled-coil-helix domain containing 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5005
    See related
    Ensembl:ENSDARG00000032919 AllianceGenome:ZFIN:ZDB-GENE-030131-5005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chchd3; mic19a; plxna4; wu:fe23h05; zgc:111837; si:rp71-18a24.1
    Summary
    Predicted to be involved in inner mitochondrial membrane organization. Predicted to be located in membrane and mitochondrion. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chchd3a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15490215..15603588, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15491460..15604833, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene plexin A4 Neighboring gene uncharacterized LOC103910431 Neighboring gene uncharacterized LOC137491534 Neighboring gene exocyst complex component 4 Neighboring gene si:ch211-92l17.1 Neighboring gene uncharacterized LOC137491535

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria. Martorano L, et al. Dis Model Mech, 2019 Mar 14. PMID 30833296, Free PMC Article
    2. Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Ota S, et al. Sci Rep, 2016 Oct 11. PMID 27725766, Free PMC Article
    3. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Huang M, et al. Nat Commun, 2022 Oct 5. PMID 36198703, Free PMC Article
    4. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
    5. Functional analysis of human hematopoietic stem cell gene expression using zebrafish. Eckfeldt CE, et al. PLoS Biol, 2005 Aug. PMID 16089502, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20420

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil-helix-coiled-coil-helix domain containing 3a
    Names
    coiled-coil-helix-coiled-coil-helix domain containing 3
    plexin A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309796.1 → NP_001296725.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BX649386, BX649446
      UniProtKB/TrEMBL
      A0A0R4IUL1, A0A8M1P7S4
      Related
      ENSDARP00000139417.2, ENSDART00000162356.2
      Conserved Domains (1) summary
      pfam05300
      Location:15 → 260
      DUF737; Protein of unknown function (DUF737)

    2. NM_214804.2 → NP_999969.2  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX649386, BX649446
      UniProtKB/TrEMBL
      A0A8M1PRC5, A0A8M9Q0D0, E7FFW8, Q5RH04
      Related
      ENSDARP00000105322.2, ENSDART00000122520.4
      Conserved Domains (1) summary
      pfam05300
      Location:15 → 265
      DUF737; Protein of unknown function (DUF737)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      15490215..15603588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300263.4 → XP_009298538.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M3ARL8, A0A8M3B1Q0
      Conserved Domains (1) summary
      pfam05300
      Location:209 → 372
      DUF737; Protein of unknown function (DUF737)

    2. XM_009300261.4 → XP_009298536.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M3ARL8, A0A8M3B8X9
      Conserved Domains (1) summary
      pfam05300
      Location:209 → 377
      DUF737; Protein of unknown function (DUF737)
    Nucleotide Protein Strain
    Heading Accession and Version

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