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    Dph7 diphthamine biosynethesis 7 [ Mus musculus (house mouse) ]

    Gene ID: 67228, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dph7provided by MGI
    Official Full Name
    diphthamine biosynethesis 7provided by MGI
    Primary source
    MGI:MGI:1914478
    See related
    Ensembl:ENSMUSG00000026975 AllianceGenome:MGI:1914478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr85; 2810443J12Rik
    Summary
    Predicted to enable diphthine methylesterase activity and protein methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be active in cytoplasm. Orthologous to human DPH7 (diphthamide biosynthesis 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.3), limb E14.5 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dph7 in Genome Data Viewer
    Location:
    2 A3; 2 16.87 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24852183..24862198)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24962171..24972186)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene STARR-positive B cell enhancer ABC_E5898 Neighboring gene STARR-positive B cell enhancer ABC_E1001 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. Wei H, et al. J Biol Chem, 2013 Apr 26. PMID 23486472, Free PMC Article
    2. Haploid genetic screens in human cells identify host factors used by pathogens. Carette JE, et al. Science, 2009 Nov 27. PMID 19965467
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables diphthine methylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphthine methylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein methylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diphthine methyltransferase
    Names
    WD repeat domain 85
    WD repeat-containing protein 85
    WD40 repeat domain 85
    diphthamide biosynthesis protein 7
    NP_001342483.1
    NP_001342485.1
    NP_001342486.1
    NP_001342487.1
    NP_001342488.1
    NP_001342489.1
    NP_001342490.1
    NP_080320.1
    XP_006498304.1
    XP_006498305.1
    XP_006498306.1
    XP_006498308.1
    XP_006498309.1
    XP_006498310.1
    XP_030107843.1
    XP_030107844.1
    XP_030107845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355554.1 → NP_001342483.1  diphthine methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AK153537, AL732585
      Conserved Domains (2) summary
      COG2319
      Location:38 → 207
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:29 → 65
      7WD40; WD40 repeat [structural motif]

    2. NM_001355556.1 → NP_001342485.1  diphthine methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform c.
      Source sequence(s)
      AL732585
      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    3. NM_001355557.1 → NP_001342486.1  diphthine methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
      Source sequence(s)
      AL732585
      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    4. NM_001355558.1 → NP_001342487.1  diphthine methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AL732585
      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    5. NM_001355559.1 → NP_001342488.1  diphthine methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform c.
      Source sequence(s)
      AL732585, BC086486
      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    6. NM_001355560.1 → NP_001342489.1  diphthine methyltransferase isoform d

      Status: VALIDATED

      Source sequence(s)
      AI430704, AL732585
      Conserved Domains (2) summary
      COG2319
      Location:16 → 134
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:46 → 82
      7WD40; WD40 repeat [structural motif]

    7. NM_001355561.1 → NP_001342490.1  diphthine methyltransferase isoform e

      Status: VALIDATED

      Source sequence(s)
      AL732585, CX221778
      Conserved Domains (2) summary
      COG2319
      Location:7 → 124
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]

    8. NM_026044.4 → NP_080320.1  diphthine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_080320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK013297, AK152000, AL732585
      Consensus CDS
      CCDS15743.1
      UniProtKB/Swiss-Prot
      A2AJ86, Q5RJV7, Q8BIT9, Q9CYU6
      Related
      ENSMUSP00000028351.4, ENSMUST00000028351.9
      Conserved Domains (3) summary
      COG2319
      Location:107 → 329
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:90 → 137
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:186 → 330
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24852183..24862198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498241.2 → XP_006498304.1  diphthine methyltransferase isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:86 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:77 → 113
      7WD40; WD40 repeat [structural motif]

    2. XM_006498242.4 → XP_006498305.1  diphthine methyltransferase isoform X2

      Conserved Domains (2) summary
      COG2319
      Location:16 → 238
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:60 → 96
      7WD40; WD40 repeat [structural motif]

    3. XM_006498245.2 → XP_006498308.1  diphthine methyltransferase isoform X4

      See identical proteins and their annotated locations for XP_006498308.1

      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    4. XM_006498246.2 → XP_006498309.1  diphthine methyltransferase isoform X4

      See identical proteins and their annotated locations for XP_006498309.1

      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    5. XM_030251983.1 → XP_030107843.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    6. XM_006498243.4 → XP_006498306.1  diphthine methyltransferase isoform X3

      Conserved Domains (2) summary
      COG2319
      Location:41 → 210
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:32 → 68
      7WD40; WD40 repeat [structural motif]

    7. XM_030251984.1 → XP_030107844.1  diphthine methyltransferase isoform X5

      Conserved Domains (2) summary
      COG2319
      Location:7 → 124
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]

    8. XM_006498247.2 → XP_006498310.1  diphthine methyltransferase isoform X4

      See identical proteins and their annotated locations for XP_006498310.1

      UniProtKB/TrEMBL
      Q3U5K4
      Conserved Domains (2) summary
      COG2319
      Location:15 → 184
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6 → 42
      7WD40; WD40 repeat [structural motif]

    9. XM_030251985.2 → XP_030107845.1  diphthine methyltransferase isoform X5

      Conserved Domains (2) summary
      COG2319
      Location:7 → 124
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYU6.1 GenPept UniProtKB/Swiss-Prot:Q9CYU6

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