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Conserved domains on  [gi|1243938383|ref|NP_001342486|]
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diphthine methyltransferase isoform c [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
18-154 1.89e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  18 IISSDSKGQLHLLMVNEGtaelQLVASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVC 97
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1243938383  98 SIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPVHHHLLLA 154
Cdd:COG2319   335 SVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
18-154 1.89e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  18 IISSDSKGQLHLLMVNEGtaelQLVASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVC 97
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1243938383  98 SIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPVHHHLLLA 154
Cdd:COG2319   335 SVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-185 3.75e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  41 LVASWPAHHFEAWIAAFNYwQTELVYSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLL 120
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1243938383 121 WDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEMP 185
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD----VETGKCLTTLRGHTDW 137
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-130 5.63e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  17 KIISSDSKGQLHLLMVnegtAELQLVASWPAHHFEAWIAAFNYWQTELVYSGGDDCLLRGWDTRMlGTPVFTSKRHCmGV 96
Cdd:PLN00181  547 QVASSNFEGVVQVWDV----ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKA-NI 620

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1243938383  97 CSIQSSPHQEHILATGSYDEHVLLWDTRNIRQPL 130
Cdd:PLN00181  621 CCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPL 654
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 83-122 1.77e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938383   83 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 122
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
18-154 1.89e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  18 IISSDSKGQLHLLMVNEGtaelQLVASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVC 97
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1243938383  98 SIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPVHHHLLLA 154
Cdd:COG2319   335 SVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
17-195 5.55e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  17 KIISSDSKGQLHLLMVNEGtaelQLVASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGTPVFTSKRHCMGV 96
Cdd:COG2319   134 TLASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  97 CSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVPVQGG-VWRLKWHPvHHHLLLAACMHNGFKILNcqkaIEEKQD 175
Cdd:COG2319   208 RSVAFSPDG-KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGsVRSVAFSP-DGRLLASGSADGTVRLWD----LATGEL 280

                         170       180
                  ....*....|....*....|
gi 1243938383 176 ITVLTSHempNSLVYGADWS 195
Cdd:COG2319   281 LRTLTGH---SGGVNSVAFS 297
WD40 COG2319
WD40 repeat [General function prediction only];
18-125 1.14e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  18 IISSDSKGQLHLLMVNEGtaelQLVASWPAHHFEAWIAAFNYWQTELVySGGDDCLLRGWDTRmLGTPVFTSKRHCMGVC 97
Cdd:COG2319   303 LASGSDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA-TGELLRTLTGHTGAVT 376

                          90       100
                  ....*....|....*....|....*...
gi 1243938383  98 SIQSSPHqEHILATGSYDEHVLLWDTRN 125
Cdd:COG2319   377 SVAFSPD-GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-185 3.75e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  41 LVASWPAHHFEAWIAAFNYwQTELVYSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLL 120
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1243938383 121 WDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEMP 185
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD----VETGKCLTTLRGHTDW 137
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-198 4.33e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 4.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  63 ELVYSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNIRqpladvPVQ------ 136
Cdd:cd00200   106 RILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK------CVAtltght 177

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1243938383 137 GGVWRLKWHPVHHHLLLAACmHNGFKILNCQKAIEekqdITVLTSHEMP-NSLVYGADWSWLF 198
Cdd:cd00200   178 GEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC----LGTLRGHENGvNSVAFSPDGYLLA 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-196 5.61e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  85 PVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKIL 164
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1243938383 165 NcqkaIEEKQDITVLTSHEmpnSLVYGADWSW 196
Cdd:cd00200    79 D----LETGECVRTLTGHT---SYVSSVAFSP 103
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-130 5.63e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938383  17 KIISSDSKGQLHLLMVnegtAELQLVASWPAHHFEAWIAAFNYWQTELVYSGGDDCLLRGWDTRMlGTPVFTSKRHCmGV 96
Cdd:PLN00181  547 QVASSNFEGVVQVWDV----ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKA-NI 620

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1243938383  97 CSIQSSPHQEHILATGSYDEHVLLWDTRNIRQPL 130
Cdd:PLN00181  621 CCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPL 654
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 83-122 1.77e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938383   83 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 122
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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