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    FUS6 COP9 signalosome complex subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825286, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FUS6
    Official Full Name
    COP9 signalosome complex subunit 1
    Primary source
    TAIR:AT3G61140
    Locus tag
    AT3G61140
    See related
    Araport:AT3G61140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA FUSCA 6; AtCSN1; ATFUS6; ATSK31; CONSTITUTIVE PHOTOMORPHOGENIC 11; COP11; COP9 SIGNALOSOME SUBUNIT 1; CSN1; EMB78; EMBRYO DEFECTIVE 78; FUSCA 6; SHAGGY-LIKE KINASE 31; SK31
    Summary
    Represses photomorphogenesis and induces skotomorphogenesis in the dark. Component of the nuclear-localized COP9 complex. Mutants display striking purple coloration due to anthocyanin accumulation in their cotyledons, first become defective during embryogenesis and exhibit limited seedling development.
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    Genomic context

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    See FUS6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (22626167..22630141)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 13 Neighboring gene galacturonosyltransferase 1 Neighboring gene homeodomain GLABROUS 1 Neighboring gene Protein kinase superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A FUSCA gene of Arabidopsis encodes a novel protein essential for plant development. Castle LA, et al. Plant Cell, 1994 Jan. PMID 8130643, Free PMC Article
    2. Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants. Wei N, et al. Photochem Photobiol, 1998 Aug. PMID 9723217
    3. Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis. Staub JM, et al. Plant Cell, 1996 Nov. PMID 8953769, Free PMC Article
    4. Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex. Karniol B, et al. Plant Cell, 1999 May. PMID 10330469, Free PMC Article
    5. The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. Karniol B, et al. FEBS Lett, 1998 Nov 13. PMID 9849901

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSA1 interacts with CSN1 and is involved in Arabidopsis seedling development in darkness.
      Title: TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness.
    2. CSN1 can mediate COP1 nuclear translocation, and COP1 interacts with CSN1-NTD through its coiled-coil domain.
      Title: Regulation of COP1 nuclear localization by the COP9 signalosome via direct interaction with CSN1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115978.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 1
    NP_567109.1
    • FUSCA 6 (FUS6); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717), 26S proteasome, regulatory subunit Rpn7 (InterPro:IPR019585); BEST Arabidopsis thaliana protein match is: COP9 signalosome complex-related / CSN complex-related (TAIR:AT3G12850.1); Has 1199 Blast hits to 1198 proteins in 240 species: Archae - 0; Bacteria - 0; Metazoa - 515; Fungi - 231; Plants - 316; Viruses - 0; Other Eukaryotes - 137 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22626167..22630141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115978.4 → NP_567109.1  COP9 signalosome complex subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45432, Q8GYL2, Q9C5F0, Q9M2E9, Q9M4G0
      UniProtKB/TrEMBL
      A0A178VFN7, A0A5S9XMN6
      Conserved Domains (2) summary
      pfam01399
      Location:293 → 397
      PCI; PCI domain
      pfam10602
      Location:104 → 278
      RPN7; 26S proteasome subunit RPN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45432.2

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