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Conserved domains on  [gi|18411857|ref|NP_567109|]
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COP9 signalosome complex subunit 1 [Arabidopsis thaliana]

Protein Classification

COP9 signalosome complex subunit 1( domain architecture ID 10566214)

The COP9 signalosome subunit 1 (CSN1) is an essential component of the CSN complex and is involved in the deubiquitination of target proteins which helps to regulate the stability and activity of a variety of proteins involved in different cellular pathways

Gene Ontology:  GO:0000338|GO:0008180|GO:2000434
PubMed:  27029275|9644972
SCOP:  4000147

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
104-278 3.03e-66

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 209.35  E-value: 3.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   104 DLAWCEAVDRRAEQKKVKLENELSSYRTNLIKESIRMGYNDFGDFYYACGMLGDAFKNYIRTRDYCTTTKHIIHMCMNAI 183
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   184 LVSIEMGQFTHVTSYVNKAEQNPETLEPM-VNAKLRCASGLAHLELKKYKLAARKFLDVNPELGNsyNEVIAPQDIATYG 262
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWeRRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS--TELISYEDVAVYG 158
                         170
                  ....*....|....*.
gi 18411857   263 GLCALASFDRSELKQK 278
Cdd:pfam10602 159 VLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
293-397 5.35e-25

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 98.44  E-value: 5.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   293 PDVRELINDFYSSRYASCLEYLASLKSNLLLDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKE 372
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 18411857   373 LEALITDNQIQARIDSHNKILYARH 397
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
104-278 3.03e-66

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 209.35  E-value: 3.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   104 DLAWCEAVDRRAEQKKVKLENELSSYRTNLIKESIRMGYNDFGDFYYACGMLGDAFKNYIRTRDYCTTTKHIIHMCMNAI 183
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   184 LVSIEMGQFTHVTSYVNKAEQNPETLEPM-VNAKLRCASGLAHLELKKYKLAARKFLDVNPELGNsyNEVIAPQDIATYG 262
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWeRRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS--TELISYEDVAVYG 158
                         170
                  ....*....|....*.
gi 18411857   263 GLCALASFDRSELKQK 278
Cdd:pfam10602 159 VLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
293-397 5.35e-25

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 98.44  E-value: 5.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   293 PDVRELINDFYSSRYASCLEYLASLKSNLLLDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKE 372
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 18411857   373 LEALITDNQIQARIDSHNKILYARH 397
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
146-412 1.63e-21

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 96.14  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 146 GDFYYACGMLGDAFKNYIRTRDYCTTTKhiihMCMNAILVSIEMGQFTHVTSYVnkaEQNPETLEPMVNA--------KL 217
Cdd:COG5187 122 AEYYCQIMDIQNGFEWMRRLMRDAMSTG----LKIDVFLCKIRLGLIYGDRKVV---EESLEVADDIIEKggdwerrnRY 194
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 218 RCASGLAHLELKKYKLAARKFLDVNPELGNSynEVIAPQDIATYGGLCALASFDRSELKQKVIDNINFRNFL---ELVPD 294
Cdd:COG5187 195 KVYKGIFKMMRRNFKEAAILLSDILPTFESS--ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEVLDVIgssEKLGS 272
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 295 VRELINDFYSSRYASCLEYLASLKSNLLL-DIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKEL 373
Cdd:COG5187 273 LVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTFGVSVEYVDRDL 352
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18411857 374 EALITDNQIQARIDSHNKILYARHADQRNATFQKVLQMG 412
Cdd:COG5187 353 GEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQG 391
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
330-412 1.38e-17

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 77.28  E-value: 1.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857    330 HVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKELEALITDNQIQARIDSHNKILYARHADQR----NATF 405
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRrsepLAQF 81

                   ....*..
gi 18411857    406 QKVLQMG 412
Cdd:smart00088  82 AETLKKL 88
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
104-278 3.03e-66

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 209.35  E-value: 3.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   104 DLAWCEAVDRRAEQKKVKLENELSSYRTNLIKESIRMGYNDFGDFYYACGMLGDAFKNYIRTRDYCTTTKHIIHMCMNAI 183
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   184 LVSIEMGQFTHVTSYVNKAEQNPETLEPM-VNAKLRCASGLAHLELKKYKLAARKFLDVNPELGNsyNEVIAPQDIATYG 262
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWeRRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS--TELISYEDVAVYG 158
                         170
                  ....*....|....*.
gi 18411857   263 GLCALASFDRSELKQK 278
Cdd:pfam10602 159 VLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
293-397 5.35e-25

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 98.44  E-value: 5.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857   293 PDVRELINDFYSSRYASCLEYLASLKSNLLLDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKE 372
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 18411857   373 LEALITDNQIQARIDSHNKILYARH 397
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
146-412 1.63e-21

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 96.14  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 146 GDFYYACGMLGDAFKNYIRTRDYCTTTKhiihMCMNAILVSIEMGQFTHVTSYVnkaEQNPETLEPMVNA--------KL 217
Cdd:COG5187 122 AEYYCQIMDIQNGFEWMRRLMRDAMSTG----LKIDVFLCKIRLGLIYGDRKVV---EESLEVADDIIEKggdwerrnRY 194
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 218 RCASGLAHLELKKYKLAARKFLDVNPELGNSynEVIAPQDIATYGGLCALASFDRSELKQKVIDNINFRNFL---ELVPD 294
Cdd:COG5187 195 KVYKGIFKMMRRNFKEAAILLSDILPTFESS--ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEVLDVIgssEKLGS 272
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 295 VRELINDFYSSRYASCLEYLASLKSNLLL-DIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKEL 373
Cdd:COG5187 273 LVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTFGVSVEYVDRDL 352
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18411857 374 EALITDNQIQARIDSHNKILYARHADQRNATFQKVLQMG 412
Cdd:COG5187 353 GEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQG 391
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
330-412 1.38e-17

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 77.28  E-value: 1.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857    330 HVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKELEALITDNQIQARIDSHNKILYARHADQR----NATF 405
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRrsepLAQF 81

                   ....*..
gi 18411857    406 QKVLQMG 412
Cdd:smart00088  82 AETLKKL 88
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
211-429 9.27e-08

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 54.15  E-value: 9.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 211 PMVNAKLRCASGLAHLELKKYKLAARKFLDVNPELGNSYNEVIAPQDIaTYGGLCALASFDRSELKQKVIDNINFRNFLE 290
Cdd:COG5159 202 PQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGFTLLKMDVKACVSL-KYMLLSKIMLNRREEVKAVLRNKNTLKHYDD 280
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411857 291 LVPDVRELINDFYSSRyaSCLEY---LASLKSNLLLDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVS 367
Cdd:COG5159 281 RMIRAMLAVAEAFGNR--SLKDFsdaLAQYSDELHQDSFIRSHLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTN 358
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18411857 368 GLEKELEALITDNQIQARIDSHNKILYARHADQRNATFQKVLQMGNEFDRDVRAMLLRANLL 429
Cdd:COG5159 359 QVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYDEALEQVEALDCVVDSLYEKASAL 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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