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    Lrp4 LDL receptor related protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrp4provided by FlyBase
    Official Full Name
    LDL receptor related protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030706
    Locus tag
    Dmel_CG8909
    See related
    AllianceGenome:FB:FBgn0030706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8909; CT25574; Dm CG8909; Dmel\CG8909; lrp4; LRP4
    Summary
    Predicted to enable calcium ion binding activity. Involved in presynaptic active zone organization. Located in axon terminus. Is expressed in adult head; brain; larval nervous system; larval ventral nerve cord; and neurons. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lrp4 in Genome Data Viewer
    Location:
    14A1-14A1; 1-52 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15910870..15921013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15804903..15815046)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene shibire Neighboring gene Cyclin D Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45000 Neighboring gene Ligand-gated chloride channel homolog 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses. DePew AT, et al. Development, 2024 Jun 1. PMID 38738619, Free PMC Article
    2. Conservation and Innovation: Versatile Roles for LRP4 in Nervous System Development. DePew AT, et al. J Dev Biol, 2021 Mar 14. PMID 33799485, Free PMC Article
    3. Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons. Mosca TJ, et al. Elife, 2017 Jun 13. PMID 28606304, Free PMC Article
    4. R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners. Douthit J, et al. Elife, 2021 May 18. PMID 34003117, Free PMC Article
    5. Cyclin D does not provide essential Cdk4-independent functions in Drosophila. Emmerich J, et al. Genetics, 2004 Oct. PMID 15514060, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in presynaptic active zone organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    LDL receptor related protein 4
    Names
    CG8909-PB
    CG8909-PC
    CG8909-PD
    Lrp4-PB
    Lrp4-PC
    Lrp4-PD
    yolkless-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15910870..15921013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169298.2 → NP_001162769.1  LDL receptor related protein 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X533
      Conserved Domains (5) summary
      smart00135
      Location:761 → 803
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:267 → 301
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1260 → 1296
      NHL; NHL repeat [structural motif]
      pfam14670
      Location:1185 → 1220
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:1260 → 1445
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_167474.3 → NP_727914.1  LDL receptor related protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXM0
      Related
      FBpp0073931
      Conserved Domains (5) summary
      smart00135
      Location:761 → 803
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:267 → 301
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1260 → 1296
      NHL; NHL repeat [structural motif]
      pfam14670
      Location:1185 → 1220
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:1260 → 1445
      NHL; NHL repeat unit of beta-propeller proteins

    3. NM_001298378.1 → NP_001285307.1  LDL receptor related protein 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X533
      Conserved Domains (5) summary
      smart00135
      Location:761 → 803
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:267 → 301
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1260 → 1296
      NHL; NHL repeat [structural motif]
      pfam14670
      Location:1185 → 1220
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:1260 → 1445
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5X533 B5X533
    Q961N3 Q961N3
    Q9VXM0 Q9VXM0

    Gene LinkOut

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