Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDC 431
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24642347    1600 KVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGS 1640
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24642347    1292 QKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNR 1334
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 24642347  347 CPEGEFKCRGGlggaggpsgQCILNRFRCDGDNDCGDWSDEENC 390
Cdd:cd00112    1 CPPNEFRCANG---------RCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24642347     988 QRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMR 1030
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347  967 IYWTDVERSTINKAHLNGSYQQRVVHS----NLVSPVGLALDwiTDKLYWTDPSTNRIEVATTNGKMrtLLIWEK----- 1037
Cdd:cd14963   69 IYVADLYNGRIQVFDPDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKL--LLEFGKpgsep 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1038 --LYKPRDIVVNPiEGFMFWSDWGDDpMIERANMDGHERVTITSKK-----LIYPNGLAIDyEKSKIYFVDGGTKTLENM 1110
Cdd:cd14963  145 geLSYPNGIAVDE-DGNIYVADSGNG-RIQVFDKNGKFIKELNGSPdgksgFVNPRGIAVD-PDGNLYVVDNLSHRVYVF 221

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 24642347 1111 NFDGS------GRQVILNGLGHPFGLDV-NEGRVFWTDW 1142
Cdd:cd14963  222 DEQGKelftfgGRGKDDGQFNLPNGLFIdDDGRLYVTDR 260

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 24642347    1643 KRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPaKIERSYLDGSNR 1686
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20
                   ....*....|....*....|....*....
gi 24642347    576 CSQKCHNTMGSFKCSCETGYILRPDLRSC 604
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 24642347    1688 VIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRR 1729
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 24642347  480 CDLGQFLCPTKQnltnlkiCVHQKHICDGHNECPAGEDEADC 521
Cdd:cd00112    1 CPPNEFRCANGR-------CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 24642347     946 IVPLDNLKH--AVALDWCSDtdFIYWTDVERSTINKAHLNGS 985
Cdd:smart00135    2 TLLSSGLGHpnGLAVDWIEG--RLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 24642347     806 ILSTHLPHP--FALTLFEDTMYWTDWNTKTVSAAD 838
Cdd:smart00135    3 LLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 24642347     267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDE 298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  442 CGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC 476
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24642347    265 TNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 24642347     441 TCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDE 473
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24642347   1185 CDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTC 1220
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 24642347  347 CPEGEFKCRGGlggaggpsgQCILNRFRCDGDNDCGDWSDEENC 390
Cdd:cd00112    1 CPPNEFRCANG---------RCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24642347     988 QRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMR 1030
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24642347    397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDC 431
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 24642347     397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDE 428
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 24642347    882 GGCSHLCLPNKTSRRCGCPIGLSLKEDGKTC 912
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24642347   1051 GFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDY 1092
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24642347     347 CPEGEFKCRGGlggaggpsgQCILNRFRCDGDNDCGDWSDE 387
Cdd:smart00192    2 CPPGEFQCDNG---------RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 24642347    1643 KRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPaKIERSYLDGSNR 1686
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1269 GYIYWSDTIENVIMSSSPDGLHVQKIVGDSlENPDGLVVDSIGRTIywadAGRHTIEVASLDGSN--RHVIAY---KDLE 1343
Cdd:COG3386   19 GRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDGRLL----VADHGRGLVRFDPADgeVTVLADeygKPLN 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1344 SPRGLALDyEAGLLFWTDWGHYRKIER-SHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYT----- 1417
Cdd:COG3386   94 RPNDGVVD-PDGRLYFTDMGEYLPTGAlYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDadgtl 172

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 24642347 1418 GNQRKLIMSSLHHPYA--LAL-SDDNIYWTDWKSKALH 1452
Cdd:COG3386  173 GNRRVFADLPDGPGGPdgLAVdADGNLWVALWGGGGVV 210

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24642347   1312 RTIYWADAG-RHTIEVASLDGSNRHVIAYKDLESPRGLALDY 1352
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1556 VVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVI-VGTDvltPNGIAVDWIADNLYWSDTDRKliEV 1634
Cdd:COG3391   60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIpVGGG---PRGLAVDPDGGRLYVADSGNG--RV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1635 SRLDGSCRKRIVEDNLGD-PRSLIVHPKKAYLFWSDWSSP--AKIErSYLDGSNRTVIITSGIGF-PTGLTIDFTNRRLL 1710
Cdd:COG3391  135 SVIDTATGKVVATIPVGAgPHGIAVDPDGKRLYVANSGSNtvSVIV-SVIDTATGKVVATIPVGGgPVGVAVSPDGRRLY 213

                 ....
gi 24642347 1711 WADA 1714
Cdd:COG3391  214 VANR 217

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20
                   ....*....|....*....|....*
gi 24642347   1801 CAQDNGGCTHLCLNRNVDYVCACPD 1825
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24642347     718 VIASYDLDKPRAIVVHPGEALAFWSDWGpNPKIERAYMDGTQR 760
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 24642347     564 DIDECQylTSPVCSQ--KCHNTMGSFKCSCETGY 595
Cdd:smart00179    1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGY 32

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347  960 WCSDtDFIYWTDVERSTINKAHLNGSyQQRVVHSNLVSPVGLALD-----WITD---KLYWTDPSTNRIEV-ATTNGKmr 1030
Cdd:COG3386   15 WDPD-GRLYWVDIPGGRIHRYDPDGG-AVEVFAEPSGRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVlADEYGK-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642347 1031 tlliweKLYKPRDIVVNPiEGFMFWSDWGDDPM---IERANMDGheRVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTL 1107
Cdd:COG3386   91 ------PLNRPNDGVVDP-DGRLYFTDMGEYLPtgaLYRVDPDG--SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 24642347 1108 ENMNFDGSG----RQV---ILNGLGHPFGLDV-NEGRVFWTDWDTKSVM 1148
Cdd:COG3386  162 YRFDLDADGtlgnRRVfadLPDGPGGPDGLAVdADGNLWVALWGGGGVV 210

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24642347    782 KIYWADAKQHA-IECSNLDGSDRNKILSTHLPHPFALTLFE 821
Cdd:pfam00058    2 RLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 24642347     634 IVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGT 671
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24642347   1008 DKLYWTDPST-NRIEVATTNGKMRTLLIWEKLYKPRDIVVNP 1048
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24642347    694 DLLFWTDSGTR-RVEVSNFQGNLRTVIASYDLDKPRAIVVHP 734
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24642347     479 QCDLGQFLCPTKQnltnlkiCVHQKHICDGHNECPAGEDE 518
Cdd:smart00192    1 TCPPGEFQCDNGR-------CIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 24642347     806 ILSTHLPHP--FALTLFEDTMYWTDWNTKTVSAAD 838
Cdd:smart00135    3 LLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 24642347     267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDE 298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24642347  442 CGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC 476
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24642347    265 TNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 24642347     441 TCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDE 473
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24642347   1185 CDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTC 1220
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 24642347  347 CPEGEFKCRGGlggaggpsgQCILNRFRCDGDNDCGDWSDEENC 390
Cdd:cd00112    1 CPPNEFRCANG---------RCIPSSWVCDGEDDCGDGSDEENC 35