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    eIF5 eukaryotic translation initiation factor 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF5provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030719
    Locus tag
    Dmel_CG9177
    See related
    AllianceGenome:FB:FBgn0030719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe3C6; CG9177; Dmel\CG9177; EIf5; EIF5
    Summary
    Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Predicted to be involved in formation of cytoplasmic translation initiation complex. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; germline cell; and mesoderm. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF5 in Genome Data Viewer
    Location:
    14A5-14A5; 1-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15987008..15991974, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15881041..15886007, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Solute carrier family 25 member 46a Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit Neighboring gene uncharacterized protein Neighboring gene extradenticle Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS. Gotoh S, et al. J Biol Chem, 2024 Mar. PMID 38301895, Free PMC Article
    2. Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex. Li Z, et al. Stem Cell Res Ther, 2022 Jul 26. PMID 35883200, Free PMC Article
    3. The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Lee S, et al. Development, 2007 May. PMID 17409115
    4. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article
    5. Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Chew SK, et al. Nature, 2009 Jul 2. PMID 19483676, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic initiation factor eIF2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5
    Names
    CG9177-PA
    CG9177-PB
    CG9177-PC
    CG9177-PD
    CG9177-PE
    CG9177-PF
    CG9177-PG
    anon-fast-evolving-3C6
    eIF5-PA
    eIF5-PB
    eIF5-PC
    eIF5-PD
    eIF5-PE
    eIF5-PF
    eIF5-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15987008..15991974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206757.2 → NP_996480.1  eukaryotic translation initiation factor 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    2. NM_206756.2 → NP_996479.1  eukaryotic translation initiation factor 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    3. NM_167477.2 → NP_727922.1  eukaryotic translation initiation factor 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Related
      FBpp0073947
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    4. NM_206755.2 → NP_996478.1  eukaryotic translation initiation factor 5, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    5. NM_132870.4 → NP_573098.1  eukaryotic translation initiation factor 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573098.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Related
      FBpp0073948
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    6. NM_206758.2 → NP_996481.1  eukaryotic translation initiation factor 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    7. NM_206754.2 → NP_996477.1  eukaryotic translation initiation factor 5, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4K0, Q0KHS2, Q9VXK6
      Conserved Domains (2) summary
      cd11561
      Location:254 → 408
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:10 → 127
      eIF-5_eIF-2B; Domain found in IF2B/IF5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXK6.1 Q9VXK6

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