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Conserved domains on  [gi|45555642|ref|NP_996479|]
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eukaryotic translation initiation factor 5, isoform E [Drosophila melanogaster]

Protein Classification

eukaryotic translation initiation factor 5( domain architecture ID 10486941)

eukaryotic translation initiation factor 5 (eIF5) plays a critical role in the translation initiation process by promoting the dissociation of eIF2-GDP from the ribosome, which is necessary for the transition from initiation to the elongation phase of protein synthesis

Gene Ontology:  GO:0005525|GO:0003743|GO:0003723|GO:0071074|GO:0005092|GO:0045296|GO:0005096
PubMed:  21686265

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 254-408 4.25e-59

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


:

Pssm-ID: 211399  Cd Length: 157  Bit Score: 190.91  E-value: 4.25e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 254 DKTEKERIDIFYELVKDKRDKKQLDDVqthKELVIEAERLDII-NKAPLVLAELLFTENIIKDVQKNRPLLLRFTlNNPK 332
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSEL---KEILKEAERLDVVkDKAVLVLAEVLFDENIVKEIKKRKALLLKLV-TDEK 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45555642 333 AQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNA 408
Cdd:cd11561  77 AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 10-129 8.14e-51

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


:

Pssm-ID: 426485  Cd Length: 115  Bit Score: 168.07  E-value: 8.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642    10 VTDIFYRYKMPRLQAKVEGKGngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhKNERFVVNGSHDVNKLQDL 89
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 45555642    90 LDGFIRKFVLCPECDNPETNLTVsaKNQTISQSCKACGFH 129
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIK--ENRLLFLKCEACGAR 115
 
Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 254-408 4.25e-59

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 190.91  E-value: 4.25e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 254 DKTEKERIDIFYELVKDKRDKKQLDDVqthKELVIEAERLDII-NKAPLVLAELLFTENIIKDVQKNRPLLLRFTlNNPK 332
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSEL---KEILKEAERLDVVkDKAVLVLAEVLFDENIVKEIKKRKALLLKLV-TDEK 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45555642 333 AQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNA 408
Cdd:cd11561  77 AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 10-129 8.14e-51

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 168.07  E-value: 8.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642    10 VTDIFYRYKMPRLQAKVEGKGngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhKNERFVVNGSHDVNKLQDL 89
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 45555642    90 LDGFIRKFVLCPECDNPETNLTVsaKNQTISQSCKACGFH 129
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIK--ENRLLFLKCEACGAR 115
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
14-129 5.98e-49

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 162.80  E-value: 5.98e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642     14 FYRYKMPRLQAKVEGKGngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDHKNeRFVVNGSHDVNKLQDLLDGF 93
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKG-RLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 45555642     94 IRKFVLCPECDNPETNLTVSakNQTISQSCKACGFH 129
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE--NRLFFLKCEACGAR 110
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
321-408 2.58e-18

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 79.26  E-value: 2.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642    321 PLLLRFTLNNPKAQRYLIGGVEQ-TVELHKgiLMSKVAGIFKLFYDLDILDEAVILEWAQKVskrhVSKNIAAEIHEKAM 399
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEfCVELEK--LGKLLPKILKSLYDADILEEEAILKWYEKA----VSAEGKKKVRKNAK 74


                   ....*....
gi 45555642    400 PFVLWLKNA 408
Cdd:smart00515  75 PFVTWLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 334-408 7.06e-17

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 74.87  E-value: 7.06e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45555642   334 QRYLIGGVEQTVELHKgILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKrhvSKNIAAEIHEKAMPFVLWLKNA 408
Cdd:pfam02020   1 QVDLLLALQEFCAKLE-ELLKLLLKILKALYDLDIVEEEAILKWWEDVSS---AEKGMKKVRKQAKPFVEWLEEA 71
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 16-127 8.76e-17

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 76.78  E-value: 8.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642  16 RYKMPRLQAKVEGKgngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhkNERFVVNGSHDVNKLQDLLDGFIR 95
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 45555642  96 KFVLCPECDNPETNLTVSAKNQTIsqSCKACG 127
Cdd:COG1601  98 EYVICPECGSPDTRLVKEGRVLML--KCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 16-127 1.53e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 67.63  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642   16 RYKMPRLQAKVEGKgngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhkNERFVVNGSHDVNKLQDLLDGFIR 95
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIE--GGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 45555642   96 KFVLCPECDNPETNLTvsaKNQTISQ-SCKACG 127
Cdd:PRK03988 101 EYVICPECGSPDTKLI---KEGRIWVlKCEACG 130
 
Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 254-408 4.25e-59

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 190.91  E-value: 4.25e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 254 DKTEKERIDIFYELVKDKRDKKQLDDVqthKELVIEAERLDII-NKAPLVLAELLFTENIIKDVQKNRPLLLRFTlNNPK 332
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSEL---KEILKEAERLDVVkDKAVLVLAEVLFDENIVKEIKKRKALLLKLV-TDEK 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45555642 333 AQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNA 408
Cdd:cd11561  77 AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 10-129 8.14e-51

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 168.07  E-value: 8.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642    10 VTDIFYRYKMPRLQAKVEGKGngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhKNERFVVNGSHDVNKLQDL 89
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 45555642    90 LDGFIRKFVLCPECDNPETNLTVsaKNQTISQSCKACGFH 129
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIK--ENRLLFLKCEACGAR 115
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
14-129 5.98e-49

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 162.80  E-value: 5.98e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642     14 FYRYKMPRLQAKVEGKGngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDHKNeRFVVNGSHDVNKLQDLLDGF 93
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKG-RLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 45555642     94 IRKFVLCPECDNPETNLTVSakNQTISQSCKACGFH 129
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE--NRLFFLKCEACGAR 110
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
321-408 2.58e-18

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 79.26  E-value: 2.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642    321 PLLLRFTLNNPKAQRYLIGGVEQ-TVELHKgiLMSKVAGIFKLFYDLDILDEAVILEWAQKVskrhVSKNIAAEIHEKAM 399
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEfCVELEK--LGKLLPKILKSLYDADILEEEAILKWYEKA----VSAEGKKKVRKNAK 74


                   ....*....
gi 45555642    400 PFVLWLKNA 408
Cdd:smart00515  75 PFVTWLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 334-408 7.06e-17

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 74.87  E-value: 7.06e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45555642   334 QRYLIGGVEQTVELHKgILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKrhvSKNIAAEIHEKAMPFVLWLKNA 408
Cdd:pfam02020   1 QVDLLLALQEFCAKLE-ELLKLLLKILKALYDLDIVEEEAILKWWEDVSS---AEKGMKKVRKQAKPFVEWLEEA 71
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 16-127 8.76e-17

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 76.78  E-value: 8.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642  16 RYKMPRLQAKVEGKgngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhkNERFVVNGSHDVNKLQDLLDGFIR 95
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 45555642  96 KFVLCPECDNPETNLTVSAKNQTIsqSCKACG 127
Cdd:COG1601  98 EYVICPECGSPDTRLVKEGRVLML--KCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 16-127 1.53e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 67.63  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642   16 RYKMPRLQAKVEGKgngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhkNERFVVNGSHDVNKLQDLLDGFIR 95
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIE--GGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 45555642   96 KFVLCPECDNPETNLTvsaKNQTISQ-SCKACG 127
Cdd:PRK03988 101 EYVICPECGSPDTKLI---KEGRIWVlKCEACG 130
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
 16-162 2.21e-12

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 65.74  E-value: 2.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642   16 RYKMPRLQAKVEGKgngiKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDhkNERFVVNGSHDVNKLQDLLDGFIR 95
Cdd:PRK12336  23 RFSIPEPKIFIEGK----TTILTNFGEIADALNRDPDHLMKFLQRELGTAGKIE--GGRAVFNGKFTEEDIQAAIDAYVD 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45555642   96 KFVLCPECDNPETNLTVSakNQTISQSCKACGFHgllKVNHKVNTFIVKnppslnpaaQGSSLTEGK 162
Cdd:PRK12336  97 EYVICSECGLPDTRLVKE--DRVLMLRCDACGAH---RPVKKRKASSET---------QREAIEEGK 149
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 255-377 1.64e-11

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 61.72  E-value: 1.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 255 KTEKERIDIFYELVKDKRDKKQLDDVQTHKelVIEAERLDIINKA-PLVLAELLFTENIIKDVQKNRPLLLRFTLNNPKA 333
Cdd:cd11473  12 KELEEDKSSDVESVKAAKSKLDLDPISLEE--VVKVLLTAVVNAVeSADSISLTQKEQLVLVLKKYGPVLRELLKLIKKD 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45555642 334 QRYLIGGVEQTVELHKGI-LMSKVAGIFKLFYDLDILDEAVILEW 377
Cdd:cd11473  90 QLYLLLKIEKLCLQLKLSeLISLLEKILDLLYDADVLSEEAILSW 134
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 310-408 3.25e-08

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 53.03  E-value: 3.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 310 ENIIKDVQKNRPLLLRFtLNNPKAQRYLIGGVE---QTVELHKGILMSkvagIFKLFYDLDILDEAVILEWAQkvSKRHV 386
Cdd:cd11558  70 EALKKLLSKWGPLLENY-VKSQDDQVELLLALEefcLESEEGGPLFAK----LLHALYDLDILEEEAILEWWE--EPDAG 142

                        90       100
                ....*....|....*....|..
gi 45555642 387 SKNIAAEIHEKAMPFVLWLKNA 408
Cdd:cd11558 143 ADEEMKKVRELVKKFIEWLEEA 164
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 307-408 3.96e-04

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 41.43  E-value: 3.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 307 LFTENIIKDVQKNRPLLLRFTlNNPKAQRYLIGGV-EQTVELHKgiLMSKVAGIFKLFYDLDILDEAVILEWaqkVSKRH 385
Cdd:cd11560  96 QIAEQALRHLKKYAPLLAAFC-TTARAELALLNKIqEYCYENMK--FMKVFQKIVKLLYKADVLSEDAILKW---YKKGH 169

                        90       100
                ....*....|....*....|....
gi 45555642 386 VSKniAAEIHEKAM-PFVLWLKNA 408
Cdd:cd11560 170 SPK--GKQVFLKQMePFVEWLQEA 191
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 264-377 4.01e-03

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 37.65  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555642 264 FYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPL-VLAELLfteniikdvQKNRPLLLRFTLNNPKAQRYLIGGVE 342
Cdd:cd11559  23 LYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPeKEKALL---------EKYAPLLQKYLDDDEQLQLQALYALQ 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45555642 343 QTVELH---KGILMSkvagIFKLFYDLDILDEAVILEW 377
Cdd:cd11559  94 ALVHTLefpKGLLLR----FFDALYDEDVIEEEAFLKW 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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