Spef2 sperm flagellar 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Spef2provided by RGD
Full Name: sperm flagellar 2provided by RGD
Primary source: RGD:620450
See related: EnsemblRapid:ENSRNOG00000058275 AllianceGenome:RGD:620450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kpl2
Summary: Predicted to enable protein dimerization activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including brain morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm flagellum assembly. Predicted to be located in Golgi apparatus and sperm flagellum. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 39.0), Lung (RPKM 24.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (60239655..60421850, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (58512489..58694718, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (58901937..59084194, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebrospinal fluid circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mucociliary clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm axoneme assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sperm flagellum assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in manchette	IBA Inferred from Biological aspect of Ancestor more info
located_in manchette	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm flagellar protein 2

Names: sperm flagellar protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415008.1 → NP_001401937.1 sperm flagellar protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2JXL6

Related

ENSRNOP00000070321.2, ENSRNOT00000086323.3
NM_001415009.1 → NP_001401938.1 sperm flagellar protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_022620.2 → NP_072142.2 sperm flagellar protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

60239655..60421850 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103075.2 → XP_038959003.1 sperm flagellar protein 2 isoform X3

UniProtKB/Swiss-Prot

Q4V8M1, Q9R095

Conserved Domains (2) summary

pfam06294
Location:5 → 97

CH_2; CH-like domain in sperm protein

cl17190
Location:616 → 799

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063282495.1 → XP_063138565.1 sperm flagellar protein 2 isoform X2
XM_063282493.1 → XP_063138563.1 sperm flagellar protein 2 isoform X1
XM_039103076.2 → XP_038959004.1 sperm flagellar protein 2 isoform X4

UniProtKB/TrEMBL

A6KGK0

Conserved Domains (1) summary

cl17190
Location:438 → 621

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039103077.2 → XP_038959005.1 sperm flagellar protein 2 isoform X6

UniProtKB/TrEMBL

A6KGK0

Conserved Domains (1) summary

cl17190
Location:177 → 360

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063282496.1 → XP_063138566.1 sperm flagellar protein 2 isoform X5